The published article titled“MicroRNA-133b Inhibits Proliferation,Cellular Migration,and Invasion via Targeting LASP1 in Hepatocarcinoma Cells”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1269–1282.
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3...The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Prostate cancer(PCa)is a multifaceted disease that envelops 1.41 million new cases globally.It is the second most common cancer reported in men.Its heterogeneity and indolent growth,coupled with incompetent early scre...Prostate cancer(PCa)is a multifaceted disease that envelops 1.41 million new cases globally.It is the second most common cancer reported in men.Its heterogeneity and indolent growth,coupled with incompetent early screening methods such as serum prostate-specific antigen level estimations and digital rectal examinations,contribute to its delayed detection,potentially leading to misdiagnosis or overtreatment.Despite the advancement in surgical methods,better management of PCa requires definitive diagnostics,prognostics,and therapeutics.PCa cells express microRNA(miRNA)on their surface as well as release miRNA into the bloodstream,which enables their noninvasive detection in body fluids like serum,plasma,and urine.miRNA acts as sponge for cir-culating RNA that regulates gene expression of crucial pathways in PCa pro-gression.In recent years,compelling evidence indicates that the use of miRNAs,individually or in combination,in the form of miRNA panels in both tissue and body fluids,together with clinicopathological parameters,might act as a diagnostic biomarker.This will increase the accuracy of risk stratification and early screening of PCa patients under active surveillance.These findings will help differentiate aggressive PCa from indolent and decipher novel therapeutic findings.We have put together a review of studies that have found and con-firmed miRNA panels in PCa tissue and PCa liquid biopsies(serum,plasma,and urine exosomes),with a focus on how they might help patients.展开更多
Acute myocardial infarction(AMI)remains a leading global cause of morbidity and mortality,with high risk of recurrent adverse cardiovascular events.Conventional diagnostic markers often lack the sensitivity needed for...Acute myocardial infarction(AMI)remains a leading global cause of morbidity and mortality,with high risk of recurrent adverse cardiovascular events.Conventional diagnostic markers often lack the sensitivity needed for early detection and prognostic stratification.Recent advances highlight the role of microRNAs(miRNAs)and their genetic polymorphisms in regulating inflammation,fibrosis,and endothelial function in atherosclerotic disease.This review summarizes evidence on circulating miRNA expression and miRNA-related single nucleotide polymorphisms as biomarkers in AMI.Literature from PubMed,Scopus,and Web of Science was evaluated,focusing on pathways involving NF-κB,interleukin-1 receptor/toll-like receptors,and JAK/STAT signaling.Circulating miRNAs such as miR-150,miR-208,miR-26a,and miR-483-5p demonstrate strong diagnostic accuracy,while polymorphisms,particularly rs2910164 in miR-146a,are consistently associated with AMI susceptibility and adverse outcomes.These findings suggest that miRNAs and their variants may serve as non-invasive tools for diagnosis and risk prediction,supporting future integration into precision cardiovascular medicine.展开更多
文摘The published article titled“MicroRNA-133b Inhibits Proliferation,Cellular Migration,and Invasion via Targeting LASP1 in Hepatocarcinoma Cells”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1269–1282.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
文摘The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Prostate cancer(PCa)is a multifaceted disease that envelops 1.41 million new cases globally.It is the second most common cancer reported in men.Its heterogeneity and indolent growth,coupled with incompetent early screening methods such as serum prostate-specific antigen level estimations and digital rectal examinations,contribute to its delayed detection,potentially leading to misdiagnosis or overtreatment.Despite the advancement in surgical methods,better management of PCa requires definitive diagnostics,prognostics,and therapeutics.PCa cells express microRNA(miRNA)on their surface as well as release miRNA into the bloodstream,which enables their noninvasive detection in body fluids like serum,plasma,and urine.miRNA acts as sponge for cir-culating RNA that regulates gene expression of crucial pathways in PCa pro-gression.In recent years,compelling evidence indicates that the use of miRNAs,individually or in combination,in the form of miRNA panels in both tissue and body fluids,together with clinicopathological parameters,might act as a diagnostic biomarker.This will increase the accuracy of risk stratification and early screening of PCa patients under active surveillance.These findings will help differentiate aggressive PCa from indolent and decipher novel therapeutic findings.We have put together a review of studies that have found and con-firmed miRNA panels in PCa tissue and PCa liquid biopsies(serum,plasma,and urine exosomes),with a focus on how they might help patients.
文摘Acute myocardial infarction(AMI)remains a leading global cause of morbidity and mortality,with high risk of recurrent adverse cardiovascular events.Conventional diagnostic markers often lack the sensitivity needed for early detection and prognostic stratification.Recent advances highlight the role of microRNAs(miRNAs)and their genetic polymorphisms in regulating inflammation,fibrosis,and endothelial function in atherosclerotic disease.This review summarizes evidence on circulating miRNA expression and miRNA-related single nucleotide polymorphisms as biomarkers in AMI.Literature from PubMed,Scopus,and Web of Science was evaluated,focusing on pathways involving NF-κB,interleukin-1 receptor/toll-like receptors,and JAK/STAT signaling.Circulating miRNAs such as miR-150,miR-208,miR-26a,and miR-483-5p demonstrate strong diagnostic accuracy,while polymorphisms,particularly rs2910164 in miR-146a,are consistently associated with AMI susceptibility and adverse outcomes.These findings suggest that miRNAs and their variants may serve as non-invasive tools for diagnosis and risk prediction,supporting future integration into precision cardiovascular medicine.
