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Dynamic characteristics and sensitivity of water hammer problems in liquid propulsion system using lattice Boltzmann method with entropy limiter
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作者 Yuqi WEI Xianggeng WEI +4 位作者 Guoqiang HE Xiao ZHAO Jinying YE Xueren WANG Hongyu CHEN 《Chinese Journal of Aeronautics》 2026年第1期18-34,共17页
The water hammer problem is an important issue in the dynamics of liquid propulsion system.This paper aims to use the Lattice Boltzmann Method(LBM)with entropy limiter to study the water hammer problems in propellant ... The water hammer problem is an important issue in the dynamics of liquid propulsion system.This paper aims to use the Lattice Boltzmann Method(LBM)with entropy limiter to study the water hammer problems in propellant feedlines.The dynamic characteristics of valve-closing water hammer and filling water hammer are investigated by this method,and the sensitivity of filling water hammer is analyzed with a single factor sensitivity analysis with 8 factors and 9 levels and a multi-factor sensitivity analysis with L_(27)(3^(13))orthogonal experiment based on range method.It is found that the solving result of LBM with entropy limiter is basically in good agreement with finite volume method,and using the entropy limiter can eliminate numerical oscillations when solving valve-closing water hammer problems and solve the numerical"blow up"when solving filling water hammer problems.It can be seen that the dynamic characteristics of valve-closing water hammer are relatively simple,while there are many factors that affect the filling water hammer and the degree of these effects varies.The effects on the maximum water hammer pressure are relatively uniform,but those on the water hammer response time vary greatly through the skewness analysis. 展开更多
关键词 Dynamic analysis Lattice Boltzmann method Liquid propulsion system Propellant transfer Sensitivity analysis Water hammer
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LIM技术在风景园林项目中的应用进展
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作者 刘瑞生 龚晨 +2 位作者 廖谋祺 麦湘颖 高伟 《广州建筑》 2026年第3期113-120,共8页
风景园林信息模型(LIM)技术作为BIM在风景园林领域的延伸,通过多源数据整合与全生命周期管理能力,为风景园林的数字化转型提供了新范式。本文旨在系统梳理LIM技术在风景园林项目中的应用进展,明确其优势与局限,为行业数字化转型提供可... 风景园林信息模型(LIM)技术作为BIM在风景园林领域的延伸,通过多源数据整合与全生命周期管理能力,为风景园林的数字化转型提供了新范式。本文旨在系统梳理LIM技术在风景园林项目中的应用进展,明确其优势与局限,为行业数字化转型提供可参考的技术路径。采用文献综述与案例列举相结合的方法,首先总结LIM的技术体系构成,进而结合设计、施工、运维三个项目阶段梳理LIM技术的具体应用路径。研究发现,LIM技术在设计阶段需协同6类软件平台,实现从点云处理、微气候模拟到信息模型构建的全流程整合;在施工阶段,可通过虚拟建造与碰撞监测,实现涵盖进度、安全、成本的动态报表生成;在运维阶段,需整合6类结构化数据,以及6类非结构化数据,形成可检索、可调用的项目数据库。同时,当前LIM在数据格式兼容性、植被参数化建模、跨平台协同等方面仍存在明显短板。LIM技术虽已初步形成技术框架,但其标准化体系尚未成熟,亟需建立统一的标准化语义框架、参数化模型库与数据接口。未来应加强LIM与GIS、BIM、IOT的深度融合,通过地域性实践,推动“数据驱动”设计范式转型。 展开更多
关键词 lim技术 风景园林项目 全生命周期 数字化 应用进展
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AGR2、LIMK1在肝癌组织中的表达及与患者预后的关系
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作者 李小冬 李红兵 +1 位作者 游宇哲 陈志强 《国际检验医学杂志》 2026年第3期375-379,共5页
目的探讨前梯度蛋白2(AGR2)、LIM激酶1(LIMK1)在肝癌组织中的表达及与患者预后的关系。方法选取2019年9月至2021年9月于威远县人民医院接受手术治疗的113例肝癌患者为研究对象。采用免疫组织化学法对组织中AGR2、LIMK1蛋白表达进行检测,... 目的探讨前梯度蛋白2(AGR2)、LIM激酶1(LIMK1)在肝癌组织中的表达及与患者预后的关系。方法选取2019年9月至2021年9月于威远县人民医院接受手术治疗的113例肝癌患者为研究对象。采用免疫组织化学法对组织中AGR2、LIMK1蛋白表达进行检测,Kaplan-Meier生存曲线分析患者3年生存率,Cox回归分析影响肝癌患者预后的因素。结果与癌旁组织相比,肝癌组织中AGR2、LIMK1阳性率均明显升高(P<0.05)。肝癌患者AGR2、LIMK1表达与TNM分期和分化程度有关(P<0.05)。113例肝癌患者3年总生存率为57.52%(65/113)。肝癌组织AGR2、LIMK1阴性表达患者3年生存率分别为73.91%(34/46)、71.43%(30/42),均高于阳性表达患者的46.27%(31/67)、49.30%(35/71),差异有统计学意义(χ^(2)=8.530,P=0.003;χ^(2)=5.291,P=0.021)。不同预后肝癌患者TNM分期、分化程度及AGR2、LIMK1阳性表达比较,差异有统计学意义(P<0.05)。TNM分期为Ⅲ期、肿瘤低分化程度及AGR2、LIMK1阳性表达是影响肝癌患者死亡的危险因素(P<0.05)。结论AGR2、LIMK1在肝癌组织中呈阳性表达,且与TNM分期和分化程度紧密相关,二者可能成为新的肝癌预后相关标志物,为肝癌的预后评估和个体化治疗提供新的思路。 展开更多
