A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication pr...A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation（SOR） iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.展开更多
At present,the effects of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs are less researched,and traditional numerical simulation methods are faced with a great number of challeng...At present,the effects of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs are less researched,and traditional numerical simulation methods are faced with a great number of challenges in the study of micro-scale flow.In this paper,the flow pattern of tight gas was studied based on the actual temperature and pressure of tight gas reservoir and the characteristic size of reservoir pore throat,and the rationality of tight gas flow was simulated by means of lattice Boltzmann method.Then,considering the influences of micro-scale effect,slippage effect and other factors,a tight gas flow model was established on the basis of LBGK-D2Q9 model,and its calculation results were compared with the analytical solutions and the numerical solutions listed in the literature.Finally,the influential laws of pore throat structure on the micro-scale seepage characteristics of tight gas were discussed.And the following research results were obtained.First,when the pressure is in the range of 3-70 MPa and the temperature is in the range of 293.15-373.15 K,the Knudsen number(Kn)is less than 0.1 and the gas flow is in the pattern of slippage flow and weak continuous flow.And in this case,it is reasonable to adopt the LBGK-D2Q9 model to simulate tight gas flow.Second,the effect of the characteristic size of the flow channel on the Kn is much greater than that of the pressure change.When the pore-throat ratio is constant,the Kn increases slowly along the throat.And its increasing trend gets more obvious with the increase of pore-throat ratio.Third,the presence of the throat makes the non-linear distribution characteristics of the pressure in the pore throat significant,and the pressure drop mainly lies in the throat.And the higher the pore-throat ratio is,the larger the pressure drop range in the throat is.Fourth,the non-linear distribution of pressure decreases the gas flow speed significantly,thus reducing the mass flow rate in the flow channel.In conclusion,the simulation result of the model established in this paper is highly coincident with the analytical solutions and the numerical solutions calculated by DSMC and IP methods in the literature,which verifies that this proposed model is reliable.The research results reveal the importance of“connecting fracture and expanding throat”in the practical development engineering of tight gas reservoirs.展开更多
Titanium-silicon(Ti-Si)alloy system shows significant potential for aerospace and automotive applications due to its superior specific strength,creep resistance,and oxidation resistance.For Si-containing Ti alloys,the...Titanium-silicon(Ti-Si)alloy system shows significant potential for aerospace and automotive applications due to its superior specific strength,creep resistance,and oxidation resistance.For Si-containing Ti alloys,the sufficient content of Si is critical for achieving these favorable performances,while excessive Si addition will result in mechanical brittleness.Herein,both physical experiments and finite element(FE)simulations are employed to investigate the micro-mechanisms of Si alloying in tailoring the mechanical properties of Ti alloys.Four typical states of Si-containing Ti alloys(solid solution state,hypoeutectoid state,near-eutectoid state,hypereutectoid state)with varying Si content(0.3-1.2 wt.%)were fabricated via in-situ alloying spark plasma sintering.Experimental results indicate that in-situ alloying of 0.6 wt.%Si enhances the alloy’s strength and ductility simultaneously due to the formation of fine and uniformly dispersed Ti_(5)Si_(3)particles,while higher content of Si(0.9 and 1.2 wt.%)results in coarser primary Ti_(5)Si_(3)agglomerations,deteriorating the ductility.FE simulations support these findings,highlighting the finer and more uniformly distributed Ti_(5)Si_(3)particles contribute to less stress concentration and promote uniform deformation across the matrix,while agglomerated Ti_(5)Si_(3)particles result in increased local stress concentrations,leading to higher chances of particle fracture and reduced ductility.This study not only elucidates the micro-mechanisms of in-situ Si alloying for tailoring the mechanical properties of Ti alloys but also aids in optimizing the design of high-performance Si-containing Ti alloys.展开更多
This study conducted the experimental investigation of aerodynamic heating of Micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL).The temperature riseof the stator is captured by the high response ...This study conducted the experimental investigation of aerodynamic heating of Micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL).The temperature riseof the stator is captured by the high response thermocouples.The eccentricity ratio and clearanceheight are guaranteed by means of instantaneous trajectory and torsion monitoring of the rotator.The result shows that the maximum temperature rise takes place upstream of the minimum clear-ance height along circumferential direction.The distribution of temperature rise presents asymmet-ric curve along axial direction,and peak value occurs near the dimensionless axial position of-0.18.The effect of aerodynamic heating becomes notable as the rotational speed is larger than3×10^(4)r/min.The effect of end leakage and the viscous dissipation have great impact on temper-ature rise of MRSFALL.More specially,the peak value of temperature rise at dimensionless clear-ance height of 0.0080 is larger than the case at dimensionless clearance height of 0.0044.Furthermore,when the eccentricity ratio is too large,the viscous dissipation is induced,and theadditional temperature rise is achieved.The heat flux identification of shear flow has been realizedby Sequential Function Specification Method(SFSM)and its estimation of thermal load has been given.The heat flux induced by the aerodynamic heating in this study varies from 950 W/m^(2)to1330 W/m^(2).展开更多
