Internationally earthquake insurance,like all other insurance (fire,auto),adopted actuarial approach in the past, which is,based on historical loss experience to determine insurance rate.Due to the fact that earthquak...Internationally earthquake insurance,like all other insurance (fire,auto),adopted actuarial approach in the past, which is,based on historical loss experience to determine insurance rate.Due to the fact that earthquake is a rare event with severe consequence,irrational determination of premium rate and lack of understanding scale of potential loss led to many insurance companies insolvent after Northridge earthquake in 1994. Along with recent advances in earth science,computer science and engineering,computerized loss estimation methodologies based on first principles have been developed to the point that losses from destructive earthquakes can be quantified with reasonable accuracy using scientific modeling techniques. This paper intends to introduce how engineering models can assist to quantify earthquake risk and how insurance industry can use this information to manage their risk in the United States and abroad.展开更多
The sensitivity engineering model of the coupling capacitance detector is built to provide the theoretic foundation for designing its circuits and electrodes scientifically. The sensitivity concept model of the capaci...The sensitivity engineering model of the coupling capacitance detector is built to provide the theoretic foundation for designing its circuits and electrodes scientifically. The sensitivity concept model of the capacitance proximity detector is discussed, and the detecting sensitivity of the coupling capacitance detector is analyzed theoretically. Then the sensitivity engineering model, which can reflect the main parameters relationship of the detecting circuit is set up based on the foregoing analyses. It is concluded that: ① the sensitivity is mainly correlative with some parameters including the voltage transmission factor of the demodulator, the oscillating voltage amplitude and the amplitude variation constant of the oscillator; ② the sensitivity is also influenced by the areas of electrodes and the distance between electrodes of the detector.展开更多
To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capab...To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.展开更多
The treatment of a multicomponent reversible reaction network is extremely complicated because largenumber of rate constants must be precisely determined and because the calculation based on these rateconstants is ted...The treatment of a multicomponent reversible reaction network is extremely complicated because largenumber of rate constants must be precisely determined and because the calculation based on these rateconstants is tedious.In order to reduce the degrees of freedom of the process,the authors propose a methodin which the reactor and the separator are regarded as a whole.Based on this approach,an N-componentreversible reaction system can be dealt with as a two—component system.Consequently,a simple and ac-cessible way of the apparent rate determination is suggested.For fiist-order reactions,an explicit,simplifiedexpression has been derived for both lumped and distributed parameter reaction systems.展开更多
A new method for simulation technology of laneway engineering seamless excavation based on 3D geoscience modeling(3DGM)was proposed to overcome the deficiency in current research.The generalized triprism(GTP)data mode...A new method for simulation technology of laneway engineering seamless excavation based on 3D geoscience modeling(3DGM)was proposed to overcome the deficiency in current research.The generalized triprism(GTP)data model was used as the basic modeling element in this method.The models of geological body were created by the method of rock pillar body partition(RPBP)modeling.The laneway engineering models were built with component method,while the corresponding triangles in sections were connected and transformed into tunnel GTP models.All the GTP models were converted into tetrahedron models based on the smallest vertex identifier(SVID).The simulation and spatial analysis of laneway engineering seamless excavation could be realized through the local hierarchical intersection(LHI)algorithm.The application case showed that the method was fast and effective,and it could meet the needs of design and spatial analysis for mine laneway engineering.展开更多
Rehabilitation engineering aims in the upmost degree to restore the lost functions for those persons with physical disability. Biomechanical modeling has been widely used for different purposes in rehabilitation engin...Rehabilitation engineering aims in the upmost degree to restore the lost functions for those persons with physical disability. Biomechanical modeling has been widely used for different purposes in rehabilitation engineering to understand the bio-展开更多
By using the hypothesis of the deformation of the straight bar and beam in mechanics of materials,a new engineering calculating model for a linear inclusion in plane is presented.Through the Kelvin's solution of a...By using the hypothesis of the deformation of the straight bar and beam in mechanics of materials,a new engineering calculating model for a linear inclusion in plane is presented.Through the Kelvin's solution of a concentrated force,the inclusion problem is reduced to solving a set of uncoupled singular integral equations which can be solved by the numerical method of singular integral equation.Based on these results,several applicable examples including an inclusion-crack problem are calculated and the results are quite satisfactory.展开更多
