To efficiently remove radioactive nuclides from nuclear industry wastewater and minimize the generation of radioactive secondary waste,this study proposes the concept of a magnetically controlled microchannel adsorber...To efficiently remove radioactive nuclides from nuclear industry wastewater and minimize the generation of radioactive secondary waste,this study proposes the concept of a magnetically controlled microchannel adsorber based on magnetic adsorbents.A novel protocol for achieving high adsorption performance in microchannel adsorbers with periodically distributed particles is developed using the particle-resolved computational fluid dynamics (CFD) method,which addresses the limitations of traditional porous media flow models.To align simulation results more closely with practical scenarios,a typical high-efficiency magnetic adsorbent,magnetic sodium alginate/cobalt-based Prussian blue (M-SA/PB-Co),was synthesized.The M-SA/PB-Co microspheres exhibit a uniform size distribution (300–600 μm),and their Cs^(+) adsorption follows the pseudo-second-order kinetic model with a Langmuir saturated adsorption capacity of 124.84 mg·g^(-1).The performance parameters of M-SA/PB-Co,obtained from characterization and adsorption experiments,were integrated into CFD simulations.CFD results indicate that as the flow velocity increases,the flow field gradually transitions with vortices expanding in scale and streamline bifurcation points shifting rearward.The Cs^(+) concentration decreases progressively along the flow direction,with a more pronounced reduction in the vortex regions downstream of particles.The characteristic velocity and characteristic concentration of specific regions surrounding the particles were extracted based on boundary layer distribution.The amount of concentration reduction of Cs^(+) through particle is positively correlated with the characteristic concentration and negatively correlated with the characteristic velocity.The number of microspheres required in the microchannel adsorber was optimized using the response surface method.Compared with industrial fixed-bed adsorbers,microchannel adsorbers exhibit 8–10 times higher processing capacity,demonstrating significant industrial application potential.展开更多
Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injecti...Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injection of hyaluronic acid(HA)is widely used to alleviate symptoms;however,its lubrication persistence,antioxidant,and anti-inflammatory abilities are limited,and it is difficult to effectively delay the early process of cartilage degeneration.Based on this,hyaluronic acid-g-lipoic acid(HA-LA)was synthesized by esterification reaction,and HA-LA microspheres were prepared by a reversed-phase emulsion method,which was combined with a macromolecular HA-LA solution to form injectable hydrogels.The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres(HA-LA MS)for the treatment of KOA and to verify its injectability,lubricity,reactive oxygen species(ROS)scavenging ability,and anti-inflammatory effects.The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability,and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect.In vitro experiments have shown that the hydrogel can efficiently scavenge ROS,reduce the expression of inflammatory factors,and is non-cytotoxic.The HA-LA MS injectable hydrogel has excellent lubricity,ROS scavenging ability,and anti-inflammatory effects in vivo,which can effectively delay the degeneration of early KOA cartilage,and its efficacy is significantly better than that of traditional hyaluronic acid,making it a promising intra-articular injection preparation.展开更多
杂种优势利用是提高大豆产量的有效策略之一,细胞质雄性不育(Cytoplasmic-nuclear Male Sterility,CMS)在大豆杂种优势利用中具有重要作用,为了阐明大豆CMS发生的分子机制,利用大豆CMS系W931A及其保持系W931B的单核小孢子(Uninucleate M...杂种优势利用是提高大豆产量的有效策略之一,细胞质雄性不育(Cytoplasmic-nuclear Male Sterility,CMS)在大豆杂种优势利用中具有重要作用,为了阐明大豆CMS发生的分子机制,利用大豆CMS系W931A及其保持系W931B的单核小孢子(Uninucleate Microspore,UM)和二胞花粉期(Binucleate Pollen,BP)花蕾进行代谢组学研究,并与转录组数据联合分析,挖掘大豆CMS相关基因及代谢途径。代谢组分析结果显示,在CMS系W931A的UM和BP阶段分别鉴定到147和305个差异代谢物,主要包括脂质及类脂分子化合物、苯丙烷及聚酮化合物和有机杂环化合物等。转录组和代谢组联合分析揭示,差异表达基因(Differentially Expressed Genes,DEGs)和差异代谢物主要参与黄酮类化合物生物合成、苯丙氨酸代谢和苯丙烷类生物合成。在花粉发育过程中,黄酮类及衍生物的合成被显著抑制,F3H(Glyma.01G166200)和FLS(Glyma.06G110600)基因在CMS系W931A中显著下调表达,推测其在相应代谢途径中发挥关键调控作用,导致花药中相关代谢物的差异,进而引发不育系花粉的败育。研究结果有助于构建大豆CMS分子调控网络,并推动大豆CMS分子机制的研究进程。展开更多
