The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities o...The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities of the reconstructed enthesis tissues.Herein,a tri-layered core–shell microfibrous scaffold with layer-specific growth factors(GFs)release is developed using coaxial electrohydrodynamic(EHD)printing for in situ cell recruitment and differentiation to facilitate gradient enthesis tissue repair.Stromal cell-derived factor-1(SDF-1)is loaded in the shell,while basic fibroblast GF,transforming GF-beta,and bone morphogenetic protein-2 are loaded in the core of the EHD-printed microfibrous scaffolds in a layer-specific manner.Correspondingly,the tri-layered microfibrous scaffolds have a core–shell fiber size of(25.7±5.1)μm,with a pore size sequentially increasing from(81.5±4.6)μm to(173.3±6.9)μm,and to(388.9±6.9μm)for the tenogenic,chondrogenic,and osteogenic instructive layers.A rapid release of embedded GFs is observed within the first 2 d,followed by a faster release of SDF-1 and a slightly slower release of differentiation GFs for approximately four weeks.The coaxial EHD-printed microfibrous scaffolds significantly promote stem cell recruitment and direct their differentiation toward tenocyte,chondrocyte,and osteocyte phenotypes in vitro.When implanted in vivo,the tri-layered core–shell microfibrous scaffolds rapidly restored the biomechanical functions and promoted enthesis tissue regeneration with native-like bone-to-tendon gradients.Our findings suggest that the microfibrous scaffolds with layer-specific GFs release may offer a promising clinical solution for enthesis regeneration.展开更多
A sinter-locked three-dimensional network of microfibrous nickel catalyst has been fabricated based on wet layup papermaking and sintering processes and this novel approach permits the production of -11 W fuel cell po...A sinter-locked three-dimensional network of microfibrous nickel catalyst has been fabricated based on wet layup papermaking and sintering processes and this novel approach permits the production of -11 W fuel cell power H2 via NH3 decomposition with a conversion of 97% at 750 ℃ in a bed of 0.6 cm^3.展开更多
Adsorption dynamics of ethane in two granular fixed beds and structured fixed beds with microfibrous composites was studied.5A zeolite membrane 5A/PSSF(paper-like sintered stainless steel fiber)and microfibrous entrap...Adsorption dynamics of ethane in two granular fixed beds and structured fixed beds with microfibrous composites was studied.5A zeolite membrane 5A/PSSF(paper-like sintered stainless steel fiber)and microfibrous entrapped activated carbon(MEAC)composites were prepared by wet layup papermaking/sintering technique and in-situ hydrothermal method.Microfibrous composites were characterized by X-ray diffraction,scanning electron microscopy and N2 adsorption/desorption.Structured fixed beds were designed by filling granular adsorbents(5A zeolite or activated carbon)and microfibrous composites at the inlet and outlet of the beds,respectively.Effects of flow rate,bed height and structure on the breakthrough curves were investigated.The length of unused bed(LUB)was determined,and Yoon–Nelson model was used to fit the breakthrough curves.The experimental results showed ethane was effectively adsorbed on the granular adsorbents and microfibrous composites.Both composites could decrease the LUB values and enhance bed utilization.All breakthrough curves fitted well to Yoon–Nelson model,with correlation coefficient exceeding 0.89.The adsorption rate of ethane could be improved in the structured fixed beds,which showed an enhanced mass transfer efficiency for ethane adsorption.LUB values of structured fixed beds with 5A/PSSF composites were larger,the bed utilization values were lower,and the adsorption rate constants were higher than those with MEAC composites under the same conditions.展开更多
The development of biomimetic scaffolds that can promote osteogenic induction and vascularization is of great importance for the repair of large bone defects.In the present study,inorganic bioactive glass(BG)and organ...The development of biomimetic scaffolds that can promote osteogenic induction and vascularization is of great importance for the repair of large bone defects.In the present study,inorganic bioactive glass(BG)and organic polycaprolactone(PCL)are effectively combined by electrospinning and electrospray techniques to construct three-dimensional(3D)BG/PCL microfibrous spheres for the repair of bulk bone defects.The hybrid fibers,as well as the as-obtained 3D structure,can mimic the composition and architecture of native bone tissues.Furthermore,the BG/PCL microfibrous spheres show excellent biocompatibility and provide sufficient space and attachment sites for cell growth.The osteogenic differentiation of bone mesenchymal stem cells is also effectively facilitated when cultured on such hybrid microfibrous spheres.In vivo investigation utilizing rat femoral condyle bone defect models demonstrates that the BG/PCL microfibrous spheres loaded with bone mesenchymal stem cells can induce angiogenesis and promote the upregulation of bone-related protein expression,thus effectively facilitating bone regeneration at the defect site.The collective findings indicate that such BG/PCL hybrid microfibrous spheres have the potential to be effective carriers of stem cells.The microfibrous spheres loaded with stem cells have promising potential to be utilized as implantable biomaterials for the repair of bone defects.展开更多
