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A Composite Loss-Based Autoencoder for Accurate and Scalable Missing Data Imputation
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作者 Thierry Mugenzi Cahit Perkgoz 《Computers, Materials & Continua》 2026年第1期1985-2005,共21页
Missing data presents a crucial challenge in data analysis,especially in high-dimensional datasets,where missing data often leads to biased conclusions and degraded model performance.In this study,we present a novel a... Missing data presents a crucial challenge in data analysis,especially in high-dimensional datasets,where missing data often leads to biased conclusions and degraded model performance.In this study,we present a novel autoencoder-based imputation framework that integrates a composite loss function to enhance robustness and precision.The proposed loss combines(i)a guided,masked mean squared error focusing on missing entries;(ii)a noise-aware regularization term to improve resilience against data corruption;and(iii)a variance penalty to encourage expressive yet stable reconstructions.We evaluate the proposed model across four missingness mechanisms,such as Missing Completely at Random,Missing at Random,Missing Not at Random,and Missing Not at Random with quantile censorship,under systematically varied feature counts,sample sizes,and missingness ratios ranging from 5%to 60%.Four publicly available real-world datasets(Stroke Prediction,Pima Indians Diabetes,Cardiovascular Disease,and Framingham Heart Study)were used,and the obtained results show that our proposed model consistently outperforms baseline methods,including traditional and deep learning-based techniques.An ablation study reveals the additive value of each component in the loss function.Additionally,we assessed the downstream utility of imputed data through classification tasks,where datasets imputed by the proposed method yielded the highest receiver operating characteristic area under the curve scores across all scenarios.The model demonstrates strong scalability and robustness,improving performance with larger datasets and higher feature counts.These results underscore the capacity of the proposed method to produce not only numerically accurate but also semantically useful imputations,making it a promising solution for robust data recovery in clinical applications. 展开更多
关键词 missing data imputation autoencoder deep learning missing mechanisms
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Unraveling the missing heritability of amyotrophic lateral sclerosis:Should we focus more on copy number variations?
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作者 Maria Guarnaccia Valentina La Cognata +2 位作者 Giulia Gentile Giovanna Morello Sebastiano Cavallaro 《Neural Regeneration Research》 2026年第5期1997-1998,共2页
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,para... Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,paralysis,and respiratory failure (Morgan and Orrell,2016). 展开更多
关键词 degeneration upper lower motor neurons unraveling neurodegenerative disorder missing heritability amyotrophic lateral sclerosis copy number variations
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Prediction of radionuclide diffusion enabled by missing data imputation and ensemble machine learning 被引量:1
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作者 Jun-Lei Tian Jia-Xing Feng +4 位作者 Jia-Cong Shen Lei Yao Jing-Yan Wang Tao Wu Yao-Lin Zhao 《Nuclear Science and Techniques》 2025年第10期47-61,共15页
Missing values in radionuclide diffusion datasets can undermine the predictive accuracy and robustness of the machine learning(ML)models.In this study,regression-based missing data imputation method using a light grad... Missing values in radionuclide diffusion datasets can undermine the predictive accuracy and robustness of the machine learning(ML)models.In this study,regression-based missing data imputation method using a light gradient boosting machine(LGBM)algorithm was employed to impute more than 60%of the missing data,establishing a radionuclide diffusion dataset containing 16 input features and 813 instances.The effective diffusion coefficient(D_(e))was predicted using ten ML models.The predictive accuracy of the ensemble meta-models,namely LGBM-extreme gradient boosting(XGB)and LGBM-categorical boosting(CatB),surpassed that of the other ML models,with R^(2)values of 0.94.The models were applied to predict the D_(e)values of EuEDTA^(−)and HCrO_(4)^(−)in saturated compacted bentonites at compactions ranging from 1200 to 1800 kg/m^(3),which were measured using a through-diffusion method.The generalization ability of the LGBM-XGB model surpassed that of LGB-CatB in predicting the D_(e)of HCrO_(4)^(−).Shapley additive explanations identified total porosity as the most significant influencing factor.Additionally,the partial dependence plot analysis technique yielded clearer results in the univariate correlation analysis.This study provides a regression imputation technique to refine radionuclide diffusion datasets,offering deeper insights into analyzing the diffusion mechanism of radionuclides and supporting the safety assessment of the geological disposal of high-level radioactive waste. 展开更多
