Dear Editor,Colorectal cancer(CRC)is a leading global cancer,causing significant mortality and morbidity,particularly among younger individuals(Spaander et al.,2023).The gut microbiota,including certain bacterial spec...Dear Editor,Colorectal cancer(CRC)is a leading global cancer,causing significant mortality and morbidity,particularly among younger individuals(Spaander et al.,2023).The gut microbiota,including certain bacterial species,has been identified as oncomicrobes and linked to CRC development(Holt,2023).展开更多
Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut mic...Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut microbiota,including in the prevalence of Enterobacteriaceae,especially pathogenic Escherichia coli(E.coli).[1]The UC diagnosis and assessment primarily rely on colonoscopy and mucosal biopsy pathology,which are limited by their invasiveness,constraints on medical resources,and potential risks and complications.Several biomarkers,such as serum C-reactive protein(CRP),fecal calprotectin,and fecal lactoferrin,are currently recommended for assessing UC disease activity.However,these markers are primarily inflammation-related factors produced by the host,not specific to IBD,and are influenced by other inflammatory states.Microbiome-related biomarkers are used as direct indicators of the gut microecosystem and have considerable potential for disease assessment and therapeutic guidance in IBD.However,current analyses of gut microbiota,such as 16S rRNA or metagenomic sequencing,are often time-consuming and costly.Siderophore,a low-molecularweight protein secreted extracellularly to chelate ferric iron,is a crucial virulence factor in iron acquisition of bacteria and fungi.The presence of siderophores can indirectly reflect bacterial abundance and activity.[2]展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2020YFA0907800)the National Natural Science Foundation of China(Grant No.32000096)the Shenzhen Science and Technology Programs(KQTD20200820145822023,ZDSYS20220606100803007 and RCJC20231211085944057).
文摘Dear Editor,Colorectal cancer(CRC)is a leading global cancer,causing significant mortality and morbidity,particularly among younger individuals(Spaander et al.,2023).The gut microbiota,including certain bacterial species,has been identified as oncomicrobes and linked to CRC development(Holt,2023).
文摘Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut microbiota,including in the prevalence of Enterobacteriaceae,especially pathogenic Escherichia coli(E.coli).[1]The UC diagnosis and assessment primarily rely on colonoscopy and mucosal biopsy pathology,which are limited by their invasiveness,constraints on medical resources,and potential risks and complications.Several biomarkers,such as serum C-reactive protein(CRP),fecal calprotectin,and fecal lactoferrin,are currently recommended for assessing UC disease activity.However,these markers are primarily inflammation-related factors produced by the host,not specific to IBD,and are influenced by other inflammatory states.Microbiome-related biomarkers are used as direct indicators of the gut microecosystem and have considerable potential for disease assessment and therapeutic guidance in IBD.However,current analyses of gut microbiota,such as 16S rRNA or metagenomic sequencing,are often time-consuming and costly.Siderophore,a low-molecularweight protein secreted extracellularly to chelate ferric iron,is a crucial virulence factor in iron acquisition of bacteria and fungi.The presence of siderophores can indirectly reflect bacterial abundance and activity.[2]
