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Unveiling micro-scale mechanisms of in-situ silicon alloying for tailoring mechanical properties in titanium alloys:Experiments and computational modeling
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作者 Sisi Tang Li Li +3 位作者 Jinlong Su Yuan Yuan Yong Han Jinglian Fan 《Journal of Materials Science & Technology》 2025年第17期150-163,共14页
Titanium-silicon(Ti-Si)alloy system shows significant potential for aerospace and automotive applications due to its superior specific strength,creep resistance,and oxidation resistance.For Si-containing Ti alloys,the... Titanium-silicon(Ti-Si)alloy system shows significant potential for aerospace and automotive applications due to its superior specific strength,creep resistance,and oxidation resistance.For Si-containing Ti alloys,the sufficient content of Si is critical for achieving these favorable performances,while excessive Si addition will result in mechanical brittleness.Herein,both physical experiments and finite element(FE)simulations are employed to investigate the micro-mechanisms of Si alloying in tailoring the mechanical properties of Ti alloys.Four typical states of Si-containing Ti alloys(solid solution state,hypoeutectoid state,near-eutectoid state,hypereutectoid state)with varying Si content(0.3-1.2 wt.%)were fabricated via in-situ alloying spark plasma sintering.Experimental results indicate that in-situ alloying of 0.6 wt.%Si enhances the alloy’s strength and ductility simultaneously due to the formation of fine and uniformly dispersed Ti_(5)Si_(3)particles,while higher content of Si(0.9 and 1.2 wt.%)results in coarser primary Ti_(5)Si_(3)agglomerations,deteriorating the ductility.FE simulations support these findings,highlighting the finer and more uniformly distributed Ti_(5)Si_(3)particles contribute to less stress concentration and promote uniform deformation across the matrix,while agglomerated Ti_(5)Si_(3)particles result in increased local stress concentrations,leading to higher chances of particle fracture and reduced ductility.This study not only elucidates the micro-mechanisms of in-situ Si alloying for tailoring the mechanical properties of Ti alloys but also aids in optimizing the design of high-performance Si-containing Ti alloys. 展开更多
关键词 Titanium alloy Spark plasma sintering micro-scale deformation behavior Mechanical property tailoring Computational modeling
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Measurement of aerodynamic heating of micro-scale rotational shearing flow and its heat flux identification
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作者 Yuan LIU Yuanwei LYU +3 位作者 Jingyang ZHANG Chunyang LI Jingzhou ZHANG Zhongwen HUANG 《Chinese Journal of Aeronautics》 2025年第4期70-90,共21页
This study conducted the experimental investigation of aerodynamic heating of Micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL).The temperature riseof the stator is captured by the high response ... This study conducted the experimental investigation of aerodynamic heating of Micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL).The temperature riseof the stator is captured by the high response thermocouples.The eccentricity ratio and clearanceheight are guaranteed by means of instantaneous trajectory and torsion monitoring of the rotator.The result shows that the maximum temperature rise takes place upstream of the minimum clear-ance height along circumferential direction.The distribution of temperature rise presents asymmet-ric curve along axial direction,and peak value occurs near the dimensionless axial position of-0.18.The effect of aerodynamic heating becomes notable as the rotational speed is larger than3×10^(4)r/min.The effect of end leakage and the viscous dissipation have great impact on temper-ature rise of MRSFALL.More specially,the peak value of temperature rise at dimensionless clear-ance height of 0.0080 is larger than the case at dimensionless clearance height of 0.0044.Furthermore,when the eccentricity ratio is too large,the viscous dissipation is induced,and theadditional temperature rise is achieved.The heat flux identification of shear flow has been realizedby Sequential Function Specification Method(SFSM)and its estimation of thermal load has been given.The heat flux induced by the aerodynamic heating in this study varies from 950 W/m^(2)to1330 W/m^(2). 展开更多
关键词 micro-scale Rotational Shearing Flow with Axial Limited-Length(MRSFALL) Hyper-rotate-speed End leakage Aerodynamic heating experimental measurement Heat flux identification
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Numerical Analysis of a Spiral-groove Dry-gas Seal Considering Micro-scale Effects 被引量:13