关键词 Machine learning Radionuclide diffusion BENTONITE Regression imputation missing data Diffusion experiments
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A Missing Friend
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作者 尤知新 杨钰(指导) 《疯狂英语(双语世界)》 2025年第2期74-75,共2页
Do you like animals?Animals are cute.Some people like loyal dogs,some like adorable cats,and others prefer fluffy bunnies.But my favorite animals are naughty hamsters because they are full of energy.With just a little... Do you like animals?Animals are cute.Some people like loyal dogs,some like adorable cats,and others prefer fluffy bunnies.But my favorite animals are naughty hamsters because they are full of energy.With just a little food and water,they can thrive.Plus,they are really affordable,unlike cats and dogs that can cost several hundred or even over a thousand yuan. 展开更多
关键词 AFFORDABILITY ANIMALS ENERGY missing friend naughty hamsters HAMSTERS
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A spatiotemporal recurrent neural network for missing data imputation in tunnel monitoring
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作者 Junchen Ye Yuhao Mao +3 位作者 Ke Cheng Xuyan Tan Bowen Du Weizhong Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期4815-4826,共12页
Given the swift proliferation of structural health monitoring(SHM)technology within tunnel engineering,there is a demand on proficiently and precisely imputing the missing monitoring data to uphold the precision of di... Given the swift proliferation of structural health monitoring(SHM)technology within tunnel engineering,there is a demand on proficiently and precisely imputing the missing monitoring data to uphold the precision of disaster prediction.In contrast to other SHM datasets,the monitoring data specific to tunnel engineering exhibits pronounced spatiotemporal correlations.Nevertheless,most methodologies fail to adequately combine these types of correlations.Hence,the objective of this study is to develop spatiotemporal recurrent neural network(ST-RNN)model,which exploits spatiotemporal information to effectively impute missing data within tunnel monitoring systems.ST-RNN consists of two moduli:a temporal module employing recurrent neural network(RNN)to capture temporal dependencies,and a spatial module employing multilayer perceptron(MLP)to capture spatial correlations.To confirm the efficacy of the model,several commonly utilized methods are chosen as baselines for conducting comparative analyses.Furthermore,parametric validity experiments are conducted to illustrate the efficacy of the parameter selection process.The experimentation is conducted using original raw datasets wherein various degrees of continuous missing data are deliberately introduced.The experimental findings indicate that the ST-RNN model,incorporating both spatiotemporal modules,exhibits superior interpolation performance compared to other baseline methods across varying degrees of missing data.This affirms the reliability of the proposed model. 展开更多
关键词 MONITORING TUNNEL Machine learning INTERPOLATION missing data
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Interpretative Challenges of the 'Missing Perilymph' Sign in PLF Diagnosis——A Letter To The Editor
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作者 Jamil Ammara 《Journal of Otology》 2025年第4期281-281,共1页
Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.954000... Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.9540001 proposing the"missing perilymph"sign on MRI as a novel radiological indicator of perilymphatic fistula(PLF).This study adds to the growing body of work seeking objective,non-invasive diagnostic methods for PLF,a condition that has long eluded definitive radiological confirmation.The avoidance of gadolinium contrast in the imaging technique is an additional strength,given increasing awareness of gadoliniumassociated risks (Starekova et al.,2024). 展开更多
关键词 perilymphatic fistula avoidance gadol perilymphatic fistula plf gadolinium contrast missing perilymph sign MRI diagnostic method
