The stereoselective construction of vicinal all-carbon quaternary stereocenters has long been a formidable synthetic challenge.Direct asymmetric coupling of a tertiary carbon nucleophile with a tertiary carbon electro...The stereoselective construction of vicinal all-carbon quaternary stereocenters has long been a formidable synthetic challenge.Direct asymmetric coupling of a tertiary carbon nucleophile with a tertiary carbon electrophile is themost straightforward approach,but it is sterically and energetically disfavored.Herein,we describe a catalytic asymmetric substitution,where racemic tertiary bromides coupled directly with racemic secondary or tertiary carbanion.展开更多
基金support from Nanyang Technological University for Tier 1 grants(RG1/19 and RG2/20)and Ministry of Education(Singapore)Tier 2 grants(no.MOE2019-T2-1-091)the University of Wollongong(VC Fellowship)and the Australian Research Council(DECRA DE210100053).
文摘The stereoselective construction of vicinal all-carbon quaternary stereocenters has long been a formidable synthetic challenge.Direct asymmetric coupling of a tertiary carbon nucleophile with a tertiary carbon electrophile is themost straightforward approach,but it is sterically and energetically disfavored.Herein,we describe a catalytic asymmetric substitution,where racemic tertiary bromides coupled directly with racemic secondary or tertiary carbanion.