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作者 WANG Bing ZHANG Huiqiang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第1期146-153,共8页
A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication pr... A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation(SOR) iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime. 展开更多
关键词 micro-scale effect spiral-groove dry-gas seal numerical analysis Reynolds equation
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Discharge characteristics of a needle-to-plate electrode at a micro-scale gap 被引量:9
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作者 王荣刚 季启政 +3 位作者 张桐恺 夏清 张宇 欧阳吉庭 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第5期126-130,共5页
To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in ai... To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in air.The effect of the needle radius and the gas pressure on the discharge characteristics are tested.The results show that when the gap is larger than 10 μm,the relation between the breakdown voltage and the gap looks like the Paschen curve;while below 10 μm,the breakdown voltage is nearly constant in the range of the tested gap.However,at the same gap distance,the breakdown voltage is still affected by the pressure and shows a trend similar to Paschen's law.The current–voltage characteristic in all the gaps is similar and follows the trend of a typical Townsend-to-glow discharge.A simple model is used to explain the non-normality of breakdown in the micro-gaps.The Townsend mechanism is suggested to control the breakdown process in this configuration before the gap reduces much smaller in air. 展开更多
关键词 needle-to-plate electrode micro-scale gap gas breakdown
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Recent Advances in Computational Simulation of Macro-,Meso-,and Micro-Scale Biomimetics Related Fluid Flow Problems 被引量:5
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作者 Y. Y. Yan 《Journal of Bionic Engineering》 SCIE EI CSCD 2007年第2期97-107,共11页
Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics (CFD) method has played a dominant r... Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics (CFD) method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method (LBM), molecular dynamics (MD), and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed. 展开更多
关键词 biomimetics computational simulation macro- meso- micro-scale HYDROPHOBIC SURFACES
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Dechlorination of Chlorinated Aliphatic Compounds by Micro-scale Al-Zn-Mg/Fe Powders as Advanced Zero-valent Iron 被引量:3
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作者 解淑民 万平玉 +3 位作者 Andrew J.Feitz GUAN Jing 杨晓波 刘小光 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第5期716-718,共3页
Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advance... Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advanced zero-valent iron are highly effective for degradation of chlorinated organic compounds. The efficiency of degradation for carbon tetrachloride and perchloroethylene is higher than 99% within a period of 2 h. The efficiency of degradation for trichloroethylene by MAF after storing for one month is equivalent to that by freshly prepared nano-size zero-valent iron particles. 展开更多
关键词 chlorinated organic compound DEGRADATION micro-scale Al-Zn-Mg/Fe powder
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Thermoelastic vibration analysis of micro-scale functionally graded material fluid-conveying pipes in elastic medium 被引量:2
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作者 TONG Guo-jun LIU Yong-shou +1 位作者 LIU Hui-chao DAI Jia-yin 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第10期2785-2796,共12页
Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is st... Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is studied.Based on modified couple stress theory and Hamilton’s principle,the governing equation and boundary conditions are obtained.The differential quadrature method(DQM)is applied to investigating the thermoelastic vibration of the FGM pipes.The effect of temperature variation,scale effect of the microtubule,micro-fluid effect,material properties,elastic coefficient of elastic medium and outer radius on thermoelastic vibration of the FGM pipes conveying fluid are studied.The results show that in the condition of considering the scale effect and micro-fluid of the microtubule,the critical dimensionless velocity of the system is higher than that of the system which calculated using classical macroscopic model.The results also show that the variations of temperature,material properties,elastic coefficient and outer radius have significant influences on the first-order dimensionless natural frequency. 展开更多