Bone defects have serious economic and clinical impacts;however,despite improvements in bone defect management,the range of clinical outcomes remains limited.A variety of biomaterials have been used to treat complex b...Bone defects have serious economic and clinical impacts;however,despite improvements in bone defect management,the range of clinical outcomes remains limited.A variety of biomaterials have been used to treat complex bone defects.However,final bone repair outcomes may be adversely affected by poor osteogenic capacity and risk of infection.Consequently,therapeutic methods are required that reduce bacterial contamination and increase the use of osteogenic biomaterials.Herein,we report the preparation of poly(lactic acid-coglycolic acid)(PLGA)microspheres coloaded with magnesium(Mg^(2+))and gallium(Ga^(3+))ions(Mg-Ga@PLGA),which can fill irregular bone defects and show good biosafety.During in vitro testing,Mg-Ga@PLGA not only showed a synergistic effect on promoting osteogenic differentiation but also inhibited osteoclastic differentiation.Moreover,we found that Mg-Ga@PLGA demonstrated an antibacterial effect.During in vivo testing,Mg Ga@PLGA exhibited strong in situ osteogenic ability.In conclusion,Mg-Ga@PLGA has good potential for treating bone defects at risk of infection.展开更多
Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and pote...Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and potent anti-tumor effect.However,certain limitations such as unstable loading,perfusion stasis,heterogeneous distribution,ectopic distribution,and insufficient dosage,restrict their clinical application.Herein,a novel personalized Y-90 carbon microsphere with high uniformity,high specific activity and high availability(^(90)Y-HUACM)is presented.It is synthesized through planar molecular complex adsorption and chemical deposition solidification.^(90)Y-HUACM exhibited controllable size,excellent biocompatibility,outstanding in vitro and in vivo stability.The radiolabeling efficiency of Y-90 exceeded 99%and the leaching rate of Y-90 is far below 0.1%.Furthermore,the excellent anti-tumor effect,nuclide loading stability,anti-reflux characteristics,precise embolization,and biosafety of^(90)Y-HUACM were validated in a rabbit VX2liver tumor model.In summary,this new,high-performance,and customizable radioactive microsphere provides a superior choice for selective internal radiation treatment of advanced liver cancer is expected to be rapidly applied in clinical practice.展开更多
Herein,porous poly(lactic-co-glycolic acid)(PLGA)microspheres were prepared to load icariin andmiR-23b for the treatment of metastatic lung cancer.The microspheres exhibited desirable aerodynamic diameter,high drug lo...Herein,porous poly(lactic-co-glycolic acid)(PLGA)microspheres were prepared to load icariin andmiR-23b for the treatment of metastatic lung cancer.The microspheres exhibited desirable aerodynamic diameter,high drug loading and encapsulation efficiency,as well as a favorable drug release profile,which was beneficial for the deposition and exposure of drugs in the lung tissues.The release solution from microspheres exhibited a favorable anti-proliferative effect by inducting cell apoptosis and arresting the cell cycle at G1 phase,and meanwhile inhibited the migration and invasion of cancer cells.More importantly,the microspheres could be effectively inhaled and accumulated in the lung tissues to trigger the in situ apoptosis of tumor cells and suppress metastasis,using mice bearing melanoma-metastatic lung cancer as a model.Furthermore,inhalation of themicrospheres showed favorable biocompatibility,barely causing tissue damage.Overall,porous PLGA microspheres provide a promising platform for the inhalable co-delivery of drugs and genes to obtain ideal therapeutic efficacy in lung cancer and other pulmonary diseases.展开更多
Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy live...Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.展开更多