The hydrophilicity, dyeing and antistatic ability of polypropylene microfibre (PPMF) were improved by plasma-induced vapor grafting with acrylic acid. The effects of plasma discharge time, power, liquid phase acrylic ...The hydrophilicity, dyeing and antistatic ability of polypropylene microfibre (PPMF) were improved by plasma-induced vapor grafting with acrylic acid. The effects of plasma discharge time, power, liquid phase acrylic acid temperature and environmental temperature on grafting yield were investigated. The existence of grafted polyacrylic acid (PAA) was verified by ESCA and ATR FT-IR. The morphology of grafted PAA was directly observed by SEM. The wicking test shows that the hydrophilicity of modified PPMF is greatly enhanced. The dyeability test of modified PPMF was carried out using Dispersion Yellow. It was found that the dye uptake ratio is linear to the weight percent of grafting. The antistatic ability was indicated by specific resistance. The specific resistance of modified PPMF was reduced to 10(6) similar to 10(7) Ohm . cm, thus the antistatic ability was considerably improved.展开更多
A series of disperse dyes bearing ether groups have been synthesized. The visible absorption spectra of them were studied, their fastness on polyester microfibres were investigated.
In this paper, bendloss characteristics of an optical fibre are investigated in detail, and the results show that the resonator with a smaller ring radius, wider free spectrum range （FSR）, higher fineness （f） and ...In this paper, bendloss characteristics of an optical fibre are investigated in detail, and the results show that the resonator with a smaller ring radius, wider free spectrum range （FSR）, higher fineness （f） and quality-factor （Q） can be achieved by using microfibres. Based on the improved fused taper technique, a high-quality microfibre with 5 ttm radius has been fabricated, and an all-fibre micro-ring resonator with a radius of only 500μm is realized using self-coiling coupling method. The good-resonant characteristic makes the all-fibre device be expected to avoid bendloss and connection loss associated with planar waveguide integration.展开更多
As the most fundamental,efficient frequency-mixing technology,second-order nonlinear optical effects have been extensively applied in the fields of advanced laser technology,microscopic imaging,and optical communicati...As the most fundamental,efficient frequency-mixing technology,second-order nonlinear optical effects have been extensively applied in the fields of advanced laser technology,microscopic imaging,and optical communication.However,overcoming the limitations of the centrosymmetric nature of traditional optical fibres and exciting second-order nonlinearity remains challenging.In this study,we demonstrate a functionally doped polymer microfibre to implement second-order nonlinear processes in an optical fibre system.Few-layer gallium selenide(GaSe)nanosheets with high nonlinear susceptibility χ^(2)are doped in polyvinyl alcohol(PVA)to fabricate the hybrid polymer microfibre,which enables strong second harmonic generation(SHG)and sum-frequency generation(SFG)with sub-milliwatt pump power.When pumped by a continuous-wave(CW)laser,the observable SHG signal was excited in the 1500-1630 nm wavelength range,exhibiting a theoretically predicted power dependence.The SFG response was also validated in the GaSe-doped PVA microfibre with the excitation of two CW pumps,with the signal intensity corresponding to the theoretical evolution tendency when the power and wavelength of the pump light were adjusted.Hence,developing GaSe-doped polymer microfibres provides a novel approach toward the fabrication and application of nonlinear optical fibre devices.展开更多
基金financially supported by the National Key Research and Development Program of China(2018YFA0703003)National Natural Science Foundation of China(82072429,52125501,82371590)+6 种基金the Program for Innovation Team of Shaanxi Province(2023-CX-TD-17)the Key Research&Development Program of Shaanxi Province(2024SF-YBXM-355,2020SF-093,2021LLRH-08)the Natural Science Foundation of Henan Province(222300420358)the Postdoctoral Project of Shaanxi Province(2023BSHYDZZ30)the Postdoctoral Fellowship Program of CPSF(GZB20230573)the Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University(2019ZYTS-02)the Fundamental Research Funds for the Central Universities.