To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in ai...To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in air.The effect of the needle radius and the gas pressure on the discharge characteristics are tested.The results show that when the gap is larger than 10 μm,the relation between the breakdown voltage and the gap looks like the Paschen curve;while below 10 μm,the breakdown voltage is nearly constant in the range of the tested gap.However,at the same gap distance,the breakdown voltage is still affected by the pressure and shows a trend similar to Paschen＇s law.The current–voltage characteristic in all the gaps is similar and follows the trend of a typical Townsend-to-glow discharge.A simple model is used to explain the non-normality of breakdown in the micro-gaps.The Townsend mechanism is suggested to control the breakdown process in this configuration before the gap reduces much smaller in air.展开更多
Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics （CFD） method has played a dominant r...Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics （CFD） method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method （LBM）, molecular dynamics （MD）, and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed.展开更多
Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advance...Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advanced zero-valent iron are highly effective for degradation of chlorinated organic compounds. The efficiency of degradation for carbon tetrachloride and perchloroethylene is higher than 99% within a period of 2 h. The efficiency of degradation for trichloroethylene by MAF after storing for one month is equivalent to that by freshly prepared nano-size zero-valent iron particles.展开更多
Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is st...Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is studied.Based on modified couple stress theory and Hamilton’s principle,the governing equation and boundary conditions are obtained.The differential quadrature method(DQM)is applied to investigating the thermoelastic vibration of the FGM pipes.The effect of temperature variation,scale effect of the microtubule,micro-fluid effect,material properties,elastic coefficient of elastic medium and outer radius on thermoelastic vibration of the FGM pipes conveying fluid are studied.The results show that in the condition of considering the scale effect and micro-fluid of the microtubule,the critical dimensionless velocity of the system is higher than that of the system which calculated using classical macroscopic model.The results also show that the variations of temperature,material properties,elastic coefficient and outer radius have significant influences on the first-order dimensionless natural frequency.展开更多
Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is th...Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is theoretically optimized to form high quality moire patterns. For a demonstration, a parallel grating is fabricated on a specimen of quartz glass. The minimum line width and the distance between two adjacent lines are both set to be 1 μm, and the frequency of grating is 500 lines/ram. The experimental results indicate that the quality of gratings is good and the relative error of the gratings pitch is about 1.5%. Based on molte method, scanning electron microscope （SEM） moire patterns are observed clearly, which manifests that gratings fabricated with the femtosecond laser exposure is suitable for micro scale deformation measurement.展开更多
A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The con...A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The concrete temperature field during vibration was also precisely calculated by accurate description of heat absorption characteristics of different parts of concrete when vibration. Based on the above method, the prediction model was used to predict the pouring temperature of a practical engineering. The comparison between actual results and simulated values shows that this method can be adopted to accurately predict the non-uniformity of concrete pouring temperature and the influence of mechanized vibration on concrete pouring temperature, and thus accurately predict pouring temperature. The control of casting temperature is crucial for preventing concrete fracture. The study provides a new method for predicting the pouring temperature of concrete structures, which has great practical value in engineering application.展开更多
Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic...Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic chemicals.Sustainable stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium carbonate.The reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP process.The precipitated biocement alters the hydro-mechanical performance of the soil mass.Usually,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)processes.Among all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium carbonate.Biomass encapsulation can potentially reduce the biochemical reaction rate and decelerate biocementation.Laboratory examination of the encapsulation process demands a thorough analysis of associated coupled effects.Despite this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP treatment.However,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial encapsulation.Given this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical relationship.Firstly,the developed BCHM model was verified and validated using numerical and experimental observations of soil column tests.Later,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal sizes.The results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal size.Furthermore,the permeability and deformation of the soil mass were affected by the simultaneous precipitation of calcium carbonate.Overall,the present study comprehended the influence of the encapsulation of bacteria on cement morphology-induced permeability,biocement-induced stresses and displacements.展开更多
The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urb...The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urban areas representation of wind around the obstacles is not possible for the pollution dispersion studies using Gaussian based modeling studies. It is widely accepted that computational fluid dynamics (CFD) tools would provide reasonably good solution to produce the wind fields around the complex structures and other land scale elements. By keeping in view of the requirement for the micro-scale dispersion, a commercial CFD model PANACHE with PANEPR developed by Fluidyn is implemented to study the micro-scale dispersion of air pollution over an urban setup at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam a coastal station in the east coast of India under stable atmospheric conditions. Meso-scale module of the PANACHE model is integrated with the data generated at the site by IGCAR under RRE (Round Robin Exercise) program to develop the flow fields. Using this flow fields, CFD model is integrated to study the micro-scale dispersion. Various pollution dispersion scenarios are developed using hypothetical emission inventory during stably stratified conditions to understand the micro-scale dispersion over different locations of coastal urban set up in the IGCAR region of Kalpakkam.展开更多
Higher concentration is beneficial for the Paste and Thickened Tailings(PTT)operation in metal mine.Partial paste thickeners are produced lower density underflow.Flocculated tailings are intended to form a water entra...Higher concentration is beneficial for the Paste and Thickened Tailings(PTT)operation in metal mine.Partial paste thickeners are produced lower density underflow.Flocculated tailings are intended to form a water entrapped network structure in thickener,which is detrimental to underflow concentration.In this study,the continuous thickening experiment was carried out for ultra-fine tungsten tailings to study the influence of rake shearing on underflow.The micro pores structure and seepage flow in tailings bed before and after shearing are studied by CT and simulation approach to reveal the shearing enhancement mechanism of thickening process.The results shown that,the underflow concentration is increased from 61.4 wt%to 69.6 wt%by rake shearing in a pilot scale thickener,the porosity decreased from 46.48%to 37.46%.The entrapped water discharged from sticks structure more than sphere spaces.In items of seepage,after shearing,the seepage flow channel of tailings underflow is becoming longer,which caused the decreasing average flow rate decreases and absolute permeability.The absolute permeability is negatively correlated with tortuosity.The rake shearing can destroy the flocs structure;change the effective stress to increase the concentration.Higher underflow concentration improves the waste recycling and water recovery rate,especially for arid areas.展开更多
A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based ...A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based on differentiation is used to get the (inverse) kinematics equations. Then a micro-scale motion precision simulation method is proposed according to finite element analysis (FEA), and the prediction of robot’s motion precision in design phase is realized. The simulation result indicates that the 6-DOF micro-manipulation robot can meet the design specification.展开更多
Rarefaction effect appears when gas flows in micro/nano channels,so it is difficult to accurately predict real gas flow rate by using the classical theory.It is necessary to establish a more accurate and universal per...Rarefaction effect appears when gas flows in micro/nano channels,so it is difficult to accurately predict real gas flow rate by using the classical theory.It is necessary to establish a more accurate and universal permeability correction model to describe the flow behavior of rarefied gas.In this work,the gas flow in a plate micro-scale channel was numerically simulated using R26 moment method,and the simulation results were compared with those of the direct simulation Monte Carlo method(DSMC method)and R13 moment method.Then,a gas permeability correction model for plate micro-scale channels and circular micro-scale channels was established based on the simulation results of the R26 moment method,and used to describe the flow behavior of rarefied gas in micro-scale channels.Finally,the gas permeability correction co-efficient for different Knudsen numbers was calculated and compared with the prediction results of the Tang model,the available experimental data and the solution of linearized Boltzmann equation.The following research results were obtained.First,when the R26 moment method is used to describe the rarefaction effect of gas,its result is accordant with the calculation result of the DSMC method,and its calculation accuracy is higher than that of R13 moment method.Second,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for plate micro-scale channels is in accordance with the experimental data and the solution of linearized Boltzmann equation.Third,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for circular micro-scale channels is accordant with the solution of linearized Boltzmann equation.In conclusion,this higher-order Knudsen's gas permeability correction model is advantageous with high prediction precision and universality,and it can be used to describe the rarefaction effect of gas in micro/nano-scale channels.展开更多