The increase in the utilization of infrared heat detection technology in military applications necessitates research on composites with improved thermal transmission performance and microwave absorption capabilities.T...The increase in the utilization of infrared heat detection technology in military applications necessitates research on composites with improved thermal transmission performance and microwave absorption capabilities.This study satisfactorily fabricated a series of MoS_(2)/BN-xyz composites(which were characterized by the weight ratio of MoS_(2)to BN,denoted by xy:z)through chemical vapor depos-ition,which resulted in their improved thermal stability and thermal transmission performance.The results show that the remaining mass of MoS_(2)/BN-101 was as high as 69.25wt%at 800℃under air atmosphere,and a temperature difference of 31.7℃was maintained between the surface temperature and the heating source at a heating temperature of 200℃.Furthermore,MoS_(2)/BN-301 exhibited an im-pressive minimum reflection loss value of-32.21 dB at 4.0 mm and a wide effective attenuation bandwidth ranging from 9.32 to 18.00 GHz(8.68 GHz).Therefore,these simplified synthesized MoS_(2)/BN-xyz composites demonstrate great potential as highly efficient con-tenders for the enhancement of microwave absorption performance and thermal conductance.展开更多
Sodium-ion batteries(SIBs)have emerged as a promising contender for next-gener-ation energy storage systems.Hard carbon is re-garded as the most promising anode for commer-cial SIB,however,the large number of defects ...Sodium-ion batteries(SIBs)have emerged as a promising contender for next-gener-ation energy storage systems.Hard carbon is re-garded as the most promising anode for commer-cial SIB,however,the large number of defects on its surface cause irreversible electrolyte consump-tion and an uneven solid electrolyte interphase film.An advanced molecular engineering strategy to coat hard carbon with polycyclic aromatic mo-lecules is reported.Specifically,polystyrene-based carbon microspheres(CSs)were first synthesized and then coated with polycyclic aromatic mo-lecules derived from coal tar pitch by spray-drying and followed by oxidation.Compared to the traditional CVD coating meth-od,this molecular framework strategy has been shown to reduce the number of defects on the surface of CSs without sacrifi-cing internal storage sites and suppressing transport kinetics in hosting the sodium ions.Besides the lower surface defect con-centration,the synthesized hybrid carbon microspheres(HCSs)have a larger grain size and more abundant closed pores,and have a higher reversible sodium storage capacity.A HCS-P-60%electrode has a capacity of 332.3 mAh g^(-1)with an initial Cou-lombic efficiency of 88.5%.It also has a superior rate performance of 246.6 mAh g^(-1)at 2 C and a 95.2%capacity retention after 100 cycles at 0.2 C.This work offers new insights into designing high-performance hard carbon microsphere anodes,advan-cing the commercialization of sodium-ion batteries.展开更多
The construction of monodisperse microporous organic microspheres is deemed a challenging issue,primarily due to the difficulty in achieving both high microporosity and uniformity within the microspheres.In this study...The construction of monodisperse microporous organic microspheres is deemed a challenging issue,primarily due to the difficulty in achieving both high microporosity and uniformity within the microspheres.In this study,a series of fluorinated monodisperse microporous microspheres are fabricated by solvothermal precipitation polymerization.The resulting fluorous methacrylate-based microspheres achieved higher than 400 m^(2)/g surface area,along with a yield of over 90%for the microspheres.Through comprehensive characterization and simulation methods,we discovered that the introduction of fluorous methacrylate monomers at high loading levels is the key factor contributing to the formation of the microporosity within the microspheres.The controlled temperature profile was found to be advantageous for achieving a high yield of microspheres and increased uniformity.Two-dimensional assemblies of these fluorinated microsphere arrays exhibited superhydrophobicity,superolephilicity,and water sliding angles below 10°.Furthermore,a three-dimensional assembly of the fluorinated microporous microsphere in a chromatographic column demonstrated significant improvement in the separation of Engelhardt agent compared to commercial columns.Our work offers a novel approach to constructing fluorinated monodisperse microporous microspheres for advanced applications.展开更多
