Objective To study efficacy and safety of Yiqi Daozhi Formula in the recoveryyof gastrointestinal function after gastric cancer surgery.Methods A total of 67 patients undergoing laparoscopic radical gastrectomy betwee...Objective To study efficacy and safety of Yiqi Daozhi Formula in the recoveryyof gastrointestinal function after gastric cancer surgery.Methods A total of 67 patients undergoing laparoscopic radical gastrectomy between April 2023 and April 2024 were selected and randomly assigned to a treatment group(33 cases)and a control group(34 cases)using a random number method.Both groups received perioperative management based on the Enhanced Recovery After Surgery(ERAS)protocol,with data collected using artificial intelligencepowered wearable electrocardiogram(ECG)recorders and continuous bowel sound auscultation recorders.The treatment group received 100 mL of concentrated Yiqi Daozhi Formula orally from the 1st to 3rd postoperative day,whereas the the control group reveived equal volume of plain water daily over the same period.Key indicators of gastrointestinal recovery encompassed the time to first flatus,bowel sound recovery,semi-liquid diet tolerance,pain scores on the 3rd postoperative day,and length of hospital stay,which were compared between the groups.Additionally,postoperative heart rate variability(HRV)indices,including standard diviation of NN intervals(SDNN),standard deviation of the average NN intervals(SDANN),percentage of difference between adjacent normal R-R intervals exceeding 50 milliseconds(pNN50),low frequency(LF),and high frequency(HF)were evaluated.Inflammatory biomarkers such as high-sensitivity C-reactive protein(hs-CRP),white blood cell(WBC),interleukin(IL)-1β,IL-2,IL-6,tumor necrosis factor-α(TNF-α),interferon-(IFN-)were assessed,alongside the incidence of postoperative complications.Results Compared to the control group,the treatment group exhibited reduced bowel sound recovery time and earlier onset of first flatus(P=0.001).On the 1st postoperative day,the treatment group exhibited decreased levels of hs-CRP,WBC,IL-1β,and IL-2(P<0.001,P<0.05).By the 3rd postoperative day,the treatment group continued to show lower levels of hs-CRP,IL-1β,and IL-2(P<0.001,P<0.05).Furthermore,the treatment group showed higher indices,specifically SDNN,SDANN,pNN50,and LF,on the third postoperative day(P<0.01,P<0.05).Conclusion The application of Yiqi Daozhi Formula post-gastrectomy in patients with gastric cancer surgery is safe,which reduces postoperative inflammatory responses,improves autonomic nervous function,and facilitates early gastrointestinal function recovery.展开更多
文摘Objective To study efficacy and safety of Yiqi Daozhi Formula in the recoveryyof gastrointestinal function after gastric cancer surgery.Methods A total of 67 patients undergoing laparoscopic radical gastrectomy between April 2023 and April 2024 were selected and randomly assigned to a treatment group(33 cases)and a control group(34 cases)using a random number method.Both groups received perioperative management based on the Enhanced Recovery After Surgery(ERAS)protocol,with data collected using artificial intelligencepowered wearable electrocardiogram(ECG)recorders and continuous bowel sound auscultation recorders.The treatment group received 100 mL of concentrated Yiqi Daozhi Formula orally from the 1st to 3rd postoperative day,whereas the the control group reveived equal volume of plain water daily over the same period.Key indicators of gastrointestinal recovery encompassed the time to first flatus,bowel sound recovery,semi-liquid diet tolerance,pain scores on the 3rd postoperative day,and length of hospital stay,which were compared between the groups.Additionally,postoperative heart rate variability(HRV)indices,including standard diviation of NN intervals(SDNN),standard deviation of the average NN intervals(SDANN),percentage of difference between adjacent normal R-R intervals exceeding 50 milliseconds(pNN50),low frequency(LF),and high frequency(HF)were evaluated.Inflammatory biomarkers such as high-sensitivity C-reactive protein(hs-CRP),white blood cell(WBC),interleukin(IL)-1β,IL-2,IL-6,tumor necrosis factor-α(TNF-α),interferon-(IFN-)were assessed,alongside the incidence of postoperative complications.Results Compared to the control group,the treatment group exhibited reduced bowel sound recovery time and earlier onset of first flatus(P=0.001).On the 1st postoperative day,the treatment group exhibited decreased levels of hs-CRP,WBC,IL-1β,and IL-2(P<0.001,P<0.05).By the 3rd postoperative day,the treatment group continued to show lower levels of hs-CRP,IL-1β,and IL-2(P<0.001,P<0.05).Furthermore,the treatment group showed higher indices,specifically SDNN,SDANN,pNN50,and LF,on the third postoperative day(P<0.01,P<0.05).Conclusion The application of Yiqi Daozhi Formula post-gastrectomy in patients with gastric cancer surgery is safe,which reduces postoperative inflammatory responses,improves autonomic nervous function,and facilitates early gastrointestinal function recovery.