关键词 functionally graded materials thermoelastic vibration micro-scale micro-fluid
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Fabrication of micro-scale gratings for moiré method with a femtosecond laser 被引量:2
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作者 Gaosheng Yan Jianguo Zhu +2 位作者 Yanlong Huang Wenfen Hao Yanjie Li 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2016年第4期171-175,共5页
Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is th... Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is theoretically optimized to form high quality moire patterns. For a demonstration, a parallel grating is fabricated on a specimen of quartz glass. The minimum line width and the distance between two adjacent lines are both set to be 1 μm, and the frequency of grating is 500 lines/ram. The experimental results indicate that the quality of gratings is good and the relative error of the gratings pitch is about 1.5%. Based on molte method, scanning electron microscope (SEM) moire patterns are observed clearly, which manifests that gratings fabricated with the femtosecond laser exposure is suitable for micro scale deformation measurement. 展开更多
关键词 micro-scale grating Femtosecond laser Moire method
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Micro-scale FEM Calculation of Concrete Temperature during Production and Casting 被引量:1
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作者 朱振泱 LIU Yi +5 位作者 ZHANG Guoxin WU Congcong WANG Zhenhong LIU Youzhi ZHANG Lei YANG Ning 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2020年第1期113-120,共8页
A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The con... A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The concrete temperature field during vibration was also precisely calculated by accurate description of heat absorption characteristics of different parts of concrete when vibration. Based on the above method, the prediction model was used to predict the pouring temperature of a practical engineering. The comparison between actual results and simulated values shows that this method can be adopted to accurately predict the non-uniformity of concrete pouring temperature and the influence of mechanized vibration on concrete pouring temperature, and thus accurately predict pouring temperature. The control of casting temperature is crucial for preventing concrete fracture. The study provides a new method for predicting the pouring temperature of concrete structures, which has great practical value in engineering application. 展开更多
关键词 concrete POURING TEMPERATURE micro-scale FINITE-ELEMENT TEMPERATURE prediction
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Coupled bio-chemo-hydro-mechanical modeling of microbially induced calcite precipitation process considering biomass encapsulation using a micro-scale relationship 被引量:1
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作者 Pavan Kumar Bhukya Nandini Adla Dali Naidu Arnepalli 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第7期2775-2789,共15页
Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic... Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic chemicals.Sustainable stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium carbonate.The reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP process.The precipitated biocement alters the hydro-mechanical performance of the soil mass.Usually,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)processes.Among all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium carbonate.Biomass encapsulation can potentially reduce the biochemical reaction rate and decelerate biocementation.Laboratory examination of the encapsulation process demands a thorough analysis of associated coupled effects.Despite this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP treatment.However,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial encapsulation.Given this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical relationship.Firstly,the developed BCHM model was verified and validated using numerical and experimental observations of soil column tests.Later,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal sizes.The results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal size.Furthermore,the permeability and deformation of the soil mass were affected by the simultaneous precipitation of calcium carbonate.Overall,the present study comprehended the influence of the encapsulation of bacteria on cement morphology-induced permeability,biocement-induced stresses and displacements. 展开更多
关键词 Biocementation process Bio-chemo-hydro-mechanical(BCHM) model Reactive transport ENCAPSULATION micro-scale
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Micro-scale Dispersion of Air Pollutants over an Urban Setup in a Coastal Region 被引量:2
