Background:The study examines the ecological impact of nano-micronutrient composites on the growth and maturation of late-planted wheat within an agroecological framework.Methods:Experiments conducted using a Randomiz...Background:The study examines the ecological impact of nano-micronutrient composites on the growth and maturation of late-planted wheat within an agroecological framework.Methods:Experiments conducted using a Randomized Block Design(RBD)with three replications and eight treatment combinations,ensured uniform plant populations prior to treatment applications.Significant variations were observed across multiple growth parameters,including tiller density per square meter and dry matter accumulation at 30,60,90,and 120 days after sowing(DAS).Results:Notably,the treatment involving RDF+20 ppm rGO-Fe+rGO-Zn with two foliar sprays at 45 and 60 DAS(T6)exhibited markedly superior growth performance compared to the control and conventional zinc and iron applications.Maximum grain yield(29.2 q/ha)was achieved in T8(RDF+20ppm rGO-Fe+rGO-Zn with two sprays at 45 and 60 DAS)whereas straw yield(50.5 q/ha),biological yield(77.1 q/ha),Harvest Index(38.7%)and Grain Straw ratio(0.6)were found maximum in RDF+20ppm rGO-Fe+rGO(Reduced Graphene oxide)−Zn with two sprays at 45 and 60 DAS(T6).Conclusion:The application of reduced graphene oxide(rGO)-based iron and zinc nanoparticles significantly improved nutrient uptake and utilization efficiency,leading to enhanced crop vigor and yield.The study underscores the ecological importance of integrating nanotechnology with nutrient management to sustain a healthy and balanced agroecosystem.This research focuses on sustainable agriculture,nanofertilizers,nutrient use efficiency,and ecological impact,which follows the Q16,Q57,and O13 JEL(Journal of Economic Literature)classification.展开更多
针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bis...针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。展开更多
The increase of CO2 in atmosphere is a main factor leading to "greenhouse effect", which causes more and more serious global environmental problems. The reduction of CO2 is a challenge for the survival of hu...The increase of CO2 in atmosphere is a main factor leading to "greenhouse effect", which causes more and more serious global environmental problems. The reduction of CO2 is a challenge for the survival of human beings, and it is also a big technical problem. CO2 fluid-rock interaction is a key scientific problem involved in geo-logical storage. The CO2 fluid-rock interaction has a variety of multi-scale changes. Due to great differences in the quantity of surface atoms and surface energy between micron-nano-sized minerals, and ions and crystals, the speed and efficiency of CO2 fluid-rock interaction on a micron-nano scale are much higher than those on other scales. As is known from the natural world, the micron-nano structures of pores and the surface chemical modification of natural porous minerals (zeolite, diatomite, sepiolite, palygorskite, halloysite, etc.) should be further investigated, which can be used as the micron-nano -mineral porous materials with high capacity and high efficiency for capturing CO2. Through simulating the adsorption capacity and process of CO2 by minerals in the natural world, the micron-nano technology is applied to calcium- and magnesium-based minerals (olivine, pyroxene, feldspar, clay, etc.) so as to improve the activity of calcium and magnesium and enlarge the reaction contact area. In this way, the efficiency of capturing and storage of CO2 by calcium- and magnesium-based minerals can be greatly improved. These minerals can also be used as the micron-nano-mineral materials with large capacity and high efficiency for capturing and storing CO2.展开更多
More than 40%of newly discovered drugs have little or no water solubility which presents a serious challenge to the successful development and commercialization of new drugs in the pharmaceutical industry.Additionally...More than 40%of newly discovered drugs have little or no water solubility which presents a serious challenge to the successful development and commercialization of new drugs in the pharmaceutical industry.Additionally,more than 90%of drugs approved since 1995 have poor solubility,poor permeability,or both.Therefore,it may be necessary to increase the dose of a poorly soluble drug to obtain the required efficacy which can lead to more side effects and higher cost to the patient.Performance of drugs can be improved by decreasing the particle size and,at the same time,increasing specific surface area,dissolution rate and the bioavailability of the drug in the human body.The routes of administration are different and listed as 60%for oral,5%for pulmonary,5%for ocular,5%for topical and 25%for injectable,approximately.The injectable drugs are the most interesting ones for nanoization,because smaller particles will increase performance,and will be useful when using micro needles.In a typical manufacturing process of APIs(active pharmaceutical ingredients)top down processes like high pressure homogenization and wet bead milling are used as standard methods to decrease the particle sizes down to a fineness range of 10 to 500 nanometers.展开更多
