Millimeter channel reactors(MCRs)have received increasing attention because of their ability to enhance treatment capacity in addition to the advantages of microchannels.In previous studies,less work has been conducte...Millimeter channel reactors(MCRs)have received increasing attention because of their ability to enhance treatment capacity in addition to the advantages of microchannels.In previous studies,less work has been conducted on the micromixing process and enhancement strategies for non-Newtonian fluids in MCRs.In this study,the micromixing efficiency in MCRs was experimentally investigated using CMC(carboxymethyl cellulose sodium)aqueous solution to simulate a non-Newtonian fluid,and the enhanced mechanism of micromixing efficiency by the addition of internals and rotation was analyzed by computational fluid dynamics(CFD)simulations.The results show that in the conventional channel,increasing the flow rate improves the micromixing efficiency when the CMC concentration is low.However,when the CMC concentration is higher,the higher the flow rate,the lower the micromixing efficiency.The highest micromixing efficiency is obtained for the rotationally coupled inner components,followed by the single rotation and the lowest is for the internals only.CFD simulations reveal that the most effective way to improve the micromixing efficiency of non-Newtonian fluids with shear-thinning behavior is to increase the shear force in the reactor,which effectively reduces the apparent viscosity.These results provide the theoretical foundation for enhancing the micromixing process of non-Newtonian fluids in small-size reactors.展开更多
Micromixing in the submerged circulative impinging stream reactor (SCISR) developed by the authors is investigated with the Bourne's reaction scheme. The values measured for the impinging velocity, u0, under the ...Micromixing in the submerged circulative impinging stream reactor (SCISR) developed by the authors is investigated with the Bourne's reaction scheme. The values measured for the impinging velocity, u0, under the conditions of SCISR normal operation, only is of the order of 0.1m·s^-1, are much slower than that inferred,suggesting low power requirement for operation. The values of the characteristic time constant for micromixing,tM, determined in the impinging velocity range of 0.184m·s^-1 < u0 < 0.326m·s^-1 are ranged from 192ms to 87 ms, showing that impinging streams promotes micromixing very efficiently. The data follow approximately the relationship of tM∝ u0^-1.5. A comparative study shows that the micromixing performance of SCISR is much better than that of the traditional stirred tank reactor. The tM values predicted with the existing theoretical model are systematically longer than those measured by about 2--3 times, implying that the regularity of impinging streams promoting micromixing is unclear yet.展开更多
Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the siz...Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the size of ~1 mm was developed by steel micro-capillary and laser drilling technology. Utilizing the Villermaux/Dushman parallel competing reaction, numerical and experimental studies were carried out to investigate the micromixing performance(expressed as the segregation index XS) of liquids inside S-CFMCR at the low flow velocity regime.The effects of various operating conditions and design parameters of S-CFMCR, e.g., inlet Reynolds number(Re),volumetric flow ratio(R), inlet diameter(d) and outlet length(L), on the quality of micromixing were studied qualitatively. It was found that the micromixing efficiency was enhanced with increasing Re, but weakened with the increase of R. Moreover, d and L also have a significant influence on micromixing. CFD results were in good agreement with experimental data. In addition, the visualization of velocity magnitude, turbulent kinetic energy and concentration distributions of various ions inside S-CFMCR was illustrated as well. Based on the incorporation model, the estimated minimum micromixing time tmof S-CFMCR is ~2 × 10-4s.展开更多
Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different visco...Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different viscosities.The experimental results showed that segregation index of the micro-channel reactor increases with the decrease of volumetric flow rate and the increase of solution viscosity.Based on the incorporation model,the micromixing time tm of the micro-channel reactor was estimated in the range of 10-4-10-3s at different viscosities,which indicated that the micro-channel reactor possesses a much better micromixing performance compared to the stirred tank(tm=0.02-0.2s).展开更多
In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter...In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter the micromixer by fluid flows and are actuated by an alternating magnetic field normal to the main flow. An important feature of micromixer which is not considered before by researchers is the particle entrance arrangement into the micromixer. This parameter could effectively affect the micromixer efficiency. There are two general micro magnetic particle entrance arrangements in magnetic bead micromixers: determined position entrance and random position entrance. In the case of determined position entrances, micro magnetic particles enter the micromixer at specific positions of entrance cross section. However, in a random position entrance,particles enter the microchannel with no order. In this study mixing efficiencies of identical magnetic bead micromixers which only differ in particle entrance arrangement are numerically investigated and compared.The results reported in this paper illustrate that the prepared computer code can be one of the most powerful and beneficial tools for the magnetic bead micromixer performance analysis. In addition, the results show that some features of the magnetic bead micromixer are strongly affected by the entrance arrangement of the particles.展开更多
