The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien...The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process.展开更多
The optimization of the waverider is constrained by the reversely designed leading edge and the constant shock angle distribution. This paper proposes a design method called the variable Leading-Edge Cone (vLEC) metho...The optimization of the waverider is constrained by the reversely designed leading edge and the constant shock angle distribution. This paper proposes a design method called the variable Leading-Edge Cone (vLEC) method to address these limitations. In the vLEC method, the waverider is directly designed from the preassigned leading edge and the variable shock angle distribution based on the Leading-Edge Cone (LEC) concept. Since the vLEC method is an approximate method, two test waveriders are designed and evaluated using numerical simulations to validate the shock design accuracy and the effectiveness of the vLEC method. The results show that the shocks of the test waveriders coincide well with the preassigned positions. Furthermore, four specifically designed application cases are conducted to analyze the performance benefits of the vLEC waveriders. The results of these cases indicate that, due to their variable shock angle distributions, the vLEC waveriders exhibit higher lift-to-drag ratios and better longitudinal static stability than conventional waveriders. Additionally, the vLEC waveriders demonstrate superior volumetric capacities near the symmetry plane, albeit with a minor decrease in volumetric efficiency.展开更多
The surrounding rock is prone to large-scale loosening and failure after the excavation of shallow large-span caverns because of the thin overlying strata and large cross-section span.The rational design of bolt suppo...The surrounding rock is prone to large-scale loosening and failure after the excavation of shallow large-span caverns because of the thin overlying strata and large cross-section span.The rational design of bolt support is very important to the safety control of surrounding rock as a common support means.The control mechanism and design method of bolt support for shallow-buried large-span caverns is carried out.The calculation method of bolt prestress and length based on arched failure and collapsed failure mode is established.The influence mechanism of different influencing factors on the bolt prestress and length is clarified.At the same time,the constant resistance energy-absorbing bolt with high strength and high toughness is developed,and the comparative test of mechanical properties is carried out.On this basis,the design method of high prestressed bolt support for shallow-buried large-span caverns is put forward,and the field test is carried out in Qingdao metro station in China.The monitoring results show that the maximum roof settlement is 6.8 mm after the new design method is adopted,and the effective control of the shallow-buried large-span caverns is realized.The research results can provide theoretical and technical support for the safety control of shallow-buried large-span caverns.展开更多
Urban rain-caused floods can not be well resolved with rising urban problem. Hence, construction of sponge park is born at the right moment. The research reviewed the concept, content and value of sponge parks and pro...Urban rain-caused floods can not be well resolved with rising urban problem. Hence, construction of sponge park is born at the right moment. The research reviewed the concept, content and value of sponge parks and proposed theory and principle of landscape design in order to seek the method of landscape design of sponge parks, improve urban eco-environment and advance harmony development between human and nature.展开更多
A microwave-H202 process for sludge pretreatment exhibited high efticiencies of releasing organics, nitrogen, and phosphorus, but large quantifies of H202 residues were detected. A uniform design method was thus emplo...A microwave-H202 process for sludge pretreatment exhibited high efticiencies of releasing organics, nitrogen, and phosphorus, but large quantifies of H202 residues were detected. A uniform design method was thus employed in this study to further optimize H202 dosage by investigating effects of pH and H202 dosage on the amount of 1-I202 residue and releases of organics, nitrogen, and phosphorus. A regression model was established with pH and H202 dosage as the independent variables, and H202 residue and releases of organics, nitrogen, and phosphorus as the dependent variables. In the optimized microwave-H202 process, the pH value of the sludge was firstly adjusted to 11.0, then the sludge was heated to 80~C and H202 was dosed at a H202 ：mixed liquor suspended solids （MLSS） ratio of 0.2, and the sludge was finally heated to 100~C by microwave irradiation. Compared to the microwave-H202 process without optimization, the H202 dosage and the utilization rate of H202 in the optimized microwave-H202 process were reduced by 80% and greatly improved by 3.87 times, respectively, when the H202：MLSS dosage ratio was decreased from 1.0 to 0.2, resulting in nearly the same release rate of soluble chemical oxygen demand in the microwave-H202 process without optimization at H202：MLSS ratio of 0.5.展开更多