文摘The rotator cuff tear has emerged as a significant global health concern.However,existing therapies fail to fully restore the intricate bone-to-tendon gradients,resulting in compromised biomechanical functionalities of the reconstructed enthesis tissues.Herein,a tri-layered core–shell microfibrous scaffold with layer-specific growth factors(GFs)release is developed using coaxial electrohydrodynamic(EHD)printing for in situ cell recruitment and differentiation to facilitate gradient enthesis tissue repair.Stromal cell-derived factor-1(SDF-1)is loaded in the shell,while basic fibroblast GF,transforming GF-beta,and bone morphogenetic protein-2 are loaded in the core of the EHD-printed microfibrous scaffolds in a layer-specific manner.Correspondingly,the tri-layered microfibrous scaffolds have a core–shell fiber size of(25.7±5.1)μm,with a pore size sequentially increasing from(81.5±4.6)μm to(173.3±6.9)μm,and to(388.9±6.9μm)for the tenogenic,chondrogenic,and osteogenic instructive layers.A rapid release of embedded GFs is observed within the first 2 d,followed by a faster release of SDF-1 and a slightly slower release of differentiation GFs for approximately four weeks.The coaxial EHD-printed microfibrous scaffolds significantly promote stem cell recruitment and direct their differentiation toward tenocyte,chondrocyte,and osteocyte phenotypes in vitro.When implanted in vivo,the tri-layered core–shell microfibrous scaffolds rapidly restored the biomechanical functions and promoted enthesis tissue regeneration with native-like bone-to-tendon gradients.Our findings suggest that the microfibrous scaffolds with layer-specific GFs release may offer a promising clinical solution for enthesis regeneration.
文摘A sinter-locked three-dimensional network of microfibrous nickel catalyst has been fabricated based on wet layup papermaking and sintering processes and this novel approach permits the production of -11 W fuel cell power H2 via NH3 decomposition with a conversion of 97% at 750 ℃ in a bed of 0.6 cm^3.
基金support from the National Natural Science Foundation of China(21776101)the National Natural Science Foundation of China(22178122)for this work.
文摘Adsorption dynamics of ethane in two granular fixed beds and structured fixed beds with microfibrous composites was studied.5A zeolite membrane 5A/PSSF(paper-like sintered stainless steel fiber)and microfibrous entrapped activated carbon(MEAC)composites were prepared by wet layup papermaking/sintering technique and in-situ hydrothermal method.Microfibrous composites were characterized by X-ray diffraction,scanning electron microscopy and N2 adsorption/desorption.Structured fixed beds were designed by filling granular adsorbents(5A zeolite or activated carbon)and microfibrous composites at the inlet and outlet of the beds,respectively.Effects of flow rate,bed height and structure on the breakthrough curves were investigated.The length of unused bed(LUB)was determined,and Yoon–Nelson model was used to fit the breakthrough curves.The experimental results showed ethane was effectively adsorbed on the granular adsorbents and microfibrous composites.Both composites could decrease the LUB values and enhance bed utilization.All breakthrough curves fitted well to Yoon–Nelson model,with correlation coefficient exceeding 0.89.The adsorption rate of ethane could be improved in the structured fixed beds,which showed an enhanced mass transfer efficiency for ethane adsorption.LUB values of structured fixed beds with 5A/PSSF composites were larger,the bed utilization values were lower,and the adsorption rate constants were higher than those with MEAC composites under the same conditions.
基金supported by Special Funds for Taishan Scholars Project of Shandong Province(No.tsqn202211125)Natural Science Foundation of Shandong Province(ZR2021YQ17)+5 种基金National Natural Science Foundation of China(82001970)Young Elite Scientists Sponsorship Program by CAST(No.YESS20200097)Shandong Province key research and development support project(2021SFGC0502)Qingdao Key Health Discipline Development Fund(2022-2024),Qingdao Clinical Research Center for Oral Diseases(22-3-7-lczx-7-nsh)Shandong Provincial Key Medical and Health Discipline of Oral Medicine(2024-2026)The authors also thank the“Advanced Biomaterials and Regenerative Medicine(ABRM)”Innovation Team supported by the Young-Talent Introduction and Cultivation Plan in the Universities of Shandong Province.
