Receptor interacting kinase-1(RIPK1)plays central roles in multiple cell death and signal transduction pathways.A recent paper describes a role for RIPK1 in sensing the levels of s-adenosyl methionine,a metabolic prod...Receptor interacting kinase-1(RIPK1)plays central roles in multiple cell death and signal transduction pathways.A recent paper describes a role for RIPK1 in sensing the levels of s-adenosyl methionine,a metabolic product of the amino acid methionine(Met),required for protein and nucleic acid methylation.Methylation of RIPK1 restricts its activity,and when the levels of Met are low,the absence of this methylation promotes RIPK1-dependent apoptosis in vitro and in vivo.展开更多
文摘Receptor interacting kinase-1(RIPK1)plays central roles in multiple cell death and signal transduction pathways.A recent paper describes a role for RIPK1 in sensing the levels of s-adenosyl methionine,a metabolic product of the amino acid methionine(Met),required for protein and nucleic acid methylation.Methylation of RIPK1 restricts its activity,and when the levels of Met are low,the absence of this methylation promotes RIPK1-dependent apoptosis in vitro and in vivo.