The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of resea...The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation stability.However,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past decades.To evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)dataset.The time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression method.The results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after 2005.We found that precipitation was the most important climatic factor influencing the growing season NDVI(P<0.05),while vegetation growth sensitivity to water and heat varied significantly in different seasons.In the case of precipitation reduction and warming in the study area,the NDVI of the VPS could still maintain an overall slow upward trend(0.04×10−3/month),indicating that the ecosystem is sustainable.Our findings suggest that the VPS has been successful in maintaining stability and sustainability under current climate change conditions and that it is possible to introduce the VPS in similar areas as a template for resistance to sand and drought hazards.展开更多
The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano...The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano-scale combustion mechanisms is essential to the development and further improvement of the next-generation technologies for extreme control of the solid propellant thrust. Both experiments and theory confirm that the micro-and nano-scale oscillatory networks excitation in the solid propellants reactionary zones is a rather universal phenomenon. In accordance with our concept,the micro-and nano-scale structures form both the fractal and self-organized wave patterns in the solid propellants reactionary zones. Control by the shape, the sizes and spacial orientation of the wave patterns allows manipulate by the energy exchange and release in the reactionary zones. A novel strategy for enhanced extreme thrust control in solid propulsion systems are based on manipulation by selforganization of the micro-and nano-scale oscillatory networks and self-organized patterns formation in the reactionary zones with use of the system of acoustic waves and electro-magnetic fields, generated by special kind of ring-shaped electric discharges along with resonance laser radiation. Application of special kind of the ring-shaped electric discharges demands the minimum expenses of energy and opens prospects for almost inertia-free control by combustion processes. Nano-sized additives will enhance self-organizing and self-synchronization of the micro-and nano-scale oscillatory networks on the nanometer scale. Suggested novel strategy opens the door for completely new ways for enhanced extreme thrust control of the solid propulsion systems.展开更多
Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac...Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.展开更多
The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmiss...The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.展开更多
Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer...Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer has attracted more and more attention and recognition.Luteolin(LUT)and glycyrrhetinic(GA)are natural compounds extracted from Chinese herbal medicine.LUT exhibits various biological activity including anti-inflammatory,antibacterial,antiviral,anti-tumor,and neuroprotective effects.GA significantly inhibits the growth and metastasis of cancer cells.However,the low water solubility of both compounds hinders their clinical applications.In this study,rod-shaped nanoparticles(NPs)self-assembled from LUT and GA were designed to enhance drug solubility and tumor-targeting capability.We verified that the assembly mechanism of the NPs was π-π stacking.These NPs significantly inhibited the proliferation of liver cancer cells while had no significant effect on normal liver cells.In a mouse model of liver cancer,these NPs demonstrated superior tumor-targeting ability due to the enhanced permeability and retention effect,and the affinity of GA for liver cancer cells,resulting in better therapeutic efficacy with lower systemic toxicity.Results of network pharmacology analysis showed that LUT and GA respectively targeted estrogen receptor 1(ESR1)protein and cyclin-dependent kinase 1(CDK1)protein to corporately induce tumor cell cycle arrest,which induced the inhibition of tumor cell proliferation.In conclusion,this study provides a novel reference for the treatment of liver cancer.展开更多
基金supported by Scientific Research Foundation for Returned Scholars of Ministry of Education of China
文摘A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation（SOR） iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.
基金Project supported by the Key Program of National Natural Science Foundation of China“Fundamental study on tight gas reservoir formation drying and tight gas seepage capacity improvement”(No.:51534006).
