Obtaining unsteady hydrodynamic performance is of great significance for seaplane design.Common methods for obtaining unsteady hydrodynamic performance data include tank test and Computational Fluid Dynamics(CFD)numer...Obtaining unsteady hydrodynamic performance is of great significance for seaplane design.Common methods for obtaining unsteady hydrodynamic performance data include tank test and Computational Fluid Dynamics(CFD)numerical simulation,which are costly and time-consuming.Therefore,it is necessary to obtain unsteady hydrodynamic performance in a low-cost and high-precision manner.Due to the strong nonlinearity,complex data distribution,and temporal characteristics of unsteady hydrodynamic performance,the prediction of it is challenging.This paper proposes a Temporal Convolutional Diffusion Model(TCDM)for predicting the unsteady hydrodynamic performance of seaplanes given design parameters.Under the framework of a classifier-free guided diffusion model,TCDM learns the distribution patterns of unsteady hydrodynamic performance data with the designed denoising module based on temporal convolutional network and captures the temporal features of unsteady hydrodynamic performance data.Using CFD simulation data,the proposed method is compared with the alternative methods to demonstrate its accuracy and generalization.This paper provides a method that enables the rapid and accurate prediction of unsteady hydrodynamic performance data,expecting to shorten the design cycle of seaplanes.展开更多
AIM：To represent mathematically the intersection between the ectatic corneal geometry and the plane of intracorneal ring implants（ICRS）in order to determine the corneal response to ICRS surgery in keratoconus（KC）...AIM：To represent mathematically the intersection between the ectatic corneal geometry and the plane of intracorneal ring implants（ICRS）in order to determine the corneal response to ICRS surgery in keratoconus（KC）.Thereafter,to present the concept and early results of a newly derived topography-guided nomogram for ICRS surgery for the treatment of keratectasia. METHODS：The corneal rings plane intersection was modelled to a conic section. Ring effect was the result of：the ring size,position（steep vs flat）,location（distance from the geometric centre of the cornea）,and the discrepancy between the ring＇s curvature and the tunnel＇s curvature.Femtosecond laser was used to create the tunnels and the incision sites were chosen according to the nomogram in order to place the thickest ring in the steepest portion of the cornea regardless of the astigmatism axis of refraction.RESULTS：The conic section had a more prolate shape in the steep area of the cornea than in the flat area,depending on the corneal sagittal curvature. Equal ring size had more flattening effect in the steep area than in the flat area. Thick segment should be implanted under the steep portion of the cornea regardless of the cylinder axis of refraction. Single segment in the steep area was sufficient in early and moderate cases of KC. The new nomogram provided more topographic regularity with significant reduction of astigmatism and better improvement in uncorrected visual acuity（UCVA）and best-corrected visual acuity（BCVA）than the conventional nomogram. CONCLUSION：The newly derived nomogram can produce better results than the conventional nomogram. Moreover,based on this concept,a new nomogram can be integrated into the femtosecond laser software to create topography-guided,customized,elliptical tunnels with modified focal asphericity that allows for customized focal flattening of the irregularly steepened ectatic cornea.展开更多
An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,198...An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,1986;Claessens et al.,1989). In our procedure,the geometric restraint of angle N-CA-C is used to generate a list of polypeptide chains,and several filters are used later to select the best conformer.The most important filter is based upon the Ramachandran scatter plot of mainchain dihedral angles PHI and PSI.Results for all test cases are satisfactory,with more than 95%of peptide planes correctly reconstructed and the overall root-mean-square deviation less than 0.5 angstrom compared with the refined X-ray coordinates.展开更多
Objective: to study the family nutrition of patients after gastric cancer surgery under the guidance of guided nursing and the development and application of Wechat management mini program, the two cooperate with each...Objective: to study the family nutrition of patients after gastric cancer surgery under the guidance of guided nursing and the development and application of Wechat management mini program, the two cooperate with each other, with the help of management platform to achieve better treatment effect. Methods: 83 patients who received radical gastrectomy for gastric cancer in our hospital from February 2017 to mid-February 2019 were included in the study. According to the random envelope method, they were divided into experimental group 41 cases and control group 42 cases. A total of 83 patients were randomly divided into two groups by drawing lots: experimental group 41 cases and control group 42 cases. After intervention, EORTCQLQ?C30 score of experimental group was higher than that of control group (all P < 0.05). The total satisfaction of experimental group was higher than that of control group (P < 0.05). Conclusion: the application effect of Wechat mini program for family nutrition support management of postoperative gastric cancer patients under the guidance of guided nursing mode is significant, which is beneficial to improve the nutritional status, satisfaction and quality of life of patients. Experimental studies show that under the guided nursing mode, the application effect of family nutrition management with small procedures for patients undergoing gastric cancer surgery is obvious, which is very beneficial to improve the nutritional status of patients, their satisfaction with the environment, and improve the quality of life.展开更多
基金supported by the Aeronautical Science Foundation of China(Nos.2018ZA52002,2019ZA052011)the National Natural Science Foundation of China(No.12472236).