关键词 前梯度蛋白2 lim激酶1 肝癌 预后
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Effects of spatial heterogeneity on pseudo-static stability of coal mine overburden dump slope,using random limit equilibrium and random finite element methods:A comparative study
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作者 Madhumita Mohanty Rajib Sarkar Sarat Kumar Das 《Earthquake Engineering and Engineering Vibration》 2025年第1期83-99,共17页
Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump mate... Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1. 展开更多
关键词 coal mine overburden dump slope random limit equilibrium method random finite element method seismic slope stability spatial heterogeneity
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组织中PITPNC1 LIMK2表达与乳腺癌切除术后复发转移的关系探讨
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作者 张昭 徐梦姗 +3 位作者 毛杨 刘申婷 黄聪聪 周美凤 《河北医学》 2026年第3期510-516,共7页
目的:探究组织中磷脂酰肌醇转运蛋白细胞质1(PITPNC1)、LIM激酶2(LIMK2)表达与乳腺癌切除术后复发转移的关系,旨在评估PITPNC1与LIMK2对现有临床预测体系的增益价值。方法:选取2020年1月至2023年1月海南省肿瘤医院205例乳腺癌患者进行... 目的:探究组织中磷脂酰肌醇转运蛋白细胞质1(PITPNC1)、LIM激酶2(LIMK2)表达与乳腺癌切除术后复发转移的关系,旨在评估PITPNC1与LIMK2对现有临床预测体系的增益价值。方法:选取2020年1月至2023年1月海南省肿瘤医院205例乳腺癌患者进行前瞻性研究,均进行改良根治术,术中收集癌组织及癌旁组织,采用免疫组织化学法测定PITPNC1、LIMK2表达。比较癌组织及癌旁组织PITPNC1、LIMK2表达,采用Logistic回归分析乳腺癌切除术后复发转移相关因素,受试者工作特征(ROC)曲线评价乳腺癌组织PITPNC1、LIMK2联合预测术后复发转移的增益价值。结果:乳腺癌患者癌组织PITPNC1、LIMK2阳性表达率均高于癌旁组织(P<0.05);205例乳腺癌患者术后完成随访200例,复发转移率为25.50%;Logistic回归分析显示,临床分期、淋巴管/血管癌栓、切缘阳性/接近、癌组织PITPNC1、LIMK2阳性表达均为乳腺癌切除术后复发转移的独立影响因素(P<0.05),且校正临床分期、淋巴管/血管癌栓、切缘阳性/接近后,癌组织PITPNC1、LIMK2阳性表达仍为乳腺癌切除术后复发转移的独立影响因素(P<0.05);常规方案临床分期、淋巴管/血管癌栓、切缘阳性/接近联合预测乳腺癌切除术后复发转移的AUC值为0.870(95%CI:0.816~0.914),新方案(癌组织PITPNC1、LIMK2联合常规方案)预测乳腺癌切除术后复发转移的AUC值为0.946(95%CI:0.905~0.973),明显高于常规方案(P<0.05),具有一定增益价值。结论:乳腺癌组织中PITPNC1与LIMK2阳性表达率较高,且其阳性表达与患者根治术后的复发转移密切相关。联合检测二者表达,有助于在早期更准确地评估术后复发转移风险,为乳腺癌术后监测与防治策略提供新思路,并提示潜在的治疗靶点。 展开更多
关键词 乳腺癌 改良根治术 磷脂酰肌醇转运蛋白细胞质1 lim激酶2 复发转移
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An efficient coal and gas outburst hazard prediction method using an improved limit equilibrium model and stress field detection
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作者 Yingjie Zhao Dazhao Song +5 位作者 Liming Qiu Majid Khan Xueqiu He Zhenlei Li Yujie Peng Anhu Wang 《International Journal of Coal Science & Technology》 2025年第2期108-122,共15页
Accurate prediction of coal and gas outburst(CGO)hazards is paramount in gas disaster prevention and control.This paper endeavors to overcome the constraints posed by traditional prediction indexes when dealing with C... Accurate prediction of coal and gas outburst(CGO)hazards is paramount in gas disaster prevention and control.This paper endeavors to overcome the constraints posed by traditional prediction indexes when dealing with CGO incidents under low gas pressure conditions.In pursuit of this objective,we have studied and established a mechanical model of the working face under abnormal stress and the excitation energy conditions of CGO,and proposed a method for predicting the risk of CGO under abnormal stress.On site application verification shows that when a strong outburst hazard level prediction is issued,there is a high possibility of outburst disasters occurring.In one of