The construction of fully closed check dam (CD) is a conventional flood prevention mechanism implemented on rivers. Fully closed CDs trap large amounts of sediments in rivers to stabilize the river slopes and control ...The construction of fully closed check dam (CD) is a conventional flood prevention mechanism implemented on rivers. Fully closed CDs trap large amounts of sediments in rivers to stabilize the river slopes and control erosion. However, fully closed CDs cannot selectively trap sediment and may easily overflow, causing them to losing their ability to mediate and hold sediments. Previous studies proposed the concept of “breathable CDs”. The researcher introduced metal slit dam (SD) that could be assembled and disassembled quickly and conveniently. Once a CD reaches maximum capacity, operators must ensure that the water channels of the dam are free from blockage. Moreover, they must inspect the internal accumulation conditions of the dam periodically or immediately following heavy typhoon rains. When necessary, either the sediment buildup in the upriver blockage must be cleared, or the transverse structure of the dam must be removed to allow fine particles to be discharged along with a moderate amount of water. These actions can free up the sediment-storing capacity of the dam for the next heavy typhoon rains. In addition, operators should also inspect the damages inflicted on the dam, such as erosion, wear and tear, and deformation conditions. Damaged components should be disassembled and repaired if possible, or recycled and reused. The present study performed channel tests to simulate closed CDs, SDs, steel pipe dam (SPDs), and steel pipe plus slit dam (SPSDs) for 50-year and 100-year frequency floods. Results were then analyzed to determine the sediment trapping (ST) effects of various CDs, the effects of “adjustable CDs”, and the changes of moderated riverbeds.展开更多
A prodouct modeling and a process planning that are two essential basses of realizing concurrent engineering are investigated , a logical modeling technique , grammar representation scheme of technology knowledge and...A prodouct modeling and a process planning that are two essential basses of realizing concurrent engineering are investigated , a logical modeling technique , grammar representation scheme of technology knowledge and architecture of expert system for process planning within con- current engineering environment are proposed. They have been utilized in a real reaserch project.展开更多
In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support ve...In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support vector regression （MRR-LSSVR） machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression （LSSVR） machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5＆. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method.展开更多
In this study,a model is developed to simulate the dynamics of an internal combustion engine,and it is calibrated and validated against reliable experimental data,making it a tool that can effectively be adopted to co...In this study,a model is developed to simulate the dynamics of an internal combustion engine,and it is calibrated and validated against reliable experimental data,making it a tool that can effectively be adopted to conduct emission predictions.In this work,the Ricardo WAVE software is applied to the simulation of a particular marine diesel engine,a four-stroke engine used in the maritime field.Results from the bench tests are used for the calibration of the model.Finally,the calibration of the model and its validation with full-scale data measured at sea are presented.The prediction includes not only the classic engine operating parameters for a comparison with surveys but also an estimate of nitrogen oxide emissions,which are compared with similar results obtained with emission factors.The calibration of the model made it possible to obtain an overlap between the simulation results and real data with an average error of approximately 7%on power,torque,and consumption.The model provides encouraging results,suggesting further applications,such as in the study on transient conditions,coupling of the engine model with the ship model for a complete simulation of the operating conditions,and optimization studies on consumption and emissions.The availability of the emission data during the sea trial and validated simulation results are the strengths and novelties of this work.展开更多
Cancer is a major stress for public well-being and is the most dreadful disease.The models used in the discovery of cancer treatment are continuously changing and extending toward advanced preclinical studies.Cancer m...Cancer is a major stress for public well-being and is the most dreadful disease.The models used in the discovery of cancer treatment are continuously changing and extending toward advanced preclinical studies.Cancer models are either naturally existing or artificially prepared experimental systems that show similar features with human tumors though the heterogeneous nature of the tumor is very familiar.The choice of the most fitting model to best reflect the given tumor system is one of the real difficulties for cancer examination.Therefore,vast studies have been conducted on the cancer models for developing a better understanding of cancer invasion,progression,and early detection.These models give an insight into cancer etiology,molecular basis,host tumor interaction,the role of microenvironment,and tumor heterogeneity in tumor metastasis.These models are also used to predict novel can-cer markers,targeted therapies,and are extremely helpful in drug development.In this review,the potential of cancer models to be used as a platform for drug screening and therapeutic discoveries are highlighted.Although none of the cancer models is regarded as ideal because each is associated with essential caveats that restraint its application yet by bridging the gap between preliminary cancer research and transla-tional medicine.However,they promise a brighter future for cancer treatment.展开更多