文摘Obtaining unsteady hydrodynamic performance is of great significance for seaplane design.Common methods for obtaining unsteady hydrodynamic performance data include tank test and Computational Fluid Dynamics(CFD)numerical simulation,which are costly and time-consuming.Therefore,it is necessary to obtain unsteady hydrodynamic performance in a low-cost and high-precision manner.Due to the strong nonlinearity,complex data distribution,and temporal characteristics of unsteady hydrodynamic performance,the prediction of it is challenging.This paper proposes a Temporal Convolutional Diffusion Model(TCDM)for predicting the unsteady hydrodynamic performance of seaplanes given design parameters.Under the framework of a classifier-free guided diffusion model,TCDM learns the distribution patterns of unsteady hydrodynamic performance data with the designed denoising module based on temporal convolutional network and captures the temporal features of unsteady hydrodynamic performance data.Using CFD simulation data,the proposed method is compared with the alternative methods to demonstrate its accuracy and generalization.This paper provides a method that enables the rapid and accurate prediction of unsteady hydrodynamic performance data,expecting to shorten the design cycle of seaplanes.
文摘AIM：To represent mathematically the intersection between the ectatic corneal geometry and the plane of intracorneal ring implants（ICRS）in order to determine the corneal response to ICRS surgery in keratoconus（KC）.Thereafter,to present the concept and early results of a newly derived topography-guided nomogram for ICRS surgery for the treatment of keratectasia. METHODS：The corneal rings plane intersection was modelled to a conic section. Ring effect was the result of：the ring size,position（steep vs flat）,location（distance from the geometric centre of the cornea）,and the discrepancy between the ring＇s curvature and the tunnel＇s curvature.Femtosecond laser was used to create the tunnels and the incision sites were chosen according to the nomogram in order to place the thickest ring in the steepest portion of the cornea regardless of the astigmatism axis of refraction.RESULTS：The conic section had a more prolate shape in the steep area of the cornea than in the flat area,depending on the corneal sagittal curvature. Equal ring size had more flattening effect in the steep area than in the flat area. Thick segment should be implanted under the steep portion of the cornea regardless of the cylinder axis of refraction. Single segment in the steep area was sufficient in early and moderate cases of KC. The new nomogram provided more topographic regularity with significant reduction of astigmatism and better improvement in uncorrected visual acuity（UCVA）and best-corrected visual acuity（BCVA）than the conventional nomogram. CONCLUSION：The newly derived nomogram can produce better results than the conventional nomogram. Moreover,based on this concept,a new nomogram can be integrated into the femtosecond laser software to create topography-guided,customized,elliptical tunnels with modified focal asphericity that allows for customized focal flattening of the irregularly steepened ectatic cornea.
文摘An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,1986;Claessens et al.,1989). In our procedure,the geometric restraint of angle N-CA-C is used to generate a list of polypeptide chains,and several filters are used later to select the best conformer.The most important filter is based upon the Ramachandran scatter plot of mainchain dihedral angles PHI and PSI.Results for all test cases are satisfactory,with more than 95%of peptide planes correctly reconstructed and the overall root-mean-square deviation less than 0.5 angstrom compared with the refined X-ray coordinates.
文摘Objective: to study the family nutrition of patients after gastric cancer surgery under the guidance of guided nursing and the development and application of Wechat management mini program, the two cooperate with each other, with the help of management platform to achieve better treatment effect. Methods: 83 patients who received radical gastrectomy for gastric cancer in our hospital from February 2017 to mid-February 2019 were included in the study. According to the random envelope method, they were divided into experimental group 41 cases and control group 42 cases. A total of 83 patients were randomly divided into two groups by drawing lots: experimental group 41 cases and control group 42 cases. After intervention, EORTCQLQ?C30 score of experimental group was higher than that of control group (all P < 0.05). The total satisfaction of experimental group was higher than that of control group (P < 0.05). Conclusion: the application effect of Wechat mini program for family nutrition support management of postoperative gastric cancer patients under the guidance of guided nursing mode is significant, which is beneficial to improve the nutritional status, satisfaction and quality of life of patients. Experimental studies show that under the guided nursing mode, the application effect of family nutrition management with small procedures for patients undergoing gastric cancer surgery is obvious, which is very beneficial to improve the nutritional status of patients, their satisfaction with the environment, and improve the quality of life.
