This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundance...This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus decrease.This dysbiosis may promote the formation and recurrence of polyps.Similar microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these conditions.Regulating the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut health.This microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.展开更多
Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evide...Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evidence that the changes in microbiome play an important role in the pathogenesis of vitiligo,they affect immune homeostasis,oxidative stress,skin barrier,and gene expression in vitiligo.The restoration of microbiome is a promising preventive and therapeutic strategy for vitiligo.Herein,we have reviewed recent studies on the vitiligo-related microbiome in an attempt to confidently identify the“core”microbiome of vitiligo patients,understand the role of microbiome in the pathogenesis of vitiligo,and explore new therapeutic strategies for vitiligo through microbial intervention.展开更多
文摘This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus decrease.This dysbiosis may promote the formation and recurrence of polyps.Similar microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these conditions.Regulating the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut health.This microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.
文摘Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evidence that the changes in microbiome play an important role in the pathogenesis of vitiligo,they affect immune homeostasis,oxidative stress,skin barrier,and gene expression in vitiligo.The restoration of microbiome is a promising preventive and therapeutic strategy for vitiligo.Herein,we have reviewed recent studies on the vitiligo-related microbiome in an attempt to confidently identify the“core”microbiome of vitiligo patients,understand the role of microbiome in the pathogenesis of vitiligo,and explore new therapeutic strategies for vitiligo through microbial intervention.