In face of energy crisis,raw materials exhaustion,environmental pollution and other environmental issues caused by the current social and economic development model,theory and method of regional architecture have been...In face of energy crisis,raw materials exhaustion,environmental pollution and other environmental issues caused by the current social and economic development model,theory and method of regional architecture have been noted and studied by persons in the field of architecture and ecology.In the paper,the author analyzes architectural region,interprets regional architecture of Mario Botta and summarizes organic theory with a view to recognizing the importance of regional architecture method and reflecting on the significance of architectural region theories at the present times under the background of current globalization and information era.展开更多
Based on the Bingham parallel-plate model, a simplified design method of shear-valve magnetorheological （MR） dampers is proposed considering the magnetic circuit optimization. Correspondingly, a new MR damper with a...Based on the Bingham parallel-plate model, a simplified design method of shear-valve magnetorheological （MR） dampers is proposed considering the magnetic circuit optimization. Correspondingly, a new MR damper with a full-length effective damping path is proposed. The prototype dampers are also fabricated and studied numerically and experimentally. According to the test results, the Bingham parallel-plate model is further modified to obtain a damping force prediction model of the proposed MR dampers. This prediction model considers the magnetic saturation phenomenon. The study indicates that the proposed simplified design method is simple, effective and reliable. The maximum damping force of the proposed MR dampers with a full-length effective damping path is at least twice as large as those of conventional MR dampers. The dynamic range of damping force increases by at least 70%. The proposed damping force prediction model considers the magnetic saturation phenomenon and it can realize the actual characteristic of MR fluids. The model is able to predict the actual damping force of MR dampers precisely.展开更多
Based on the matching conditions of different fluid regions, the eigenfunction expansion method is used to develop a theoretical formula for wave reflection in front of the perforated structure with a partially slit f...Based on the matching conditions of different fluid regions, the eigenfunction expansion method is used to develop a theoretical formula for wave reflection in front of the perforated structure with a partially slit front wall. The accuracy of the solution is verified by comparing the numerical results with experimental data. In addition, a new hydraulic design method is developed by derivation of the theoretical formula with respect to the porosity of the slit wall, and the results of this design method is drafted for harbour engineers to use.展开更多
To improve the design speed and reduce the design cost for the previous blade design method, a modified inverse design method is presented. In the new method, after a series of physical and mathematical simplification...To improve the design speed and reduce the design cost for the previous blade design method, a modified inverse design method is presented. In the new method, after a series of physical and mathematical simplifications, a sail?like constrained area is proposed, which can be used to configure di erent runner blade shapes. Then, the new method is applied to redesign and optimize the runner blade of the scale core component of the 1400?MW canned nuclear coolant pump in an established multi?optimization system compromising the Computational Fluid Dynamics(CFD) analysis, the Response Surface Methodology(RSM) and the Non?dominated Sorting Genetic Algorithm?II(NSGA?II). After the execution of the optimization procedure, three optimal samples were ultimately obtained. Then, through comparative analysis using the target runner blade, it was found that the maximum e ciency improvement reached 1.6%, while the head improvement was about 10%. Overall, a promising runner blade inverse design method which will benefit the hydraulic design of the mixed?flow pump has been proposed.展开更多
Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve dif...Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve difficult technical problems encountered in the design process. Introducing QFD and TRIZ into the conceptual design of the pumping unit combines advantages of these two theories, therefore meeting different demands of different users. It can tell us “What should we do it” with QFD and “How should we do it” with TRIZ. The conceptual design method, which is based on QFD and TRIZ, is introduced andused to analyze and evaluate the conceptual design project of a pumping unit.展开更多
The optimization of metamorphic mechanisms is different from that of the conventional mechanisms for its characteristics of multi-configuration. There exist complex coupled design variables and constraints in its mult...The optimization of metamorphic mechanisms is different from that of the conventional mechanisms for its characteristics of multi-configuration. There exist complex coupled design variables and constraints in its multiple different configuration optimization models. To achieve the compatible optimized results of these coupled design variables, an optimization method for metamorphic mechanisms is developed in the paper based on the principle of multidisciplinary design optimization（MDO）. Firstly, the optimization characteristics of the metamorphic mechanism are summarized distinctly by proposing the classification of design variables and constraints as well as coupling interactions among its different configuration optimization models. Further, collaborative optimization technique which is used in MDO is adopted for achieving the overall optimization performance. The whole optimization process is then proposed by constructing a two-level hierarchical scheme with global optimizer and configuration optimizer loops. The method is demonstrated by optimizing a planar five-bar metamorphic mechanism which has two configurations,and results show that it can achieve coordinated optimization results for the same parameters in different configuration optimization models.展开更多
