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Optimizing Fine-Tuning in Quantized Language Models:An In-Depth Analysis of Key Variables
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作者 Ao Shen Zhiquan Lai +1 位作者 Dongsheng Li Xiaoyu Hu 《Computers, Materials & Continua》 SCIE EI 2025年第1期307-325,共19页
Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning paradigm.While this approach allows models to specialize in speci... Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning paradigm.While this approach allows models to specialize in specific tasks with reduced training costs,the substantial memory requirements during fine-tuning present a barrier to broader deployment.Parameter-Efficient Fine-Tuning(PEFT)techniques,such as Low-Rank Adaptation(LoRA),and parameter quantization methods have emerged as solutions to address these challenges by optimizing memory usage and computational efficiency.Among these,QLoRA,which combines PEFT and quantization,has demonstrated notable success in reducing memory footprints during fine-tuning,prompting the development of various QLoRA variants.Despite these advancements,the quantitative impact of key variables on the fine-tuning performance of quantized LLMs remains underexplored.This study presents a comprehensive analysis of these key variables,focusing on their influence across different layer types and depths within LLM architectures.Our investigation uncovers several critical findings:(1)Larger layers,such as MLP layers,can maintain performance despite reductions in adapter rank,while smaller layers,like self-attention layers,aremore sensitive to such changes;(2)The effectiveness of balancing factors depends more on specific values rather than layer type or depth;(3)In quantization-aware fine-tuning,larger layers can effectively utilize smaller adapters,whereas smaller layers struggle to do so.These insights suggest that layer type is a more significant determinant of fine-tuning success than layer depth when optimizing quantized LLMs.Moreover,for the same discount of trainable parameters,reducing the trainable parameters in a larger layer is more effective in preserving fine-tuning accuracy than in a smaller one.This study provides valuable guidance for more efficient fine-tuning strategies and opens avenues for further research into optimizing LLM fine-tuning in resource-constrained environments. 展开更多
关键词 Large-scale Language Model Parameter-Efficient Fine-Tuning parameter quantization key variable trainable parameters experimental analysis
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Equivalent Conditions of Complete Convergence for Weighted Sums of Sequences of i.i.d.Random Variables under Sublinear Expectations
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作者 XU Mingzhou CHENG Kun 《应用概率统计》 北大核心 2025年第3期339-352,共14页
The complete convergence for weighted sums of sequences of independent,identically distributed random variables under sublinear expectation space is studied.By moment inequality and truncation methods,we establish the... The complete convergence for weighted sums of sequences of independent,identically distributed random variables under sublinear expectation space is studied.By moment inequality and truncation methods,we establish the equivalent conditions of complete convergence for weighted sums of sequences of independent,identically distributed random variables under sublinear expectation space.The results complement the corresponding results in probability space to those for sequences of independent,identically distributed random variables under sublinear expectation space. 展开更多
关键词 complete convergence weighted sums i.i.d.random variables sublinear expectation
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Complete f-Moment Convergence for Sung’s Type Weighted Sums of Negatively Superadditive Dependent Random Variables
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作者 HU Xueping WANG Liuliu +1 位作者 HU Ke XU Zhonghao 《应用概率统计》 北大核心 2025年第4期585-601,共17页
In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergen... In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergence of NSD random variables.We establish and improve a general result on the complete f-moment convergence for Sung’s type randomly weighted sums of NSD random variables under some general assumptions.As an application,we show the complete consistency for the randomly weighted estimator in a nonparametric regression model based on NSD errors. 展开更多
关键词 Marcinkiewicz-Zygmund inequality Rosenthal-type inequality Sung’s type randomly weighted sums negatively superadditive dependent random variables complete f-moment convergence
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Influence of ambient geochemical and microbiological variables on the bacterial diversity in a cold seep ecosystem in North Indian Ocean