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作者 Srikanth Madala A.N.V. Satyanarayana V. Krishna Prasad 《Open Journal of Air Pollution》 2012年第2期51-58,共8页
The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urb... The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urban areas representation of wind around the obstacles is not possible for the pollution dispersion studies using Gaussian based modeling studies. It is widely accepted that computational fluid dynamics (CFD) tools would provide reasonably good solution to produce the wind fields around the complex structures and other land scale elements. By keeping in view of the requirement for the micro-scale dispersion, a commercial CFD model PANACHE with PANEPR developed by Fluidyn is implemented to study the micro-scale dispersion of air pollution over an urban setup at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam a coastal station in the east coast of India under stable atmospheric conditions. Meso-scale module of the PANACHE model is integrated with the data generated at the site by IGCAR under RRE (Round Robin Exercise) program to develop the flow fields. Using this flow fields, CFD model is integrated to study the micro-scale dispersion. Various pollution dispersion scenarios are developed using hypothetical emission inventory during stably stratified conditions to understand the micro-scale dispersion over different locations of coastal urban set up in the IGCAR region of Kalpakkam. 展开更多
关键词 CFD PBL MESO-SCALE micro-scale DISPERSION
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Micro-Scale Motion Precision Simulation Method for a New-Type 6-DOF Micro-Manipulation Robot
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作者 叶鑫 张之敬 王豫枢 《Journal of Beijing Institute of Technology》 EI CAS 2007年第4期414-418,共5页
A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based ... A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based on differentiation is used to get the (inverse) kinematics equations. Then a micro-scale motion precision simulation method is proposed according to finite element analysis (FEA), and the prediction of robot’s motion precision in design phase is realized. The simulation result indicates that the 6-DOF micro-manipulation robot can meet the design specification. 展开更多
关键词 micro-scale 6-DOF micro-manipulation robot kinematics characteristic motion precision simulation
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Higher-order Knudsen's permeability correction model for rarefied gas in micro-scale channels 被引量:1
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作者 Lu Yinbin 《Natural Gas Industry B》 2019年第5期502-508,共7页
Rarefaction effect appears when gas flows in micro/nano channels,so it is difficult to accurately predict real gas flow rate by using the classical theory.It is necessary to establish a more accurate and universal per... Rarefaction effect appears when gas flows in micro/nano channels,so it is difficult to accurately predict real gas flow rate by using the classical theory.It is necessary to establish a more accurate and universal permeability correction model to describe the flow behavior of rarefied gas.In this work,the gas flow in a plate micro-scale channel was numerically simulated using R26 moment method,and the simulation results were compared with those of the direct simulation Monte Carlo method(DSMC method)and R13 moment method.Then,a gas permeability correction model for plate micro-scale channels and circular micro-scale channels was established based on the simulation results of the R26 moment method,and used to describe the flow behavior of rarefied gas in micro-scale channels.Finally,the gas permeability correction co-efficient for different Knudsen numbers was calculated and compared with the prediction results of the Tang model,the available experimental data and the solution of linearized Boltzmann equation.The following research results were obtained.First,when the R26 moment method is used to describe the rarefaction effect of gas,its result is accordant with the calculation result of the DSMC method,and its calculation accuracy is higher than that of R13 moment method.Second,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for plate micro-scale channels is in accordance with the experimental data and the solution of linearized Boltzmann equation.Third,the gas permeability correction coefficient which is calculated by using the higher-order Knudsen's gas permeability correction model for circular micro-scale channels is accordant with the solution of linearized Boltzmann equation.In conclusion,this higher-order Knudsen's gas permeability correction model is advantageous with high prediction precision and universality,and it can be used to describe the rarefaction effect of gas in micro/nano-scale channels. 展开更多
