BACKGROUND Wernekink commissural syndrome(WCS)is a distinct midbrain syndrome that involves the caudal tegmentum of the midbrain and selectively damages the Wernekink commissure involved in the decussation of the supe...BACKGROUND Wernekink commissural syndrome(WCS)is a distinct midbrain syndrome that involves the caudal tegmentum of the midbrain and selectively damages the Wernekink commissure involved in the decussation of the superior cerebellar peduncle in midbrain.The aim of the study was to explore the clinical manifestations,imaging characteristics,and differential diagnosis of WCS in midbrain infarction to provide reference for clinicians in the diagnosis of WCS.CASE SUMMARY The clinical data of 4 patients with WCS with midbrain infarction were analyzed retrospectively.WCS is a rare syndrome that can be diagnosed based on its characteristic symptoms and imaging findings of magnetic resonance imaging.CONCLUSION Clinicians should look for this syndrome in cases of bilateral cerebellar dysfunction and eye movement disorders.展开更多
Hypertrophic olivary degeneration(HOD)arises from lesions of the dentato-rubro-olivary pathway(GuillaineMollaret triangle),and bilateral HOD is the rarest.Our patient,a 42-year-old man with bilateral HOD caused by uni...Hypertrophic olivary degeneration(HOD)arises from lesions of the dentato-rubro-olivary pathway(GuillaineMollaret triangle),and bilateral HOD is the rarest.Our patient,a 42-year-old man with bilateral HOD caused by unilateral midbrain infarction,had both increased dizziness and ataxia as the first symptoms.HOD has no effective treatment and is easily misdiagnosed as other diseases in clinical practice.Our case demonstrated unique HOD symptomatology and emphasizes the important role of magnetic resonance imaging in diagnosing HOD.The use of gabapentin relieved nystagmus in our patient and may provide a reference for the future treatment of such patients.展开更多
文摘BACKGROUND Wernekink commissural syndrome(WCS)is a distinct midbrain syndrome that involves the caudal tegmentum of the midbrain and selectively damages the Wernekink commissure involved in the decussation of the superior cerebellar peduncle in midbrain.The aim of the study was to explore the clinical manifestations,imaging characteristics,and differential diagnosis of WCS in midbrain infarction to provide reference for clinicians in the diagnosis of WCS.CASE SUMMARY The clinical data of 4 patients with WCS with midbrain infarction were analyzed retrospectively.WCS is a rare syndrome that can be diagnosed based on its characteristic symptoms and imaging findings of magnetic resonance imaging.CONCLUSION Clinicians should look for this syndrome in cases of bilateral cerebellar dysfunction and eye movement disorders.
基金supported by a 2019 Joint Construction Project of the Henan Provincial Health Committee and Ministry of Health(Grant no.SB201901061)the Henan Key Laboratory of Neurorestoratology(Grant no.HNSJXF-2021-004).
文摘Hypertrophic olivary degeneration(HOD)arises from lesions of the dentato-rubro-olivary pathway(GuillaineMollaret triangle),and bilateral HOD is the rarest.Our patient,a 42-year-old man with bilateral HOD caused by unilateral midbrain infarction,had both increased dizziness and ataxia as the first symptoms.HOD has no effective treatment and is easily misdiagnosed as other diseases in clinical practice.Our case demonstrated unique HOD symptomatology and emphasizes the important role of magnetic resonance imaging in diagnosing HOD.The use of gabapentin relieved nystagmus in our patient and may provide a reference for the future treatment of such patients.
