Dear Editor,Porcine astrovirus(PAstV)is a swine enteric virus which can cause diarrhea and vomiting in pigs,particularly in neonatal piglets(Fang et al.,2019;Su etal.,2020).PAstVwasfirstdetectedby electron microscopyi...Dear Editor,Porcine astrovirus(PAstV)is a swine enteric virus which can cause diarrhea and vomiting in pigs,particularly in neonatal piglets(Fang et al.,2019;Su etal.,2020).PAstVwasfirstdetectedby electron microscopyinthe fecal samples from diarrheal piglets in 1980(Bridger,1980).Based on viral genomes,PAstV is divided into five distinct genotypes(PAstV1-PAstV5)(Fang et al.,2019;Mi et al.,2020;Su et al.,2020).The PAstV5 was the main genotype prevalent in China.Xiao reported a positivity rate of 24.8%for PAstV5 as the predominant genotype in Hunan Province(Xiao et al.,2017).Cai reported a positive rate of 7.5%for PAstV5 in Sichuan Province(Cai et al.,2016).A study in Yunnan Province revealed a total infection rate of 39.9%for PAstV2 and PAstV5(Ren et al.,2022).The PAstV genome open read frame 2(ORF2)encodes for a~90 kDa structural polyprotein called capsid protein(Cap)(Arias and DuBois,2017).The region including amino acids(aa)1-415(N-terminus)of the Cap ishighly conserved,and the region starting at aa 416(C-terminus)is extremely variable(Ren et al.,2022).Moreover,the Cap can bind to host cell receptors and is the main target of neutralizing antibodies(Ricemeyer et al.,2022).展开更多
基金supported by grants from the Henan Province Key Research and Development Special Project(231111113100)the Henan Province Natural Science Foundation Interdisciplinary Innovation Research Group Project(232300421001)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(YJS2023SZ13).
文摘Dear Editor,Porcine astrovirus(PAstV)is a swine enteric virus which can cause diarrhea and vomiting in pigs,particularly in neonatal piglets(Fang et al.,2019;Su etal.,2020).PAstVwasfirstdetectedby electron microscopyinthe fecal samples from diarrheal piglets in 1980(Bridger,1980).Based on viral genomes,PAstV is divided into five distinct genotypes(PAstV1-PAstV5)(Fang et al.,2019;Mi et al.,2020;Su et al.,2020).The PAstV5 was the main genotype prevalent in China.Xiao reported a positivity rate of 24.8%for PAstV5 as the predominant genotype in Hunan Province(Xiao et al.,2017).Cai reported a positive rate of 7.5%for PAstV5 in Sichuan Province(Cai et al.,2016).A study in Yunnan Province revealed a total infection rate of 39.9%for PAstV2 and PAstV5(Ren et al.,2022).The PAstV genome open read frame 2(ORF2)encodes for a~90 kDa structural polyprotein called capsid protein(Cap)(Arias and DuBois,2017).The region including amino acids(aa)1-415(N-terminus)of the Cap ishighly conserved,and the region starting at aa 416(C-terminus)is extremely variable(Ren et al.,2022).Moreover,the Cap can bind to host cell receptors and is the main target of neutralizing antibodies(Ricemeyer et al.,2022).