Confined impinging jet reactor(CIJR)offers advantages for chemical rapid processes and has become an important new reactor used in the chemical industry.The micromixing efficiency in a T-shaped CIJR for two tubes of i...Confined impinging jet reactor(CIJR)offers advantages for chemical rapid processes and has become an important new reactor used in the chemical industry.The micromixing efficiency in a T-shaped CIJR for two tubes of inner diameter of 3 mm was studied by using a parallel competing iodide–iodate reaction as the working system.In this work,the effects of different operating conditions,such as impinging velocity and acid concentration,on segregation index were investigated.In addition,the effects of the inner nozzles diameter and the distance L between the jet axis and the top wall of the mixing chamber on the micromixing efficiency were also considered.It is concluded that the best range of L in this CIJR is 6.5–12.5 mm.Based on the incorporation model,the estimated minimum micromixing time tmof CIJR approximately equals to 2×10-4s.These experimental results indicate clearly that CIJR possesses a much better micromixing performance compared with the conventional stirred tank(micromixing time of 2×10-3to 2×10-2s).Hence,it can be envisioned that CIJR has more promising applications in various industrial processes.展开更多
A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM micro...A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.展开更多
The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is unde...The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and matrices.Drawing inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this complexity.The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids.Notably,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing method.This advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.展开更多
This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study t...This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study the effects of the inlet velocity, the jet intensity and frequency, and the jet location on the mixing efficiency, 3-D numerical simulations of the micromixer have been carried out. It has been found that when the jet intensity and the frequency are fixed, the mixing efficiency increases when Re 〈 50, and decreases when Re 〉 50 with the best mixing efficiency achieved at Re = 50. When the ratio of the jet velocity magnitude to the inlet velocity is taken as 10 and the jet frequency is 100 Hz, the mixing index reaches the highest value. It has also been found that to get better mixing efficiency, the orifice of the synthetic jet should be asymmetrically located away from the channel＇s centerline.展开更多
The parallel-competing iodide-iodate reaction scheme was used to study the micromixing performance in a multi-phase stirred tank of 0.3 m diameter.The impeller combination consisted of a half elliptical blade disk tur...The parallel-competing iodide-iodate reaction scheme was used to study the micromixing performance in a multi-phase stirred tank of 0.3 m diameter.The impeller combination consisted of a half elliptical blade disk turbine below two down-pimping wide-blade hydrofoils,identified as HEDT + 2WH_D.Nitrogen and glass beads of100 μm diameter and density 2500 kg-m^(-3) were used as the dispersed phases.The micromixing could be improved by sparging gas because of its additional potential energy.Also,micromixing could be improved by the solid particles with high kinetic energy near the impeller tip.In a gas-solid-liquid system,the gas-liquid film vibration with damping,due to the frequent collisions between the bubbles and particles,led to the decrease of the turbulence level in the liquid and caused eventually the deterioration of the micromixing.A Damping Film Dissipation model is formulated to shed light on the above micromixing performances.At last,the micromixing time t_m according to the incorporation model varied from 1.9 ms to 6.7 ms in our experiments.展开更多
In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting te...In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting technology and the factors to improve mixing efficiency.Villermaux-Dushman reaction system and Compute Fluid Design(CFD)simulation were conducted to investigate the performance and the mechanism of this novel micromixer to improve mixing efficiency.The research found that the best mixing efficiency of this novel micromixer could be gained when the inner units divided fluid into five pieces with a uniform volume.Compared with a conventional micromixer without obstacle in the channel,the micromixer designed in this research achieved higher mixing efficiency and reduce the pressure drop by 10.34%.The mixing behaviour in this novel micromixer was discussed,which mainly contains two types:collisions and swirls.Via collisions,the fluid micro masses would hit each other directly,which broke the boundaries of micro masses and promoted the interchange of species in the whole flow field.In swirls,the fluid micro masses were drawn into thin and long slices,which increased the size of the contact area and enhanced molecule diffusion.Finally,the application scheme of this novel micromixer was briefly discussed.展开更多
Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow cha...Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow characteristics and micromixing performance inside the MOCJM were investigated using experiments and computational fluid dynamics(CFD)simulations based on the Villermaux/Dushman system and the finite-rate/modified eddy-dissipation model.The optimal A value was correlated with the characteristic parameters of MOCJMs to develop a CFD calculation method applicable to the study of the micromixing performance of the MOCJMs.Then the micromixing efficiency was evaluated using the segregation index XS,and the effects of operational and geometric parameters such as mixing flow Reynolds number(ReM),flow ratio(RF),total jet area(ST),the number of jet orifices(n),and outlet configuration on the micromixing efficiency were investigated.It was found that the intensive turbulent region generated by interactions between jets,as well as between jets and crossflows,facilitated rapid reactions.XS decreased with increasing ReM and decreasing RF.Furthermore,MOCJMs with lower ST,four jet orifices,and the narrower outlet configuration demonstrated a better micromixing efficiency.This study contributes to a deeper understanding of the micromixing performance of MOCJMs and provides valuable guidance for their design,optimization,and industrial application.展开更多
A CFD simulation was carried out to investigate the mixing process in a Y-shape micromixer with the software Fluent 6.3. The definition of the "diffusion angle" is proposed to describe the molecular diffusio...A CFD simulation was carried out to investigate the mixing process in a Y-shape micromixer with the software Fluent 6.3. The definition of the "diffusion angle" is proposed to describe the molecular diffusion process associated with the flow at low Reynolds number. The linear relationship between the diffusion angle and the Peclet number(Pe) is determined by both theoretical analysis and numerical simulation. Moreover, the simulation results reveal that the diffusion angle is only related to the Peclet number whilst it is irrelevant to the changes of Re(Reynolds number) and Sc(Schmidt number). The range of Peclet number and Reynolds number for experimental measurement are also suggested as Pe≤10000 and Re≤10.展开更多
Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes w...Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes was designed to generate Dean flow,which was used to enhance the liquid-liquid micromixing performance.The Villermaux-Dushman probe reaction was employed to characterize the micromixing performance in different curved capillary microreactors.The effects of experiment parameters such as liquid flow rate,inner diameter,tube length,and curve diameter on micromixing performance were systematically investigated.Under the optimal conditions,the minimum value of the segmentation factor XS was 0.008.It was worth noting that at the low Reynolds number(Re<30),the change of curved shape on the capillary microreactor can significantly improve the micromixing performance with XS reduced by 37.5%.Further,the correlations of segment index XS with dimensionless factor such as Reynolds number or Dean number were developed,which can be used to predict the liquid-liquid micromixing performance in capillary microreactors.展开更多
Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of mi...Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of micromixer,this paper carries out a high-fidelity numerical simu-lation and a parametrial experimental study on a well-established design.A passive tracer is induced in the numerical simulation to analyze mixing dynamics induced by the staggered herring-bone structures.Three effects are identified to reveal the underlying mechanisms,including folding,stretching,and splitting.To the authors’knowledge,the splitting effect is identified for the first time by the isosurface of the passive tracer,to show the high efficiency of the staggered herring-bone design.The micromixer is then used to synthesize lipid nanoparticles by mixing a mixture of lipid and poly(lactic-co-glycolic acid)(PLGA)solutions with deionized water.Under a wide mass ratio of lipid and PLGA solutions,nanoparticles with good monodispersity are synthesized to reflect the good compatibility of the micromixer and the mixture.In addition,an optimized mass ratio is identified from the parametrical experiment.展开更多
The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on rea...The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on reaction selectivity with multiple impellers at different feed points has been investigated. It was confirmed that glass beads as a second phase were suitable for the study. The segregation index has changed significantly only for the medium-sized particles at relatively high solid holdups. The cloud formation was clearly observed for the medium-sized particles at a concentration of 12.12 wt. %. When feeding into the clear liquid above the cloud, the value of the segregation index increased significantly. However, in the presence of particles of 1-1.25 mm, the influence on the selectivity was negligible when the agitation speed was increased.展开更多
The laminar flow structure and mixing performance of T-shaped and double-T-shaped micromixers with rectangular cross-section have been investigated using computational fluid dynamic (CFD) simulation. FLUENT software i...The laminar flow structure and mixing performance of T-shaped and double-T-shaped micromixers with rectangular cross-section have been investigated using computational fluid dynamic (CFD) simulation. FLUENT software is used to evaluate the mixing efficiency. The numerical simulation results show that the presented double-T-micromixer is highly efficient over T-shaped micromixer. The performance of double-T-micromixer with and without static mixing elements (SME) is also investigated. The enhancement in mixing performance is thought to be caused by the generation of eddies and lateral velocity component when the mixture flows through these elements. Mixing efficiency as higher as 97% is reached within a mixing length of 320 μm downstream from the first T-junction with the enhancement of three SMEs.展开更多