Based on characteristic of the associated mining of multi-coal seam and the engineering geological characteristics of overburden,the mining impact pattern of multi- seam mining and the dynamic fracture mechanism of ov...Based on characteristic of the associated mining of multi-coal seam and the engineering geological characteristics of overburden,the mining impact pattern of multi- seam mining and the dynamic fracture mechanism of overburden were characterized by applying the engineering geological mechanical model test.The related strata movement parameters and influence area of multi-seam mining were obtained,the strike boundary angle is 61°,the full extraction coefficient is 0.93,the greatest subsidence angle is 81°,the horizontal movement factor is 0.38,the deviation of inflection point/mining deep is 0.11. The development height of caving zone and water flowing fractured zone of multi-seam mining were calculated,is 32 m and 81.5 m separatly.The assess of influence degree of coal layer safety mining is that,there exists the possibility of water and sand inflow when mining,some messures for mine water prevention and control should be used,and the mining thickness should be local strictly limit.展开更多
When a laser is transmitted in fog, and the water droplets will scatter and absorb the laser, which affects the intensity of the laser transmission and the accuracy of radar detection. Therefore, it is of great signif...When a laser is transmitted in fog, and the water droplets will scatter and absorb the laser, which affects the intensity of the laser transmission and the accuracy of radar detection. Therefore, it is of great significance to study the laser transmission in the fog. At present, the main method of calculating the scattering and attenuation characteristics of fog is based on the radiation transmission theory, which is realized by a large number of numerical calculations or physical simulation methods, which takes time and cannot meet the requirements for obtaining the fast and accurate results. Therefore, in this paper established are a new laser forward attenuation model and backward attenuation model in low visibility fog. It is found that in low visibility environments, the results calculated by the Monte Carlo method are more accurate than those from most of the existing forward attenuation models. For the cases of 0.86-μm, 1.06-μm, 1.315-μm, 10.6-μm typical lasers incident on different fogs with different visibilities, a backscatter model is established, the error between the fitting result and the calculation result is analyzed, the backward attenuation fitting parameters of the new model are tested, and a more accurate fitting result is obtained.展开更多
Volumetric efficiency and air charge estimation is one of the most demanding tasks in control of today's internal combustion engines.Specifically,using three-way catalytic converter involves strict control of the ...Volumetric efficiency and air charge estimation is one of the most demanding tasks in control of today's internal combustion engines.Specifically,using three-way catalytic converter involves strict control of the air/fuel ratio around the stoichiometric point and hence requires an accurate model for air charge estimation.However,high degrees of complexity and nonlinearity of the gas flow in the internal combustion engine make air charge estimation a challenging task.This is more obvious in engines with variable valve timing systems in which gas flow is more complex and depends on more functional variables.This results in models that are either quite empirical(such as look-up tables),not having interpretability and extrapolation capability,or physically based models which are not appropriate for onboard applications.Solving these problems,a novel semi-empirical model was proposed in this work which only needed engine speed,load,and valves timings for volumetric efficiency prediction.The accuracy and generalizability of the model is shown by its test on numerical and experimental data from three distinct engines.Normalized test errors are 0.0316,0.0152 and 0.24 for the three engines,respectively.Also the performance and complexity of the model were compared with neural networks as typical black box models.While the complexity of the model is less than half of the complexity of neural networks,and its computational cost is approximately 0.12 of that of neural networks and its prediction capability in the considered case studies is usually more.These results show the superiority of the proposed model over conventional black box models such as neural networks in terms of accuracy,generalizability and computational cost.展开更多