The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost ...The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.展开更多
NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加...NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加亲民的价格,赋予更多领域充足的算力支持。展开更多
Infectious bone defects represent a substantial challenge in clinical practice,necessitating the deployment of advanced therapeutic strategies.This study presents a treatment modality that merges a mild photothermal t...Infectious bone defects represent a substantial challenge in clinical practice,necessitating the deployment of advanced therapeutic strategies.This study presents a treatment modality that merges a mild photothermal therapy hydrogel with a pulsed drug delivery mechanism.The system is predicated on a hydrogel matrix that is thermally responsive,characteristic of bone defect sites,facilitating controlled and site-specific drug release.The cornerstone of this system is the incorporation of mild photothermal nanoparticles,which are activated within the temperature range of 40–43°C,thereby enhancing the precision and efficacy of drug delivery.Our findings demonstrate that the photothermal response significantly augments the localized delivery of therapeutic agents,mitigating systemic side effects and bolstering efficacy at the defect site.The synchronized pulsed release,cooperated with mild photothermal therapy,effectively addresses infection control,and promotes bone regeneration.This approach signifies a considerable advancement in the management of infectious bone defects,offering an effective and patient-centric alternative to traditional methods.Our research endeavors to extend its applicability to a wider spectrum of tissue regeneration scenarios,underscoring its transformative potential in the realm of regenerative medicine.展开更多
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.展开更多
建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0...建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0.999。在0.25,0.50,2.50μg/kg 3个加标水平下,回收率为92.3%~117.0%,RSD<4.0%(n=6),定量限(LOQ)0.25μg/kg,使用该方法对进口坚果、超市售坚果和小摊贩售坚果进行检测,发现阳性样品检出率为1.0%,小摊贩售样阳性样品检出率高达4.0%。该方法前处理快速简单、灵敏度和准确度高,可满足坚果中吡噻菌胺残留检测的要求。展开更多
文摘Background:The study examines the ecological impact of nano-micronutrient composites on the growth and maturation of late-planted wheat within an agroecological framework.Methods:Experiments conducted using a Randomized Block Design(RBD)with three replications and eight treatment combinations,ensured uniform plant populations prior to treatment applications.Significant variations were observed across multiple growth parameters,including tiller density per square meter and dry matter accumulation at 30,60,90,and 120 days after sowing(DAS).Results:Notably,the treatment involving RDF+20 ppm rGO-Fe+rGO-Zn with two foliar sprays at 45 and 60 DAS(T6)exhibited markedly superior growth performance compared to the control and conventional zinc and iron applications.Maximum grain yield(29.2 q/ha)was achieved in T8(RDF+20ppm rGO-Fe+rGO-Zn with two sprays at 45 and 60 DAS)whereas straw yield(50.5 q/ha),biological yield(77.1 q/ha),Harvest Index(38.7%)and Grain Straw ratio(0.6)were found maximum in RDF+20ppm rGO-Fe+rGO(Reduced Graphene oxide)−Zn with two sprays at 45 and 60 DAS(T6).Conclusion:The application of reduced graphene oxide(rGO)-based iron and zinc nanoparticles significantly improved nutrient uptake and utilization efficiency,leading to enhanced crop vigor and yield.The study underscores the ecological importance of integrating nanotechnology with nutrient management to sustain a healthy and balanced agroecosystem.This research focuses on sustainable agriculture,nanofertilizers,nutrient use efficiency,and ecological impact,which follows the Q16,Q57,and O13 JEL(Journal of Economic Literature)classification.
文摘针对香菇育种过程中表型性状考察困难、人工测量费时费力的问题,提出一种适用于Jetson Orin Nano平台部署的香菇菌棒表型测量方法。使用手机和工业相机对3种不同数据来源的香菇菌棒进行图像采集,标注香菇菌落数据集并进行增强;比较了Bisenet、Stdcseg、U-net、Deeplabv3p、PP-liteseg 5个分割模型在Test-A、Test-B和Test-C测试集上的分割效果,结果表明PP-liteseg的普适性优于其他网络,PP-liteseg分割模型在3个测试集上的平均交并比超过97.53%,平均像素准确率高于99.49%,推理单幅图像耗时660 ms;为进一步平衡模型准确性和实时性,采用量化蒸馏方式对PP-liteseg模型进行压缩,并部署到Jetson Orin Nano平台上,压缩后的模型在Test-B测试集上的平均交并比和平均像素准确率分别为97.50%和99.51%,推理单幅图像耗时43.63 ms,比压缩前缩短近64%;采用PP-liteseg分割香菇菌棒图像,提取菌落表型,再根据菌落径向长度和轴向宽度得到菌丝生长长度,与人工测量值相比,菌丝生长长度平均绝对百分比误差、均方根误差和决定系数分别为1.874%、0.148 cm、0.918;采用该方法测量了6个菌株在连续4 d内的菌丝生长长度,结果表明,6个菌株的菌丝生长速度无论在单日还是在整个培养期内均有差异,其中49号和168号菌株差异最大。研究表明,本文方法适用于香菇菌棒表型测量,并能够以良好的准确性和实时性在Jetson Orin Nano平台上运行。
基金supported jointly by the National Natural Science Foundation of China (Grant No.40602031)the Fundamental Research Funds for the Central Universities (Grant No.CUGL090213)the Natural Science Foundation of Hubei Province (Grant No.2011045003)