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作者 Delcy R.Nazareth Maria Judith Gonsalves Nitisha Sangodkar 《Geoscience Frontiers》 2025年第3期153-163,共11页
Cold seeps are oases for biological communities on the sea floor around hydrocarbon emission pathways.Microbial utilization of methane and other hydrocarbons yield products that fuel rich chemosynthetic communities at... Cold seeps are oases for biological communities on the sea floor around hydrocarbon emission pathways.Microbial utilization of methane and other hydrocarbons yield products that fuel rich chemosynthetic communities at these sites.One such site in the cold seep ecosystem of Krishna-Godavari basin(K-G basin)along the east coast of India,discovered in Feb 2018 at a depth of 1800 m was assessed for its bacterial diversity.The seep bacterial communities were dominated by phylum Proteobacteria(57%),Firmicutes(16%)and unclassified species belonging to the family Helicobacteriaceae.The surface sediments of the seep had maximum OTUs(operational taxonomic units)(2.27×10^(3))with a Shannon alpha diversity index of 8.06.In general,environmental parameters like total organic carbon(p<0.01),sulfate(p<0.001),sulfide(p<0.05)and methane(p<0.01)were responsible for shaping the bacterial community of the cold seep ecosystem in the K-G Basin.Environmental parameters play a significant role in changing the bacterial diversity richness between different cold seep environments in the oceans. 展开更多
关键词 Sediments Environmental variables PROTEOBACTERIA Cold seep ecosystem Organic matter
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On α-Bloch Functions in Several Complex Variables
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作者 ZHU Ting YANG Liu 《Chinese Quarterly Journal of Mathematics》 2025年第1期93-102,共10页
In this paper,we establish characterizations of α-Bloch functions and little α-Bloch functions on the unit ball as well as the unit polydisk of C^(m),which generalize and improve results of Aulaskari-Lappan,Minda,Au... In this paper,we establish characterizations of α-Bloch functions and little α-Bloch functions on the unit ball as well as the unit polydisk of C^(m),which generalize and improve results of Aulaskari-Lappan,Minda,Aulaskari-Wulan,and Wu.Some examples are also given to complement our theory. 展开更多
关键词 α-Bloch function Littleα-Bloch function Several complex variables Partial derivative
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Complete q-Order Moment Convergence of Moving Average Processes Generated by Negatively Dependent Random Variables under Sub-Linear Expectations
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作者 Mingzhou XU 《Journal of Mathematical Research with Applications》 2025年第3期395-410,共16页
Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+... Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+n),n≥1}under some proper conditions,where{Yi,-∞<i<∞}is a doubly infinite sequence of negatively dependent random variables under sub-linear expectations.These results extend and complement the relevant results in probability space. 展开更多
关键词 moving average processes negatively dependent random variables complete moment convergence sub-linear expectations
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Mapping soil organic carbon in fragmented agricultural landscapes:The efficacy and interpretability of multi-category remote sensing variables
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作者 Yujiao Wei Yiyun Chen +6 位作者 Jiaxue Wang Peiheng Yu Lu Xu Chi Zhang Huanfeng Shen Yaolin Liu Ganlin Zhang 《Journal of Integrative Agriculture》 2025年第11期4395-4414,共20页
Accurately mapping the spatial distribution of soil organic carbon(SOC)is crucial for guiding agricultural management and improving soil carbon sequestration,especially in fragmented agricultural landscapes.Although r... Accurately mapping the spatial distribution of soil organic carbon(SOC)is crucial for guiding agricultural management and improving soil carbon sequestration,especially in fragmented agricultural landscapes.Although remote sensing provides spatially continuous environmental information about heterogeneous agricultural landscapes,its relationship with SOC remains unclear.In this study,we hypothesized that multi-category remote sensing-derived variables can enhance our understanding of SOC variation within complex landscape conditions.Taking the Qilu Lake watershed in Yunnan,China,as a case study area and based on 216 topsoil samples collected from irrigation areas,we applied the extreme gradient boosting(XGBoost)model to investigate the contributions of vegetation indices(VI),brightness indices(BI),moisture indices(MI),and spectral transformations(ST,principal component analysis and tasseled cap transformation)to SOC mapping.The results showed that ST contributed the most to SOC prediction accuracy,followed by