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Near telomere-to-telomere genome assemblies of Silkie Gallus gallus and Mallard Anas platyrhynchos restored the structure of chromosomes and “missing” genes in birds
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作者 Qiangsen Zhao Zhongtao Yin Zhuocheng Hou 《Journal of Animal Science and Biotechnology》 2025年第2期517-530,共14页
Background Chickens and ducks are vital sources of animal protein for humans.Recent pangenome studies suggest that a single genome is insufficient to represent the genetic information of a species,highlighting the nee... Background Chickens and ducks are vital sources of animal protein for humans.Recent pangenome studies suggest that a single genome is insufficient to represent the genetic information of a species,highlighting the need for more comprehensive genomes.The bird genome has more than tens of microchromosomes,but comparative genomics,annotations,and the discovery of variations are hindered by inadequate telomere-to-telomere level assemblies.We aim to complete the chicken and duck genomes,recover missing genes,and reveal common and unique chromosomal features between birds.Results The near telomere-to-telomere genomes of Silkie Gallus gallus and Mallard Anas platyrhynchos were successfully assembled via multiple high-coverage complementary technologies,with quality values of 36.65 and 44.17 for Silkie and Mallard,respectively;and BUSCO scores of 96.55%and 96.97%for Silkie and Mallard,respectively;the mapping rates reached over 99.52%for both assembled genomes,these evaluation results ensured high completeness and accuracy.We successfully annotated 20,253 and 19,621 protein-coding genes for Silkie and Mallard,respectively,and assembled gap-free sex chromosomes in Mallard for the first time.Comparative analysis revealed that microchromosomes differ from macrochromosomes in terms of GC content,repetitive sequence abundance,gene density,and levels of 5mC methylation.Different types of arrangements of centromeric repeat sequence centromeres exist in both Silkie and the Mallard genomes,with Mallard centromeres being invaded by CR1.The highly heterochromatic W chromosome,which serves as a refuge for ERVs,contains disproportionately long ERVs.Both Silkie and the Mallard genomes presented relatively high 5mC methylation levels on sex chromosomes and microchromosomes,and the telomeres and centromeres presented significantly higher 5mC methylation levels than the whole genome.Finally,we recovered 325 missing genes via our new genomes and annotated TNFA in Mallard for the first time,revealing conserved protein structures and tissue-specific expression.Conclusions The near telomere-to-telomere assemblies in Mallard and Silkie,with the first gap-free sex chromosomes in ducks,significantly enhanced our understanding of genetic structures in birds,specifically highlighting the distinctive chromosome features between the chicken and duck genomes.This foundational work also provides a series of newly identified missing genes for further investigation. 展开更多
关键词 AVIAN CENTROMERE missing gene Telomere-to-telomere genome 5mC methylation level
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Changbaishan Volcanism:Is Seamount Subduction the Missing Piece?
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作者 Xiaobo He Mingli He +4 位作者 Yibing Li Jiashun Hu Fabin Pan Zhensheng Wang Jianshe Lei 《Journal of Earth Science》 2025年第5期2337-2340,共4页
0 INTRODUCTION Changbaishan volcanism,located on the border of China and North Korea,has been a subject of extensive research due to its unique geological features and active volcanic history(Wan et al.,2024).Two prim... 0 INTRODUCTION Changbaishan volcanism,located on the border of China and North Korea,has been a subject of extensive research due to its unique geological features and active volcanic history(Wan et al.,2024).Two primary models have been proposed to explain the origin of Changbaishan volcanism(CV). 展开更多
关键词 missing piece changbaishan volcanism cv active volcanic history seamount subduction changbaishan volcanismlocated research models Changbaishan volcanism geological features
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Relationship between Psychological Security and Fear of Missing Out among University Students:A Moderated Mediation Model
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作者 Xiaowen Wan Wenbin Sheng +5 位作者 Rong Huang Cheng Zeng Xu Zhou Yuan Wu Xiaohui Cao Xiaoke Chen 《International Journal of Mental Health Promotion》 2025年第2期215-229,共15页
Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psyc... Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psychological security(PS)and FoMO by analyzing the mediating role of social networking addiction(SNA)and the moderating role of social self-efficacy(SSE).Methods:We collected a sample of 1181 college students(with a mean age of 19.671.38 years)from five universities in a province of China's Mainland through cluster sampling.Data±were gathered using the psychological security questionnaire(PSQ),the FoMO scale,the SNA scale,and the perceived social self-efficacy(PSSE)scale.Data analysis employed independent-sample t-tests,one-way analysis of variance(ANOVA),Harman’s single-factor test,confirmatory factor analysis,and moderated mediation analysis.Results:The results of the mediation model and moderated mediation model analyses showed the following key findings:(1)PS is significantly negatively correlated with FoMO;(2)SNA mediates the relationship between PS and FoMO;(3)SSE positively moderates the relationship between PS and FoMO;and(4)SSE also positively moderates the relationship between PS and SNA.Conclusion:University students’PS not only directly impacts FoMO but also indirectly influences it through SNA.Additionally,SSE positively moderates both the direct path and the first half of the mediation path,indicating that enhancing students’PS and SSE can help alleviate their SNA and FoMO,promoting their psychological and behavioral well-being. 展开更多
关键词 College student fear of missing out psychological security social networking addiction social self-efficacy
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Reply to:Interpretative Challenges of the'Missing Perilymph'Sign in PLF Diagnosis——A Thoughtful Discussion
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作者 Jing Zou 《Journal of Otology》 2025年第4期282-282,共1页
Dear Editor,I am writing in response to Jamil's letter,"Interpretative Challenges of the Missing Perilymph'Sign in PLF Diagnosis."I concur with the author's emphasis on the necessity for cautious... Dear Editor,I am writing in response to Jamil's letter,"Interpretative Challenges of the Missing Perilymph'Sign in PLF Diagnosis."I concur with the author's emphasis on the necessity for cautious interpretation of low-signal areas as evidence of active perilymph leakage,requiring correlation with clinical findings,surgical confirmation,and longitudinal imaging changes. 展开更多
关键词 interpretative challenges PLF diagnosis perilymph leakagerequiring missing perilymph sign clinical findingssurgical clinical findings longitudinal imaging changes cautious interpretation
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Dynamic Relative Advantage-Driven Multi-Fault Synergistic Diagnosis Method for Motors under Imbalanced Missing Data Rates
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作者 Zhenpeng Teng Xiaojian Yi Biao Wang 《Journal of Dynamics, Monitoring and Diagnostics》 2025年第2期111-120,共10页
Missing data handling is vital for multi-sensor information fusion fault diagnosis of motors to prevent the accuracy decay or even model failure,and some promising results have been gained in several current studies.T... Missing data handling is vital for multi-sensor information fusion fault diagnosis of motors to prevent the accuracy decay or even model failure,and some promising results have been gained in several current studies.These studies,however,have the following limitations:1)effective supervision is neglected for missing data across different fault types and 2)imbalance in missing rates among fault types results in inadequate learning during model training.To overcome the above limitations,this paper proposes a dynamic relative advantagedriven multi-fault synergistic diagnosis method to accomplish accurate fault diagnosis of motors under imbalanced missing data rates.Firstly,a cross-fault-type generalized synergistic diagnostic strategy is established based on variational information bottleneck theory,which is able to ensure sufficient supervision in handling missing data.Then,a dynamic relative advantage assessment technique is designed to reduce diagnostic accuracy decay caused by imbalanced missing data rates.The proposed method is validated using multi-sensor data from motor fault simulation experiments,and experimental results demonstrate its effectiveness and superiority in improving diagnostic accuracy and generalization under imbalanced missing data rates. 展开更多
关键词 data missing motor fault relative advantage synergistic diagnosis
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Missing rings of Larix sibirica associated with climatic elements on the Altai Mountains,China
