Background: No method for the clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease (sCJD) has been established exce pt for pathologic examination. Objective: To identify a reliable marker for the clinical...Background: No method for the clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease (sCJD) has been established exce pt for pathologic examination. Objective: To identify a reliable marker for the clinical diagnosis of MM2-type sCJD.Methods: CSF, EEG, and neuro imaging studie s were performed in eight patients with MM2-type sCJD confirmed by neuropatholo gic,genetic, and western blot analyses. Results: The eight cases were pathologic ally classified into the cortical (n= 2), thalamic (n = 5), and combined (cortic othalamic) (n =1) forms. The cortical form was characterized by late-onset,slow ly progressive dementia, cortical hyperintensity signals on diffusion-weighted imaging (DWI) of brain, and elevated levels of CSF 14-3-3 protein. The thalami c form showed various neurologic manifestations including dementia, ataxia, and pyramidal and extrapyramidal signs with onset at various ages and relatively lon g disease duration. Characteristic EEG and MRI abnormalities were almost absent. However, all four patients examined with cerebral blood flow (CBF) study using SPECT showed reduction of the CBF in the thalamus as well as the cerebral cortex . The combined form had features of both the cortical and the thalamic forms, sh owing cortical hyperintensity signals on DWI and hypometabolism of the thalamus on [18F]2-fluoro-2-deoxy-D-glucose PET. Conclusion: For the clinical diagno sis of MM2-type sporadic Creutzfeldt-Jakob disease,cortical hyperintensity sig nals on diffusion-weighted MRI are useful for the cortical form and thalamic hy poperfusion or hypometabolism on cerebral blood flow SPECT or [18F]2-fluoro-2 -deoxy-D-glucose PET for the thalamic form.展开更多
Linear推出采用小型20mm2封装的RS485/RS232多协议收发器LTC2873。该器件集成了提供现今市场上最紧凑的多协议IC所必需的全部功能。LTC2873支持±26k V HBM ESD总线保护,为3V^5.5V系统提供坚固的软件可选接口。一个简单的逻辑接口...Linear推出采用小型20mm2封装的RS485/RS232多协议收发器LTC2873。该器件集成了提供现今市场上最紧凑的多协议IC所必需的全部功能。LTC2873支持±26k V HBM ESD总线保护,为3V^5.5V系统提供坚固的软件可选接口。一个简单的逻辑接口支持低至1.7V的电压,允许将共享总线重新配置为一个RS232单端收发器或一个半双工RS485差分收发器。此外。展开更多
AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glauc...AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.展开更多
A set of force field parameters for the radical cation of diazabicycle alkane are derived by "substracting" nonbonded molecular mechanics energies (MM2 method) from corresponding molecular orbital energies (...A set of force field parameters for the radical cation of diazabicycle alkane are derived by "substracting" nonbonded molecular mechanics energies (MM2 method) from corresponding molecular orbital energies (MNDO method) using a model compound containing the chemical structure to be parameterized. A general discussion of the N, N’ two-center three electrones bond in radical cations. The results are satisfactory.展开更多
文摘Background: No method for the clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease (sCJD) has been established exce pt for pathologic examination. Objective: To identify a reliable marker for the clinical diagnosis of MM2-type sCJD.Methods: CSF, EEG, and neuro imaging studie s were performed in eight patients with MM2-type sCJD confirmed by neuropatholo gic,genetic, and western blot analyses. Results: The eight cases were pathologic ally classified into the cortical (n= 2), thalamic (n = 5), and combined (cortic othalamic) (n =1) forms. The cortical form was characterized by late-onset,slow ly progressive dementia, cortical hyperintensity signals on diffusion-weighted imaging (DWI) of brain, and elevated levels of CSF 14-3-3 protein. The thalami c form showed various neurologic manifestations including dementia, ataxia, and pyramidal and extrapyramidal signs with onset at various ages and relatively lon g disease duration. Characteristic EEG and MRI abnormalities were almost absent. However, all four patients examined with cerebral blood flow (CBF) study using SPECT showed reduction of the CBF in the thalamus as well as the cerebral cortex . The combined form had features of both the cortical and the thalamic forms, sh owing cortical hyperintensity signals on DWI and hypometabolism of the thalamus on [18F]2-fluoro-2-deoxy-D-glucose PET. Conclusion: For the clinical diagno sis of MM2-type sporadic Creutzfeldt-Jakob disease,cortical hyperintensity sig nals on diffusion-weighted MRI are useful for the cortical form and thalamic hy poperfusion or hypometabolism on cerebral blood flow SPECT or [18F]2-fluoro-2 -deoxy-D-glucose PET for the thalamic form.
文摘Linear推出采用小型20mm2封装的RS485/RS232多协议收发器LTC2873。该器件集成了提供现今市场上最紧凑的多协议IC所必需的全部功能。LTC2873支持±26k V HBM ESD总线保护,为3V^5.5V系统提供坚固的软件可选接口。一个简单的逻辑接口支持低至1.7V的电压,允许将共享总线重新配置为一个RS232单端收发器或一个半双工RS485差分收发器。此外。
文摘AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.
文摘A set of force field parameters for the radical cation of diazabicycle alkane are derived by "substracting" nonbonded molecular mechanics energies (MM2 method) from corresponding molecular orbital energies (MNDO method) using a model compound containing the chemical structure to be parameterized. A general discussion of the N, N’ two-center three electrones bond in radical cations. The results are satisfactory.