MI,VI,and BI,with improvements in R2 of 29.27,26.83,19.51,and 14.43%,respectively.The dominance of ST can be attributed to the fact that it contains richer remote sensing spectral information.The optimal SOC prediction model integrated soil properties,topographic factors,location factors,and landscape metrics,as well as remote sensing-derived variables,and achieved RMSE and MAE of 15.05 and 11.42 g kg-1,and R2 and CCC of 0.57 and 0.72,respectively.The Shapley additive explanations deciphered the nonlinear and threshold effects that exist between soil moisture,vegetation status,soil brightness and SOC.Compared with traditional linear regression models,interpretable machine learning has advantages in prediction accuracy and revealing the influences of variables that reflect landscape characteristics on SOC.Overall,this study not only reveals how remote sensing-derived variables contribute to our understanding of SOC distribution in fragmented agricultural landscapes but also clarifies their efficacy.Through interpretable machine learning,we can further elucidate the causes of SOC variation,which is important for sustainable soil management and agricultural practices. 展开更多
关键词 soil organic carbon remote sensing-derived variables Shapley additive explanations efficacy and interpretability fragmented agricultural landscapes
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On the Spatial Distribution of Luminous Blue Variables in the Galaxy M33
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作者 A.Kostenkov S.Fabrika +6 位作者 A.Kaldybekova S.Fedorchenko Y.Solovyeva E.Dedov A.Sarkisyan A.Vinokurov O.Sholukhova 《Research in Astronomy and Astrophysics》 2025年第4期136-149,共14页
In the current paper,we present a study of the spatial distribution of luminous blue variables(LBVs)and various LBV candidates(c LBVs)with respect to OB associations in the galaxy M33.The identification of blue star g... In the current paper,we present a study of the spatial distribution of luminous blue variables(LBVs)and various LBV candidates(c LBVs)with respect to OB associations in the galaxy M33.The identification of blue star groups was based on the LGGS data and was carried out by two clustering algorithms with initial parameters determined during simulations of random stellar fields.We have found that the distribution of distances to the nearest OB association obtained for the LBV/c LBV sample is close to that for massive stars with Minit>20 M⊙and WolfRayet stars.This result is in good agreement with the standard assumption that LBVs represent an intermediate stage in the evolution of the most massive stars.However,some objects from the LBV/cLBV sample,particularly Fe II-emission stars,demonstrated severe isolation compared to other massive stars,which,together with certain features of their spectra,implicitly indicates that the nature of these objects and other LBVs/cLBVs may differ radically. 展开更多
关键词 stars:massive stars:evolution stars:winds outflows stars:variables:S Doradus (stars:)binaries:general galaxies:individual(M33)
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Plant Traits and Soil Chemical Variables During a Secondary Vegetation Succession in Abandoned Fields on the Loess Plateau 被引量:80
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作者 王国宏 《Acta Botanica Sinica》 CSCD 2002年第8期990-998,共9页
Species dynamics in terms of both plant biological traits, ecological strategies and species richness as well as soil chemical variables during a secondary succession in abandoned fields on the Loess Plateau along a t... Species dynamics in terms of both plant biological traits, ecological strategies and species richness as well as soil chemical variables during a secondary succession in abandoned fields on the Loess Plateau along a temporal sere from 3 a to 149 a were studied. The results indicated that (I) Soil total C and N increased while soil pH, total K and Na decreased with years since abandonment. No noticeable trend was found in the case of soil P along the successional sere. On the other hand, total CaO of the surface layer (0 - 10 cm) decreased, but that of the two deeper layer, (20 - 30 cm, 40 - 50 cm) increased with years since abandonment. Soil C, N, K and P decreased, while Na, CaO and soil pH increased with increasing soil depth. (2) Species richness peaked at both mid-stage of the successional sere and the intermediate portion of soil chemical variables gradient. (3) An ideal dominant species in the early successional stage were annuals with stable seed pool, CR-life strategy, S-regeneration strategy, and strong competitive ability on relatively poor soil, while perennials capable of intensive lateral spread and colonal ability, requiring high nutrient supply, and having Clife strategy would be the dominant species in the subsequent stages. Plant traits, such as perennial-life