This study demonstrates a one-step synthesis strategy for fabricating aptamer-conjugated emodin liposomes(Apt-EMO@Lip)through the integration of microfluidic technology and machine learning.We developed a novel vein g...This study demonstrates a one-step synthesis strategy for fabricating aptamer-conjugated emodin liposomes(Apt-EMO@Lip)through the integration of microfluidic technology and machine learning.We developed a novel vein groove and horseshoe-shaped micromixer(VGHM)that synergistically combines biomimetic vein-groove microstructures(VGM)with horseshoe-shaped splitting-confluence channels(HSM),achieving exceptional mixing efficiency(99.93%at outlet).Both blank liposomes(Blank@Lip)and Apt-EMO@Lip prepared via VGHM display monodisperse size distributions with narrow polydispersity indices,along with superior in vitro stability and biocompatibility.Systematic investigation of microfluidic parameters reveals that flow rate ratio(FRR)and solvent selection critically influence liposomal characteristics,while total flow rate(TFR)shows negligible impact on nanoparticle synthesis.Compared with conventional thin-film hydration methods,the VGHM approach reduces liposome preparation time by 95%while maintaining equivalent physicochemical properties,significantly lowering production costs and establishing a more efficient platform for nanocarrier fabrication.Innovatively,we developed a CNN-LSTM-Attention multivariate regression model incorporating a Newton-Raphson-based optimization(NRBO)algorithm,achieving superior predictive accuracy for liposome size(R^(2)=0.9574,root-mean-square error(RMSE)=6.52 nm).This machine learning framework provides an intelligent parameter optimization tool for nanomedicine development.In vitro experiments demonstrated that emodin-loaded liposomes(EMO@Lip)exhibited sustained-release properties(58.62%cumulative release over 48 h)and effectively suppressed lipopolysaccharide(LPS)-induced secretion of pro-inflammatory mediators(NO,tumor necrosis factor-α(TNF-α),IL-6,IL-1β)-in RAW264.7 macrophages.The Caco-2 scratch assay further confirms EMO@Lip's ability to enhance intestinal epithelial barrier repair and comprehensively ameliorate ulcerative colitis pathology.This strategy significantly enhances drug enrichment efficiency at inflammatory sites via aptamer modification,establishing a novel,efficient,and safe nanomedicine delivery platform for precision-targeted ulcerative colitis therapy.The modular design enables high-throughput continuous production,thereby demonstrating exceptional clinical translation potential and industrial scalability.展开更多
The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were desi...The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were designed. The conclusions drawn from this thesis are helpful for the practical usage.展开更多
In this work, we present a three dimensional micromixer which consists of two layers of spiral channels overlapped together in the vertical direction. This micromixer is designed by using a smooth channel twisted into...In this work, we present a three dimensional micromixer which consists of two layers of spiral channels overlapped together in the vertical direction. This micromixer is designed by using a smooth channel twisted into double-layer spiral geometry with simple topological structure. Based on the principle of Dean effects, this kind of structure is beneficial to produce, enhance and sustain the Dean vortices, which can perturb the laminar fluid effectively. In order to improve the mixing performance, the detailed parameters have been optimized by using the computational fluid dynamics software. The results indicate that the erect channel which is connected with the two layers of spiral channels plays a critical role for well mixing. Meanwhile, the effect of mixing has been identified in a fabricated glass-micromixer. The mixing efficiency of 90% has been achieved by optimizing the flow rate and the structure of the erect channel. Thus, this micromixer has manifested high mixing efficiency and presents good practicability in the versatile microfluidic systems.展开更多
基金supported by the National Natural Science Foundation of China(22078009)National Key Research Program of China(2021YFC3001102,2021YFC3001100).
文摘Millimeter channel reactors(MCRs)have received increasing attention because of their ability to enhance treatment capacity in addition to the advantages of microchannels.In previous studies,less work has been conducted on the micromixing process and enhancement strategies for non-Newtonian fluids in MCRs.In this study,the micromixing efficiency in MCRs was experimentally investigated using CMC(carboxymethyl cellulose sodium)aqueous solution to simulate a non-Newtonian fluid,and the enhanced mechanism of micromixing efficiency by the addition of internals and rotation was analyzed by computational fluid dynamics(CFD)simulations.The results show that in the conventional channel,increasing the flow rate improves the micromixing efficiency when the CMC concentration is low.However,when the CMC concentration is higher,the higher the flow rate,the lower the micromixing efficiency.The highest micromixing efficiency is obtained for the rotationally coupled inner components,followed by the single rotation and the lowest is for the internals only.CFD simulations reveal that the most effective way to improve the micromixing efficiency of non-Newtonian fluids with shear-thinning behavior is to increase the shear force in the reactor,which effectively reduces the apparent viscosity.These results provide the theoretical foundation for enhancing the micromixing process of non-Newtonian fluids in small-size reactors.
