A new numerical manifold （NMM） method is derived on the basis of quartic uniform B-spline interpolation. The analysis shows that the new interpolation function possesses higher-order continuity and polynomial consis...A new numerical manifold （NMM） method is derived on the basis of quartic uniform B-spline interpolation. The analysis shows that the new interpolation function possesses higher-order continuity and polynomial consistency compared with the conven- tional NMM. The stiffness matrix of the new element is well-conditioned. The proposed method is applied for the numerical example of thin plate bending. Based on the prin- ciple of minimum potential energy, the manifold matrices and equilibrium equation are deduced. Numerical results reveal that the NMM has high interpolation accuracy and rapid convergence for the global cover function and its higher-order partial derivatives.展开更多
目的探索建立侵袭性真菌感染治疗药品临床综合评价指标体系,并展开实证研究,以期为临床合理用药提供评价方法学参考。方法基于文献综述和相关指南,采用德尔菲法构建侵袭性真菌感染治疗药品的临床综合评价指标体系及评价细则,并以两性霉...目的探索建立侵袭性真菌感染治疗药品临床综合评价指标体系,并展开实证研究,以期为临床合理用药提供评价方法学参考。方法基于文献综述和相关指南,采用德尔菲法构建侵袭性真菌感染治疗药品的临床综合评价指标体系及评价细则,并以两性霉素B脱氧胆酸盐(amphotericin B deoxycholate,AmBd)、两性霉素B脂质体(liposomal amphotericin B,L-AmB)和两性霉素B胆固醇硫酸酯复合物(amphotericin B colloidal dispersion,ABCD)为例展开实证研究。结果经专家论证,最终确定了6个一级指标和13个二级指标、相应权重及量化评分细则,根据评价证据进行打分,得到ABCD、L-AmB和AmBd在治疗侵袭性真菌病的临床综合价值得分分别为73.50、70.50和49.50分。结论实证研究表明,ABCD的临床综合价值较L-AmB和AmBd更高。侵袭性真菌感染治疗药品临床综合评价指标体系可为临床合理用药提供参考依据。展开更多
基金supported by the Fund of National Engineering and Research Center for Highways in Mountain Area(No.gsgzj-2012-05)the Fundamental Research Funds for the Central Universities of China(No.CDJXS12240003)the Scientific Research Foundation of State Key Laboratory of Coal Mine Disaster Dynamics and Control(No.2011DA105287-MS201213)
文摘A new numerical manifold （NMM） method is derived on the basis of quartic uniform B-spline interpolation. The analysis shows that the new interpolation function possesses higher-order continuity and polynomial consistency compared with the conven- tional NMM. The stiffness matrix of the new element is well-conditioned. The proposed method is applied for the numerical example of thin plate bending. Based on the prin- ciple of minimum potential energy, the manifold matrices and equilibrium equation are deduced. Numerical results reveal that the NMM has high interpolation accuracy and rapid convergence for the global cover function and its higher-order partial derivatives.
文摘目的探索建立侵袭性真菌感染治疗药品临床综合评价指标体系,并展开实证研究,以期为临床合理用药提供评价方法学参考。方法基于文献综述和相关指南,采用德尔菲法构建侵袭性真菌感染治疗药品的临床综合评价指标体系及评价细则,并以两性霉素B脱氧胆酸盐(amphotericin B deoxycholate,AmBd)、两性霉素B脂质体(liposomal amphotericin B,L-AmB)和两性霉素B胆固醇硫酸酯复合物(amphotericin B colloidal dispersion,ABCD)为例展开实证研究。结果经专家论证,最终确定了6个一级指标和13个二级指标、相应权重及量化评分细则,根据评价证据进行打分,得到ABCD、L-AmB和AmBd在治疗侵袭性真菌病的临床综合价值得分分别为73.50、70.50和49.50分。结论实证研究表明,ABCD的临床综合价值较L-AmB和AmBd更高。侵袭性真菌感染治疗药品临床综合评价指标体系可为临床合理用药提供参考依据。
