In recent years,the concept of“precision microbiome”has received a lot of attention from researchers.It involves the precise analysis and typing of microbiota in specific hosts(e.g.,humans or animals)using advanced ...In recent years,the concept of“precision microbiome”has received a lot of attention from researchers.It involves the precise analysis and typing of microbiota in specific hosts(e.g.,humans or animals)using advanced tools like high-throughput sequencing,genomics,and artificial intelligence(AI).These tools help explore the complex interactions between microbiota and hosts to provide more precise and personalized treatment strategies[1,2].With the maturation of omics technologies and data analysis techniques,the essential role of gut microbiota in immune system maturation,barrier function maintenance,and metabolic regulation has become increasingly recognized[3].However,the“hodgepodge”approach of traditional fecal microbiota transplantation(FMT)cannot be appropriately controlled in clinical applications.This challenge has spurred the emergence of targeted interventions focused on specific functional core probiotics.Unlike traditional FMT,this approach aims to precisely identify and target microbial functional genes and metabolic pathways,selecting core probiotics for application,to improve host health and prevent or manage diseases[4].This article reviews the advantages and limitations of traditional FMT and core probiotic targeted therapy while exploring the future directions of precision microbiome research.展开更多
基金supported by the National Natural Science Foundation of China(grant 82300345)National High-Level Hospital Clinical Research Funding(2023-GSP-QN-23,China)。
文摘In recent years,the concept of“precision microbiome”has received a lot of attention from researchers.It involves the precise analysis and typing of microbiota in specific hosts(e.g.,humans or animals)using advanced tools like high-throughput sequencing,genomics,and artificial intelligence(AI).These tools help explore the complex interactions between microbiota and hosts to provide more precise and personalized treatment strategies[1,2].With the maturation of omics technologies and data analysis techniques,the essential role of gut microbiota in immune system maturation,barrier function maintenance,and metabolic regulation has become increasingly recognized[3].However,the“hodgepodge”approach of traditional fecal microbiota transplantation(FMT)cannot be appropriately controlled in clinical applications.This challenge has spurred the emergence of targeted interventions focused on specific functional core probiotics.Unlike traditional FMT,this approach aims to precisely identify and target microbial functional genes and metabolic pathways,selecting core probiotics for application,to improve host health and prevent or manage diseases[4].This article reviews the advantages and limitations of traditional FMT and core probiotic targeted therapy while exploring the future directions of precision microbiome research.