基金Supported by the National Natural Science Foundation of China (No. 29276260, No. 20176043).
文摘Micromixing in the submerged circulative impinging stream reactor (SCISR) developed by the authors is investigated with the Bourne's reaction scheme. The values measured for the impinging velocity, u0, under the conditions of SCISR normal operation, only is of the order of 0.1m·s^-1, are much slower than that inferred,suggesting low power requirement for operation. The values of the characteristic time constant for micromixing,tM, determined in the impinging velocity range of 0.184m·s^-1 < u0 < 0.326m·s^-1 are ranged from 192ms to 87 ms, showing that impinging streams promotes micromixing very efficiently. The data follow approximately the relationship of tM∝ u0^-1.5. A comparative study shows that the micromixing performance of SCISR is much better than that of the traditional stirred tank reactor. The tM values predicted with the existing theoretical model are systematically longer than those measured by about 2--3 times, implying that the regularity of impinging streams promoting micromixing is unclear yet.
基金Supported by the National Natural Science Foundation of China(21576012)the National Key Research and Development Program of China(2017YFB0307202)
文摘Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the size of ~1 mm was developed by steel micro-capillary and laser drilling technology. Utilizing the Villermaux/Dushman parallel competing reaction, numerical and experimental studies were carried out to investigate the micromixing performance(expressed as the segregation index XS) of liquids inside S-CFMCR at the low flow velocity regime.The effects of various operating conditions and design parameters of S-CFMCR, e.g., inlet Reynolds number(Re),volumetric flow ratio(R), inlet diameter(d) and outlet length(L), on the quality of micromixing were studied qualitatively. It was found that the micromixing efficiency was enhanced with increasing Re, but weakened with the increase of R. Moreover, d and L also have a significant influence on micromixing. CFD results were in good agreement with experimental data. In addition, the visualization of velocity magnitude, turbulent kinetic energy and concentration distributions of various ions inside S-CFMCR was illustrated as well. Based on the incorporation model, the estimated minimum micromixing time tmof S-CFMCR is ~2 × 10-4s.
基金Supported by the National-Natural Science Foundation of China （20821004, 20806004） and the National High Technology Research and Development Program of China （2007AA030207, 2006AA030202, 2006AA030203）.
文摘Micromixing efficiency of viscous media in Y-type micro-channel reactor was studied by using iodide-iodate test reaction as working system.Experiments were carried out in water-glycerin mixtures with 7 different viscosities.The experimental results showed that segregation index of the micro-channel reactor increases with the decrease of volumetric flow rate and the increase of solution viscosity.Based on the incorporation model,the micromixing time tm of the micro-channel reactor was estimated in the range of 10-4-10-3s at different viscosities,which indicated that the micro-channel reactor possesses a much better micromixing performance compared to the stirred tank(tm=0.02-0.2s).
文摘In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter the micromixer by fluid flows and are actuated by an alternating magnetic field normal to the main flow. An important feature of micromixer which is not considered before by researchers is the particle entrance arrangement into the micromixer. This parameter could effectively affect the micromixer efficiency. There are two general micro magnetic particle entrance arrangements in magnetic bead micromixers: determined position entrance and random position entrance. In the case of determined position entrances, micro magnetic particles enter the micromixer at specific positions of entrance cross section. However, in a random position entrance,particles enter the microchannel with no order. In this study mixing efficiencies of identical magnetic bead micromixers which only differ in particle entrance arrangement are numerically investigated and compared.The results reported in this paper illustrate that the prepared computer code can be one of the most powerful and beneficial tools for the magnetic bead micromixer performance analysis. In addition, the results show that some features of the magnetic bead micromixer are strongly affected by the entrance arrangement of the particles.