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作者 Kailong Guo Tongwen Zhang +10 位作者 Yonghui Wang Xiaoxia Gou Shulong Yu Huaming Shang Ruibo Zhang Li Qin Shengxia Jiang Kexiang Liu Dong Guo Ruxianguli Abureheman Yulin Guo 《Journal of Forestry Research》 2025年第1期359-370,共12页
The physiological structure and growth of trees in extreme environments(freezing temperatures,prolonged drought,wildfires,pest infestations,and diseases)can be inhibited,including radial growth,and stagnant growth or ... The physiological structure and growth of trees in extreme environments(freezing temperatures,prolonged drought,wildfires,pest infestations,and diseases)can be inhibited,including radial growth,and stagnant growth or missing annual rings is highly possible.In this study,we analyzed the radial growth of Siberian larch(Larix sibirica)in the Hongshanzui area of the Altai Mountains,China.The overall missing ring rate at the sampling point was 2.39%,with years with the highest missing rings since meteorological site data were available(1960)identified as 1960,1961,1971,1973,1985,1987,and 1995.Radial growth in high altitudes was mainly affected by temperatures in May and June(average temperature,average minimum temperature,and average maximum temperature).Frequent periods of freezing may lead to missing annual rings.However,while Larix sibirica shows resilience after prolonged freezing temperatures,it still requires time for the trees to return to normal growth levels. 展开更多
关键词 missing tree rings Low growing season temperatures Altai Mountains Ecological resilience Larix sibirica
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A Novel Reduced Error Pruning Tree Forest with Time-Based Missing Data Imputation(REPTF-TMDI)for Traffic Flow Prediction
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作者 Yunus Dogan Goksu Tuysuzoglu +4 位作者 Elife Ozturk Kiyak Bita Ghasemkhani Kokten Ulas Birant Semih Utku Derya Birant 《Computer Modeling in Engineering & Sciences》 2025年第8期1677-1715,共39页
Accurate traffic flow prediction(TFP)is vital for efficient and sustainable transportation management and the development of intelligent traffic systems.However,missing data in real-world traffic datasets poses a sign... Accurate traffic flow prediction(TFP)is vital for efficient and sustainable transportation management and the development of intelligent traffic systems.However,missing data in real-world traffic datasets poses a significant challenge to maintaining prediction precision.This study introduces REPTF-TMDI,a novel method that combines a Reduced Error Pruning Tree Forest(REPTree Forest)with a newly proposed Time-based Missing Data Imputation(TMDI)approach.The REP Tree Forest,an ensemble learning approach,is tailored for time-related traffic data to enhance predictive accuracy and support the evolution of sustainable urbanmobility solutions.Meanwhile,the TMDI approach exploits temporal patterns to estimate missing values reliably whenever empty fields are encountered.The proposed method was evaluated using hourly traffic flow data from a major U.S.roadway spanning 2012-2018,incorporating temporal features(e.g.,hour,day,month,year,weekday),holiday indicator,and weather conditions(temperature,rain,snow,and cloud coverage).Experimental results demonstrated that the REPTF-TMDI method outperformed conventional imputation techniques across various missing data ratios by achieving an average 11.76%improvement in terms of correlation coefficient(R).Furthermore,REPTree Forest achieved improvements of 68.62%in RMSE and 70.52%in MAE compared to existing state-of-the-art models.These findings highlight the method’s ability to significantly boost traffic flow prediction accuracy,even in the presence of missing data,thereby contributing to the broader objectives of sustainable urban transportation systems. 展开更多
关键词 Machine learning traffic flow prediction missing data imputation reduced error pruning tree(REPTree) sustainable transportation systems traffic management artificial intelligence
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Handling missing data in large-scale TBM datasets:Methods,strategies,and applications
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作者 Haohan Xiao Ruilang Cao +5 位作者 Zuyu Chen Chengyu Hong Jun Wang Min Yao Litao Fan Teng Luo 《Intelligent Geoengineering》 2025年第3期109-125,共17页