文摘The increase of CO2 in atmosphere is a main factor leading to "greenhouse effect", which causes more and more serious global environmental problems. The reduction of CO2 is a challenge for the survival of human beings, and it is also a big technical problem. CO2 fluid-rock interaction is a key scientific problem involved in geo-logical storage. The CO2 fluid-rock interaction has a variety of multi-scale changes. Due to great differences in the quantity of surface atoms and surface energy between micron-nano-sized minerals, and ions and crystals, the speed and efficiency of CO2 fluid-rock interaction on a micron-nano scale are much higher than those on other scales. As is known from the natural world, the micron-nano structures of pores and the surface chemical modification of natural porous minerals (zeolite, diatomite, sepiolite, palygorskite, halloysite, etc.) should be further investigated, which can be used as the micron-nano -mineral porous materials with high capacity and high efficiency for capturing CO2. Through simulating the adsorption capacity and process of CO2 by minerals in the natural world, the micron-nano technology is applied to calcium- and magnesium-based minerals (olivine, pyroxene, feldspar, clay, etc.) so as to improve the activity of calcium and magnesium and enlarge the reaction contact area. In this way, the efficiency of capturing and storage of CO2 by calcium- and magnesium-based minerals can be greatly improved. These minerals can also be used as the micron-nano-mineral materials with large capacity and high efficiency for capturing and storing CO2.
文摘More than 40%of newly discovered drugs have little or no water solubility which presents a serious challenge to the successful development and commercialization of new drugs in the pharmaceutical industry.Additionally,more than 90%of drugs approved since 1995 have poor solubility,poor permeability,or both.Therefore,it may be necessary to increase the dose of a poorly soluble drug to obtain the required efficacy which can lead to more side effects and higher cost to the patient.Performance of drugs can be improved by decreasing the particle size and,at the same time,increasing specific surface area,dissolution rate and the bioavailability of the drug in the human body.The routes of administration are different and listed as 60%for oral,5%for pulmonary,5%for ocular,5%for topical and 25%for injectable,approximately.The injectable drugs are the most interesting ones for nanoization,because smaller particles will increase performance,and will be useful when using micro needles.In a typical manufacturing process of APIs(active pharmaceutical ingredients)top down processes like high pressure homogenization and wet bead milling are used as standard methods to decrease the particle sizes down to a fineness range of 10 to 500 nanometers.
基金supported by the National Natural Science Foundation of China(No.21777139)the National Key Research and Development Program of China(No.2017YFA0207003).
文摘The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.
文摘NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加亲民的价格,赋予更多领域充足的算力支持。
基金supported by the National Natural Science Foundation of China(32171354,82222015,82171001)The National Key Research and Development Program of China2023YFC2413600Research Funding from West China School/Hospital of Stomatology,Sichuan University(No.RCDWIS2023-1).
文摘Infectious bone defects represent a substantial challenge in clinical practice,necessitating the deployment of advanced therapeutic strategies.This study presents a treatment modality that merges a mild photothermal therapy hydrogel with a pulsed drug delivery mechanism.The system is predicated on a hydrogel matrix that is thermally responsive,characteristic of bone defect sites,facilitating controlled and site-specific drug release.The cornerstone of this system is the incorporation of mild photothermal nanoparticles,which are activated within the temperature range of 40–43°C,thereby enhancing the precision and efficacy of drug delivery.Our findings demonstrate that the photothermal response significantly augments the localized delivery of therapeutic agents,mitigating systemic side effects and bolstering efficacy at the defect site.The synchronized pulsed release,cooperated with mild photothermal therapy,effectively addresses infection control,and promotes bone regeneration.This approach signifies a considerable advancement in the management of infectious bone defects,offering an effective and patient-centric alternative to traditional methods.Our research endeavors to extend its applicability to a wider spectrum of tissue regeneration scenarios,underscoring its transformative potential in the realm of regenerative medicine.
文摘Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.
文摘建立Sin-QuECh ERS Nano-超高效液相色谱串联质谱法测定坚果中吡噻菌胺酰胺类杀菌剂残留的方法。采用电喷雾正离子模式下多反应监测(MRM)模式进行检测,外标法定量。结果表明,吡噻菌胺在质量浓度10~500μg/L内具有良好的线性关系,R2>0.999。在0.25,0.50,2.50μg/kg 3个加标水平下,回收率为92.3%~117.0%,RSD<4.0%(n=6),定量限(LOQ)0.25μg/kg,使用该方法对进口坚果、超市售坚果和小摊贩售坚果进行检测,发现阳性样品检出率为1.0%,小摊贩售样阳性样品检出率高达4.0%。该方法前处理快速简单、灵敏度和准确度高,可满足坚果中吡噻菌胺残留检测的要求。