the three locations where we predicted strong outburst hazards,a small outburst occurred,and the accuracy of the prediction was higher than the traditional drilling cuttings index S and drilling cuttings gas desorption index q.Finally,we discuss the mechanism of CGO under the action of stress anomalies.Based on the analysis of stress distribution changes and energy accumulation characteristics of coal under abnormal stress,this article believes that the increase in outburst risk caused by high stress abnormal gradient is mainly due to two reasons:(1)The high stress abnormal gradient leads to an increase in the plastic zone of the coal seam.After the working face advances,it indirectly leads to an increase in the gas expansion energy that can be released from the coal seam before reaching a new stress equilibrium.(2)Abnormal stress leads to increased peak stress of coal body in front of working face.When coal body in elastic area transforms to plastic area,its failure speed is accelerated,which induces accelerated gas desorption and aggravates the risk of outburst. 展开更多
关键词 Coal and gas outburst Mechanical model INSTABILITY Seismic wave tomography Prediction method
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Dynamics of Nonlinear Rossby Waves With the Derivative-Expansion Method
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作者 TIAN Hongxiao ZHANG Ruigang LIU Quansheng 《应用数学和力学》 北大核心 2026年第3期313-328,共16页
Nonlinear Rossby waves are used to describe typical wave phenomena in large-scale atmosphere andocean.Owing to the nonlinearity of the involved problems,the weakly nonlinear method,ie the derivative ex-pansion method,... Nonlinear Rossby waves are used to describe typical wave phenomena in large-scale atmosphere andocean.Owing to the nonlinearity of the involved problems,the weakly nonlinear method,ie the derivative ex-pansion method,was mainly used to investigate Rossby waves under the combined effects of the generalizedβ-effect and the basic flow effect.The derivative expansion method has the advantage of capturing the multi-scalecharacteristics of wave processes simultaneously.In the case where the perturbation expansion is independentof secular terms,the nonlinear equations describing the amplitude evolution of nonlinear waves were derived,such as the Korteweg-de Vries equation,the Boussinesq equation and Zakharov-Kuznetsov equation.Both quali-tative and quantitative analyses indicate that the generalizedβ-effect is the key factor inducing the evolution ofRossby solitary waves. 展开更多
关键词 planetary Rossby waves generalized beta effect derivative-expansion method nonlinear equation
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基于LIM的无人机倾斜摄影技术在景观改造中的应用
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作者 尤传钰 李发明 《现代园艺》 2026年第5期189-191,195,共4页
在数字中国战略推动下,风景园林领域加速向智慧化、数字化方向转型。LIM技术在三维建模和信息集成方面具有显著优势,但在获取真实地形地貌数据方面存在一定局限性。无人机倾斜摄影技术能够快速生成高精度实景三维模型,为LIM提供精准的... 在数字中国战略推动下,风景园林领域加速向智慧化、数字化方向转型。LIM技术在三维建模和信息集成方面具有显著优势,但在获取真实地形地貌数据方面存在一定局限性。无人机倾斜摄影技术能够快速生成高精度实景三维模型,为LIM提供精准的数据支持。本研究以天津城建大学煦园景观提升项目为实践案例,深入探索LIM技术与无人机倾斜摄影技术的融合应用路径。通过采用多源数据融合技术,系统开展实地信息采集、数据处理和高精度三维地理信息模型构建,实现对场地现状的精确分析与景观设计方案的优化。结果显示,2种技术的有机结合显著提升了景观设计工作的精确度和效率,加速了风景园林项目向全生命周期数字化管理模式的转型进程,为智慧城市建设中的景观规划与管理提供坚实的技术支撑和实践经验。 展开更多
关键词 lim 无人机倾斜摄影 景观改造
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Influence of SiC Content on Foaming Stability,Cell Structure,and Compression Performance of SiC/Al-Based Composite Foam Prepared by Two-Step Foaming Method