history, C-, CR-, SC-, SR-, S- and R-life strategies, W-, S-, Bs- VBs- and V-regeneration strategies, were over- represented throughout the whole sere among the other species. (4) Some traits, such as C-, SC-life strategies, ability of clonality, perennial-life history, well-developed lateral spread ability, V- and VBs-regeneration strategies, seed animal. dispersal mode, flowering time of autumn, fruit types of legumen and nut, were more or less correlated with increased soil total C, N and K, while S-, SR-, R-, CR-life strategies, annual-, biannual-life history, non-clonal ability, S-regeneration strategy, poor lateral spread ability, and fruit types of utricle, capsule were associated with increased soil total Na, CaO and pH. The results suggested that steppes should be the dominant native vegetation coinciding with the large-scaled eco-climatic conditions on the Loess Plateau. 展开更多
关键词 abandoned fields plant trait soil chemical variable SUCCESSION Loess Plateau
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Multiple attribute decision making method based on trapezoid fuzzy linguistic variables 被引量:4
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作者 梁雪春 陈森发 《Journal of Southeast University(English Edition)》 EI CAS 2008年第4期478-481,共4页
The problem of multiple attribute decision making under fuzzy linguistic environments, in which decision makers can only provide their preferences (attribute values)in the form of trapezoid fuzzy linguistic variable... The problem of multiple attribute decision making under fuzzy linguistic environments, in which decision makers can only provide their preferences (attribute values)in the form of trapezoid fuzzy linguistic variables(TFLV), is studied. The formula of the degree of possibility between two TFLVs is defined, and some of its characteristics are studied. Based on the degree of possibility of fuzzy linguistic variables, an approach to ranking the decision alternatives in multiple attribute decision making with TFLV is developed. The trapezoid fuzzy linguistic weighted averaging (TFLWA) operator method is utilized to aggregate the decision information, and then all the alternatives are ranked by comparing the degree of possibility of TFLV. The method can carry out linguistic computation processes easily without loss of linguistic information, and thus makes the decision results reasonable and effective. Finally, the implementation process of the proposed method is illustrated and analyzed by a practical example. 展开更多
关键词 trapezoid fuzzy linguistic variables degree of possibility multiple attribute decision making
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线性Errors-in-Variables模型在确定汶川地震主震断层面中的应用 被引量:7
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作者 王福昌 曹慧荣 万永革 《数理统计与管理》 CSSCI 北大核心 2010年第3期381-390,共10页
首先介绍线性Errors-in-Variables模型,给出求解回归系数的奇异值分解(SVD)算法和MATLAB源代码,其次指出在模型中所有变量均具有不可忽略的误差时,全最小二乘法得到回归系数估计更接近于模型中的真实系数,并通过理论分析和计算机仿真说... 首先介绍线性Errors-in-Variables模型,给出求解回归系数的奇异值分解(SVD)算法和MATLAB源代码,其次指出在模型中所有变量均具有不可忽略的误差时,全最小二乘法得到回归系数估计更接近于模型中的真实系数,并通过理论分析和计算机仿真说明了这一结果,最后将线性模型和算法用于确定汶川大地震主震断层面,取得了与震源机制解一致的结果,说明了模型和算法的有效性。 展开更多
关键词 线性Errors-in-variables模型 奇异值分解 断层面参数 汶川余震
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Errors-in-variables模型的参数估计 被引量:3
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作者 时正华 袁永生 《曲阜师范大学学报(自然科学版)》 CAS 2005年第1期35-37,共3页
介绍了Errors_in_variables模型 ,利用Fisher得分算法 ,给出了在自变量的随机影响因素和因变量的随机影响因素相互独立和无重复测量数据情况下Errors_in_variables模型参数估计的迭代公式 .
关键词 随机自变量 Errors-in-variables模型 Fisher得分算法
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Construction of crash prediction model of freeway basic segment based on interactive influence of explanatory variables
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作者 王晓飞 李新伟 +2 位作者 符锌砂 赵立萱 刘小峰 《Journal of Southeast University(English Edition)》 EI CAS 2015年第2期276-281,共6页
In order to improve the prediction precision of the safety performance function (SPF) of freeway basic segments, design and crash data of 640 segments are collected from different institutions. Three negative binomi... In order to improve the prediction precision of the safety performance function (SPF) of freeway basic segments, design and crash data of 640 segments are collected from different institutions. Three negative binomial (NB) regression models and three generalized negative binomial (GNB) regression models are built to prove that the interactive influence of explanatory variables plays an important role in fitting goodness. The effective use of the GNB model in analyzing the interactive influence of explanatory variables and predicting freeway basic segments is demonstrated. Among six models, the two models (one is the NB model and the other is the GNB model. ) which consider the interactive influence of the annual average daily traffic (AADT) and length are more reasonable for predicting results. Furthermore, a comprehensive study is carried out to prove that when considering the interactive influence, the NB and GNB models have almost the same fitting performance in estimating the crashes, among which the GNB model is slightly better for prediction performance. 展开更多
