Micro-scaled light-emitting diode(LED)technology has emerged as a transformative tool in biomedical applications,offering innovative solutions across disease surveillance,treatment,and symptom rehabilitation.In diseas...Micro-scaled light-emitting diode(LED)technology has emerged as a transformative tool in biomedical applications,offering innovative solutions across disease surveillance,treatment,and symptom rehabilitation.In disease surveillance,micro-scaled LEDs enable real-time,noninvasive monitoring of physiological parameters through wearable devices,such as skin-like health patches and wireless pulse oximeters;these systems leverage the miniaturization,low power consumption,and high precision of micro-scaled LEDs to track heart rate,blood oxygenation,and neural activity with exceptional accuracy.For disease treatment,micro-scaled LEDs play a pivotal role in optogenetic stimulation and phototherapy.By delivering specific light wavelengths,they enable precise cellular control for cardiac regeneration,neural modulation,and targeted cancer therapies,such as photodynamic therapy with reduced invasiveness.In addition,wireless micro-scaled LED systems facilitate localized and sustained treatments for conditions such as diabetic retinopathy.For symptom rehabilitation,micro-scaled LED-based devices enhance functional and aesthetic outcomes,exemplified by optical cochlear implants for high-resolution hearing restoration and flexible photostimulation patches for hair regrowth.The performance of micro-scale LEDs also brings new possibilities to the field of brain–computer interface.These applications highlight the versatility of micro-scaled LEDs in improving patient quality of life through minimally invasive,energy-efficient,and biocompatible solutions.Although there are still challenges in long-term stability and scalability,the integration of micro-scaled LEDs with advanced biomedical technologies promises to redefine personalized healthcare and therapeutic efficacy.展开更多
Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation.It has been proven that cells are extremely sensitive to the nanoscaled str...Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation.It has been proven that cells are extremely sensitive to the nanoscaled structure and show multifarious phenotypes.Though a vital function of microstructure on osseointegration has been confirmed,the cell performances response to different microscaled structure is needed to be further dissected and in depth understood.In this work,the ordered micro–nano hierarchical structures with varying micro-scaled pits were precisely fabricated on titanium successfully by the combination of electrochemical,chemical etching and anodization as well.In vitro systematical assessments indicated that the micro–nano multilevel structures on titanium exhibited excellent cells adhesion and spreading ability,as well as steerable proliferation and osteogenic differentiation behaviors.It is shown that smaller micro-pits and lower roughness of the hierarchical structures enabled faster cell propagation.Despite cell growth was delayed on micro–nano titanium with relatively larger cell-match-size micro-pits and roughness,osteogenic-specific genes were significantly elevated.Furthermore,the alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization of MC3T3-E1 on multiscaled titanium were suppressed by a large margin after adding IWP-2(an inhibitor of Wnt/b-catenin signal pathway),indicating this pathway played a crucial part in cell osteogenic differentiation modulated by micro–nano structures.展开更多
基金supported by the 2024 Key Technological Innovation and Industrialization Project of Fujian Province(Grant No.2024G021)the National Natural Science Foundation of China(Grant No.62274138)+3 种基金the Natural Science Foundation of Fujian Province of China(Grant No.2023J06012)the Science and Technology Plan Project in Fujian Province of China(Grant No.2021H0011)the Fundamental Research Funds for the Central Universities(Grant No.20720230029)the Compound Semiconductor Technology Collaborative Innovation Platform Project of FuXiaQuan National Independent Innovation Demonstration Zone(Grant No.3502ZCQXT2022005)。
文摘Micro-scaled light-emitting diode(LED)technology has emerged as a transformative tool in biomedical applications,offering innovative solutions across disease surveillance,treatment,and symptom rehabilitation.In disease surveillance,micro-scaled LEDs enable real-time,noninvasive monitoring of physiological parameters through wearable devices,such as skin-like health patches and wireless pulse oximeters;these systems leverage the miniaturization,low power consumption,and high precision of micro-scaled LEDs to track heart rate,blood oxygenation,and neural activity with exceptional accuracy.For disease treatment,micro-scaled LEDs play a pivotal role in optogenetic stimulation and phototherapy.By delivering specific light wavelengths,they enable precise cellular control for cardiac regeneration,neural modulation,and targeted cancer therapies,such as photodynamic therapy with reduced invasiveness.In addition,wireless micro-scaled LED systems facilitate localized and sustained treatments for conditions such as diabetic retinopathy.For symptom rehabilitation,micro-scaled LED-based devices enhance functional and aesthetic outcomes,exemplified by optical cochlear implants for high-resolution hearing restoration and flexible photostimulation patches for hair regrowth.The performance of micro-scale LEDs also brings new possibilities to the field of brain–computer interface.These applications highlight the versatility of micro-scaled LEDs in improving patient quality of life through minimally invasive,energy-efficient,and biocompatible solutions.Although there are still challenges in long-term stability and scalability,the integration of micro-scaled LEDs with advanced biomedical technologies promises to redefine personalized healthcare and therapeutic efficacy.
基金financial supports from the National Natural Science Foundation of China(grant no.21773199,51571169,21621091)the State Key Project of Research and Development(grant no.2016YFC1100301).
文摘Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation.It has been proven that cells are extremely sensitive to the nanoscaled structure and show multifarious phenotypes.Though a vital function of microstructure on osseointegration has been confirmed,the cell performances response to different microscaled structure is needed to be further dissected and in depth understood.In this work,the ordered micro–nano hierarchical structures with varying micro-scaled pits were precisely fabricated on titanium successfully by the combination of electrochemical,chemical etching and anodization as well.In vitro systematical assessments indicated that the micro–nano multilevel structures on titanium exhibited excellent cells adhesion and spreading ability,as well as steerable proliferation and osteogenic differentiation behaviors.It is shown that smaller micro-pits and lower roughness of the hierarchical structures enabled faster cell propagation.Despite cell growth was delayed on micro–nano titanium with relatively larger cell-match-size micro-pits and roughness,osteogenic-specific genes were significantly elevated.Furthermore,the alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization of MC3T3-E1 on multiscaled titanium were suppressed by a large margin after adding IWP-2(an inhibitor of Wnt/b-catenin signal pathway),indicating this pathway played a crucial part in cell osteogenic differentiation modulated by micro–nano structures.