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作者 Huang Wenzhan Liu Tao +3 位作者 Chen Yao Wang Lucai Wu Jianguo You Xiaohong 《稀有金属材料与工程》 北大核心 2026年第4期890-898,共9页
SiC/Al-based composite foams were prepared by a two-step foaming method.The influence of the SiC content and its distribution uniformity on the foaming stability,cell structure,and mechanical properties of the aluminu... SiC/Al-based composite foams were prepared by a two-step foaming method.The influence of the SiC content and its distribution uniformity on the foaming stability,cell structure,and mechanical properties of the aluminum foams was investigated.The macro/micro-features of the aluminum foams were characterized and analyzed.Results demonstrate that an appropriate increase in SiC content and the uniform distribution of SiC can improve the foaming stability,optimize the cell diameter and cell wall thickness,ameliorate the cell distribution,and enhance the hardness and compressive strength of the aluminum foams.However,either insufficient or excessive SiC leads to uneven distribution of SiC particles,which is unfavorable to foaming stability and good cell structure formation.With 6wt%SiC,both the foaming stability and cell structure of the aluminum foam reach the optimal state,resulting in the highest compressive strength and optimal energy absorption capacity. 展开更多
关键词 aluminum foam two-step foaming method foaming stability cell structure HARDNESS compressive strength
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A New Inversion-free Iterative Method for Solving the Nonlinear Matrix Equation and Its Application in Optimal Control
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作者 GAO Xiangyu XIE Weiwei ZHANG Lina 《应用数学》 北大核心 2026年第1期143-150,共8页
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ... In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method. 展开更多
关键词 Nonlinear matrix equation Maximal positive definite solution Inversion-free iterative method Optimal control
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Broadband ground motion simulation and analysis of a near-fault 3D basin-mountain coupling site based on the hybrid method
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作者 Liu Zhongxian Tang Kang +2 位作者 Li Chengcheng Yuan Xiaoming Zhang Hai 《Earthquake Engineering and Engineering Vibration》 2026年第1期87-110,共24页
This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SE... This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions. 展开更多
关键词 hybrid ground motion simulation method spectral element method three-dimensional stochastic finite fault method near-fault basin-mountain coupling effect basin effect nonlinear effect
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Study on the effect of preparation method on denitration performance of Co-modified Ce/TiO_(2) catalyst
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作者 YU Chao ZHANG Boya +2 位作者 SHEN Kai HAN Yuxuan ZHANG Yaping 《燃料化学学报(中英文)》 北大核心 2026年第3期79-91,共13页