文摘At present,the effects of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs are less researched,and traditional numerical simulation methods are faced with a great number of challenges in the study of micro-scale flow.In this paper,the flow pattern of tight gas was studied based on the actual temperature and pressure of tight gas reservoir and the characteristic size of reservoir pore throat,and the rationality of tight gas flow was simulated by means of lattice Boltzmann method.Then,considering the influences of micro-scale effect,slippage effect and other factors,a tight gas flow model was established on the basis of LBGK-D2Q9 model,and its calculation results were compared with the analytical solutions and the numerical solutions listed in the literature.Finally,the influential laws of pore throat structure on the micro-scale seepage characteristics of tight gas were discussed.And the following research results were obtained.First,when the pressure is in the range of 3-70 MPa and the temperature is in the range of 293.15-373.15 K,the Knudsen number(Kn)is less than 0.1 and the gas flow is in the pattern of slippage flow and weak continuous flow.And in this case,it is reasonable to adopt the LBGK-D2Q9 model to simulate tight gas flow.Second,the effect of the characteristic size of the flow channel on the Kn is much greater than that of the pressure change.When the pore-throat ratio is constant,the Kn increases slowly along the throat.And its increasing trend gets more obvious with the increase of pore-throat ratio.Third,the presence of the throat makes the non-linear distribution characteristics of the pressure in the pore throat significant,and the pressure drop mainly lies in the throat.And the higher the pore-throat ratio is,the larger the pressure drop range in the throat is.Fourth,the non-linear distribution of pressure decreases the gas flow speed significantly,thus reducing the mass flow rate in the flow channel.In conclusion,the simulation result of the model established in this paper is highly coincident with the analytical solutions and the numerical solutions calculated by DSMC and IP methods in the literature,which verifies that this proposed model is reliable.The research results reveal the importance of“connecting fracture and expanding throat”in the practical development engineering of tight gas reservoirs.
基金supported by the Natural Science Foundation of Hunan Province(Grant No.2023JJ40353)the National Key Research and Development Program of China(No.2019YFE03120001).
文摘Titanium-silicon(Ti-Si)alloy system shows significant potential for aerospace and automotive applications due to its superior specific strength,creep resistance,and oxidation resistance.For Si-containing Ti alloys,the sufficient content of Si is critical for achieving these favorable performances,while excessive Si addition will result in mechanical brittleness.Herein,both physical experiments and finite element(FE)simulations are employed to investigate the micro-mechanisms of Si alloying in tailoring the mechanical properties of Ti alloys.Four typical states of Si-containing Ti alloys(solid solution state,hypoeutectoid state,near-eutectoid state,hypereutectoid state)with varying Si content(0.3-1.2 wt.%)were fabricated via in-situ alloying spark plasma sintering.Experimental results indicate that in-situ alloying of 0.6 wt.%Si enhances the alloy’s strength and ductility simultaneously due to the formation of fine and uniformly dispersed Ti_(5)Si_(3)particles,while higher content of Si(0.9 and 1.2 wt.%)results in coarser primary Ti_(5)Si_(3)agglomerations,deteriorating the ductility.FE simulations support these findings,highlighting the finer and more uniformly distributed Ti_(5)Si_(3)particles contribute to less stress concentration and promote uniform deformation across the matrix,while agglomerated Ti_(5)Si_(3)particles result in increased local stress concentrations,leading to higher chances of particle fracture and reduced ductility.This study not only elucidates the micro-mechanisms of in-situ Si alloying for tailoring the mechanical properties of Ti alloys but also aids in optimizing the design of high-performance Si-containing Ti alloys.
基金supports from the National Natural Science Foundation of China(No.52206091)the Aeronautical Science Foundation of China(No.201928052008)the Natural Science Foundation of Jiangsu Province,China(No.BK20210303)。
文摘This study conducted the experimental investigation of aerodynamic heating of Micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL).The temperature riseof the stator is captured by the high response thermocouples.The eccentricity ratio and clearanceheight are guaranteed by means of instantaneous trajectory and torsion monitoring of the rotator.The result shows that the maximum temperature rise takes place upstream of the minimum clear-ance height along circumferential direction.The distribution of temperature rise presents asymmet-ric curve along axial direction,and peak value occurs near the dimensionless axial position of-0.18.The effect of aerodynamic heating becomes notable as the rotational speed is larger than3×10^(4)r/min.The effect of end leakage and the viscous dissipation have great impact on temper-ature rise of MRSFALL.More specially,the peak value of temperature rise at dimensionless clear-ance height of 0.0080 is larger than the case at dimensionless clearance height of 0.0044.Furthermore,when the eccentricity ratio is too large,the viscous dissipation is induced,and theadditional temperature rise is achieved.The heat flux identification of shear flow has been realizedby Sequential Function Specification Method(SFSM)and its estimation of thermal load has been given.The heat flux induced by the aerodynamic heating in this study varies from 950 W/m^(2)to1330 W/m^(2).