关键词 micro-scales Rarefied gas Gas permeability correction model Knudsen number Moment method Prediction precision UNIVERSALITY
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Response of revegetation to climate change with meso- and micro-scale remote sensing in an arid desert of China
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作者 Guang Song BingYao Wang +2 位作者 JingYao Sun YanLi Wang XinRong Li 《Research in Cold and Arid Regions》 CSCD 2021年第1期43-52,共10页
The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of resea... The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation stability.However,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past decades.To evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)dataset.The time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression method.The results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after 2005.We found that precipitation was the most important climatic factor influencing the growing season NDVI(P<0.05),while vegetation growth sensitivity to water and heat varied significantly in different seasons.In the case of precipitation reduction and warming in the study area,the NDVI of the VPS could still maintain an overall slow upward trend(0.04×10−3/month),indicating that the ecosystem is sustainable.Our findings suggest that the VPS has been successful in maintaining stability and sustainability under current climate change conditions and that it is possible to introduce the VPS in similar areas as a template for resistance to sand and drought hazards. 展开更多
关键词 vegetation activity climate change NDVI trend restored ecosystem meso-and micro-scale
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Effect of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs 被引量:1
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作者 Zhang Liehui Liu Xiangyu +2 位作者 Zhao Yulong Zhou Yuan Shan Baochao 《Natural Gas Industry B》 2020年第2期160-167,共8页
At present,the effects of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs are less researched,and traditional numerical simulation methods are faced with a great number of challeng... At present,the effects of pore throat structure on micro-scale seepage characteristics of tight gas reservoirs are less researched,and traditional numerical simulation methods are faced with a great number of challenges in the study of micro-scale flow.In this paper,the flow pattern of tight gas was studied based on the actual temperature and pressure of tight gas reservoir and the characteristic size of reservoir pore throat,and the rationality of tight gas flow was simulated by means of lattice Boltzmann method.Then,considering the influences of micro-scale effect,slippage effect and other factors,a tight gas flow model was established on the basis of LBGK-D2Q9 model,and its calculation results were compared with the analytical solutions and the numerical solutions listed in the literature.Finally,the influential laws of pore throat structure on the micro-scale seepage characteristics of tight gas were discussed.And the following research results were obtained.First,when the pressure is in the range of 3-70 MPa and the temperature is in the range of 293.15-373.15 K,the Knudsen number(Kn)is less than 0.1 and the gas flow is in the pattern of slippage flow and weak continuous flow.And in this case,it is reasonable to adopt the LBGK-D2Q9 model to simulate tight gas flow.Second,the effect of the characteristic size of the flow channel on the Kn is much greater than that of the pressure change.When the pore-throat ratio is constant,the Kn increases slowly along the throat.And its increasing trend gets more obvious with the increase of pore-throat ratio.Third,the presence of the throat makes the non-linear distribution characteristics of the pressure in the pore throat significant,and the pressure drop mainly lies in the throat.And the higher the pore-throat ratio is,the larger the pressure drop range in the throat is.Fourth,the non-linear distribution of pressure decreases the gas flow speed significantly,thus reducing the mass flow rate in the flow channel.In conclusion,the simulation result of the model established in this paper is highly coincident with the analytical solutions and the numerical solutions calculated by DSMC and IP methods in the literature,which verifies that this proposed model is reliable.The research results reveal the importance of“connecting fracture and expanding throat”in the practical development engineering of tight gas reservoirs. 展开更多
