Long COVID,characterized by a constellation of persistent symptoms following acute severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,represents a growing public health challenge with significant imp...Long COVID,characterized by a constellation of persistent symptoms following acute severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,represents a growing public health challenge with significant impacts on multiple organ systems,particularly the respiratory tract.Symptoms such as chronic cough,fatigue,and neurocognitive dysfunction often continue for months,impairing quality of life and functional capacity.The respiratory microbiome,comprising dynamic communities of bacteria,viruses,and fungi,is essential for maintaining immune homeostasis and epithelial defense.Its alteration during SARS-CoV-2 infection may underpin many of the prolonged inflammatory and structural changes observed in long COVID patients.展开更多
基金supported by the National Key Research&Development Program of China(Nos.2023YFA1800900,2018YFC0910502)the National Natural Science Foundation of China(Nos.32071465,31871334,31671374).
文摘Long COVID,characterized by a constellation of persistent symptoms following acute severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,represents a growing public health challenge with significant impacts on multiple organ systems,particularly the respiratory tract.Symptoms such as chronic cough,fatigue,and neurocognitive dysfunction often continue for months,impairing quality of life and functional capacity.The respiratory microbiome,comprising dynamic communities of bacteria,viruses,and fungi,is essential for maintaining immune homeostasis and epithelial defense.Its alteration during SARS-CoV-2 infection may underpin many of the prolonged inflammatory and structural changes observed in long COVID patients.