基金Supported by the National Natural Science Foundation of China(21206002,21121064,20990224)the State Key Laboratory of Chemical Engineering(SKL-Ch E-13A03)
文摘Confined impinging jet reactor(CIJR)offers advantages for chemical rapid processes and has become an important new reactor used in the chemical industry.The micromixing efficiency in a T-shaped CIJR for two tubes of inner diameter of 3 mm was studied by using a parallel competing iodide–iodate reaction as the working system.In this work,the effects of different operating conditions,such as impinging velocity and acid concentration,on segregation index were investigated.In addition,the effects of the inner nozzles diameter and the distance L between the jet axis and the top wall of the mixing chamber on the micromixing efficiency were also considered.It is concluded that the best range of L in this CIJR is 6.5–12.5 mm.Based on the incorporation model,the estimated minimum micromixing time tmof CIJR approximately equals to 2×10-4s.These experimental results indicate clearly that CIJR possesses a much better micromixing performance compared with the conventional stirred tank(micromixing time of 2×10-3to 2×10-2s).Hence,it can be envisioned that CIJR has more promising applications in various industrial processes.
基金the financial support from the National Natural Science Foundation of China(21808059)the Fundamental Research Funds for the Central Universities(JKA01221712).
文摘A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.
基金supported by the National Key Research and Development Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(No.52275294).
文摘The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and matrices.Drawing inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this complexity.The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids.Notably,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing method.This advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.
基金the National Natural Science Foundation of China(10372099)
文摘This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study the effects of the inlet velocity, the jet intensity and frequency, and the jet location on the mixing efficiency, 3-D numerical simulations of the micromixer have been carried out. It has been found that when the jet intensity and the frequency are fixed, the mixing efficiency increases when Re 〈 50, and decreases when Re 〉 50 with the best mixing efficiency achieved at Re = 50. When the ratio of the jet velocity magnitude to the inlet velocity is taken as 10 and the jet frequency is 100 Hz, the mixing index reaches the highest value. It has also been found that to get better mixing efficiency, the orifice of the synthetic jet should be asymmetrically located away from the channel＇s centerline.
基金Supported by the National Natural Science Foundation of China(20990224,21121064,21206002)
文摘The parallel-competing iodide-iodate reaction scheme was used to study the micromixing performance in a multi-phase stirred tank of 0.3 m diameter.The impeller combination consisted of a half elliptical blade disk turbine below two down-pimping wide-blade hydrofoils,identified as HEDT + 2WH_D.Nitrogen and glass beads of100 μm diameter and density 2500 kg-m^(-3) were used as the dispersed phases.The micromixing could be improved by sparging gas because of its additional potential energy.Also,micromixing could be improved by the solid particles with high kinetic energy near the impeller tip.In a gas-solid-liquid system,the gas-liquid film vibration with damping,due to the frequent collisions between the bubbles and particles,led to the decrease of the turbulence level in the liquid and caused eventually the deterioration of the micromixing.A Damping Film Dissipation model is formulated to shed light on the above micromixing performances.At last,the micromixing time t_m according to the incorporation model varied from 1.9 ms to 6.7 ms in our experiments.
基金supported by the National Natural Science Foundation of China(51775196)Guangdong Province Science and Technology Project(2017B090912003,2017B090911014)+3 种基金High-level Personnel Special Support Plan of Guangdong Province(2016TQ03X289)Guangzhou Star of Pearl River Talent Project(201710010064)the Fundamental Research Funds for the Central Universities(Project Nos.2018ZD30,2019MS060)Guangzhou Science and Technology Project(201704030097).
文摘In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting technology and the factors to improve mixing efficiency.Villermaux-Dushman reaction system and Compute Fluid Design(CFD)simulation were conducted to investigate the performance and the mechanism of this novel micromixer to improve mixing efficiency.The research found that the best mixing efficiency of this novel micromixer could be gained when the inner units divided fluid into five pieces with a uniform volume.Compared with a conventional micromixer without obstacle in the channel,the micromixer designed in this research achieved higher mixing efficiency and reduce the pressure drop by 10.34%.The mixing behaviour in this novel micromixer was discussed,which mainly contains two types:collisions and swirls.Via collisions,the fluid micro masses would hit each other directly,which broke the boundaries of micro masses and promoted the interchange of species in the whole flow field.In swirls,the fluid micro masses were drawn into thin and long slices,which increased the size of the contact area and enhanced molecule diffusion.Finally,the application scheme of this novel micromixer was briefly discussed.
基金the financial support from the Shanghai Sailing Program,China(21YF1409500)the National Natural Science Foundation of China(22308100,22308105)+1 种基金the State Key Laboratory of Chemical Engineering(SKL-ChE-23Z01)the National Science Fund for Distinguished Young Scholars of China(22225804).