Viscoelastic dampers（VEDs） are one of the most common passive control devices used in new and retrofit building projects which reduce the structure responses and dissipate seismic energy during an earthquake.Various...Viscoelastic dampers（VEDs） are one of the most common passive control devices used in new and retrofit building projects which reduce the structure responses and dissipate seismic energy during an earthquake.Various methods to design this kind of dampers have been proposed based on the desired level of additional damping,eigenvalue assignment,modal strain energy,linear quadratic regulator control theories,and other approaches.In the current engineering practice,the popular method is the one based on the modal strain energy that uses the inter-story lateral stiffness as one of the main variables for damper design.However,depending on the configuration of the structure,in some cases the resulting interstory lateral stiffness can be very large.Consequently,the dampers size would also be large producing much more damping than that effectively necessary,resulting in an increase of the overall cost of the supplemental damping system and causing excessive stress on the structural elements connected to the dampers.In this paper an alternative practical design method for structures with VEDs is proposed.This method uses the inter-story shear forces as one of the main variables to accomplish the damper design compared to what was done in previous studies.Nonlinear time-history analyses were conducted on a 7-story reinforced concrete（RC） structure to check the reliability and effectiveness of the proposed method.Comparisons on the seismic performance between the structure without dampers and that equipped with VEDs were carried out.It is concluded that the proposed method results in a very suitable size of dampers,which are able to improve the performance of the structure at all levels of earthquake ground motions and satisfying the drift requirement prescribed in the codes.展开更多
A new multi-level analysis method of introducing the super-element modeling method, derived from the multi-level analysis method first proposed by O. F. Hughes, has been proposed in this paper to solve the problem of ...A new multi-level analysis method of introducing the super-element modeling method, derived from the multi-level analysis method first proposed by O. F. Hughes, has been proposed in this paper to solve the problem of high time cost in adopting a rational-based optimal design method for ship structural design. Furthermore,the method was verified by its effective application in optimization of the mid-ship section of a container ship. A full 3-D FEM model of a ship,suffering static and quasi-static loads, was used as the analyzing object for evaluating the structural performance of the mid-ship module, including static strength and buckling performance. Research results reveal that this new method could substantially reduce the computational cost of the rational-based optimization problem without decreasing its accuracy, which increases the feasibility and economic efficiency of using a rational-based optimal design method in ship structural design.展开更多
Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, wh...Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, which do not follow the existing criterions and codes. Many researchers began to research the special problems caused by larger height-width ratio isolation structures. The overturning effect of high height-width ratio structures with rubber bearing is firstly studied. Considering the main factors, such as the height-width ratio of structures, type of site, the designed basic acceleration of ground motion and the decouple factor in horizon, computing experiment is defined with the Uniform Design Method, which is also known as designing isolation structure. The forces of the bearing under edge of structures based on the position of the rubber bearing are calculated. The result indicates that the rubber bearings will lose its functionality under very high tension and compressing force of earthquake motion in horizon and vertical, when the height-width ratio is over a certain value. Thus, based on the calculation result of isolation structures defined in the uniform design method, regression analysis is conducted, and also the rubber edge force regression formula are gotten, which has higher correlation and smaller standard deviation. This formula can be used to roughly calculate whether the pull force occurs at the edge of the building. By the edge bearings of isolation structure minimum force formula, the height-width ratio limited value of the isolation structure is deducted when rubber bearing has minimum force of zero.展开更多
