Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of t...Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of the in vivo tumor microenvironment(TME),limiting their utility for drug resistance research.Therefore,three-dimensional(3D)tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms.In this review,various cancer 3D models,including spheroids,organoids,scaffold-based models,and bioprinted models,are comprehensively evaluated with a focus on their application in drug resistance studies.We discuss the materials,properties,and advantages of each model,highlighting their ability to better mimic the TME and represent complex mechanisms of drug resistance such as epithelial-mesenchymal transition(EMT),drug efflux,and tumor-stroma interactions.Furthermore,we investigate the limitations of these models,including scalability,reproducibility and technical challenges,as well as their potential therapeutic impact on personalized medicine.Through a thorough comparison of model performance,we provide insights into the strengths and weaknesses of each approach and offer guidance for model selection based on specific research needs.展开更多
【目的】解决钢箱系杆拱桥的钢拱肋在施工过程中精度控制难度大和耗时长的问题。【方法】以某钢箱系杆拱桥为工程背景,采用建筑信息模型(building information modeling,BIM)及3D激光扫描技术,对拱肋钢构件在加工制作与拼接过程中的质...【目的】解决钢箱系杆拱桥的钢拱肋在施工过程中精度控制难度大和耗时长的问题。【方法】以某钢箱系杆拱桥为工程背景,采用建筑信息模型(building information modeling,BIM)及3D激光扫描技术,对拱肋钢构件在加工制作与拼接过程中的质量检测进行信息化管控。【结果】BIM技术结合3D激光扫描技术可快速地检测钢拱肋构件的质量并监测拱肋施工线形;钢箱拱肋构件的最大制作误差在1.2 mm以内,构件在拼接过程中的最大误差在1.1 mm以内,以上误差均满足设计规范的要求;与传统检测方法相比,点云数据在各坐标轴方向的偏差为1.0~3.0 mm,平均偏差为1.2~1.5 mm,具有较高的可靠性。【结论】基于BIM+3D激光扫描技术,可实现钢箱拱肋构件施工过程中拱肋线形质量的动态管控。展开更多
背景:3D打印技术可根据患者实际病情和治疗需求设计构建模型、手术导板和个性化植入体或固定物,在创伤性骨折修复中展示了巨大的应用前景。目的:综述3D打印技术在创伤性骨折中的应用。方法:检索Web of science、PubMed和中国知网数据库2...背景:3D打印技术可根据患者实际病情和治疗需求设计构建模型、手术导板和个性化植入体或固定物,在创伤性骨折修复中展示了巨大的应用前景。目的:综述3D打印技术在创伤性骨折中的应用。方法:检索Web of science、PubMed和中国知网数据库2020-2024年发表的创伤骨科领域3D打印技术应用的相关文献,英文检索词为“traumatic fracture,3D printing technology,digital model,surgical guide”,中文检索词为“创伤性骨折,3D打印技术,数字模型,手术导板”,经筛选和分析,最终纳入60篇文献进行分析。结果与结论:①创伤性骨折是各种致伤因素导致的骨骼连续性中断和完整性破坏的骨折现象,以可靠方案提高复位愈合效果,已成为骨外科相关研究领域亟需解决的热点问题;②3D打印技术是以数字模型数据为基础的,运用粉末状金属或聚合物等可黏合成型材料以立体光刻、沉积建模和光聚合物喷射等形式制造满足需求三维实体的技术,在数字骨科生物医学领域应用广泛;③3D打印技术在疾病诊断、术前规划、重建骨折三维模型、定制骨科植入体、定制固定支具及假肢、手术导板制作和骨缺损修复等方面发挥了显著的优势,可根据患者实际病情和治疗需求设计构建模型、手术导板和个性化植入体或固定物,为创伤性骨折的治疗提供了新的思路。展开更多
