Osteoarthritis(OA)is a degenerative joint disease with significant clinical and societal impact.Traditional diagnostic methods,including subjective clinical assessments and imaging techniques such as X-rays and MRIs,a...Osteoarthritis(OA)is a degenerative joint disease with significant clinical and societal impact.Traditional diagnostic methods,including subjective clinical assessments and imaging techniques such as X-rays and MRIs,are often limited in their ability to detect early-stage OA or capture subtle joint changes.These limitations result in delayed diagnoses and inconsistent outcomes.Additionally,the analysis of omics data is challenged by the complexity and high dimensionality of biological datasets,making it difficult to identify key molecular mechanisms and biomarkers.Recent advancements in artificial intelligence(AI)offer transformative potential to address these challenges.This review systematically explores the integration of AI into OA research,focusing on applications such as AI-driven early screening and risk prediction from electronic health records(EHR),automated grading and morphological analysis of imaging data,and biomarker discovery through multi-omics integration.By consolidating progress across clinical,imaging,and omics domains,this review provides a comprehensive perspective on how AI is reshaping OA research.The findings have the potential to drive innovations in personalized medicine and targeted interventions,addressing longstanding challenges in OA diagnosis and management.展开更多
1.Introduction The synthesis of bulk nanostructured multiphase(NM)mate-rials with extreme properties such as high hardness and strength is one of the most interesting research topics in materials science and engineeri...1.Introduction The synthesis of bulk nanostructured multiphase(NM)mate-rials with extreme properties such as high hardness and strength is one of the most interesting research topics in materials science and engineering[1].At present,NM alloys can be produced by several synthesis methods,including sintering of nanocomposites[2,3],physical or chemical vapour deposition(PVD or CVD)[4],crystallization of metallic glasses[5],and severe plastic deforma-tion(SPD)[6-8].However,industry applications of bulk NM alloys produced by these methods are significantly restricted by their ge-ometrical and size limitations.Thus,the fabrication of large-scale NM alloys remains challenging.展开更多
Macroporous cation exchange resin beads were subjected to hydrothermal treatment in a ZIF-8 yielding solution,resulting in resin beads–MOF composite.The resin beads were employed as a shaping template,providing carri...Macroporous cation exchange resin beads were subjected to hydrothermal treatment in a ZIF-8 yielding solution,resulting in resin beads–MOF composite.The resin beads were employed as a shaping template,providing carrier and support for the growth of MOF crystals.The conditions of synthesis were optimized so as to obtain maximum MOF loading.The final composites and their intermediates were characterized with complementary physicochemical methods,including XRD,SEM,thermal analysis(TG)and nitrogen sorption.The obtained composites were employed for water decontamination by targeting a dye(methyl blue)and a medical(antibiotic)contaminant.The composite adsorbent showed excellent recyclable removal ability,and exceeded the performance of its building components,i.e.,the cation exchange beads and pure ZIF-8 material.展开更多
A nickel(Ⅱ)–borohydride complex bearing a macrocyclic tridentate N-donor ligand,[Ni(Me_(3)-TACN)(BH_(4))-(CH_(3)CN)]+(Me_(3)-TACN=1,4,7-trimethyl-1,4,7-triazacyclononane),was prepared,isolated,and characterized by v...A nickel(Ⅱ)–borohydride complex bearing a macrocyclic tridentate N-donor ligand,[Ni(Me_(3)-TACN)(BH_(4))-(CH_(3)CN)]+(Me_(3)-TACN=1,4,7-trimethyl-1,4,7-triazacyclononane),was prepared,isolated,and characterized by various physicochemical methods,including UV-vis,ESI-MS,IR and X-ray analyses.The structural and spectroscopic characterization clearly shows that the borohydride ligand is bound to the high-spin nickel(Ⅱ)center in an η^(2)-manner.Density functional theory calculations provided geometric information of 2,showing that the η^(2)-binding of borohydride to the nickel center is more favorable than the η^(3)-binding mode in CH_(3)CN.The complex is paramagnetic with an effective magnetic moment of 2.9μB consistent with a d^(8) high-spin system.The reactivity of the high-spin nickel(Ⅱ)–borohydride complex was examined in dehalogenation with numerous halocarbons.A kinetic isotope effect value of 1.7 was observed in the dehalogenation of CHCl_(3) by the nickel(Ⅱ)–borohydride complex.Kinetic studies and isotopic labeling experiments implicate that hydride ion or hydrogen atom transfer from the borohydride group is the rate determining step.The positive Hammett ρ value of 1.2,obtained in the reactions of[Ni(Me_(3)-TACN)(BH_(4))(CH_(3)CN)]^(+) and para-substituted benzoyl chloride,indicates that the dehalogenation by the nickel(Ⅱ)–borohydride species occurs via a nucleophilic reaction.展开更多
基金supported by the National Natural Science Foundation of China(82302757)Shenzhen Science and Technology Program(JCY20240813145204006,SGDX20201103095600002,JCYJ20220818103417037,KJZD20230923115200002)+1 种基金Shenzhen Key Laboratory of Digital Surgical Printing Project(ZDSYS201707311542415)Shenzhen Development and Reform Program(XMHT20220106001).
