Aim: To study the apoptotic rate (AR) and the androgen and estrogen milieu in the proximal and distal ductal sys-tems of prostate, in order to help exploring the effects of these factors on prostatic growth and the pa...Aim: To study the apoptotic rate (AR) and the androgen and estrogen milieu in the proximal and distal ductal sys-tems of prostate, in order to help exploring the effects of these factors on prostatic growth and the pathogenesis of be-nign prostatic hypertrophy (BPH). Methods: The proximal and distal ends of the ductal system were incised from20 normal prostate as well as the hypertrophic prostate tissue from 20 patients with BPH. The AR was determined bythe DNA end-labeling method and dihydrotestosterone (DHT) and estrodiol (E_2), by radioimmunoassay. Results:There was no significant difference in DHT and E_2 density between the proximal and distal ends of the ductal systems innormal prostate. E_2 appeared to be higher in BPH than in normal prostatic tissues, but the difference was statistically in-significant. In normal prostatic tissue, the AR was significantly higher in the distal than in the proximal ends of theductal system (P<0.05), while the AR of the proximal ends was significantly higher (P <0.01) than that in theBPH tissue. No significant correlation was noted between the DHT and E_2 density and the AR both in the normalprostate and BPH tissues. Conclusion: The paper is the first time describing a difference in AR in different regionsof the ductal system of normal prostate, while the hormonal milieu is similar, indicating a functional inhomogeneity ofthese regions. A low AR in the proximal duct, where BPH originates, and an even lower AR in the BPH tissue, sug-gesting the participation of apoptosis in the BPH pathogenesis.展开更多
This paper is preoccupied with the delineation of the dialectic of poverty and wealth in Festus Iyayi＇s Violence. The unbridled struggle between the bourgeois and the proletariat in the novel constitutes the onus of ...This paper is preoccupied with the delineation of the dialectic of poverty and wealth in Festus Iyayi＇s Violence. The unbridled struggle between the bourgeois and the proletariat in the novel constitutes the onus of the dialectical materialism which underlies an axiomatic focus of societal superstructure. An application of Kenneth Boulding＇s theory of protest to the Nigerian social milieu, poignantly reveals that there is a potent foregrounding of the class stratification between the rich and the poor. The paper will further examine how this dichotomy between the highly placed and the down trodden in the novel has graphically accentuated the poverty index in contemporary Nigeria.展开更多
Tensta-Rinkeby and Skarholmen are two suburbs of Stockholm which are characterized of a multi-ethnic and multi-religious population created by immigration during the last decades. Many of those living in Tensta-Rinkeb...Tensta-Rinkeby and Skarholmen are two suburbs of Stockholm which are characterized of a multi-ethnic and multi-religious population created by immigration during the last decades. Many of those living in Tensta-Rinkeby and Skaholmen are Muslims, and others are Christians-native Protestants or Catholic and Orthodox immigrants. This article presents data from interviews with Muslim and Christian informants, leaders as well as lay persons, on how they look upon each other across religious borders. The information is classified and interpreted according to models used by scholars in theology of religion. Some informants give vague answers due to the fact that issues of assessing beliefs of others are seldom treated in their churches and mosques. Articulated opinions can be classified from a replacement to an acceptance-model with a bulk of proponents for a fulfillment-model in the middle. Finally the article discusses the importance of how religious actors teach and act in multi-religious milieus.展开更多
Objective To compare the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin (EPO). Methods Thirty patients aged 8-21 yr, undergoing surgical correction of kyphosc...Objective To compare the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin (EPO). Methods Thirty patients aged 8-21 yr, undergoing surgical correction of kyphoscoliosis were randomly divided into two groups of fifteen:group A and group B. In group A patients received homologous transfusion during operation, while in group B shed blood was collected from operative field and after filtration RBCs were separated by a differential centrifugation and washed in normal saline and reinfused. Anesthesia was induced with fentanyl 2 μg· kg-1 ,propofol 1 mg·kg-1 and vecuronium 0.1 mg·kg-1 and maintained with inhalation of isoflurane and 50 % N2O in oxygen and intermittent iv boluses of vecuronium and fentanyl. Blood routine, blood gases, electrolytes, plasma osmotic pressure and activated clotting time (ACT) were measured before operation, 2 h after skin incision and at the end of surgery. Blood EPO concentration was measured before operation,at the end展开更多
G protein-coupled receptor 37(GPR37)is an orphan receptor predominantly expressed in the brain,particularly in oligodendrocytes and certain types of neurons.Notably,it has been shown that the N-terminal domain of GPR3...G protein-coupled receptor 37(GPR37)is an orphan receptor predominantly expressed in the brain,particularly in oligodendrocytes and certain types of neurons.Notably,it has been shown that the N-terminal domain of GPR37 undergoes proteolysis under normal physiological conditions,resulting in the formation of cleaved receptor forms and the release of its ectodomain(ecto-GPR37)into the extracellular milieu(Mattila et al.,2021).Importantly,ecto-GPR37 density is increased in cerebrospinal fluid(CSF)of patients suffering from sporadic Parkinson’s disease(PD),together with an abnormal GPR37 processing in post-mortem PD substantia nigra(Moratóet al.,2021;Figure 1A).展开更多