This paper focuses on the prediction of the safe autorotation landing operations of a helicopter following engine failure.The autorotation landing procedure is formulated as a nonlinear optimal control problem based o...This paper focuses on the prediction of the safe autorotation landing operations of a helicopter following engine failure.The autorotation landing procedure is formulated as a nonlinear optimal control problem based on an augmented six-degree-of-freedom rigid-body flight dynamic model.First,the cost function and constraints are properly selected.The direct transcription approach is then employed to solve the optimal control problem.For a UH-60 helicopter,the optimal solutions with the rigid-body model are compared with those obtained using a two-dimensional point-mass model.It is found that the optimal solutions using the two different models show reasonably good agreement,and furthermore the optimal solutions using the rigid-body model involve the time histories of angular rates and attitudes,lateral velocity and position,as well as pitch controls.Finally the optimal control formulations with different cost functions are proposed for taking account of 1-s time delay and minimum touchdown speed.The calculated control strategies and trajectories are realistic.展开更多
A speed control analysis for an in-line gasoline fueled internal combustion(IC)engine is presented for the purpose of alleviation of high frequency oscillations in engine revolutions.A dynamic cylinder-by-cylinder mod...A speed control analysis for an in-line gasoline fueled internal combustion(IC)engine is presented for the purpose of alleviation of high frequency oscillations in engine revolutions.A dynamic cylinder-by-cylinder model is proposed,base on slider-crank mechanism,which is extended to develop a digital governor providing a high fidelity estimation of rotary speed oscillation for hybrid vehicle engines.A modified PID controller that P and I gain is placed in feedback path is also described for hybrid electric vehicle(HEV)engine speed regulation,By comparison between measured and estimated signals,it is demonstrated that a good agreement has been achieved and the governor behaves an excellent damping speed ripple.展开更多
To predict the effect of the liquid rocket engine combustion chamber conditions on the impingement spray, the conventional uncoupled spray model for impinging injectors is extended by considering the coupling of the j...To predict the effect of the liquid rocket engine combustion chamber conditions on the impingement spray, the conventional uncoupled spray model for impinging injectors is extended by considering the coupling of the jet impingement process and the ambient gas field. The new coupled model consists of the plain-orifice sub-model, the jet-jet impingement sub-model and the droplet collision sub-model. The parameters of the child droplet are determined with the jet-jet impingement sub-model using correlations about the liquid jet parameters and the chamber conditions.The overall model is benchmarked under various impingement angles, jet momentum and offcenter ratios. Agreement with the published experimental data validates the ability of the model to predict the key spray characteristics, such as the mass flux and mixture ratio distributions in quiescent air. Besides, impinging sprays under changing ambient pressure and non-uniform gas flow are investigated to explore the effect of liquid rocket engine chamber conditions. First, a transient impingement spray during engine start-up phase is simulated with prescribed pressure profile. The minimum average droplet diameter is achieved when the orifices work in cavitation state, and is about 30% smaller than the steady single phase state. Second, the effect of non-uniform gas flow produces off-center impingement and the rotated spray fan by 38°. The proposed model suggests more reasonable impingement spray characteristics than the uncoupled one and can be used as the first step in the complex simulation of coupling impingement spray and combustion in liquid rocket engines.展开更多
文摘Internationally earthquake insurance,like all other insurance (fire,auto),adopted actuarial approach in the past, which is,based on historical loss experience to determine insurance rate.Due to the fact that earthquake is a rare event with severe consequence,irrational determination of premium rate and lack of understanding scale of potential loss led to many insurance companies insolvent after Northridge earthquake in 1994. Along with recent advances in earth science,computer science and engineering,computerized loss estimation methodologies based on first principles have been developed to the point that losses from destructive earthquakes can be quantified with reasonable accuracy using scientific modeling techniques. This paper intends to introduce how engineering models can assist to quantify earthquake risk and how insurance industry can use this information to manage their risk in the United States and abroad.
文摘The sensitivity engineering model of the coupling capacitance detector is built to provide the theoretic foundation for designing its circuits and electrodes scientifically. The sensitivity concept model of the capacitance proximity detector is discussed, and the detecting sensitivity of the coupling capacitance detector is analyzed theoretically. Then the sensitivity engineering model, which can reflect the main parameters relationship of the detecting circuit is set up based on the foregoing analyses. It is concluded that: ① the sensitivity is mainly correlative with some parameters including the voltage transmission factor of the demodulator, the oscillating voltage amplitude and the amplitude variation constant of the oscillator; ② the sensitivity is also influenced by the areas of electrodes and the distance between electrodes of the detector.