This study systematically conducted preparation optimization and performance investigations on Co-modified Ce/TiO_(2) catalysts,with a focus on examining how preparation methods and Co loading regulate the catalyst’s... This study systematically conducted preparation optimization and performance investigations on Co-modified Ce/TiO_(2) catalysts,with a focus on examining how preparation methods and Co loading regulate the catalyst’s low-temperature denitrification activity.After identifying optimal preparation parameters via condition screening,multiple characterization techniques-including BET,XRD,XPS,H_(2)-TPR and in situ DRIFTS-were employed to deeply analyze the catalyst’s physicochemical properties and reaction mechanism.Results demonstrated that compared to the impregnation and co-precipitation methods,the Ce-Co_(0.025)/TiO_(2)-SG catalyst(prepared by the sol-gel method with a Co/Ti mass ratio of 0.025)exhibited significantly superior denitrification activity:NO conversion remained stably above 95%in the 225−350℃ temperature range,and it displayed high N_(2) selectivity.Characterization analysis revealed that abundant surface oxygen vacancies,a high proportion of Ce^(3+) species,and prominent acidic sites collectively contributed to enhancing its low-temperature denitrification performance.This work provides reference value for the development of highly efficient low-temperature denitrification catalysts. 展开更多
关键词 preparation method Co Ce/TiO_(2) low-temperature denitration NH_(3)-SCR
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Guided waves in sandwich plates:revealing an approximate threshold of contrast material properties for Legendre polynomial method limitations
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作者 Abir Dardouri Cherif Othmani +2 位作者 Issam Ben Salah Bo Zhang Anouar Njeh 《Acta Mechanica Sinica》 2025年第6期143-157,共15页
Legendre polynomial method is well-known in modeling acoustic wave characteristics.This method uses for the mechanical displacements a single polynomial expansion over the entire sandwich layers.This results in a limi... Legendre polynomial method is well-known in modeling acoustic wave characteristics.This method uses for the mechanical displacements a single polynomial expansion over the entire sandwich layers.This results in a limitation in the accuracy of the field profile restitution.Thus,it can deal with the guided waves in layered sandwich only when the material properties of adjacent layers do not change significantly.Despite the great efforts regarding this issue in the literature,there remain open questions.One of them is:“what is the exact threshold of contrasting material properties of adjacent layers for which this polynomial method cannot correctly restitute the roots of guided waves?”We investigated this numerical issue using the calculated guided phase velocities in 0°/φ/0°-carbon fibre reinforced plastics(CFRP)sandwich plates with gradually increasing angleφ.Then,we approached this numerical problem by varying the middle layer thickness h90°for the 0°/90°/0°-CFRP sandwich structure,and we proposed an exact thickness threshold of the middle layer for the Legendre polynomial method limitations.We showed that the polynomial method fails to calculate the quasi-symmetric Lamb mode in 0°/φ/0°-CFRP whenφ>25°.Moreover,we introduced a new Lamb mode so-called minimum-group-velocity that has never been addressed in literature. 展开更多
关键词 0°/φ/0°-CFRP sandwich plates Contrast material properties Guided dispersion curves Legendre polynomial method Minimum-group-velocity
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蟾毒灵调节LIMK1-Cofilin1通路对肺癌细胞增殖、迁移和上皮间质转化的影响
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作者 白月琴 刘畅 +1 位作者 张梦馨 樊佳鑫 《广州中医药大学学报》 2026年第1期206-213,共8页