基金supported by National Natural Science Foundation of China(11475019)the Electrostatic Research Foundation of Liu Shanghe Academicians and Experts Workstation,Beijing Orient Institute of Measurement and Test(BOIMTLSHJD20161002)
文摘To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in air.The effect of the needle radius and the gas pressure on the discharge characteristics are tested.The results show that when the gap is larger than 10 μm,the relation between the breakdown voltage and the gap looks like the Paschen curve;while below 10 μm,the breakdown voltage is nearly constant in the range of the tested gap.However,at the same gap distance,the breakdown voltage is still affected by the pressure and shows a trend similar to Paschen＇s law.The current–voltage characteristic in all the gaps is similar and follows the trend of a typical Townsend-to-glow discharge.A simple model is used to explain the non-normality of breakdown in the micro-gaps.The Townsend mechanism is suggested to control the breakdown process in this configuration before the gap reduces much smaller in air.
文摘Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics （CFD） method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method （LBM）, molecular dynamics （MD）, and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed.
文摘Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advanced zero-valent iron are highly effective for degradation of chlorinated organic compounds. The efficiency of degradation for carbon tetrachloride and perchloroethylene is higher than 99% within a period of 2 h. The efficiency of degradation for trichloroethylene by MAF after storing for one month is equivalent to that by freshly prepared nano-size zero-valent iron particles.
文摘Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is studied.Based on modified couple stress theory and Hamilton’s principle,the governing equation and boundary conditions are obtained.The differential quadrature method(DQM)is applied to investigating the thermoelastic vibration of the FGM pipes.The effect of temperature variation,scale effect of the microtubule,micro-fluid effect,material properties,elastic coefficient of elastic medium and outer radius on thermoelastic vibration of the FGM pipes conveying fluid are studied.The results show that in the condition of considering the scale effect and micro-fluid of the microtubule,the critical dimensionless velocity of the system is higher than that of the system which calculated using classical macroscopic model.The results also show that the variations of temperature,material properties,elastic coefficient and outer radius have significant influences on the first-order dimensionless natural frequency.
基金support from the National Natural Science Foundation of China (11372118 and 11302082)
文摘Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is theoretically optimized to form high quality moire patterns. For a demonstration, a parallel grating is fabricated on a specimen of quartz glass. The minimum line width and the distance between two adjacent lines are both set to be 1 μm, and the frequency of grating is 500 lines/ram. The experimental results indicate that the quality of gratings is good and the relative error of the gratings pitch is about 1.5%. Based on molte method, scanning electron microscope （SEM） moire patterns are observed clearly, which manifests that gratings fabricated with the femtosecond laser exposure is suitable for micro scale deformation measurement.
基金Supported by the National Key Research and Development Project of China(No.2018YFC0406703)the National Natural Science Foundation of China(Nos.51779277,51579252,51439005)+2 种基金the Special Scientific Research Project of the State Key Laboratory of Simulation and Regulation of Water Cycles in River Basins(No.2016ZY10)a Special Scientific Research Project of the China Institute of Water Resources and Hydropower Research(Nos.SS0145B392016,SS0145B612017)the Special Scientific Research Project of the China Institute of Water Resources and Hydropower Research(No.KY1799).
文摘A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The concrete temperature field during vibration was also precisely calculated by accurate description of heat absorption characteristics of different parts of concrete when vibration. Based on the above method, the prediction model was used to predict the pouring temperature of a practical engineering. The comparison between actual results and simulated values shows that this method can be adopted to accurately predict the non-uniformity of concrete pouring temperature and the influence of mechanized vibration on concrete pouring temperature, and thus accurately predict pouring temperature. The control of casting temperature is crucial for preventing concrete fracture. The study provides a new method for predicting the pouring temperature of concrete structures, which has great practical value in engineering application.
基金the funding support from the Ministry of Education,Government of India,under the Prime Minister Research Fellowship programme(Grant Nos.SB21221901CEPMRF008347 and SB22230217CEPMRF008347).