基金The Basic Research of COSTIND,China (No.D0420060521)
文摘To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.
文摘The treatment of a multicomponent reversible reaction network is extremely complicated because largenumber of rate constants must be precisely determined and because the calculation based on these rateconstants is tedious.In order to reduce the degrees of freedom of the process,the authors propose a methodin which the reactor and the separator are regarded as a whole.Based on this approach,an N-componentreversible reaction system can be dealt with as a two—component system.Consequently,a simple and ac-cessible way of the apparent rate determination is suggested.For fiist-order reactions,an explicit,simplifiedexpression has been derived for both lumped and distributed parameter reaction systems.
文摘A new method for simulation technology of laneway engineering seamless excavation based on 3D geoscience modeling(3DGM)was proposed to overcome the deficiency in current research.The generalized triprism(GTP)data model was used as the basic modeling element in this method.The models of geological body were created by the method of rock pillar body partition(RPBP)modeling.The laneway engineering models were built with component method,while the corresponding triangles in sections were connected and transformed into tunnel GTP models.All the GTP models were converted into tetrahedron models based on the smallest vertex identifier(SVID).The simulation and spatial analysis of laneway engineering seamless excavation could be realized through the local hierarchical intersection(LHI)algorithm.The application case showed that the method was fast and effective,and it could meet the needs of design and spatial analysis for mine laneway engineering.
基金Research Grant Council of Hong Kong (GRF Project nos PolyU5331 /07E,PolyU5352 /08E)a grant from Ministry of Sciences and Technology,China (No 2006BAI22B00)
文摘Rehabilitation engineering aims in the upmost degree to restore the lost functions for those persons with physical disability. Biomechanical modeling has been widely used for different purposes in rehabilitation engineering to understand the bio-
基金The project supported by National Natural Science Foundation of China.
文摘By using the hypothesis of the deformation of the straight bar and beam in mechanics of materials,a new engineering calculating model for a linear inclusion in plane is presented.Through the Kelvin's solution of a concentrated force,the inclusion problem is reduced to solving a set of uncoupled singular integral equations which can be solved by the numerical method of singular integral equation.Based on these results,several applicable examples including an inclusion-crack problem are calculated and the results are quite satisfactory.
文摘The construction of fully closed check dam (CD) is a conventional flood prevention mechanism implemented on rivers. Fully closed CDs trap large amounts of sediments in rivers to stabilize the river slopes and control erosion. However, fully closed CDs cannot selectively trap sediment and may easily overflow, causing them to losing their ability to mediate and hold sediments. Previous studies proposed the concept of “breathable CDs”. The researcher introduced metal slit dam (SD) that could be assembled and disassembled quickly and conveniently. Once a CD reaches maximum capacity, operators must ensure that the water channels of the dam are free from blockage. Moreover, they must inspect the internal accumulation conditions of the dam periodically or immediately following heavy typhoon rains. When necessary, either the sediment buildup in the upriver blockage must be cleared, or the transverse structure of the dam must be removed to allow fine particles to be discharged along with a moderate amount of water. These actions can free up the sediment-storing capacity of the dam for the next heavy typhoon rains. In addition, operators should also inspect the damages inflicted on the dam, such as erosion, wear and tear, and deformation conditions. Damaged components should be disassembled and repaired if possible, or recycled and reused. The present study performed channel tests to simulate closed CDs, SDs, steel pipe dam (SPDs), and steel pipe plus slit dam (SPSDs) for 50-year and 100-year frequency floods. Results were then analyzed to determine the sediment trapping (ST) effects of various CDs, the effects of “adjustable CDs”, and the changes of moderated riverbeds.
文摘A prodouct modeling and a process planning that are two essential basses of realizing concurrent engineering are investigated , a logical modeling technique , grammar representation scheme of technology knowledge and architecture of expert system for process planning within con- current engineering environment are proposed. They have been utilized in a real reaserch project.