【目的】探讨蟾毒灵调节LIM激酶1(LIMK1)-Cofilin1通路对肺癌细胞增殖、迁移和上皮间质转化的影响。【方法】培养肺癌细胞A549,将其分成对照组、蟾毒灵组(40 ng/mL)、LIMK1组(转染pcDNA-LIMK1质粒)、蟾毒灵+NC组(40 ng/mL蟾毒灵+转染pcD... 【目的】探讨蟾毒灵调节LIM激酶1(LIMK1)-Cofilin1通路对肺癌细胞增殖、迁移和上皮间质转化的影响。【方法】培养肺癌细胞A549,将其分成对照组、蟾毒灵组(40 ng/mL)、LIMK1组(转染pcDNA-LIMK1质粒)、蟾毒灵+NC组(40 ng/mL蟾毒灵+转染pcDNA-NC质粒)及蟾毒灵+LIMK1组(40 ng/mL蟾毒灵+转染pcDNA-LIMK1质粒)。克隆形成实验观察细胞克隆形成情况;MTT法检测细胞活性;划痕愈合实验检测细胞迁移能力;Transwell实验检测细胞侵袭能力;流式细胞术检测细胞凋亡水平;Western Blot法检测细胞凋亡、上皮间质转化和LIMK1-Cofilin1通路相关蛋白表达水平。【结果】与对照组比较,蟾毒灵组细胞克隆形成率、MTT吸光度(OD)值、划痕愈合率、细胞侵袭数及B细胞淋巴瘤/白血病2(Bcl-2)、波形蛋白(Vimentin)、N-钙黏着蛋白(N-cadherin)、磷酸化(p)-LIMK1和p-Cofilin1蛋白表达量降低(P<0.05),细胞凋亡率及Bcl-2相关X蛋白(Bax)、上皮钙黏蛋白(E-cadherin)蛋白表达量增加(P<0.05),而LIMK1组细胞克隆形成率、MTT OD值、划痕愈合率、细胞侵袭数及Bcl-2、Vimentin、N-cadherin、p-LIMK1和p-Cofilin1蛋白表达量增加(P<0.05),细胞凋亡率及Bax、E-cadherin蛋白表达量下降(P<0.05);与蟾毒灵+NC组比较,蟾毒灵+LIMK1组细胞克隆形成率、MTT OD值、划痕愈合率、细胞侵袭数及Bcl-2、 Vimentin、 N-cadherin、 p-LIMK1和p-Cofilin1蛋白表达量增加(P<0.05),细胞凋亡率及Bax、E-cadherin蛋白表达量减少(P<0.05)。与LIMK1组比较,蟾毒灵+LIMK1组克隆形成率、MTT OD值、划痕愈合率、细胞侵袭数及Bcl-2、Vimentin、N-cadherin、p-LIMK1和p-Cofilin1蛋白表达量降低(P<0.05),细胞凋亡率及Bax、E-cadherin蛋白表达量增加(P<0.05)。【结论】蟾毒灵可能通过抑制LIMK1-Cofilin1通路抑制肺癌细胞增殖、迁移和上皮间质转化。 展开更多
关键词 蟾毒灵 肺癌 增殖 迁移 上皮间质转化 lim激酶1 Cofilin1 A549细胞
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Establishment of a Determination Method for Fruit Texture in Chieh-qua Using Texture Analyzer
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作者 Ying WANG Xuan DU Na LIU 《Agricultural Biotechnology》 2026年第1期54-59,共6页
[Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and pun... [Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and puncture,the index data of the fruit were obtained by setting different trigger forces,deformation levels,test speeds,as well as puncture speeds and puncture depths.The data included TPA hardness,adhesiveness,springiness,cohesiveness,gumminess,chewiness,resilience,as well as skin hardness,skin toughness,flesh hardness,fracturability,and compactness.[Results]Different deformation levels had a significant impact on all parameters.Hardness,adhesiveness,gumminess and chewiness showed a trend of first increasing and then decreasing with the deformation level increasing.When the deformation level was 30%,the adhesiveness,gumminess and chewiness reached their maximum values.When the deformation level was 50%,TPA hardness reached its maximum.When the compression speed was 3 mm/s,the measured values of TPA hardness,adhesiveness,chewiness,and resilience were at their maximums.The skin hardness varied significantly under different trigger forces.When the trigger force was 15 g,the skin hardness reached a maximum value of 944.63 g,and the skin toughness,flesh hardness,fracturability,and compactness also reach their maximum values respectively.When the puncture depth was 12 mm,the flesh hardness and skin toughness reached their maximums of 682.51 g and 1.82 mm,respectively.In the TPA mode,the flesh hardness of chieh-qua showed an extremely significant negative correlation with springiness,cohesiveness,and resilience(P<0.01).The fruit fracturability detected by puncture had an extremely significant positive correlation with compactness(P<0.01).[Conclusions]The evaluation method for measuring chieh-qua texture by combining TPA and the puncture mode could accurately and quantitatively reflect the differences in the flesh texture quality of chieh-qua.The optimal parameters for texture measurement of chieh-qua fruit were determined as a 15 g trigger force with 50%deformation and a 3 mm/s compression speed in TPA mode,and a 15 g trigger force with a 12 mm puncture depth in puncture mode.Puncture speed was found to have no significant effect on the texture indices of chieh-qua. 展开更多