Microsphere assisted microscopy(MAM)has been rapidly developed to meet the measurement needs of microstructures.MAM can be integrated with optical interference microscopy(OIM)to achieve high lateral resolution surface...Microsphere assisted microscopy(MAM)has been rapidly developed to meet the measurement needs of microstructures.MAM can be integrated with optical interference microscopy(OIM)to achieve high lateral resolution surface profile measurement.However,the microspheres introduce intricate phase changes,resulting in optical path asymmetry which is very challenging to compensate for.This limitation constrains the application of MAM in OIM.In this paper,simulation analysis reveals that the phase transmission of the microsphere is influenced by parameters such as microsphere diameter and its relative position to the sample.It is concluded that a unique compensation process must be adopted for each individual microsphere.Addressing this issue,we proposed a phase compensation algorithm based on the three-dimensional position control of the microsphere and integrated it into our combined system of MAM and white light interferometry(WLI),reducing the phase errors introduced by the microspheres while enhancing the lateral resolution of optical system.This approach improved the profile measurement accuracy,offering a perspective for optically measuring the surface profile of intricate microstructures.展开更多
To improve the controlled release ability,we prepared attapulgite into microspheres by spray drying.This research began with a thorough thermogravimetric analysis to optimize attapulgite's heat treatment for drug ...To improve the controlled release ability,we prepared attapulgite into microspheres by spray drying.This research began with a thorough thermogravimetric analysis to optimize attapulgite's heat treatment for drug loading.By advanced spray drying,attapulgite was transformed into microspheres,refining its drug release characteristics.Various parameters were examined,achieving optimal particle size and morphology at 25%solid content,2.5%dispersant,and 3% binder.Attapulgite microspheres demonstrated exceptional encapsulation efficiency,exceeding 95% for doxorubicin hydrochloride,highlighting their versatility in drug delivery.FTIR and XRD were used to predict changes in material properties after spray drying.Notably,cytotoxicity tests confirmed the high biocompatibility of attapulgite microspheres,devoid of cell death induction.Attapulgite microsphere loaded with doxorubicin enable sustained drug release and maintain killing ability against tumor cells.This study confirms the viability of spray dried attapulgite microspheres for efficient drug loading and delivery and provides insights for innovative drug delivery systems that utilize the unique properties of attapulgite to advance therapeutics.展开更多
基金Dalian distinguished young scholars program(2022RJ17)the Dalian excellent young talents program(2023RY037)provided funding for this study.
文摘To efficiently remove radioactive nuclides from nuclear industry wastewater and minimize the generation of radioactive secondary waste,this study proposes the concept of a magnetically controlled microchannel adsorber based on magnetic adsorbents.A novel protocol for achieving high adsorption performance in microchannel adsorbers with periodically distributed particles is developed using the particle-resolved computational fluid dynamics (CFD) method,which addresses the limitations of traditional porous media flow models.To align simulation results more closely with practical scenarios,a typical high-efficiency magnetic adsorbent,magnetic sodium alginate/cobalt-based Prussian blue (M-SA/PB-Co),was synthesized.The M-SA/PB-Co microspheres exhibit a uniform size distribution (300–600 μm),and their Cs^(+) adsorption follows the pseudo-second-order kinetic model with a Langmuir saturated adsorption capacity of 124.84 mg·g^(-1).The performance parameters of M-SA/PB-Co,obtained from characterization and adsorption experiments,were integrated into CFD simulations.CFD results indicate that as the flow velocity increases,the flow field gradually transitions with vortices expanding in scale and streamline bifurcation points shifting rearward.The Cs^(+) concentration decreases progressively along the flow direction,with a more pronounced reduction in the vortex regions downstream of particles.The characteristic velocity and characteristic concentration of specific regions surrounding the particles were extracted based on boundary layer distribution.The amount of concentration reduction of Cs^(+) through particle is positively correlated with the characteristic concentration and negatively correlated with the characteristic velocity.The number of microspheres required in the microchannel adsorber was optimized using the response surface method.Compared with industrial fixed-bed adsorbers,microchannel adsorbers exhibit 8–10 times higher processing capacity,demonstrating significant industrial application potential.