The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains...The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains has become a top priority.Antimicrobial peptides(AMPs),a ubiquitous class of naturally occurring compounds with broadspectrum antipathogenic activity,hold significant promise as an effective solution to the current antimicrobial resistance(AMR)crisis.Several AMPs have been identified and evaluated for their therapeutic application,with many already in the drug development pipeline.Their distinct properties,such as high target specificity,potency,and ability to bypass microbial resistance mechanisms,make AMPs a promising alternative to traditional antibiotics.Nonetheless,several challenges,such as high toxicity,lability to proteolytic degradation,low stability,poor pharmacokinetics,and high production costs,continue to hamper their clinical applicability.Therefore,recent research has focused on optimizing the properties of AMPs to improve their performance.By understanding the physicochemical properties of AMPs that correspond to their activity,such as amphipathicity,hydrophobicity,structural conformation,amino acid distribution,and composition,researchers can design AMPs with desired and improved performance.In this review,we highlight some of the key strategies used to optimize the performance of AMPs,including rational design and de novo synthesis.We also discuss the growing role of predictive computational tools,utilizing artificial intelligence and machine learning,in the design and synthesis of highly efficacious lead drug candidates.展开更多
Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure...Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.展开更多
The reliability of post grouting pile axial resistance was studied by proposing a design method for its probabilistic limit state,which is represented by the partial coefficients of load,end,and side resistance.The hy...The reliability of post grouting pile axial resistance was studied by proposing a design method for its probabilistic limit state,which is represented by the partial coefficients of load,end,and side resistance.The hyperbolic,modified hyperbolic,and polynomial models were employed to predict the ultimate bearing capacity of test piles that were not loaded to damage in field tests.The results were used for the calculation and calibration of the reliability index.The reliability of the probabilistic limit state design method was verified by an engineering case.The results show that the prediction results obtained from the modified hyperbolic model are closest to those obtained through the static load test.The proposed corresponding values of total,side,and end resistance partial coefficients are 1.84,1.66,and 2.73 when the dead and live load partial coefficients are taken as 1.1 and 1.4,respectively.Meanwhile,the corresponding partial coefficients of total,side,and end resistance are 1.70,1.56,and 2.34 when the dead and live load partial coefficients are taken as 1.2 and 1.4,respectively.展开更多
Design is a high-level and complex thinking activity of human beings,using existing knowledge and technology to solve problems and create new things.With the rise and development of intelligent manufacturing,design ha...Design is a high-level and complex thinking activity of human beings,using existing knowledge and technology to solve problems and create new things.With the rise and development of intelligent manufacturing,design has increasingly reflected its importance in the product life cycle.Firstly,the concept and connotation of complex product design is expounded systematically,and the different types of design are discussed.The four schools of design theory are introduced,including universal design,axiomatic design,TRIZ and general design.Then the research status of complex product design is analyzed,such as innovative design,digital design,modular design,reliability optimization design,etc.Finally,three key scientific issues worthy of research in the future are indicated,and five research trends of“newer,better,smarter,faster,and greener”are summarized,aiming to provide references for the equipment design and manufacturing industry.展开更多
Sensitivity analysis and topology optimization of microstructures using strain energy-based method is presented. Compared with homogenization method, the strain energy-based method has advantages of higher computing e...Sensitivity analysis and topology optimization of microstructures using strain energy-based method is presented. Compared with homogenization method, the strain energy-based method has advantages of higher computing efficiency and simplified programming. Both the dual convex programming method and perimeter constraint scheme are used to optimize the 2D and 3D microstructures. Numerical results indicate that the strain energy-based method has the same effectiveness as that of homogenization method for orthotropic materials.展开更多
Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase variations.The present study investigated...Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase variations.The present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid casting.The focus was primarily on the robustness of mechanical properties based on Taguchi design method.By analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 h.In a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory robustness.The hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.展开更多
基金the National Natural Science Foundation of China(No.52275378)the National Key Laboratory for Precision Hot Processing of Metals(6142909200208)。
文摘The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process.
基金supported by grants from the National Natural Science Foundation of China(No.U20B2006)the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110145)Young Elite Scientists Sponsorship Program by China Association for Science and Technology(No.2022QNRC001).