文摘Aim: To study the apoptotic rate (AR) and the androgen and estrogen milieu in the proximal and distal ductal sys-tems of prostate, in order to help exploring the effects of these factors on prostatic growth and the pathogenesis of be-nign prostatic hypertrophy (BPH). Methods: The proximal and distal ends of the ductal system were incised from20 normal prostate as well as the hypertrophic prostate tissue from 20 patients with BPH. The AR was determined bythe DNA end-labeling method and dihydrotestosterone (DHT) and estrodiol (E_2), by radioimmunoassay. Results:There was no significant difference in DHT and E_2 density between the proximal and distal ends of the ductal systems innormal prostate. E_2 appeared to be higher in BPH than in normal prostatic tissues, but the difference was statistically in-significant. In normal prostatic tissue, the AR was significantly higher in the distal than in the proximal ends of theductal system (P<0.05), while the AR of the proximal ends was significantly higher (P <0.01) than that in theBPH tissue. No significant correlation was noted between the DHT and E_2 density and the AR both in the normalprostate and BPH tissues. Conclusion: The paper is the first time describing a difference in AR in different regionsof the ductal system of normal prostate, while the hormonal milieu is similar, indicating a functional inhomogeneity ofthese regions. A low AR in the proximal duct, where BPH originates, and an even lower AR in the BPH tissue, sug-gesting the participation of apoptosis in the BPH pathogenesis.
文摘This paper is preoccupied with the delineation of the dialectic of poverty and wealth in Festus Iyayi＇s Violence. The unbridled struggle between the bourgeois and the proletariat in the novel constitutes the onus of the dialectical materialism which underlies an axiomatic focus of societal superstructure. An application of Kenneth Boulding＇s theory of protest to the Nigerian social milieu, poignantly reveals that there is a potent foregrounding of the class stratification between the rich and the poor. The paper will further examine how this dichotomy between the highly placed and the down trodden in the novel has graphically accentuated the poverty index in contemporary Nigeria.
文摘Tensta-Rinkeby and Skarholmen are two suburbs of Stockholm which are characterized of a multi-ethnic and multi-religious population created by immigration during the last decades. Many of those living in Tensta-Rinkeby and Skaholmen are Muslims, and others are Christians-native Protestants or Catholic and Orthodox immigrants. This article presents data from interviews with Muslim and Christian informants, leaders as well as lay persons, on how they look upon each other across religious borders. The information is classified and interpreted according to models used by scholars in theology of religion. Some informants give vague answers due to the fact that issues of assessing beliefs of others are seldom treated in their churches and mosques. Articulated opinions can be classified from a replacement to an acceptance-model with a bulk of proponents for a fulfillment-model in the middle. Finally the article discusses the importance of how religious actors teach and act in multi-religious milieus.
文摘Objective To compare the effects of autotransfusion and homologous transfusion on milieu interieur and secretion of erythropoietin (EPO). Methods Thirty patients aged 8-21 yr, undergoing surgical correction of kyphoscoliosis were randomly divided into two groups of fifteen:group A and group B. In group A patients received homologous transfusion during operation, while in group B shed blood was collected from operative field and after filtration RBCs were separated by a differential centrifugation and washed in normal saline and reinfused. Anesthesia was induced with fentanyl 2 μg· kg-1 ,propofol 1 mg·kg-1 and vecuronium 0.1 mg·kg-1 and maintained with inhalation of isoflurane and 50 % N2O in oxygen and intermittent iv boluses of vecuronium and fentanyl. Blood routine, blood gases, electrolytes, plasma osmotic pressure and activated clotting time (ACT) were measured before operation, 2 h after skin incision and at the end of surgery. Blood EPO concentration was measured before operation,at the end
基金FEDER/Ministerio de Ciencia,Innovacióny Universidades-Agencia Estatal de Investigación(PID2023-147425OB-I00 to FC)Agència de Gestiód’Ajuts Universitaris i de Recerca(AGAUR)-Generalitat de Catalunya(2021 SGR 00698 to FC).
文摘G protein-coupled receptor 37(GPR37)is an orphan receptor predominantly expressed in the brain,particularly in oligodendrocytes and certain types of neurons.Notably,it has been shown that the N-terminal domain of GPR37 undergoes proteolysis under normal physiological conditions,resulting in the formation of cleaved receptor forms and the release of its ectodomain(ecto-GPR37)into the extracellular milieu(Mattila et al.,2021).Importantly,ecto-GPR37 density is increased in cerebrospinal fluid(CSF)of patients suffering from sporadic Parkinson’s disease(PD),together with an abnormal GPR37 processing in post-mortem PD substantia nigra(Moratóet al.,2021;Figure 1A).