文摘Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow characteristics and micromixing performance inside the MOCJM were investigated using experiments and computational fluid dynamics(CFD)simulations based on the Villermaux/Dushman system and the finite-rate/modified eddy-dissipation model.The optimal A value was correlated with the characteristic parameters of MOCJMs to develop a CFD calculation method applicable to the study of the micromixing performance of the MOCJMs.Then the micromixing efficiency was evaluated using the segregation index XS,and the effects of operational and geometric parameters such as mixing flow Reynolds number(ReM),flow ratio(RF),total jet area(ST),the number of jet orifices(n),and outlet configuration on the micromixing efficiency were investigated.It was found that the intensive turbulent region generated by interactions between jets,as well as between jets and crossflows,facilitated rapid reactions.XS decreased with increasing ReM and decreasing RF.Furthermore,MOCJMs with lower ST,four jet orifices,and the narrower outlet configuration demonstrated a better micromixing efficiency.This study contributes to a deeper understanding of the micromixing performance of MOCJMs and provides valuable guidance for their design,optimization,and industrial application.
基金Project(51106184)supported by the National Natural Science Foundation of China
文摘A CFD simulation was carried out to investigate the mixing process in a Y-shape micromixer with the software Fluent 6.3. The definition of the "diffusion angle" is proposed to describe the molecular diffusion process associated with the flow at low Reynolds number. The linear relationship between the diffusion angle and the Peclet number(Pe) is determined by both theoretical analysis and numerical simulation. Moreover, the simulation results reveal that the diffusion angle is only related to the Peclet number whilst it is irrelevant to the changes of Re(Reynolds number) and Sc(Schmidt number). The range of Peclet number and Reynolds number for experimental measurement are also suggested as Pe≤10000 and Re≤10.
基金supports of National Natural Science Foundation of China(22308057)Outstanding Talent Introduction Funds from Fuzhou University(0040-511175)Fuzhou University Testing Fund of precious apparatus(2023T003).
文摘Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes was designed to generate Dean flow,which was used to enhance the liquid-liquid micromixing performance.The Villermaux-Dushman probe reaction was employed to characterize the micromixing performance in different curved capillary microreactors.The effects of experiment parameters such as liquid flow rate,inner diameter,tube length,and curve diameter on micromixing performance were systematically investigated.Under the optimal conditions,the minimum value of the segmentation factor XS was 0.008.It was worth noting that at the low Reynolds number(Re<30),the change of curved shape on the capillary microreactor can significantly improve the micromixing performance with XS reduced by 37.5%.Further,the correlations of segment index XS with dimensionless factor such as Reynolds number or Dean number were developed,which can be used to predict the liquid-liquid micromixing performance in capillary microreactors.
基金supported by the National Natural Science Foundation of China(No.11772343)the Beijing Institute of Technology Research Fund Program for Young Scholars.
文摘Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of micromixer,this paper carries out a high-fidelity numerical simu-lation and a parametrial experimental study on a well-established design.A passive tracer is induced in the numerical simulation to analyze mixing dynamics induced by the staggered herring-bone structures.Three effects are identified to reveal the underlying mechanisms,including folding,stretching,and splitting.To the authors’knowledge,the splitting effect is identified for the first time by the isosurface of the passive tracer,to show the high efficiency of the staggered herring-bone design.The micromixer is then used to synthesize lipid nanoparticles by mixing a mixture of lipid and poly(lactic-co-glycolic acid)(PLGA)solutions with deionized water.Under a wide mass ratio of lipid and PLGA solutions,nanoparticles with good monodispersity are synthesized to reflect the good compatibility of the micromixer and the mixture.In addition,an optimized mass ratio is identified from the parametrical experiment.
文摘The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on reaction selectivity with multiple impellers at different feed points has been investigated. It was confirmed that glass beads as a second phase were suitable for the study. The segregation index has changed significantly only for the medium-sized particles at relatively high solid holdups. The cloud formation was clearly observed for the medium-sized particles at a concentration of 12.12 wt. %. When feeding into the clear liquid above the cloud, the value of the segregation index increased significantly. However, in the presence of particles of 1-1.25 mm, the influence on the selectivity was negligible when the agitation speed was increased.