目的 探讨3D建模精准穿刺治疗高血压脑出血的临床效果与安全性。方法 选取2022年7月—2024年6月如东县人民医院脑外科收治的92例高血压脑出血手术患者,按照治疗方法不同分为观察组(n=46)和对照组(n=46),观察组实施3D Slicer建模评估定...目的 探讨3D建模精准穿刺治疗高血压脑出血的临床效果与安全性。方法 选取2022年7月—2024年6月如东县人民医院脑外科收治的92例高血压脑出血手术患者,按照治疗方法不同分为观察组(n=46)和对照组(n=46),观察组实施3D Slicer建模评估定位精准穿刺,对照组实施传统开颅手术。对比两组围手术期指标、格拉斯哥预后量表(Glasgow Outcome Scale,GOS)评分、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、术中不良事件与术后并发症发生情况,术后随访1年,统计两组预后情况、日常生活能力量表(Activity of Daily Living Scale,ADL)评分。结果 与对照组相比,观察组手术时间、术中出血量、血肿清除率、住院天数更优,差异均有统计学意义(P均<0.05)。观察组术后4周的GOS评分及术后8周的NIHSS评分优于对照组,差异均有统计学意义(P均<0.05)。两组术中不良事件发生率比较,差异无统计学意义(P>0.05)。观察组并发症发生率、致残和病死率低于对照组,差异均有统计学意义(P均<0.05)。术后随访1年,观察组ADL评分为(82.31±7.15)分,高于对照组的(71.68±6.47)分,差异有统计学意义(t=7.477,P<0.001)。结论3D建模精准穿刺治疗高血压脑出血的临床效果确切,可有效定位和清除血肿,减少并发症、致残和病死率。展开更多
基金funded by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia(grant numbers 451-03-136/2025-03/200007 and 451-03-136/2025-03/200042).
文摘Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of the in vivo tumor microenvironment(TME),limiting their utility for drug resistance research.Therefore,three-dimensional(3D)tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms.In this review,various cancer 3D models,including spheroids,organoids,scaffold-based models,and bioprinted models,are comprehensively evaluated with a focus on their application in drug resistance studies.We discuss the materials,properties,and advantages of each model,highlighting their ability to better mimic the TME and represent complex mechanisms of drug resistance such as epithelial-mesenchymal transition(EMT),drug efflux,and tumor-stroma interactions.Furthermore,we investigate the limitations of these models,including scalability,reproducibility and technical challenges,as well as their potential therapeutic impact on personalized medicine.Through a thorough comparison of model performance,we provide insights into the strengths and weaknesses of each approach and offer guidance for model selection based on specific research needs.
文摘目的 探讨3D建模精准穿刺治疗高血压脑出血的临床效果与安全性。方法 选取2022年7月—2024年6月如东县人民医院脑外科收治的92例高血压脑出血手术患者,按照治疗方法不同分为观察组(n=46)和对照组(n=46),观察组实施3D Slicer建模评估定位精准穿刺,对照组实施传统开颅手术。对比两组围手术期指标、格拉斯哥预后量表(Glasgow Outcome Scale,GOS)评分、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、术中不良事件与术后并发症发生情况,术后随访1年,统计两组预后情况、日常生活能力量表(Activity of Daily Living Scale,ADL)评分。结果 与对照组相比,观察组手术时间、术中出血量、血肿清除率、住院天数更优,差异均有统计学意义(P均<0.05)。观察组术后4周的GOS评分及术后8周的NIHSS评分优于对照组,差异均有统计学意义(P均<0.05)。两组术中不良事件发生率比较,差异无统计学意义(P>0.05)。观察组并发症发生率、致残和病死率低于对照组,差异均有统计学意义(P均<0.05)。术后随访1年,观察组ADL评分为(82.31±7.15)分,高于对照组的(71.68±6.47)分,差异有统计学意义(t=7.477,P<0.001)。结论3D建模精准穿刺治疗高血压脑出血的临床效果确切,可有效定位和清除血肿,减少并发症、致残和病死率。
