Cyclometalated Pd(Ⅱ)and Pt(Ⅱ)complexes of unsymmetrical phosphonium ylides Ph_(2)P(CH_(2))_(n)PPh_(2)vC(H)C(O)C_(6)H_(4)R(R=Ph,n=2(Y^(1));R=NO_(2),n=1(Y^(2)))have been prepared through a simple procedure to explore ...Cyclometalated Pd(Ⅱ)and Pt(Ⅱ)complexes of unsymmetrical phosphonium ylides Ph_(2)P(CH_(2))_(n)PPh_(2)vC(H)C(O)C_(6)H_(4)R(R=Ph,n=2(Y^(1));R=NO_(2),n=1(Y^(2)))have been prepared through a simple procedure to explore new directions in stereoselective catalysis and antitumor metallodrugs.The new pallada-and platinacycle complexes have been characterized by spectroscopic,crystallographic,and density functional theory methods.Catalytic activity and in vitro cytotoxicity of these compounds,as assessed,respectively,using the Mizoroki-Heck reaction and a human tumor cell line,have been evaluated.In particular,a mechanistic pathway of the Heck reaction catalyzed by Pd(Ⅱ)complex(1)with a chelating P,C-ligand has been investigated by DFT studies.The computational results were in agreement with those of experiments,which demonstrate the high stereoselectivity in the Pd-catalyzed Csp^(2)-Csp^(2) cross coupling reaction and the origin of an observed coordination mode in the prepared complexes.In this article,the cytotoxicity effects of four-coordinated Pt(Ⅱ)complex(2)against MCF-7 cells clearly reveal its great potential as an antitumor agent.展开更多
基金Funding of our research from the Bu-Ali Sina University is gratefully acknowledged.
文摘Cyclometalated Pd(Ⅱ)and Pt(Ⅱ)complexes of unsymmetrical phosphonium ylides Ph_(2)P(CH_(2))_(n)PPh_(2)vC(H)C(O)C_(6)H_(4)R(R=Ph,n=2(Y^(1));R=NO_(2),n=1(Y^(2)))have been prepared through a simple procedure to explore new directions in stereoselective catalysis and antitumor metallodrugs.The new pallada-and platinacycle complexes have been characterized by spectroscopic,crystallographic,and density functional theory methods.Catalytic activity and in vitro cytotoxicity of these compounds,as assessed,respectively,using the Mizoroki-Heck reaction and a human tumor cell line,have been evaluated.In particular,a mechanistic pathway of the Heck reaction catalyzed by Pd(Ⅱ)complex(1)with a chelating P,C-ligand has been investigated by DFT studies.The computational results were in agreement with those of experiments,which demonstrate the high stereoselectivity in the Pd-catalyzed Csp^(2)-Csp^(2) cross coupling reaction and the origin of an observed coordination mode in the prepared complexes.In this article,the cytotoxicity effects of four-coordinated Pt(Ⅱ)complex(2)against MCF-7 cells clearly reveal its great potential as an antitumor agent.