关键词 CHIEH-QUA Texture analyzer Texture quality Determination method
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A novel scaling method for the elastic ring supporting structure of an aero-engine rotor system: analytical and experimental investigations
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作者 Lei LI Tianyue MA +4 位作者 Zhong LUO Dongwu GAO Xiangdong GE Hui MA Shibin WANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期1-18,共18页
The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometr... The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometric distortions, leading to a diminution in the predictive accuracy of the distorted similitude. To address this challenge, this study formulates a novel set of scaling laws, tailored to account for the intricate geometric distortions associated with elastic rings. The proposed scaling laws are formulated based on the intrinsic deformation characteristics of elastic rings, rather than the traditional systemic governing equations. Numerical and experimental cases are conducted to assess the efficacy and precision of the proposed scaling laws, and the obtained results are compared with those achieved by traditional methods. The outcomes demonstrate that the scaling laws put forth by this study significantly enhance the predictive capabilities for deformations of elastic rings. 展开更多
关键词 rotor system AERO-ENGINE elastic ring scaling method supporting structure
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Multiphysics Implicit Coupling Method for Fluid,Particles,and Large-Deformation Structures
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作者 Xiangxiang Wang Hualong Xie +3 位作者 Yue Yu Min Li Yubin Wang Fei Xing 《Computer Modeling in Engineering & Sciences》 2026年第2期367-401,共35页
This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,Calcu... This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems. 展开更多
关键词 Fluid-particle-structure interaction large deformation partitioned method non-intrusive coupling
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A Cost-Effective Approach to Precisely Estimate Singlet-Triplet Energy Gaps in MR-TADF Molecules:Combining Delta Self-Consistent Field and Time-Dependent Density Functional Theory Methods
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作者 Qian Jina Dong Wang 《Chinese Journal of Chemical Physics》 2026年第1期41-50,I0021-I0032,I0042,共23页
As a novel class of purely organic fluores-cent materials,multiple resonance thermal-ly activated delayed fluorescence(MR-TADF)compounds hold significant promise for next-generation display technologies.The efficiency... As a novel class of purely organic fluores-cent materials,multiple resonance thermal-ly activated delayed fluorescence(MR-TADF)compounds hold significant promise for next-generation display technologies.The efficiency of exciton utilization and the overall performance of organic light-emit-ting devices are closely linked to the singlet-triplet energy gap(ΔE_(ST))of MR-TADF emitters.Identifying an economic and accu-rate theoretical approach to predictΔE_(ST)would be beneficial for high-throughput screening and facilitate the inverse design of MR-TADF molecules.In this study,we evaluated the S_(1)state energy(E(S_(1))),T_(1)state ener-gy(E(T_(1))),andΔE_(ST)using three different physical interpretations:adiabatic excitation ener-gy,vertical