基金financially supported by the National Natural Science Foundation of China(Nos.82272472 and 52373146)。
文摘Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injection of hyaluronic acid(HA)is widely used to alleviate symptoms;however,its lubrication persistence,antioxidant,and anti-inflammatory abilities are limited,and it is difficult to effectively delay the early process of cartilage degeneration.Based on this,hyaluronic acid-g-lipoic acid(HA-LA)was synthesized by esterification reaction,and HA-LA microspheres were prepared by a reversed-phase emulsion method,which was combined with a macromolecular HA-LA solution to form injectable hydrogels.The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres(HA-LA MS)for the treatment of KOA and to verify its injectability,lubricity,reactive oxygen species(ROS)scavenging ability,and anti-inflammatory effects.The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability,and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect.In vitro experiments have shown that the hydrogel can efficiently scavenge ROS,reduce the expression of inflammatory factors,and is non-cytotoxic.The HA-LA MS injectable hydrogel has excellent lubricity,ROS scavenging ability,and anti-inflammatory effects in vivo,which can effectively delay the degeneration of early KOA cartilage,and its efficacy is significantly better than that of traditional hyaluronic acid,making it a promising intra-articular injection preparation.
基金supported by grants from the National Natural Science Foundation of China(Nos.31971106,BWS21L013,and 21WS09002).
文摘Bone defects have serious economic and clinical impacts;however,despite improvements in bone defect management,the range of clinical outcomes remains limited.A variety of biomaterials have been used to treat complex bone defects.However,final bone repair outcomes may be adversely affected by poor osteogenic capacity and risk of infection.Consequently,therapeutic methods are required that reduce bacterial contamination and increase the use of osteogenic biomaterials.Herein,we report the preparation of poly(lactic acid-coglycolic acid)(PLGA)microspheres coloaded with magnesium(Mg^(2+))and gallium(Ga^(3+))ions(Mg-Ga@PLGA),which can fill irregular bone defects and show good biosafety.During in vitro testing,Mg-Ga@PLGA not only showed a synergistic effect on promoting osteogenic differentiation but also inhibited osteoclastic differentiation.Moreover,we found that Mg-Ga@PLGA demonstrated an antibacterial effect.During in vivo testing,Mg Ga@PLGA exhibited strong in situ osteogenic ability.In conclusion,Mg-Ga@PLGA has good potential for treating bone defects at risk of infection.
基金supported by the National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2018ZX09201018–028)the nuclear energy development projects of China during the 13thFive Year Plan periodthe key research and development project of the Sichuan Provincial Department of Science and Technology(No.18ZDYF1466)。
文摘Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and potent anti-tumor effect.However,certain limitations such as unstable loading,perfusion stasis,heterogeneous distribution,ectopic distribution,and insufficient dosage,restrict their clinical application.Herein,a novel personalized Y-90 carbon microsphere with high uniformity,high specific activity and high availability(^(90)Y-HUACM)is presented.It is synthesized through planar molecular complex adsorption and chemical deposition solidification.^(90)Y-HUACM exhibited controllable size,excellent biocompatibility,outstanding in vitro and in vivo stability.The radiolabeling efficiency of Y-90 exceeded 99%and the leaching rate of Y-90 is far below 0.1%.Furthermore,the excellent anti-tumor effect,nuclide loading stability,anti-reflux characteristics,precise embolization,and biosafety of^(90)Y-HUACM were validated in a rabbit VX2liver tumor model.In summary,this new,high-performance,and customizable radioactive microsphere provides a superior choice for selective internal radiation treatment of advanced liver cancer is expected to be rapidly applied in clinical practice.