基金co-supported by Aeronautical Science Foundation of China (No. 2010ZB52011)Funding of Jiangsu Innovation Program for Graduate Education (No.CXLX11_0213)
文摘In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support vector regression （MRR-LSSVR） machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression （LSSVR） machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5＆. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method.
基金Open access funding provided by Universita degli Studi di Napoli Federico II within the CRUI-CARE Agreement.
文摘In this study,a model is developed to simulate the dynamics of an internal combustion engine,and it is calibrated and validated against reliable experimental data,making it a tool that can effectively be adopted to conduct emission predictions.In this work,the Ricardo WAVE software is applied to the simulation of a particular marine diesel engine,a four-stroke engine used in the maritime field.Results from the bench tests are used for the calibration of the model.Finally,the calibration of the model and its validation with full-scale data measured at sea are presented.The prediction includes not only the classic engine operating parameters for a comparison with surveys but also an estimate of nitrogen oxide emissions,which are compared with similar results obtained with emission factors.The calibration of the model made it possible to obtain an overlap between the simulation results and real data with an average error of approximately 7%on power,torque,and consumption.The model provides encouraging results,suggesting further applications,such as in the study on transient conditions,coupling of the engine model with the ship model for a complete simulation of the operating conditions,and optimization studies on consumption and emissions.The availability of the emission data during the sea trial and validated simulation results are the strengths and novelties of this work.
文摘Cancer is a major stress for public well-being and is the most dreadful disease.The models used in the discovery of cancer treatment are continuously changing and extending toward advanced preclinical studies.Cancer models are either naturally existing or artificially prepared experimental systems that show similar features with human tumors though the heterogeneous nature of the tumor is very familiar.The choice of the most fitting model to best reflect the given tumor system is one of the real difficulties for cancer examination.Therefore,vast studies have been conducted on the cancer models for developing a better understanding of cancer invasion,progression,and early detection.These models give an insight into cancer etiology,molecular basis,host tumor interaction,the role of microenvironment,and tumor heterogeneity in tumor metastasis.These models are also used to predict novel can-cer markers,targeted therapies,and are extremely helpful in drug development.In this review,the potential of cancer models to be used as a platform for drug screening and therapeutic discoveries are highlighted.Although none of the cancer models is regarded as ideal because each is associated with essential caveats that restraint its application yet by bridging the gap between preliminary cancer research and transla-tional medicine.However,they promise a brighter future for cancer treatment.
基金the National Natural Science Foundation of China(40372123)
文摘Based on characteristic of the associated mining of multi-coal seam and the engineering geological characteristics of overburden,the mining impact pattern of multi- seam mining and the dynamic fracture mechanism of overburden were characterized by applying the engineering geological mechanical model test.The related strata movement parameters and influence area of multi-seam mining were obtained,the strike boundary angle is 61°,the full extraction coefficient is 0.93,the greatest subsidence angle is 81°,the horizontal movement factor is 0.38,the deviation of inflection point/mining deep is 0.11. The development height of caving zone and water flowing fractured zone of multi-seam mining were calculated,is 32 m and 81.5 m separatly.The assess of influence degree of coal layer safety mining is that,there exists the possibility of water and sand inflow when mining,some messures for mine water prevention and control should be used,and the mining thickness should be local strictly limit.
基金supported by the National Natural Science Foundation of China (Grant Nos. 61571355 and 61401342)。
文摘When a laser is transmitted in fog, and the water droplets will scatter and absorb the laser, which affects the intensity of the laser transmission and the accuracy of radar detection. Therefore, it is of great significance to study the laser transmission in the fog. At present, the main method of calculating the scattering and attenuation characteristics of fog is based on the radiation transmission theory, which is realized by a large number of numerical calculations or physical simulation methods, which takes time and cannot meet the requirements for obtaining the fast and accurate results. Therefore, in this paper established are a new laser forward attenuation model and backward attenuation model in low visibility fog. It is found that in low visibility environments, the results calculated by the Monte Carlo method are more accurate than those from most of the existing forward attenuation models. For the cases of 0.86-μm, 1.06-μm, 1.315-μm, 10.6-μm typical lasers incident on different fogs with different visibilities, a backscatter model is established, the error between the fitting result and the calculation result is analyzed, the backward attenuation fitting parameters of the new model are tested, and a more accurate fitting result is obtained.