基金Supported by 863 Programs of the National High Technology Research and Development Program of China (No.2006AA05Z316 No.2006AA030202)
文摘The laminar flow structure and mixing performance of T-shaped and double-T-shaped micromixers with rectangular cross-section have been investigated using computational fluid dynamic (CFD) simulation. FLUENT software is used to evaluate the mixing efficiency. The numerical simulation results show that the presented double-T-micromixer is highly efficient over T-shaped micromixer. The performance of double-T-micromixer with and without static mixing elements (SME) is also investigated. The enhancement in mixing performance is thought to be caused by the generation of eddies and lateral velocity component when the mixture flows through these elements. Mixing efficiency as higher as 97% is reached within a mixing length of 320 μm downstream from the first T-junction with the enhancement of three SMEs.
基金supported by Yantai Science and Technology Innovation Development Plan Key Basic Research Projects(No.2023JCYJ048)Special Supporting Funds for Leading Talents above Provincial Level in Yantai(No.220-20230002)+4 种基金Young Taishan Scholars Program of Shandong Province of China(No.tsqn202103091)Shandong Provincial Natural Science Foundation(No.ZR2024ME052)Ludong University introduced talents and started funding project(No.LD22065)Project supported by the Young Scientists Fund of the National Natural Science Foundation of China(No.32202024)Project supported by the Young Scientists Fund of Shandong Provincial Natural Science Foundation(No.ZR2024QC103).
文摘This study demonstrates a one-step synthesis strategy for fabricating aptamer-conjugated emodin liposomes(Apt-EMO@Lip)through the integration of microfluidic technology and machine learning.We developed a novel vein groove and horseshoe-shaped micromixer(VGHM)that synergistically combines biomimetic vein-groove microstructures(VGM)with horseshoe-shaped splitting-confluence channels(HSM),achieving exceptional mixing efficiency(99.93%at outlet).Both blank liposomes(Blank@Lip)and Apt-EMO@Lip prepared via VGHM display monodisperse size distributions with narrow polydispersity indices,along with superior in vitro stability and biocompatibility.Systematic investigation of microfluidic parameters reveals that flow rate ratio(FRR)and solvent selection critically influence liposomal characteristics,while total flow rate(TFR)shows negligible impact on nanoparticle synthesis.Compared with conventional thin-film hydration methods,the VGHM approach reduces liposome preparation time by 95%while maintaining equivalent physicochemical properties,significantly lowering production costs and establishing a more efficient platform for nanocarrier fabrication.Innovatively,we developed a CNN-LSTM-Attention multivariate regression model incorporating a Newton-Raphson-based optimization(NRBO)algorithm,achieving superior predictive accuracy for liposome size(R^(2)=0.9574,root-mean-square error(RMSE)=6.52 nm).This machine learning framework provides an intelligent parameter optimization tool for nanomedicine development.In vitro experiments demonstrated that emodin-loaded liposomes(EMO@Lip)exhibited sustained-release properties(58.62%cumulative release over 48 h)and effectively suppressed lipopolysaccharide(LPS)-induced secretion of pro-inflammatory mediators(NO,tumor necrosis factor-α(TNF-α),IL-6,IL-1β)-in RAW264.7 macrophages.The Caco-2 scratch assay further confirms EMO@Lip's ability to enhance intestinal epithelial barrier repair and comprehensively ameliorate ulcerative colitis pathology.This strategy significantly enhances drug enrichment efficiency at inflammatory sites via aptamer modification,establishing a novel,efficient,and safe nanomedicine delivery platform for precision-targeted ulcerative colitis therapy.The modular design enables high-throughput continuous production,thereby demonstrating exceptional clinical translation potential and industrial scalability.
文摘The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were designed. The conclusions drawn from this thesis are helpful for the practical usage.
基金We gratefully acknowledge the financial support from Ministry of Science and Technology of China，the National Natural Science Foundation of China，Chinese Academy of Sciences
文摘In this work, we present a three dimensional micromixer which consists of two layers of spiral channels overlapped together in the vertical direction. This micromixer is designed by using a smooth channel twisted into double-layer spiral geometry with simple topological structure. Based on the principle of Dean effects, this kind of structure is beneficial to produce, enhance and sustain the Dean vortices, which can perturb the laminar fluid effectively. In order to improve the mixing performance, the detailed parameters have been optimized by using the computational fluid dynamics software. The results indicate that the erect channel which is connected with the two layers of spiral channels plays a critical role for well mixing. Meanwhile, the effect of mixing has been identified in a fabricated glass-micromixer. The mixing efficiency of 90% has been achieved by optimizing the flow rate and the structure of the erect channel. Thus, this micromixer has manifested high mixing efficiency and presents good practicability in the versatile microfluidic systems.