文摘The optimization of the waverider is constrained by the reversely designed leading edge and the constant shock angle distribution. This paper proposes a design method called the variable Leading-Edge Cone (vLEC) method to address these limitations. In the vLEC method, the waverider is directly designed from the preassigned leading edge and the variable shock angle distribution based on the Leading-Edge Cone (LEC) concept. Since the vLEC method is an approximate method, two test waveriders are designed and evaluated using numerical simulations to validate the shock design accuracy and the effectiveness of the vLEC method. The results show that the shocks of the test waveriders coincide well with the preassigned positions. Furthermore, four specifically designed application cases are conducted to analyze the performance benefits of the vLEC waveriders. The results of these cases indicate that, due to their variable shock angle distributions, the vLEC waveriders exhibit higher lift-to-drag ratios and better longitudinal static stability than conventional waveriders. Additionally, the vLEC waveriders demonstrate superior volumetric capacities near the symmetry plane, albeit with a minor decrease in volumetric efficiency.
基金Project(2023YFC3805700) supported by the National Key Research and Development Program of ChinaProjects(42477166,42277174) supported by the National Natural Science Foundation of China+2 种基金Project(2024JCCXSB01) supported by the Fundamental Research Funds for the Central Universities,ChinaProject(KFJJ24-01M) supported by the State Key Laboratory of Explosion Science and Safety Protection,Beijing Institute of Technology,ChinaProject(HLCX-2024-04) supported by the Open Foundation of Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources,China。
文摘The surrounding rock is prone to large-scale loosening and failure after the excavation of shallow large-span caverns because of the thin overlying strata and large cross-section span.The rational design of bolt support is very important to the safety control of surrounding rock as a common support means.The control mechanism and design method of bolt support for shallow-buried large-span caverns is carried out.The calculation method of bolt prestress and length based on arched failure and collapsed failure mode is established.The influence mechanism of different influencing factors on the bolt prestress and length is clarified.At the same time,the constant resistance energy-absorbing bolt with high strength and high toughness is developed,and the comparative test of mechanical properties is carried out.On this basis,the design method of high prestressed bolt support for shallow-buried large-span caverns is put forward,and the field test is carried out in Qingdao metro station in China.The monitoring results show that the maximum roof settlement is 6.8 mm after the new design method is adopted,and the effective control of the shallow-buried large-span caverns is realized.The research results can provide theoretical and technical support for the safety control of shallow-buried large-span caverns.
文摘Urban rain-caused floods can not be well resolved with rising urban problem. Hence, construction of sponge park is born at the right moment. The research reviewed the concept, content and value of sponge parks and proposed theory and principle of landscape design in order to seek the method of landscape design of sponge parks, improve urban eco-environment and advance harmony development between human and nature.
基金supported by the National Natural Science Foundation of China (No. 51008297)the Hi-Tech Research and Development Program (863) of China(No. 2007AA06Z347)the National Major Science & Technology Projects for Water Pollution Control and Management (No. 2012ZX07202-005)
文摘A microwave-H202 process for sludge pretreatment exhibited high efticiencies of releasing organics, nitrogen, and phosphorus, but large quantifies of H202 residues were detected. A uniform design method was thus employed in this study to further optimize H202 dosage by investigating effects of pH and H202 dosage on the amount of 1-I202 residue and releases of organics, nitrogen, and phosphorus. A regression model was established with pH and H202 dosage as the independent variables, and H202 residue and releases of organics, nitrogen, and phosphorus as the dependent variables. In the optimized microwave-H202 process, the pH value of the sludge was firstly adjusted to 11.0, then the sludge was heated to 80~C and H202 was dosed at a H202 ：mixed liquor suspended solids （MLSS） ratio of 0.2, and the sludge was finally heated to 100~C by microwave irradiation. Compared to the microwave-H202 process without optimization, the H202 dosage and the utilization rate of H202 in the optimized microwave-H202 process were reduced by 80% and greatly improved by 3.87 times, respectively, when the H202：MLSS dosage ratio was decreased from 1.0 to 0.2, resulting in nearly the same release rate of soluble chemical oxygen demand in the microwave-H202 process without optimization at H202：MLSS ratio of 0.5.