absorption energy,and vertical emission energy.We employed the time-depen-dent density functional theory(TDDFT)and delta self-consistent field(ΔSCF)methods to calculate E(S_(1)),E(T_(1)),andΔE_(ST)for 20 MR-TADF molecules reported in the literature.We compared these calculated values with experimental data obtained from fluorescence spec-troscopy at room-temperature(or 77 K)and phosphorescence spectroscopy conducted at 77 K.Our findings indicate that the vertical absorption energy at the S0 state minimum,deter-mined by theΔSCF method,accurately predicts the S_(1)state energy.Similarly,the vertical absorption energy at the S0 state minimum,calculated using the TDDFT method,effectively predicts the T_(1)state energy.TheΔE_(ST)derived from the difference between these two excita-tion energies exhibited the smallest mean absolute error of only 0.039 eV compared to the ex-perimental values.This combination represents the most accurate and cost-effective method reported to date for predicting theΔE_(ST)of MR-TADF molecules,and can be integrated into AI-driven inverse design workflows for new emitters. 展开更多
关键词 Organic light-emitting diode Multiple resonance thermally activated delayed fluorescence emitter Single-triplet energy gap Delta self-consistent field method Time-de-pendent density functional theory method
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Synchronization Stability Analysis of Multi-VSC Grid-connected System via Multi-scale Method
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作者 Meng Huang Yangjian Ling +3 位作者 Han Yan Xikun Fu Xiaoming Zha Herbert Ho-Ching Iu 《CSEE Journal of Power and Energy Systems》 2026年第1期282-293,共12页
In a multiple voltage source converter(VSC)system,the nonlinear characteristics of phase-locked loops(PLLs)and their interactions have a significant influence on the synchronization stability of converters.In this pap... In a multiple voltage source converter(VSC)system,the nonlinear characteristics of phase-locked loops(PLLs)and their interactions have a significant influence on the synchronization stability of converters.In this paper,these influences are investigated from the perspective of the time domain.First,a novel time-domain model of the multi-VSC system is obtained by using a multi-scale method.On this basis,a stability criterion is proposed to assess the synchronization stability of the system.Then,the accuracy of the time-domain model and its stability criterion in various conditions are discussed.Moreover,the negative impact of the interaction on the system is quantified.Finally,the above theoretical analysis is also verified in the controller hardware-in-the-loop(CHIL)experiments. 展开更多
关键词 Multi-scale method multi-VSC phase-locked loops synchronization stability time-domain model
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Healthcare professionals’perspectives on disclosure of diagnosis and related issues in childhood cancer:A mixed methods systematic review
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作者 Run Xie Xiaoyan Huang +4 位作者 Yiran Du Ying Gu Qiongfang Kang Hongsheng Wang Daqian Zhu 《International Journal of Nursing Sciences》 2026年第1期96-104,I0006,共10页
Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of... Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process. 展开更多
关键词 Communication CANCER DISCLOSURE Healthcare professionals Mixed methods PEDIATRIC Systematic review
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