Intervening in the microbial environment holds promise for enhancing antitumor efficacy by reshaping the tumor microenvironment,yet few strategies have been reported.In a study led by Zou and coworkers,oral hydrogels ...Intervening in the microbial environment holds promise for enhancing antitumor efficacy by reshaping the tumor microenvironment,yet few strategies have been reported.In a study led by Zou and coworkers,oral hydrogels are introduced to regulate the microbiota balance in the intestines and tumors,triggering an antitumor immune response.This work presents a microbiota-targeted drug delivery system that demonstrates notable efficacy in colon targeting and colon retention for the treatment of colorectal cancer.This represents a significant clinical advancement in treating colorectal cancer,which is particularly vulnerable to microbial infitration.展开更多
基金support from School of Chemical Science and Engineering,Tongji University.
文摘Intervening in the microbial environment holds promise for enhancing antitumor efficacy by reshaping the tumor microenvironment,yet few strategies have been reported.In a study led by Zou and coworkers,oral hydrogels are introduced to regulate the microbiota balance in the intestines and tumors,triggering an antitumor immune response.This work presents a microbiota-targeted drug delivery system that demonstrates notable efficacy in colon targeting and colon retention for the treatment of colorectal cancer.This represents a significant clinical advancement in treating colorectal cancer,which is particularly vulnerable to microbial infitration.