文摘In face of energy crisis,raw materials exhaustion,environmental pollution and other environmental issues caused by the current social and economic development model,theory and method of regional architecture have been noted and studied by persons in the field of architecture and ecology.In the paper,the author analyzes architectural region,interprets regional architecture of Mario Botta and summarizes organic theory with a view to recognizing the importance of regional architecture method and reflecting on the significance of architectural region theories at the present times under the background of current globalization and information era.
基金The National Basic Research Program of China(973 Program)under Grant No.2011CB013606the Major Research Plan of the National Natural Science Foundation of China under Grant No.91315301-06+2 种基金the National Natural Science Foundation of China under Grant No.51378343the Natural Science Foundation of Tianjin,China under Grant No.13JCZDJC35200the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No.20110032110042
文摘Based on the Bingham parallel-plate model, a simplified design method of shear-valve magnetorheological （MR） dampers is proposed considering the magnetic circuit optimization. Correspondingly, a new MR damper with a full-length effective damping path is proposed. The prototype dampers are also fabricated and studied numerically and experimentally. According to the test results, the Bingham parallel-plate model is further modified to obtain a damping force prediction model of the proposed MR dampers. This prediction model considers the magnetic saturation phenomenon. The study indicates that the proposed simplified design method is simple, effective and reliable. The maximum damping force of the proposed MR dampers with a full-length effective damping path is at least twice as large as those of conventional MR dampers. The dynamic range of damping force increases by at least 70%. The proposed damping force prediction model considers the magnetic saturation phenomenon and it can realize the actual characteristic of MR fluids. The model is able to predict the actual damping force of MR dampers precisely.
文摘Based on the matching conditions of different fluid regions, the eigenfunction expansion method is used to develop a theoretical formula for wave reflection in front of the perforated structure with a partially slit front wall. The accuracy of the solution is verified by comparing the numerical results with experimental data. In addition, a new hydraulic design method is developed by derivation of the theoretical formula with respect to the porosity of the slit wall, and the results of this design method is drafted for harbour engineers to use.
基金National Basic Research Program of China(973 Program,Grant No.2015CB057301)Research and Innovation in Science and Technology Major Project of Liaoning Province,China(Grant No.201410001)Collaborative Innovation Center of Major Machine Manufacturing in Liaoning Province,China
文摘To improve the design speed and reduce the design cost for the previous blade design method, a modified inverse design method is presented. In the new method, after a series of physical and mathematical simplifications, a sail?like constrained area is proposed, which can be used to configure di erent runner blade shapes. Then, the new method is applied to redesign and optimize the runner blade of the scale core component of the 1400?MW canned nuclear coolant pump in an established multi?optimization system compromising the Computational Fluid Dynamics(CFD) analysis, the Response Surface Methodology(RSM) and the Non?dominated Sorting Genetic Algorithm?II(NSGA?II). After the execution of the optimization procedure, three optimal samples were ultimately obtained. Then, through comparative analysis using the target runner blade, it was found that the maximum e ciency improvement reached 1.6%, while the head improvement was about 10%. Overall, a promising runner blade inverse design method which will benefit the hydraulic design of the mixed?flow pump has been proposed.
文摘Quality function deployment （QFD） is a quality system, that can help to design novel products that meet customers＇ needs. Theory of inventive problem solving （TRIZ） is a very powerful tool in helping to solve difficult technical problems encountered in the design process. Introducing QFD and TRIZ into the conceptual design of the pumping unit combines advantages of these two theories, therefore meeting different demands of different users. It can tell us “What should we do it” with QFD and “How should we do it” with TRIZ. The conceptual design method, which is based on QFD and TRIZ, is introduced andused to analyze and evaluate the conceptual design project of a pumping unit.
