Detection and monitoring of pathogens is a central aspect of maintaining public health.Rare and neglected zoonotic viruses have the potential to evolve and expand exponentially,leading to unforeseen outbreaks,epidemic...Detection and monitoring of pathogens is a central aspect of maintaining public health.Rare and neglected zoonotic viruses have the potential to evolve and expand exponentially,leading to unforeseen outbreaks,epidemics,and pandemics.The emerging multiomics and meta-omics techniques and workflows,such as proteogenomics and meta-genomics,offer the potential for the detection of harmful pathogens,as well as opportunities for the discovery of previously unknown bacterial,parasitic,or viral pathogens.Multiomics and meta-omics workflows provide molecular information for tracking pathogens and understanding the effectiveness of spread mitigation strategies.In addition to environmental monitoring,multiomics and meta-omics approaches have the potential for clinical applications and in-depth characterization of novel pathogens.In this review,we discuss recent applications of multiomics and meta-omics techniques,their advantages over traditional methods,and their potential implementations in biomedical research,environmental studies,and healthcare.We critically assess the benefits and challenges of multiomics and meta-omics studies and discuss their future perspectives.展开更多
文摘Detection and monitoring of pathogens is a central aspect of maintaining public health.Rare and neglected zoonotic viruses have the potential to evolve and expand exponentially,leading to unforeseen outbreaks,epidemics,and pandemics.The emerging multiomics and meta-omics techniques and workflows,such as proteogenomics and meta-genomics,offer the potential for the detection of harmful pathogens,as well as opportunities for the discovery of previously unknown bacterial,parasitic,or viral pathogens.Multiomics and meta-omics workflows provide molecular information for tracking pathogens and understanding the effectiveness of spread mitigation strategies.In addition to environmental monitoring,multiomics and meta-omics approaches have the potential for clinical applications and in-depth characterization of novel pathogens.In this review,we discuss recent applications of multiomics and meta-omics techniques,their advantages over traditional methods,and their potential implementations in biomedical research,environmental studies,and healthcare.We critically assess the benefits and challenges of multiomics and meta-omics studies and discuss their future perspectives.