文摘The development of biomimetic scaffolds that can promote osteogenic induction and vascularization is of great importance for the repair of large bone defects.In the present study,inorganic bioactive glass(BG)and organic polycaprolactone(PCL)are effectively combined by electrospinning and electrospray techniques to construct three-dimensional(3D)BG/PCL microfibrous spheres for the repair of bulk bone defects.The hybrid fibers,as well as the as-obtained 3D structure,can mimic the composition and architecture of native bone tissues.Furthermore,the BG/PCL microfibrous spheres show excellent biocompatibility and provide sufficient space and attachment sites for cell growth.The osteogenic differentiation of bone mesenchymal stem cells is also effectively facilitated when cultured on such hybrid microfibrous spheres.In vivo investigation utilizing rat femoral condyle bone defect models demonstrates that the BG/PCL microfibrous spheres loaded with bone mesenchymal stem cells can induce angiogenesis and promote the upregulation of bone-related protein expression,thus effectively facilitating bone regeneration at the defect site.The collective findings indicate that such BG/PCL hybrid microfibrous spheres have the potential to be effective carriers of stem cells.The microfibrous spheres loaded with stem cells have promising potential to be utilized as implantable biomaterials for the repair of bone defects.
文摘The hydrophilicity, dyeing and antistatic ability of polypropylene microfibre (PPMF) were improved by plasma-induced vapor grafting with acrylic acid. The effects of plasma discharge time, power, liquid phase acrylic acid temperature and environmental temperature on grafting yield were investigated. The existence of grafted polyacrylic acid (PAA) was verified by ESCA and ATR FT-IR. The morphology of grafted PAA was directly observed by SEM. The wicking test shows that the hydrophilicity of modified PPMF is greatly enhanced. The dyeability test of modified PPMF was carried out using Dispersion Yellow. It was found that the dye uptake ratio is linear to the weight percent of grafting. The antistatic ability was indicated by specific resistance. The specific resistance of modified PPMF was reduced to 10(6) similar to 10(7) Ohm . cm, thus the antistatic ability was considerably improved.
文摘A series of disperse dyes bearing ether groups have been synthesized. The visible absorption spectra of them were studied, their fastness on polyester microfibres were investigated.
基金Project supported by the National Natural Science Foundation of China(Grant No60607001)the Natural Science Foundation of Beijing,China(Grant No4052023)the Talents of Beijing Jiaotong University,Beijing,China(Grant No2007RC015)
文摘In this paper, bendloss characteristics of an optical fibre are investigated in detail, and the results show that the resonator with a smaller ring radius, wider free spectrum range （FSR）, higher fineness （f） and quality-factor （Q） can be achieved by using microfibres. Based on the improved fused taper technique, a high-quality microfibre with 5 ttm radius has been fabricated, and an all-fibre micro-ring resonator with a radius of only 500μm is realized using self-coiling coupling method. The good-resonant characteristic makes the all-fibre device be expected to avoid bendloss and connection loss associated with planar waveguide integration.
基金primarily supported by the National Natural Science Foundation of China(Nos.62375223,62322510,and 61975166)the Key Research and Development Program(Grant No.2022YFA1404800).
文摘As the most fundamental,efficient frequency-mixing technology,second-order nonlinear optical effects have been extensively applied in the fields of advanced laser technology,microscopic imaging,and optical communication.However,overcoming the limitations of the centrosymmetric nature of traditional optical fibres and exciting second-order nonlinearity remains challenging.In this study,we demonstrate a functionally doped polymer microfibre to implement second-order nonlinear processes in an optical fibre system.Few-layer gallium selenide(GaSe)nanosheets with high nonlinear susceptibility χ^(2)are doped in polyvinyl alcohol(PVA)to fabricate the hybrid polymer microfibre,which enables strong second harmonic generation(SHG)and sum-frequency generation(SFG)with sub-milliwatt pump power.When pumped by a continuous-wave(CW)laser,the observable SHG signal was excited in the 1500-1630 nm wavelength range,exhibiting a theoretically predicted power dependence.The SFG response was also validated in the GaSe-doped PVA microfibre with the excitation of two CW pumps,with the signal intensity corresponding to the theoretical evolution tendency when the power and wavelength of the pump light were adjusted.Hence,developing GaSe-doped polymer microfibres provides a novel approach toward the fabrication and application of nonlinear optical fibre devices.