文摘Osteoarthritis(OA)is a degenerative joint disease with significant clinical and societal impact.Traditional diagnostic methods,including subjective clinical assessments and imaging techniques such as X-rays and MRIs,are often limited in their ability to detect early-stage OA or capture subtle joint changes.These limitations result in delayed diagnoses and inconsistent outcomes.Additionally,the analysis of omics data is challenged by the complexity and high dimensionality of biological datasets,making it difficult to identify key molecular mechanisms and biomarkers.Recent advancements in artificial intelligence(AI)offer transformative potential to address these challenges.This review systematically explores the integration of AI into OA research,focusing on applications such as AI-driven early screening and risk prediction from electronic health records(EHR),automated grading and morphological analysis of imaging data,and biomarker discovery through multi-omics integration.By consolidating progress across clinical,imaging,and omics domains,this review provides a comprehensive perspective on how AI is reshaping OA research.The findings have the potential to drive innovations in personalized medicine and targeted interventions,addressing longstanding challenges in OA diagnosis and management.
基金funding from the Australian Research Council(ARC Discovery Project,Nos.DP200101408 and DP230100183).
文摘1.Introduction The synthesis of bulk nanostructured multiphase(NM)mate-rials with extreme properties such as high hardness and strength is one of the most interesting research topics in materials science and engineering[1].At present,NM alloys can be produced by several synthesis methods,including sintering of nanocomposites[2,3],physical or chemical vapour deposition(PVD or CVD)[4],crystallization of metallic glasses[5],and severe plastic deforma-tion(SPD)[6-8].However,industry applications of bulk NM alloys produced by these methods are significantly restricted by their ge-ometrical and size limitations.Thus,the fabrication of large-scale NM alloys remains challenging.
基金the National Natural Science Foundation of China(21571079,21621001,21390394,21571076 and 21571078)for their financial support.V.V.and Q.F acknowledge the support from the Thousand Talents Program(China).
文摘Macroporous cation exchange resin beads were subjected to hydrothermal treatment in a ZIF-8 yielding solution,resulting in resin beads–MOF composite.The resin beads were employed as a shaping template,providing carrier and support for the growth of MOF crystals.The conditions of synthesis were optimized so as to obtain maximum MOF loading.The final composites and their intermediates were characterized with complementary physicochemical methods,including XRD,SEM,thermal analysis(TG)and nitrogen sorption.The obtained composites were employed for water decontamination by targeting a dye(methyl blue)and a medical(antibiotic)contaminant.The composite adsorbent showed excellent recyclable removal ability,and exceeded the performance of its building components,i.e.,the cation exchange beads and pure ZIF-8 material.
基金supported by NRF(2014R1A1A2056051)the Ministry of Science,ICT and Future Planning(DGIST R&D Program 15-BD-0403&15-HRLA-02,KCRC 2014M1A8A1049320,and 2015M3D3A1064890)the Ministry of Oceans and Fisheries(Marine Biotechnology Program 20150220)of Korea(J.C.).
文摘A nickel(Ⅱ)–borohydride complex bearing a macrocyclic tridentate N-donor ligand,[Ni(Me_(3)-TACN)(BH_(4))-(CH_(3)CN)]+(Me_(3)-TACN=1,4,7-trimethyl-1,4,7-triazacyclononane),was prepared,isolated,and characterized by various physicochemical methods,including UV-vis,ESI-MS,IR and X-ray analyses.The structural and spectroscopic characterization clearly shows that the borohydride ligand is bound to the high-spin nickel(Ⅱ)center in an η^(2)-manner.Density functional theory calculations provided geometric information of 2,showing that the η^(2)-binding of borohydride to the nickel center is more favorable than the η^(3)-binding mode in CH_(3)CN.The complex is paramagnetic with an effective magnetic moment of 2.9μB consistent with a d^(8) high-spin system.The reactivity of the high-spin nickel(Ⅱ)–borohydride complex was examined in dehalogenation with numerous halocarbons.A kinetic isotope effect value of 1.7 was observed in the dehalogenation of CHCl_(3) by the nickel(Ⅱ)–borohydride complex.Kinetic studies and isotopic labeling experiments implicate that hydride ion or hydrogen atom transfer from the borohydride group is the rate determining step.The positive Hammett ρ value of 1.2,obtained in the reactions of[Ni(Me_(3)-TACN)(BH_(4))(CH_(3)CN)]^(+) and para-substituted benzoyl chloride,indicates that the dehalogenation by the nickel(Ⅱ)–borohydride species occurs via a nucleophilic reaction.