关键词 CRASH FREEWAY safety performance function( SPF interactive influence of explanatory variables generalized negative binomial (GNB)
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基于errors-in-variables的预测模型及其应用 被引量:5
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作者 程龙生 《数理统计与管理》 CSSCI 北大核心 2005年第2期55-59,共5页
预测是统计学实际应用的一个主要方面,多元线性回归预测是一种很好的方法,广泛地应用在各种实际领域,但其局限性及不足也是明显的。本文以一种新的观点认识数据,即认为变量的观测里均含有误差,同时认为不应删除经慎重选择进来的解释变... 预测是统计学实际应用的一个主要方面,多元线性回归预测是一种很好的方法,广泛地应用在各种实际领域,但其局限性及不足也是明显的。本文以一种新的观点认识数据,即认为变量的观测里均含有误差,同时认为不应删除经慎重选择进来的解释变量。为此,本文提出了一种新的多元预测方法———多元线性EIV预测。本文还考虑了新预测模型的一个实例应用,并从相对偏差上与多元回归预测进行了比较,从而揭示了多元线性EIV预测的先进性及较好的预测精度。 展开更多
关键词 预测 回归分析 Errors-in-variables(EIV) 结构关系模型
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一类线性errors-in-variables模型的参数强相合估计及其a.s.收敛速度 被引量:1
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作者 程龙生 姚景尹 《高校应用数学学报(A辑)》 CSCD 北大核心 1996年第3期313-320,共8页
本文讨论了如下一类线性errors-in-variables模型——多元线性结构关系模型β′xk+α=0,ξk=xk+εk.{k=1,2,…,n.其中,{xk:k=1,2,…,n}为一组i.i.d.的m维随机向量,{... 本文讨论了如下一类线性errors-in-variables模型——多元线性结构关系模型β′xk+α=0,ξk=xk+εk.{k=1,2,…,n.其中,{xk:k=1,2,…,n}为一组i.i.d.的m维随机向量,{εk:k=1,2,…,n}是i.i.d.的随机误差,E(ε1)=0,Var(ε1)=σ2Im.且{xk:k=1,2,…,n}与{εk:k=1,2,…,n}相互独立.在一些条件下,我们证明了估计量β,α,σ2的强相合性、唯一性,并给出了估计量的收敛速度为o(n-1-1q),这里q∈[1,2). 展开更多
关键词 收敛速度 线性模型 强相合估计 多元分析
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The Influences of Affective Variables on and Implications for English Teaching and Learning
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作者 张莹 《海外英语》 2014年第23期286-288,共3页
Admittedly cognitive variables such as intelligence and aptitude exert great impact on English learning. Affective variables, however, are of intense importance in determining English learning as well, because affect ... Admittedly cognitive variables such as intelligence and aptitude exert great impact on English learning. Affective variables, however, are of intense importance in determining English learning as well, because affect is a starting machine that sets the learning mechanism in motion and learning will run into difficulty if affect does not work properly. Besides, there is mounting interest in exploring the affective domain. Therefore, this paper focuses upon the analyses of four affective variables(attitude, motivation, self-esteem and anxiety) that have bearings on English learning and sets forth Implications for English teaching. 展开更多
关键词 AFFECTIVE variables ENGLISH TEACHING and learning
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Real Time Study and Related Variables
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作者 武小青 《海外英语》 2016年第18期208-209,共2页
This paper first, illustrates the advantages of applying real time study to linguistic researches. Second, this paper also compares linguistic variables with linguistic variant; nasality, stronger constraint and weake... This paper first, illustrates the advantages of applying real time study to linguistic researches. Second, this paper also compares linguistic variables with linguistic variant; nasality, stronger constraint and weaker constraint have been clearly defined as well. 展开更多
关键词 real time linguistic variable CONSTRAINT NASALITY
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Spatial Interpolation of Soil Texture Using Compositional Kriging and Regression Kriging with Consideration of the Characteristics of Compositional Data and Environment Variables 被引量:18
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作者 ZHANG Shi-wen SHEN Chong-yang +3 位作者 CHEN Xiao-yang YE Hui-chun HUANG Yuan-fang LAI Shuang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2013年第9期1673-1683,共11页
The spatial interpolation for soil texture does not necessarily satisfy the constant sum and nonnegativity constraints. Meanwhile, although numeric and categorical variables have been used as auxiliary variables to im... The spatial interpolation for soil texture does not necessarily satisfy the constant sum and nonnegativity constraints. Meanwhile, although numeric and categorical variables have been used as auxiliary variables to improve prediction accuracy of soil attributes such as soil organic matter, they (especially the categorical variables) are rarely used in spatial prediction of soil texture. The objective of our study was to comparing the performance of the methods for spatial prediction of soil texture with consideration of the characteristics of compositional data and auxiliary variables. These methods include the ordinary kriging with the symmetry logratio transform, regression kriging with the symmetry logratio