基金the fundamental support of the National Natural Science Foundation of China (Nos. 51105013, 51125020)the Beijing Natural Science Foundation of China (No. 3133042)the fundamental support provided by the China Scholarship Council and the State Key Laboratory of Robotics and System (HIT)
文摘The optimization of metamorphic mechanisms is different from that of the conventional mechanisms for its characteristics of multi-configuration. There exist complex coupled design variables and constraints in its multiple different configuration optimization models. To achieve the compatible optimized results of these coupled design variables, an optimization method for metamorphic mechanisms is developed in the paper based on the principle of multidisciplinary design optimization（MDO）. Firstly, the optimization characteristics of the metamorphic mechanism are summarized distinctly by proposing the classification of design variables and constraints as well as coupling interactions among its different configuration optimization models. Further, collaborative optimization technique which is used in MDO is adopted for achieving the overall optimization performance. The whole optimization process is then proposed by constructing a two-level hierarchical scheme with global optimizer and configuration optimizer loops. The method is demonstrated by optimizing a planar five-bar metamorphic mechanism which has two configurations,and results show that it can achieve coordinated optimization results for the same parameters in different configuration optimization models.
基金National Key Research and Development Program of China under Grant No.2016YFC0701101the National Nature Science Foundation of China under Grant No.51678449
文摘Viscoelastic dampers（VEDs） are one of the most common passive control devices used in new and retrofit building projects which reduce the structure responses and dissipate seismic energy during an earthquake.Various methods to design this kind of dampers have been proposed based on the desired level of additional damping,eigenvalue assignment,modal strain energy,linear quadratic regulator control theories,and other approaches.In the current engineering practice,the popular method is the one based on the modal strain energy that uses the inter-story lateral stiffness as one of the main variables for damper design.However,depending on the configuration of the structure,in some cases the resulting interstory lateral stiffness can be very large.Consequently,the dampers size would also be large producing much more damping than that effectively necessary,resulting in an increase of the overall cost of the supplemental damping system and causing excessive stress on the structural elements connected to the dampers.In this paper an alternative practical design method for structures with VEDs is proposed.This method uses the inter-story shear forces as one of the main variables to accomplish the damper design compared to what was done in previous studies.Nonlinear time-history analyses were conducted on a 7-story reinforced concrete（RC） structure to check the reliability and effectiveness of the proposed method.Comparisons on the seismic performance between the structure without dampers and that equipped with VEDs were carried out.It is concluded that the proposed method results in a very suitable size of dampers,which are able to improve the performance of the structure at all levels of earthquake ground motions and satisfying the drift requirement prescribed in the codes.
基金Supported by the Project of Ministry of Education and Finance(No.200512)the Project of the State Key Laboratory of ocean engineering(GKZD010053-10)
文摘A new multi-level analysis method of introducing the super-element modeling method, derived from the multi-level analysis method first proposed by O. F. Hughes, has been proposed in this paper to solve the problem of high time cost in adopting a rational-based optimal design method for ship structural design. Furthermore,the method was verified by its effective application in optimization of the mid-ship section of a container ship. A full 3-D FEM model of a ship,suffering static and quasi-static loads, was used as the analyzing object for evaluating the structural performance of the mid-ship module, including static strength and buckling performance. Research results reveal that this new method could substantially reduce the computational cost of the rational-based optimization problem without decreasing its accuracy, which increases the feasibility and economic efficiency of using a rational-based optimal design method in ship structural design.
文摘Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, which do not follow the existing criterions and codes. Many researchers began to research the special problems caused by larger height-width ratio isolation structures. The overturning effect of high height-width ratio structures with rubber bearing is firstly studied. Considering the main factors, such as the height-width ratio of structures, type of site, the designed basic acceleration of ground motion and the decouple factor in horizon, computing experiment is defined with the Uniform Design Method, which is also known as designing isolation structure. The forces of the bearing under edge of structures based on the position of the rubber bearing are calculated. The result indicates that the rubber bearings will lose its functionality under very high tension and compressing force of earthquake motion in horizon and vertical, when the height-width ratio is over a certain value. Thus, based on the calculation result of isolation structures defined in the uniform design method, regression analysis is conducted, and also the rubber edge force regression formula are gotten, which has higher correlation and smaller standard deviation. This formula can be used to roughly calculate whether the pull force occurs at the edge of the building. By the edge bearings of isolation structure minimum force formula, the height-width ratio limited value of the isolation structure is deducted when rubber bearing has minimum force of zero.