文摘Volumetric efficiency and air charge estimation is one of the most demanding tasks in control of today's internal combustion engines.Specifically,using three-way catalytic converter involves strict control of the air/fuel ratio around the stoichiometric point and hence requires an accurate model for air charge estimation.However,high degrees of complexity and nonlinearity of the gas flow in the internal combustion engine make air charge estimation a challenging task.This is more obvious in engines with variable valve timing systems in which gas flow is more complex and depends on more functional variables.This results in models that are either quite empirical(such as look-up tables),not having interpretability and extrapolation capability,or physically based models which are not appropriate for onboard applications.Solving these problems,a novel semi-empirical model was proposed in this work which only needed engine speed,load,and valves timings for volumetric efficiency prediction.The accuracy and generalizability of the model is shown by its test on numerical and experimental data from three distinct engines.Normalized test errors are 0.0316,0.0152 and 0.24 for the three engines,respectively.Also the performance and complexity of the model were compared with neural networks as typical black box models.While the complexity of the model is less than half of the complexity of neural networks,and its computational cost is approximately 0.12 of that of neural networks and its prediction capability in the considered case studies is usually more.These results show the superiority of the proposed model over conventional black box models such as neural networks in terms of accuracy,generalizability and computational cost.
文摘This paper focuses on the prediction of the safe autorotation landing operations of a helicopter following engine failure.The autorotation landing procedure is formulated as a nonlinear optimal control problem based on an augmented six-degree-of-freedom rigid-body flight dynamic model.First,the cost function and constraints are properly selected.The direct transcription approach is then employed to solve the optimal control problem.For a UH-60 helicopter,the optimal solutions with the rigid-body model are compared with those obtained using a two-dimensional point-mass model.It is found that the optimal solutions using the two different models show reasonably good agreement,and furthermore the optimal solutions using the rigid-body model involve the time histories of angular rates and attitudes,lateral velocity and position,as well as pitch controls.Finally the optimal control formulations with different cost functions are proposed for taking account of 1-s time delay and minimum touchdown speed.The calculated control strategies and trajectories are realistic.
基金supported by National Hi-tech Research and Development Program of China(863 Program,No.2001AA501211).
文摘A speed control analysis for an in-line gasoline fueled internal combustion(IC)engine is presented for the purpose of alleviation of high frequency oscillations in engine revolutions.A dynamic cylinder-by-cylinder model is proposed,base on slider-crank mechanism,which is extended to develop a digital governor providing a high fidelity estimation of rotary speed oscillation for hybrid vehicle engines.A modified PID controller that P and I gain is placed in feedback path is also described for hybrid electric vehicle(HEV)engine speed regulation,By comparison between measured and estimated signals,it is demonstrated that a good agreement has been achieved and the governor behaves an excellent damping speed ripple.
文摘To predict the effect of the liquid rocket engine combustion chamber conditions on the impingement spray, the conventional uncoupled spray model for impinging injectors is extended by considering the coupling of the jet impingement process and the ambient gas field. The new coupled model consists of the plain-orifice sub-model, the jet-jet impingement sub-model and the droplet collision sub-model. The parameters of the child droplet are determined with the jet-jet impingement sub-model using correlations about the liquid jet parameters and the chamber conditions.The overall model is benchmarked under various impingement angles, jet momentum and offcenter ratios. Agreement with the published experimental data validates the ability of the model to predict the key spray characteristics, such as the mass flux and mixture ratio distributions in quiescent air. Besides, impinging sprays under changing ambient pressure and non-uniform gas flow are investigated to explore the effect of liquid rocket engine chamber conditions. First, a transient impingement spray during engine start-up phase is simulated with prescribed pressure profile. The minimum average droplet diameter is achieved when the orifices work in cavitation state, and is about 30% smaller than the steady single phase state. Second, the effect of non-uniform gas flow produces off-center impingement and the rotated spray fan by 38°. The proposed model suggests more reasonable impingement spray characteristics than the uncoupled one and can be used as the first step in the complex simulation of coupling impingement spray and combustion in liquid rocket engines.