transform, and compositional kriging (CK) approaches. The root mean squared error (RMSE), the relative improvement value of RMSE and Aitchison's distance (DA) were all utilized to assess the accuracy of prediction and the mean squared deviation ratio was used to evaluate the goodness of fit of the theoretical estimate of error. The results showed that the prediction methods utilized in this paper could enable interpolation results of soil texture to satisfy the constant sum and nonnegativity constraints. Prediction accuracy and model fitting effect of the CK approach were better, suggesting that the CK method was more appropriate for predicting soil texture. The CK method is directly interpolated on soil texture, which ensures that it is optimal unbiased estimator. If the environment variables are appropriately selected as auxiliary variables, spatial variability of soil texture can be predicted reasonably and accordingly the predicted results will be satisfied. 展开更多
关键词 compositional kriging auxiliary variables regression kriging symmetry logratio transform
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Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma 被引量:8
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作者 Shuhei Komatsu Daisuke Ichikawa +7 位作者 Mahito Miyamae Hiroki Shimizu Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji 《World Journal of Gastroenterology》 SCIE CAS 2015年第2期549-555,共7页
AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric cancer.METHODS: We analyzed 446 patients who underwent curative gastrectomy ... AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric cancer.METHODS: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P < 0.0001), more aggressive lymphatic invasion(P = 0.0011), and deeper tumor invasion(P < 0.0001). In addition, they exhibited significantly worse overall survival rates than did patients with non-mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer. 展开更多
关键词 mixed-type GASTRIC cancer HISTOLOGICAL TYPE Progno
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Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa 被引量:10
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作者 Qian Zhong Qi Sun +6 位作者 Gui-fang Xu Xiu-Qin Fan Yuan-Yuan Xu Fei Liu Shi-Yi Song Chun-Yan Peng Lei Wang 《World Journal of Gastroenterology》 SCIE CAS 2018年第1期87-95,共9页
AIM To investigate the relationship between histological mixed-type of early gastric cancer(EGC) in the mucosa and submucosa and lymph node metastasis(LNM).METHODS This study included 298 patients who underwent gastre... AIM To investigate the relationship between histological mixed-type of early gastric cancer(EGC) in the mucosa and submucosa and lymph node metastasis(LNM).METHODS This study included 298 patients who underwent gastrectomy for EGC between 2005 and 2012. Enrolled lesions were divided into groups of pure differentiated(pure D), pure undifferentiated(pure U), and mixed-type according to the proportion of the differentiated and undifferentiated components observed under a microscope. We reviewed the clinicopathological features, including age, sex, location, size, gross type, lymphovascular invasion, ulceration, and LNM, among the three groups. furthermore, we evaluated the predictors of LNM in the mucosa-confined EGC.RESULTS Of the 298 patients, 165(55.4%) had mucosa-confined EGC and 133(44.6%) had submucosa-invasive EGC. Only 13(7.9%) cases of mucosa-confined EGC and 30(22.6%) cases of submucosa-invasive EGC were observed to have LNM. The submucosal invasion(OR = 4.58, 95%CI: 1.23-16.97, P = 0.023), pure U type(OR = 4.97, 95%CI: 1.21-20.39, P = 0.026), and mixedtype(OR = 5.84, 95%CI: 1.05-32.61, P = 0.044) were independent risk factors for LNM in EGC. The rate of LNM in mucosa-confined EGC was higher in the mixedtype group(P = 0.012) and pure U group(P = 0.010) than in the pure D group, but no significant difference was found between the mixed-type group and pure U group(P = 0.739). Similarly, the rate of LNM in the submucosa-invasive EGC was higher in the mixedtype(P = 0.012) and pure U group(P = 0.009) than in the pure D group but was not significantly different between the mixed-type and pure U group(P = 0.375). Multivariate logistic analysis showed that only female sex(OR = 5.83, 95%CI: 1.64-20.70, P = 0.028) and presence of lymphovascular invasion(OR = 13.18, 95%CI: 1.39-125.30, P = 0.020) were independent risk factors for LNM in mucosa-confined EGC, while histological type was not an independent risk factor for LNM in mucosa-confined EGC(P = 0.106).CONCLUSION for mucosal EGC, histological mixed-type is not an independent risk factor for LNM and could be managed in the same way as the undifferentiated type. 展开更多
关键词 early gastric carcinoma mixed-type LYMPH node metastasis MUCOSA lymphovascular invasion
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