Substantial advancements have been achieved in Tunnel Boring Machine(TBM)technology and monitoring systems,yet the presence of missing data impedes accurate analysis and interpretation of TBM monitoring results.This s... Substantial advancements have been achieved in Tunnel Boring Machine(TBM)technology and monitoring systems,yet the presence of missing data impedes accurate analysis and interpretation of TBM monitoring results.This study aims to investigate the issue of missing data in extensive TBM datasets.Through a comprehensive literature review,we analyze the mechanism of missing TBM data and compare different imputation methods,including statistical analysis and machine learning algorithms.We also examine the impact of various missing patterns and rates on the efficacy of these methods.Finally,we propose a dynamic interpolation strategy tailored for TBM engineering sites.The research results show that K-Nearest Neighbors(KNN)and Random Forest(RF)algorithms can achieve good interpolation results;As the missing rate increases,the interpolation effect of different methods will decrease;The interpolation effect of block missing is poor,followed by mixed missing,and the interpolation effect of sporadic missing is the best.On-site application results validate the proposed interpolation strategy's capability to achieve robust missing value interpolation effects,applicable in ML scenarios such as parameter optimization,attitude warning,and pressure prediction.These findings contribute to enhancing the efficiency of TBM missing data processing,offering more effective support for large-scale TBM monitoring datasets. 展开更多
关键词 Tunnel boring machine(TBM) missing data imputation Machine learning(ML) Time series interpolation Data preprocessing Real-time data stream
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A Modified Deep Residual-Convolutional Neural Network for Accurate Imputation of Missing Data
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作者 Firdaus Firdaus Siti Nurmaini +8 位作者 Anggun Islami Annisa Darmawahyuni Ade Iriani Sapitri Muhammad Naufal Rachmatullah Bambang Tutuko Akhiar Wista Arum Muhammad Irfan Karim Yultrien Yultrien Ramadhana Noor Salassa Wandya 《Computers, Materials & Continua》 2025年第2期3419-3441,共23页
Handling missing data accurately is critical in clinical research, where data quality directly impacts decision-making and patient outcomes. While deep learning (DL) techniques for data imputation have gained attentio... Handling missing data accurately is critical in clinical research, where data quality directly impacts decision-making and patient outcomes. While deep learning (DL) techniques for data imputation have gained attention, challenges remain, especially when dealing with diverse data types. In this study, we introduce a novel data imputation method based on a modified convolutional neural network, specifically, a Deep Residual-Convolutional Neural Network (DRes-CNN) architecture designed to handle missing values across various datasets. Our approach demonstrates substantial improvements over existing imputation techniques by leveraging residual connections and optimized convolutional layers to capture complex data patterns. We evaluated the model on publicly available datasets, including Medical Information Mart for Intensive Care (MIMIC-III and MIMIC-IV), which contain critical care patient data, and the Beijing Multi-Site Air Quality dataset, which measures environmental air quality. The proposed DRes-CNN method achieved a root mean square error (RMSE) of 0.00006, highlighting its high accuracy and robustness. We also compared with Low Light-Convolutional Neural Network (LL-CNN) and U-Net methods, which had RMSE values of 0.00075 and 0.00073, respectively. This represented an improvement of approximately 92% over LL-CNN and 91% over U-Net. The results showed that this DRes-CNN-based imputation method outperforms current state-of-the-art models. These results established DRes-CNN as a reliable solution for addressing missing data. 展开更多
关键词 Data imputation missing data deep learning deep residual convolutional neural network
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Determination of DNA Content from Three Types of Bone Sample to Establish the Bone Sampling Guideline for Missing Person and Unidentified Body Examination
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作者 CHALAMPOO Wongworavivat NATTIDA Srinak +2 位作者 SOMRUETAI Satmun ANILLADA Nettakul WORAWEE Waiyawuth 《刑事技术》 2025年第3期319-322,共4页