关键词 Tight gas reservoir Lattice Boltzmann method Pore throat structure micro-scale flow Seepage characteristic Slippage effect
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A novel strategy of smart manipulation by micro-scale oscillatory networks of the reactionary zones for enhanced extreme thrust control of the next-generation solid propulsion systems
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作者 Alexander N.Lukin 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2018年第5期635-642,共8页
The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano... The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano-scale combustion mechanisms is essential to the development and further improvement of the next-generation technologies for extreme control of the solid propellant thrust. Both experiments and theory confirm that the micro-and nano-scale oscillatory networks excitation in the solid propellants reactionary zones is a rather universal phenomenon. In accordance with our concept,the micro-and nano-scale structures form both the fractal and self-organized wave patterns in the solid propellants reactionary zones. Control by the shape, the sizes and spacial orientation of the wave patterns allows manipulate by the energy exchange and release in the reactionary zones. A novel strategy for enhanced extreme thrust control in solid propulsion systems are based on manipulation by selforganization of the micro-and nano-scale oscillatory networks and self-organized patterns formation in the reactionary zones with use of the system of acoustic waves and electro-magnetic fields, generated by special kind of ring-shaped electric discharges along with resonance laser radiation. Application of special kind of the ring-shaped electric discharges demands the minimum expenses of energy and opens prospects for almost inertia-free control by combustion processes. Nano-sized additives will enhance self-organizing and self-synchronization of the micro-and nano-scale oscillatory networks on the nanometer scale. Suggested novel strategy opens the door for completely new ways for enhanced extreme thrust control of the solid propulsion systems. 展开更多
关键词 Solid propulsion systems EXTREME thrust control Reactionary ZONES micro-scale OSCILLATORY NETWORKS Self-organized wave patterns Energy-releasing areas
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SorCS1基因的特点及其对慢性肾脏病和其他疾病的影响 被引量:3
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作者 刘伟 李洋 +3 位作者 朱珊 王公臣 徐海岩 林雪松 《医学综述》 2016年第18期3575-3579,F0003,共6页
SorCS1是哺乳动物细胞I型跨膜受体家族成员之一。该家族成员在N端有一个共同的Vps10P结构域,均可以与相应的配体结合,在细胞内将蛋白转运到溶酶体,并在包涵体运送到高尔基氏体的运输过程和信号转导方面起重要作用。SorCS1含有多个亚型,... SorCS1是哺乳动物细胞I型跨膜受体家族成员之一。该家族成员在N端有一个共同的Vps10P结构域,均可以与相应的配体结合,在细胞内将蛋白转运到溶酶体,并在包涵体运送到高尔基氏体的运输过程和信号转导方面起重要作用。SorCS1含有多个亚型,并与慢性肾脏病、阿尔茨海默病、帕金森病、额颞叶变性等神经组织退化性疾病以及糖尿病慢性神经病变的发生有密切的关系。 展开更多
关键词 慢性肾脏病 阿尔茨海默病 2型糖尿病 sorcS1
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SorCS3在脑部疾病中的研究进展
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作者 李欣 徐海岩 +3 位作者 曲彦杰 李东亮 付柯蒙 朱珊 《医学综述》 CAS 2021年第22期4428-4434,共7页
SorCS3是哺乳动物Ⅰ型跨膜受体家族的成员之一,该家族成员在N端具有共同的VPS10p结构域,主要在中枢和外周神经系统的神经元细胞中高表达,可参与或介导信号转导、配体内化和转运,在调节神经元活力和功能方面起重要作用。SorCS3的表达减... SorCS3是哺乳动物Ⅰ型跨膜受体家族的成员之一,该家族成员在N端具有共同的VPS10p结构域,主要在中枢和外周神经系统的神经元细胞中高表达,可参与或介导信号转导、配体内化和转运,在调节神经元活力和功能方面起重要作用。SorCS3的表达减少或功能障碍可能与神经系统破坏性疾病有关,从而导致抑郁症和阿尔茨海默病等脑部疾病的发生和发展。因此,深入研究SorCS3与相关脑部疾病之间的关系,挖掘SorCS3的潜在临床价值,了解其引发疾病的分子机制,有望为脑部疾病的诊断和治疗提供新途径。 展开更多
关键词 脑疾病 抑郁症 阿尔茨海默病 sorcS3 VPS10p
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SorCS1基因在阿尔茨海默病病理机制中的研究进展
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作者 李越 曹欣雨 +2 位作者 李东亮 李志良 徐海岩 《医学综述》 CAS 2021年第10期1909-1913,共5页
阿尔茨海默病(AD)是一种与多因素相关且不可逆的老年神经退行性疾病。AD主要由细胞外神经炎斑块聚积以及细胞内神经元纤维缠结等引起,但具体发病机制目前尚不明确。其中,淀粉样蛋白沉积是AD发病的主要原因,而蛋白质分选受体SorCS1基因... 阿尔茨海默病(AD)是一种与多因素相关且不可逆的老年神经退行性疾病。AD主要由细胞外神经炎斑块聚积以及细胞内神经元纤维缠结等引起,但具体发病机制目前尚不明确。其中,淀粉样蛋白沉积是AD发病的主要原因,而蛋白质分选受体SorCS1基因在调控淀粉样前体蛋白(APP)的运输途径和淀粉样蛋白产生中扮演重要角色。AD病理状态下,蛋白的加工与转运不仅参与胞内APP加工、β淀粉样蛋白(Aβ)生成的过程,还参与将胞内生成的Aβ转运至胞外的过程。SorCS1作为蛋白转运中的关键因子,可能在AD疾病的发生、发展过程中起关键作用。以SorCS1作为AD的分子靶标并发掘上下游信号通路,对探索AD的发病机制及治疗方式均具有重要的临床意义。 展开更多
关键词 阿尔茨海默病 sorcS1 淀粉样前体蛋白 Β淀粉样蛋白 蛋白转运
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SorCS蛋白在神经退行性疾病中的研究进展
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作者 姜雪琦 李志良 +3 位作者 张雪丹 刘音杉 付柯蒙 徐海岩 《医学综述》 2021年第3期471-476,共6页
Sor CS受体家族在神经元中作为细胞内蛋白分选的中央调节剂,与多种脑部疾病相关,液泡分选蛋白10结构域是Sor CS蛋白家族共有的结构特征,可与相应配体结合,参与介导胞吞作用,并靶向转运蛋白质。近年来,Sor CS受体家族在阿尔茨海默病(AD)... Sor CS受体家族在神经元中作为细胞内蛋白分选的中央调节剂,与多种脑部疾病相关,液泡分选蛋白10结构域是Sor CS蛋白家族共有的结构特征,可与相应配体结合,参与介导胞吞作用,并靶向转运蛋白质。近年来,Sor CS受体家族在阿尔茨海默病(AD)、癫痫、亨廷顿舞蹈症等神经退行性疾病发病机制中的作用备受关注。对Sor CS受体家族的结构、分布特征及其在神经退行性疾病中调控机制的研究可为AD等神经退行性疾病的治疗提供新思路。 展开更多
关键词 神经退行性病 sorcS受体家族 液泡分选蛋白10结构域 阿尔茨海默病 癫痫 亨廷顿舞蹈症
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