文摘Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic chemicals.Sustainable stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium carbonate.The reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP process.The precipitated biocement alters the hydro-mechanical performance of the soil mass.Usually,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)processes.Among all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium carbonate.Biomass encapsulation can potentially reduce the biochemical reaction rate and decelerate biocementation.Laboratory examination of the encapsulation process demands a thorough analysis of associated coupled effects.Despite this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP treatment.However,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial encapsulation.Given this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical relationship.Firstly,the developed BCHM model was verified and validated using numerical and experimental observations of soil column tests.Later,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal sizes.The results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal size.Furthermore,the permeability and deformation of the soil mass were affected by the simultaneous precipitation of calcium carbonate.Overall,the present study comprehended the influence of the encapsulation of bacteria on cement morphology-induced permeability,biocement-induced stresses and displacements.
文摘The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urban areas representation of wind around the obstacles is not possible for the pollution dispersion studies using Gaussian based modeling studies. It is widely accepted that computational fluid dynamics (CFD) tools would provide reasonably good solution to produce the wind fields around the complex structures and other land scale elements. By keeping in view of the requirement for the micro-scale dispersion, a commercial CFD model PANACHE with PANEPR developed by Fluidyn is implemented to study the micro-scale dispersion of air pollution over an urban setup at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam a coastal station in the east coast of India under stable atmospheric conditions. Meso-scale module of the PANACHE model is integrated with the data generated at the site by IGCAR under RRE (Round Robin Exercise) program to develop the flow fields. Using this flow fields, CFD model is integrated to study the micro-scale dispersion. Various pollution dispersion scenarios are developed using hypothetical emission inventory during stably stratified conditions to understand the micro-scale dispersion over different locations of coastal urban set up in the IGCAR region of Kalpakkam.
基金This work was supported by funding from the National Natural Science Foundation of China Projects(51834001,51704094,U170420041)the China Postdoctoral Science Foundation(2020M672226)+2 种基金Program for Science&Technology Innovation Talents in Universities of Henan Province(19HASTIT047)Key Science Research Project in Universities of Henan Province(19B620001,20A620004)Henan Polytechnic University Science Fund for Distinguished Young Scholars(J2020-3).
文摘Higher concentration is beneficial for the Paste and Thickened Tailings(PTT)operation in metal mine.Partial paste thickeners are produced lower density underflow.Flocculated tailings are intended to form a water entrapped network structure in thickener,which is detrimental to underflow concentration.In this study,the continuous thickening experiment was carried out for ultra-fine tungsten tailings to study the influence of rake shearing on underflow.The micro pores structure and seepage flow in tailings bed before and after shearing are studied by CT and simulation approach to reveal the shearing enhancement mechanism of thickening process.The results shown that,the underflow concentration is increased from 61.4 wt%to 69.6 wt%by rake shearing in a pilot scale thickener,the porosity decreased from 46.48%to 37.46%.The entrapped water discharged from sticks structure more than sphere spaces.In items of seepage,after shearing,the seepage flow channel of tailings underflow is becoming longer,which caused the decreasing average flow rate decreases and absolute permeability.The absolute permeability is negatively correlated with tortuosity.The rake shearing can destroy the flocs structure;change the effective stress to increase the concentration.Higher underflow concentration improves the waste recycling and water recovery rate,especially for arid areas.
基金the Research Fund for the Doctoral Programof Higher Education(20060007023)
文摘A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based on differentiation is used to get the (inverse) kinematics equations. Then a micro-scale motion precision simulation method is proposed according to finite element analysis (FEA), and the prediction of robot’s motion precision in design phase is realized. The simulation result indicates that the 6-DOF micro-manipulation robot can meet the design specification.
文摘Rarefaction effect appears when gas flows in micro/nano channels,so it is difficult to accurately predict real gas flow rate by using the classical theory.It is necessary to establish a more accurate and universal permeability correction model to describe the flow behavior of rarefied gas.In this work,the gas flow in a plate micro-scale channel was numerically simulated using R26 moment method,and the simulation results were compared with those of the direct simulation Monte Carlo method(DSMC method)and R13 moment method.Then,a gas permeability correction model for plate micro-scale channels and circular micro-scale channels was established based on the simulation results of the R26 moment method,and used to describe the flow behavior of rarefied gas in micro-scale channels.Finally,the gas permeability correction co-efficient for different Knudsen numbers was calculated and compared with the prediction results of the Tang model,the available experimental data and the solution of linearized Boltzmann equation.The following research results were obtained.First,when the R26 moment method is used to describe the rarefaction effect of gas,its result is accordant with the calculation result of the DSMC method,and its calculation accuracy is higher than that of R13 moment method.Second,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for plate micro-scale channels is in accordance with the experimental data and the solution of linearized Boltzmann equation.Third,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for circular micro-scale channels is accordant with the solution of linearized Boltzmann equation.In conclusion,this higher-order Knudsen's gas permeability correction model is advantageous with high prediction precision and universality,and it can be used to describe the rarefaction effect of gas in micro/nano-scale channels.