基金This work was supported by the National Natural Science Foundation of China(31930015,32200397)Ministry of Science and Technology of China(2018YFA0801403)+3 种基金Chinese Academy of Sciences(XDB31000000,KFJ-BRP-008-003)Yunnan Province Grant(202003AD150008,202002AA100007)Kunming Science and Technology Bureau(2023SCP001)New Cornerstone Investigator Program。
文摘The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains has become a top priority.Antimicrobial peptides(AMPs),a ubiquitous class of naturally occurring compounds with broadspectrum antipathogenic activity,hold significant promise as an effective solution to the current antimicrobial resistance(AMR)crisis.Several AMPs have been identified and evaluated for their therapeutic application,with many already in the drug development pipeline.Their distinct properties,such as high target specificity,potency,and ability to bypass microbial resistance mechanisms,make AMPs a promising alternative to traditional antibiotics.Nonetheless,several challenges,such as high toxicity,lability to proteolytic degradation,low stability,poor pharmacokinetics,and high production costs,continue to hamper their clinical applicability.Therefore,recent research has focused on optimizing the properties of AMPs to improve their performance.By understanding the physicochemical properties of AMPs that correspond to their activity,such as amphipathicity,hydrophobicity,structural conformation,amino acid distribution,and composition,researchers can design AMPs with desired and improved performance.In this review,we highlight some of the key strategies used to optimize the performance of AMPs,including rational design and de novo synthesis.We also discuss the growing role of predictive computational tools,utilizing artificial intelligence and machine learning,in the design and synthesis of highly efficacious lead drug candidates.
基金Project(2004G016-B) supported by the Science and Technology Development Program of Railways Department,China
文摘Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.
基金The National Natural Science Foundation of China(No.51878160,52008100,52078128).
文摘The reliability of post grouting pile axial resistance was studied by proposing a design method for its probabilistic limit state,which is represented by the partial coefficients of load,end,and side resistance.The hyperbolic,modified hyperbolic,and polynomial models were employed to predict the ultimate bearing capacity of test piles that were not loaded to damage in field tests.The results were used for the calculation and calibration of the reliability index.The reliability of the probabilistic limit state design method was verified by an engineering case.The results show that the prediction results obtained from the modified hyperbolic model are closest to those obtained through the static load test.The proposed corresponding values of total,side,and end resistance partial coefficients are 1.84,1.66,and 2.73 when the dead and live load partial coefficients are taken as 1.1 and 1.4,respectively.Meanwhile,the corresponding partial coefficients of total,side,and end resistance are 1.70,1.56,and 2.34 when the dead and live load partial coefficients are taken as 1.2 and 1.4,respectively.
基金National Natural Science Foundation of China(Grant Nos.51935009,51875517)Zhejiang Provincial Natural Science Foundation of China(Grant No.LY20E050015).
文摘Design is a high-level and complex thinking activity of human beings,using existing knowledge and technology to solve problems and create new things.With the rise and development of intelligent manufacturing,design has increasingly reflected its importance in the product life cycle.Firstly,the concept and connotation of complex product design is expounded systematically,and the different types of design are discussed.The four schools of design theory are introduced,including universal design,axiomatic design,TRIZ and general design.Then the research status of complex product design is analyzed,such as innovative design,digital design,modular design,reliability optimization design,etc.Finally,three key scientific issues worthy of research in the future are indicated,and five research trends of“newer,better,smarter,faster,and greener”are summarized,aiming to provide references for the equipment design and manufacturing industry.
基金National Natural Science Foundation of China （90405016, 10676028） 973 Program （2006CB601205）+1 种基金 863 Project （2006AA04Z 122） Aeronautical Science Foundation （04B53080, 2006ZA 53006） and 111 Project （B07050）
文摘Sensitivity analysis and topology optimization of microstructures using strain energy-based method is presented. Compared with homogenization method, the strain energy-based method has advantages of higher computing efficiency and simplified programming. Both the dual convex programming method and perimeter constraint scheme are used to optimize the 2D and 3D microstructures. Numerical results indicate that the strain energy-based method has the same effectiveness as that of homogenization method for orthotropic materials.
文摘Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase variations.The present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid casting.The focus was primarily on the robustness of mechanical properties based on Taguchi design method.By analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 h.In a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory robustness.The hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.