基金the National Natural Science Foundation of China(32271319 and 32071267)the Science and Technology Department of Jilin Province(YDZJ202301ZYTS537 and 20240402035GH)+1 种基金the Development and Reform Commission of Jilin Province(2023C015)the“Medicine+X”cross-innovation team of Bethune Medical Department of Jilin University“Leading the Charge with Open Competition”construction project(2022JBGS04).
文摘Herein,porous poly(lactic-co-glycolic acid)(PLGA)microspheres were prepared to load icariin andmiR-23b for the treatment of metastatic lung cancer.The microspheres exhibited desirable aerodynamic diameter,high drug loading and encapsulation efficiency,as well as a favorable drug release profile,which was beneficial for the deposition and exposure of drugs in the lung tissues.The release solution from microspheres exhibited a favorable anti-proliferative effect by inducting cell apoptosis and arresting the cell cycle at G1 phase,and meanwhile inhibited the migration and invasion of cancer cells.More importantly,the microspheres could be effectively inhaled and accumulated in the lung tissues to trigger the in situ apoptosis of tumor cells and suppress metastasis,using mice bearing melanoma-metastatic lung cancer as a model.Furthermore,inhalation of themicrospheres showed favorable biocompatibility,barely causing tissue damage.Overall,porous PLGA microspheres provide a promising platform for the inhalable co-delivery of drugs and genes to obtain ideal therapeutic efficacy in lung cancer and other pulmonary diseases.
文摘Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.
基金supported by the Science and Technology Department of Qinghai Province,China(No.2022-ZJ-932Q).
文摘The increase in the utilization of infrared heat detection technology in military applications necessitates research on composites with improved thermal transmission performance and microwave absorption capabilities.This study satisfactorily fabricated a series of MoS_(2)/BN-xyz composites(which were characterized by the weight ratio of MoS_(2)to BN,denoted by xy:z)through chemical vapor depos-ition,which resulted in their improved thermal stability and thermal transmission performance.The results show that the remaining mass of MoS_(2)/BN-101 was as high as 69.25wt%at 800℃under air atmosphere,and a temperature difference of 31.7℃was maintained between the surface temperature and the heating source at a heating temperature of 200℃.Furthermore,MoS_(2)/BN-301 exhibited an im-pressive minimum reflection loss value of-32.21 dB at 4.0 mm and a wide effective attenuation bandwidth ranging from 9.32 to 18.00 GHz(8.68 GHz).Therefore,these simplified synthesized MoS_(2)/BN-xyz composites demonstrate great potential as highly efficient con-tenders for the enhancement of microwave absorption performance and thermal conductance.
文摘Sodium-ion batteries(SIBs)have emerged as a promising contender for next-gener-ation energy storage systems.Hard carbon is re-garded as the most promising anode for commer-cial SIB,however,the large number of defects on its surface cause irreversible electrolyte consump-tion and an uneven solid electrolyte interphase film.An advanced molecular engineering strategy to coat hard carbon with polycyclic aromatic mo-lecules is reported.Specifically,polystyrene-based carbon microspheres(CSs)were first synthesized and then coated with polycyclic aromatic mo-lecules derived from coal tar pitch by spray-drying and followed by oxidation.Compared to the traditional CVD coating meth-od,this molecular framework strategy has been shown to reduce the number of defects on the surface of CSs without sacrifi-cing internal storage sites and suppressing transport kinetics in hosting the sodium ions.Besides the lower surface defect con-centration,the synthesized hybrid carbon microspheres(HCSs)have a larger grain size and more abundant closed pores,and have a higher reversible sodium storage capacity.A HCS-P-60%electrode has a capacity of 332.3 mAh g^(-1)with an initial Cou-lombic efficiency of 88.5%.It also has a superior rate performance of 246.6 mAh g^(-1)at 2 C and a 95.2%capacity retention after 100 cycles at 0.2 C.This work offers new insights into designing high-performance hard carbon microsphere anodes,advan-cing the commercialization of sodium-ion batteries.