The Central Institute of Forensic Science(CIFS)has been providing DNA testing services to Thai people since 2002.Bone accounts for majority of the biological specimens tested,constituting approximately 26%in total evi... The Central Institute of Forensic Science(CIFS)has been providing DNA testing services to Thai people since 2002.Bone accounts for majority of the biological specimens tested,constituting approximately 26%in total evidence.DNA recovery from the bone is challenging owing to degradation and the presence of inhibitors.Therefore,guidelines for bone selection,extraction,and DNA typing are essential for the routine laboratory of CIFS to maximize DNA yield,and minimize time and cost.In this study,we extracted three types of bones:femur,occipital,and petrous,from 12 bodies using a modified organic extraction and silica-based method.The success rate of the Short Tandem Repeat(STR)typing was determined through the number of reportable loci.Furthermore,analysis of mitochondrial DNA(mtDNA)was performed using the massively parallel sequencing technique.Coverage and variant analyses of all samples were evaluated.The results indicate that the femur exhibits the highest success rate in STR typing.The results,in decreasing order,are as follows:femur>petrous>occipital.We determined that silica-based extraction is the most efficient technique for the STR typing;however,modified organic extraction can be used as an alternative method in obtaining mtDNA.The outcome from this study could serve as a guide for identifying human remains and missing persons in the CIFS laboratory,as well as other Thai forensic laboratories. 展开更多
关键词 missing persons mitochondrial DNA massively parallel sequencing
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Fear of missing out: A brief overview of origin, theoretical underpinnings and relationship with mental health 被引量:9
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作者 Mayank Gupta Aditya Sharma 《World Journal of Clinical Cases》 SCIE 2021年第19期4881-4889,共9页
Fear of missing out(FoMO)is a unique term introduced in 2004 to describe a phenomenon observed on social networking sites.FoMO includes two processes;firstly,perception of missing out,followed up with a compulsive beh... Fear of missing out(FoMO)is a unique term introduced in 2004 to describe a phenomenon observed on social networking sites.FoMO includes two processes;firstly,perception of missing out,followed up with a compulsive behavior to maintain these social connections.We are interested in understanding the complex construct of FoMO and its relations to the need to belong and form stable interpersonal relationships.It is associated with a range of negative life experiences and feelings,due to it being considered a problematic attachment to social media.We have provided a general review of the literature and have summarized the findings in relation to mental health,social functioning,sleep,academic performance and productivity,neuro-developmental disorders,and physical well-being.We have also discussed the treatment options available for FoMo based on cognitive behavior therapy.It imperative that new findings on FoMO are communicated to the clinical community as it has diagnostic implications and could be a confounding variable in those who do not respond to treatment as usual. 展开更多
关键词 Fear of missing out Mental health Physical well-being Academic performance Fear of missing out-reduction Problematic social media
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Modelling method with missing values based on clustering and support vector regression 被引量:2
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作者 Ling Wang Dongmei Fu Qing Li Zhichun Mu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第1期142-147,共6页
Most real application processes belong to a complex nonlinear system with incomplete information. It is difficult to estimate a model by assuming that the data set is governed by a global model. Moreover, in real proc... Most real application processes belong to a complex nonlinear system with incomplete information. It is difficult to estimate a model by assuming that the data set is governed by a global model. Moreover, in real processes, the available data set is usually obtained with missing values. To overcome the shortcomings of global modeling and missing data values, a new modeling method is proposed. Firstly, an incomplete data set with missing values is partitioned into several clusters by a K-means with soft constraints (KSC) algorithm, which incorporates soft constraints to enable clustering with missing values. Then a local model based on each group is developed by using SVR algorithm, which adopts a missing value insensitive (MVI) kernel to investigate the missing value estimation problem. For each local model, its valid area is gotten as well. Simulation results prove the effectiveness of the current local model and the estimation algorithm. 展开更多
关键词 MODELING missing value K-means with soft constraints clustering missing value insensitive kernel.
