Spared regions of the damaged central nervous system undergo dynamic remodelling and exhibit a remarkable potential for therapeutic exploitation1.Lesion-remote astrocytes(LRAs),which interact with viable neurons and g...Spared regions of the damaged central nervous system undergo dynamic remodelling and exhibit a remarkable potential for therapeutic exploitation1.Lesion-remote astrocytes(LRAs),which interact with viable neurons and glia,undergo reactive transformations whose molecular and functional properties are poorly understood2.Here,using multiple transcriptional profiling methods,we investigated LRAs from spared regions of mouse spinal cord following traumatic spinal cord injury.展开更多
Recent predictions suggest that oxides,such as MgO and CaO,could serve as hosts of spin defects with long coherence times and thus be promising materials for quantum applications.However,in most cases,specific defects...Recent predictions suggest that oxides,such as MgO and CaO,could serve as hosts of spin defects with long coherence times and thus be promising materials for quantum applications.However,in most cases,specific defects have not yet been identified.Here,by using a high-throughput firstprinciples framework and advanced electronic structure methods,we identify a negatively charged complex between a nitrogen interstitial and a magnesium vacancy in MgO with favorable electronic and optical properties for hybrid quantumtechnologies.Weshow that this NV^(−)center has stable triplet ground and excited states,with singlet shelving states enabling optical initialization and spindependent readout.We predict several properties,including absorption,emission,and zero-phonon line energies,as well as zero-field splitting tensor,and hyperfine interaction parameters,which can aid in the experimental identification of this defect.Our calculations show that due to a strong pseudo-Jahn Teller effect and low-frequency phonon modes,the NV^(−)center in MgO is subject to a substantial vibronic coupling.We discuss design strategies to reduce such coupling and increase the Debye-Waller factor,including the effect of strain and the localization of the defect states.Wepropose that the favorable properties of the NV^(−)defect,along with the technological maturity of MgO,could enable hybrid classical-quantum applications,such as spintronic quantum sensors and single qubit gates.展开更多
文摘Spared regions of the damaged central nervous system undergo dynamic remodelling and exhibit a remarkable potential for therapeutic exploitation1.Lesion-remote astrocytes(LRAs),which interact with viable neurons and glia,undergo reactive transformations whose molecular and functional properties are poorly understood2.Here,using multiple transcriptional profiling methods,we investigated LRAs from spared regions of mouse spinal cord following traumatic spinal cord injury.
基金the support from the Maria Goeppert Mayer Named Fellowship,under the Laboratory Directed Research and Development(LDRD)funding from Argonne National Laboratory,provided by the Director,Office of Science,of the U.S.Department of Energy under Contract No.DE-AC02-06CH11357support from the Swedish e-science Research Centre(SeRC),the Knut and Alice Wallenberg Foundation through the WBSQD2 project(Grant No.2018.0071)+5 种基金the Swedish Research Council(VR)Grant No.2022-00276supported by the Air Force Office of Scientific Research(AFOSR)through the CFIRE grant#FA95502310667This work used several codes,including the WEST code whose development is supported by MICCoM,which is part of the Computational Materials Sciences Program funded by the U.S.Department of Energy,Office of Science,Basic Energy Sciences,Materials Sciences,and Engineering Division through Argonne National LaboratoryThis research used resources of the National Energy Research Scientific Computing Center(NERSC),a Department of Energy Office of Science User Facility using NERSC award DDR-ERCAP0029604,resources of the University of Chicago Research Computing Center,and resources of the Argonne Leadership Computing Facilitya U.S.Department of Energy(DOE)Office of Science user facility at Argonne National Laboratory,which is supported by the Office of Science of the U.S.DOE under Contract No.DE-AC02-06CH11357The ADAQ computations were enabled by resources provided by the National Academic Infrastructure for Supercomputing in Sweden(NAISS)at the Swedish National Infrastructure for Computing(SNIC)at Tetralith,partially funded by the Swedish Research Council through grant agreement no.2022-06725.
文摘Recent predictions suggest that oxides,such as MgO and CaO,could serve as hosts of spin defects with long coherence times and thus be promising materials for quantum applications.However,in most cases,specific defects have not yet been identified.Here,by using a high-throughput firstprinciples framework and advanced electronic structure methods,we identify a negatively charged complex between a nitrogen interstitial and a magnesium vacancy in MgO with favorable electronic and optical properties for hybrid quantumtechnologies.Weshow that this NV^(−)center has stable triplet ground and excited states,with singlet shelving states enabling optical initialization and spindependent readout.We predict several properties,including absorption,emission,and zero-phonon line energies,as well as zero-field splitting tensor,and hyperfine interaction parameters,which can aid in the experimental identification of this defect.Our calculations show that due to a strong pseudo-Jahn Teller effect and low-frequency phonon modes,the NV^(−)center in MgO is subject to a substantial vibronic coupling.We discuss design strategies to reduce such coupling and increase the Debye-Waller factor,including the effect of strain and the localization of the defect states.Wepropose that the favorable properties of the NV^(−)defect,along with the technological maturity of MgO,could enable hybrid classical-quantum applications,such as spintronic quantum sensors and single qubit gates.