基金supported by Natural Science Foundation of Shandong Province(No.ZR2022MB033)Science and Technology Bureau of Jinan City(No.2021GXRC105)University of Jinan Disciplinary Cross-Convergence Construction Project 2023(No.XKJC-202302)。
文摘The construction of monodisperse microporous organic microspheres is deemed a challenging issue,primarily due to the difficulty in achieving both high microporosity and uniformity within the microspheres.In this study,a series of fluorinated monodisperse microporous microspheres are fabricated by solvothermal precipitation polymerization.The resulting fluorous methacrylate-based microspheres achieved higher than 400 m^(2)/g surface area,along with a yield of over 90%for the microspheres.Through comprehensive characterization and simulation methods,we discovered that the introduction of fluorous methacrylate monomers at high loading levels is the key factor contributing to the formation of the microporosity within the microspheres.The controlled temperature profile was found to be advantageous for achieving a high yield of microspheres and increased uniformity.Two-dimensional assemblies of these fluorinated microsphere arrays exhibited superhydrophobicity,superolephilicity,and water sliding angles below 10°.Furthermore,a three-dimensional assembly of the fluorinated microporous microsphere in a chromatographic column demonstrated significant improvement in the separation of Engelhardt agent compared to commercial columns.Our work offers a novel approach to constructing fluorinated monodisperse microporous microspheres for advanced applications.
基金supported by National Natural Science Foundation of China(No.52275540).
文摘Microsphere assisted microscopy(MAM)has been rapidly developed to meet the measurement needs of microstructures.MAM can be integrated with optical interference microscopy(OIM)to achieve high lateral resolution surface profile measurement.However,the microspheres introduce intricate phase changes,resulting in optical path asymmetry which is very challenging to compensate for.This limitation constrains the application of MAM in OIM.In this paper,simulation analysis reveals that the phase transmission of the microsphere is influenced by parameters such as microsphere diameter and its relative position to the sample.It is concluded that a unique compensation process must be adopted for each individual microsphere.Addressing this issue,we proposed a phase compensation algorithm based on the three-dimensional position control of the microsphere and integrated it into our combined system of MAM and white light interferometry(WLI),reducing the phase errors introduced by the microspheres while enhancing the lateral resolution of optical system.This approach improved the profile measurement accuracy,offering a perspective for optically measuring the surface profile of intricate microstructures.
基金Funded by the Major Special Projects of Technological Innovation of Hubei Province(No.2017ACA168)the Open Fund Project of Sanya Science and Education Innovation Park of Wuhan University of Technology(No.2021KF0012)the Guangdong Basic and Applied Basic Research Foundation(No.2021B1515120091)。
文摘To improve the controlled release ability,we prepared attapulgite into microspheres by spray drying.This research began with a thorough thermogravimetric analysis to optimize attapulgite's heat treatment for drug loading.By advanced spray drying,attapulgite was transformed into microspheres,refining its drug release characteristics.Various parameters were examined,achieving optimal particle size and morphology at 25%solid content,2.5%dispersant,and 3% binder.Attapulgite microspheres demonstrated exceptional encapsulation efficiency,exceeding 95% for doxorubicin hydrochloride,highlighting their versatility in drug delivery.FTIR and XRD were used to predict changes in material properties after spray drying.Notably,cytotoxicity tests confirmed the high biocompatibility of attapulgite microspheres,devoid of cell death induction.Attapulgite microsphere loaded with doxorubicin enable sustained drug release and maintain killing ability against tumor cells.This study confirms the viability of spray dried attapulgite microspheres for efficient drug loading and delivery and provides insights for innovative drug delivery systems that utilize the unique properties of attapulgite to advance therapeutics.