基金The authors gratefully acknowledge the editor and two anonymous reviewers for valuable comments on the manuscript.We also acknowledge DingHai Zhang for their help in the data analysis.This work was supported by the Funds for Creative Research Groups of China(Grant No.41621001)the National Natural Science Foundation of China(Grant Nos.41530746+1 种基金41901064)the Foundation for Excellent Youth Scholars of NIEER,CAS.
文摘The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation stability.However,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past decades.To evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)dataset.The time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression method.The results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after 2005.We found that precipitation was the most important climatic factor influencing the growing season NDVI(P<0.05),while vegetation growth sensitivity to water and heat varied significantly in different seasons.In the case of precipitation reduction and warming in the study area,the NDVI of the VPS could still maintain an overall slow upward trend(0.04×10−3/month),indicating that the ecosystem is sustainable.Our findings suggest that the VPS has been successful in maintaining stability and sustainability under current climate change conditions and that it is possible to introduce the VPS in similar areas as a template for resistance to sand and drought hazards.
基金supported by the Western-Caucasus Research Center
文摘The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano-scale combustion mechanisms is essential to the development and further improvement of the next-generation technologies for extreme control of the solid propellant thrust. Both experiments and theory confirm that the micro-and nano-scale oscillatory networks excitation in the solid propellants reactionary zones is a rather universal phenomenon. In accordance with our concept,the micro-and nano-scale structures form both the fractal and self-organized wave patterns in the solid propellants reactionary zones. Control by the shape, the sizes and spacial orientation of the wave patterns allows manipulate by the energy exchange and release in the reactionary zones. A novel strategy for enhanced extreme thrust control in solid propulsion systems are based on manipulation by selforganization of the micro-and nano-scale oscillatory networks and self-organized patterns formation in the reactionary zones with use of the system of acoustic waves and electro-magnetic fields, generated by special kind of ring-shaped electric discharges along with resonance laser radiation. Application of special kind of the ring-shaped electric discharges demands the minimum expenses of energy and opens prospects for almost inertia-free control by combustion processes. Nano-sized additives will enhance self-organizing and self-synchronization of the micro-and nano-scale oscillatory networks on the nanometer scale. Suggested novel strategy opens the door for completely new ways for enhanced extreme thrust control of the solid propulsion systems.
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.
基金supported by the National Key R&D Program of China(No.2017YFB0304402)。
文摘The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.
基金the financial support from Henan Province Natural Science Foundation(No.252300420583)Henan Provincial Science and Technology Research Project(Nos.242102310455,242102310473,242102310517)the Key Project of Science and Technology Research funded by the Henan Provincial Department of Education(No.24A350002)。
文摘Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer has attracted more and more attention and recognition.Luteolin(LUT)and glycyrrhetinic(GA)are natural compounds extracted from Chinese herbal medicine.LUT exhibits various biological activity including anti-inflammatory,antibacterial,antiviral,anti-tumor,and neuroprotective effects.GA significantly inhibits the growth and metastasis of cancer cells.However,the low water solubility of both compounds hinders their clinical applications.In this study,rod-shaped nanoparticles(NPs)self-assembled from LUT and GA were designed to enhance drug solubility and tumor-targeting capability.We verified that the assembly mechanism of the NPs was π-π stacking.These NPs significantly inhibited the proliferation of liver cancer cells while had no significant effect on normal liver cells.In a mouse model of liver cancer,these NPs demonstrated superior tumor-targeting ability due to the enhanced permeability and retention effect,and the affinity of GA for liver cancer cells,resulting in better therapeutic efficacy with lower systemic toxicity.Results of network pharmacology analysis showed that LUT and GA respectively targeted estrogen receptor 1(ESR1)protein and cyclin-dependent kinase 1(CDK1)protein to corporately induce tumor cell cycle arrest,which induced the inhibition of tumor cell proliferation.In conclusion,this study provides a novel reference for the treatment of liver cancer.