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家蚕glial cell missing(BmGcm)基因鉴定、表达、亚细胞定位和功能
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作者 张奎 潘光照 +4 位作者 苏晶晶 谈娟 徐曼 李钰添 崔红娟 《中国农业科学》 CAS CSCD 北大核心 2018年第7期1401-1411,共11页
【目的】鉴定、克隆家蚕(Bombyx mori)glial cell missing(Bm Gcm)基因,分析其m RNA表达及亚细胞定位特征。制备多克隆抗体,同时在细胞水平进行过表达,检测Gcm对细胞增殖和周期的影响,为探究Bm Gcm功能打下基础。【方法】利用RACE方法... 【目的】鉴定、克隆家蚕(Bombyx mori)glial cell missing(Bm Gcm)基因,分析其m RNA表达及亚细胞定位特征。制备多克隆抗体,同时在细胞水平进行过表达,检测Gcm对细胞增殖和周期的影响,为探究Bm Gcm功能打下基础。【方法】利用RACE方法克隆获得Bm Gcm全长c DNA序列,利用ORF Finder和SMART等在线工具对Bm Gcm基本序列特征和结构信息进行分析,运用Clustalx和MEGA 6.0等软件对多物种Gcm蛋白进行同源序列比对和进化分析。采用RT-PCR和q RT-PCR方法检测Bm Gcm的表达情况。利用原核表达系统获得重组蛋白,通过蛋白纯化和免疫小鼠制备多克隆抗体,运用Western blot对抗体进行检测。构建Bm Gcm表达载体,转染家蚕胚胎细胞系,分析其亚细胞定位情况,同时利用EDU细胞增殖标记和流式细胞仪对其功能进行探索。【结果】Bm Gcm(BGIBMGA006182)定位于4号染色体的nscaf2847上,其基因全长4046 bp,包含4个外显子和3个内含子。其c DNA全长1734 bp,包含166 bp的5′UTR、227 bp的3′UTR和1341 bp的完整开放阅读框(ORF)。该基因编码446个氨基酸残基,预测蛋白分子量为50.61 k D,等电点5.557,含有典型的GCM结构域。多重比对结果显示GCM结构域在不同物种间具有高度的保守性,进化分析显示昆虫Gcm蛋白单独聚为一支,其中Bm Gcm蛋白与帝王蝶同源蛋白亲缘关系最为接近。表达分析结果显示Bm Gcm在胚胎发育第4天表达达到峰值,随后表达水平逐渐下调,而在幼虫阶段,Bm Gcm主要表达于中肠、精巢和卵巢。将Bm Gcm完整的开放阅读框序列构建至原核表达系统,经IPTG诱导和亲和层析纯化获得高纯度重组蛋白,通过免疫小鼠获得了多克隆抗体,Western blot检测该抗体可以特异性识别重组蛋白。在家蚕细胞系中过表达Bm Gcm蛋白,结果显示其定位于细胞核。在细胞水平,过表达Bm Gcm会明显抑制细胞增殖,将细胞周期阻滞于G1/S期。【结论】克隆鉴定得到Bmgcm全长序列,获得其表达和亚细胞定位信息。通过原核表达、蛋白纯化和免疫小鼠制备了可用的多克隆抗体。细胞实验发现Bm Gcm可以显著抑制增殖和影响正常的细胞周期进程。 展开更多
关键词 家蚕glial cell missing基因(BmGcm) 克隆 表达分析 抗体制备 过表达
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Cause Analysis on the Missing Report of First Thunderstorm Weather in Shenyang City in 2010
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作者 隋东 刘凯 +2 位作者 韦涛 祖歌 曹志贤 《Meteorological and Environmental Research》 CAS 2010年第10期71-74,共4页
The first thunderstorm weather appeared in southern Shenyang on May 2,2010 and did not bring about severe lightning disaster for Shenyang region,but forecast service had poor effect without forecasting thunderstorm we... The first thunderstorm weather appeared in southern Shenyang on May 2,2010 and did not bring about severe lightning disaster for Shenyang region,but forecast service had poor effect without forecasting thunderstorm weather accurately.In our paper,the reasons for missing report of this thunderstorm weather were analyzed,and analysis on thunderstorm potential was carried out by means of mesoscale analysis technique,providing technical index and vantage point for the prediction of thunderstorm potential.The results showed that the reasons for missing report of this weather process were as follows:surface temperature at prophase was constantly lower going against the development of convective weather;the interpreting and analyzing ability of numerical forecast product should be improved;the forecast result of T639 model was better than that of Japanese numerical forecast;the study and application of mesoscale analysis technique should be strengthened,and this service was formally developed after thunderstorm weather on June 1,2010. 展开更多
关键词 THUNDERSTORM missing report Cause analysis:Predicting vantage point China
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