2026年1月,索尼Cine Alta V 2分体拓展系统Mini正式上市。其内置CineAltaV 2的8.6K全画幅CMOS传感器,搭配插入式ND滤镜,可创造出色的、富有质感的影像表现。值得一提的是,其头部体积比前一代减小了约70%,更便携的设计为创作者在有限空...2026年1月,索尼Cine Alta V 2分体拓展系统Mini正式上市。其内置CineAltaV 2的8.6K全画幅CMOS传感器,搭配插入式ND滤镜,可创造出色的、富有质感的影像表现。值得一提的是,其头部体积比前一代减小了约70%,更便携的设计为创作者在有限空间进行手持、极限动作等拍摄提供更多的创作自由。除了适应紧凑环境的拍摄外,索尼Cine Alta V 2分体拓展系统Mini还可用于3D、VR拍摄。此外,新品还配备多个安装点,方便轻松连接多种配件,可拆卸的电缆线材质更软、操控更灵活,使拍摄更高效,使用场景更多元。展开更多
The aim of this study was to prepare diphenhydramine hydrochloride (DPH)-loaded orally fast-disintegrating mini-tablets (OFDMTs) containing either L-aspartic acid (Asp) or L-glutamic acid (Glu) as bitterness-suppressa...The aim of this study was to prepare diphenhydramine hydrochloride (DPH)-loaded orally fast-disintegrating mini-tablets (OFDMTs) containing either L-aspartic acid (Asp) or L-glutamic acid (Glu) as bitterness-suppressant, to characterize the prepared tablets and to evaluate their bitterness under conditions mimicking those of the oral cavity. The preparation of five formulation batches of the OFDMTs involved mixing DPH, with or without two different concentrations of Asp or Glu, and a premix containing a disintegrating agent. When all ingredients were well mixed, the mixture was directly compacted to form small (4 mm diameter) DPH-loaded OFDMTs. There were only small differences between the tablets with respect to mass, diameter, width and hardness. The disintegration times of the five formulation batches of DPH-loaded OFDMTs were measured using the OD-mate, a disintegration test apparatus in which conditions resemble those of the oral cavity. The disintegration times were all within 10 s of exposure to a medium representing the inside of the oral cavity. Rapid release profiles were observed for DPH, Asp and Glu in these dissolution tests. The taste sensor outputs of samples taken at different times (5 - 30 s) from the dissolution test solutions of the four DPH-loaded OFDMTs containing Asp or Glu were significantly inhibited compared with those of control DPH-loaded OFDMT. These results suggest that the inclusion of Asp or Glu in DPH-loaded OFDMTs is sufficient to mask bitterness in the oral cavity for the first 30 s after the tablet is placed in the mouth. It is anticipated that swallowing will have taken place within 30 s.展开更多
文摘2026年1月,索尼Cine Alta V 2分体拓展系统Mini正式上市。其内置CineAltaV 2的8.6K全画幅CMOS传感器,搭配插入式ND滤镜,可创造出色的、富有质感的影像表现。值得一提的是,其头部体积比前一代减小了约70%,更便携的设计为创作者在有限空间进行手持、极限动作等拍摄提供更多的创作自由。除了适应紧凑环境的拍摄外,索尼Cine Alta V 2分体拓展系统Mini还可用于3D、VR拍摄。此外,新品还配备多个安装点,方便轻松连接多种配件,可拆卸的电缆线材质更软、操控更灵活,使拍摄更高效,使用场景更多元。
文摘The aim of this study was to prepare diphenhydramine hydrochloride (DPH)-loaded orally fast-disintegrating mini-tablets (OFDMTs) containing either L-aspartic acid (Asp) or L-glutamic acid (Glu) as bitterness-suppressant, to characterize the prepared tablets and to evaluate their bitterness under conditions mimicking those of the oral cavity. The preparation of five formulation batches of the OFDMTs involved mixing DPH, with or without two different concentrations of Asp or Glu, and a premix containing a disintegrating agent. When all ingredients were well mixed, the mixture was directly compacted to form small (4 mm diameter) DPH-loaded OFDMTs. There were only small differences between the tablets with respect to mass, diameter, width and hardness. The disintegration times of the five formulation batches of DPH-loaded OFDMTs were measured using the OD-mate, a disintegration test apparatus in which conditions resemble those of the oral cavity. The disintegration times were all within 10 s of exposure to a medium representing the inside of the oral cavity. Rapid release profiles were observed for DPH, Asp and Glu in these dissolution tests. The taste sensor outputs of samples taken at different times (5 - 30 s) from the dissolution test solutions of the four DPH-loaded OFDMTs containing Asp or Glu were significantly inhibited compared with those of control DPH-loaded OFDMT. These results suggest that the inclusion of Asp or Glu in DPH-loaded OFDMTs is sufficient to mask bitterness in the oral cavity for the first 30 s after the tablet is placed in the mouth. It is anticipated that swallowing will have taken place within 30 s.
