The effects of 2-[p-(Dimethylamino)styryl] pyridine methiodide(DSPM)on slow response action potential(SRAP)and slow inward current(Isi) of guinea pig papillary muscles were studied by intracellular microelectrodes and...The effects of 2-[p-(Dimethylamino)styryl] pyridine methiodide(DSPM)on slow response action potential(SRAP)and slow inward current(Isi) of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques.The APA and V_(max) of SRAP induced by high K￣+were decreased after 50 min of perfusion with DSPM solu- tion. Isi was suppressed from a peak value of8.8± 1.6μA to 5.7± 1.8μA, The results indicated that DSPM has a selective blocking effect on calcium channel.展开更多
The intra-molecular addition reaction of Grignard reagent with quaternary C=N bond of benzimidazole methiodide salt is reported, and a novel method for the synthesis of cycloundecanone is provided.
The addition-hydrolysis reaction of benzimidazolium salt with some mono- and bifunctional amine nucleophiles is reported, and a novel method of biomimetic synthesis for formamides and heterocycle compounds is provided.
Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is rep...Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is reported and a novel method for the preparation of various kinds of cycloalkanedione is provided.展开更多
文摘The effects of 2-[p-(Dimethylamino)styryl] pyridine methiodide(DSPM)on slow response action potential(SRAP)and slow inward current(Isi) of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques.The APA and V_(max) of SRAP induced by high K￣+were decreased after 50 min of perfusion with DSPM solu- tion. Isi was suppressed from a peak value of8.8± 1.6μA to 5.7± 1.8μA, The results indicated that DSPM has a selective blocking effect on calcium channel.
基金National Natural Science Foundation of China Provincial Natural Science Foundation of Shaanxi Province
文摘The intra-molecular addition reaction of Grignard reagent with quaternary C=N bond of benzimidazole methiodide salt is reported, and a novel method for the synthesis of cycloundecanone is provided.
基金This work was supported by the National Natural Science Foundation of China(NO.20172041)Provincial Natural Science Foundation of Shaanxi Province.
文摘The addition-hydrolysis reaction of benzimidazolium salt with some mono- and bifunctional amine nucleophiles is reported, and a novel method of biomimetic synthesis for formamides and heterocycle compounds is provided.
文摘Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is reported and a novel method for the preparation of various kinds of cycloalkanedione is provided.
