Organs are fundamental anatomical entities within the human body,each performing distinct physiological functions and serving as sites for various pathological conditions.Current medical research and treatment focus p...Organs are fundamental anatomical entities within the human body,each performing distinct physiological functions and serving as sites for various pathological conditions.Current medical research and treatment focus primarily on the individual as a whole or on cellular and genetic levels.However,due to the absence of well-established in vitro organ culture techniques and models,research at the mesoscopic level of organs significantly lags behind microscopic and macroscopic investigations.This lag restricts the efficient translation of research outcomes and constrains the potential for regional research and precise treatment of diseased organs.Although murine models and cell lines contribute to the understanding of organ biology and associated diseases,they fail to replicate crucial aspects of human organ complexity and metabolic functions.Notably,failures in clinical trials have often been attributed to inaccurate modeling,particularly in animal models.展开更多
基金supported by grants from China Postdoctoral Science Foundation,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,China(No.2022M723604)National Natural Science Foundation of China(Nos.822706886,81570587 and 81700557)+7 种基金the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology(Nos.2013A061401007 and 2017B030314018)Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project(No.2015A030308010)Guangdong Provincial Funds for High-end Medical Equipment(No.2020B1111140003)Science and Technology Program of Guangzhou(No.201704020150)the Natural Science Foundations of Guangdong Province(Nos.2016A030310141 and 2020A1515010091)Young Teachers Training Project of Sun Yat-Sen University(No.K0401068)Colin New Star of Sun Yat-Sen University(No.R08027)the Guangdong Science and Technology Innovation Strategy(Nos.pdjh2022b0010 and pdjh2023a0002).
文摘Organs are fundamental anatomical entities within the human body,each performing distinct physiological functions and serving as sites for various pathological conditions.Current medical research and treatment focus primarily on the individual as a whole or on cellular and genetic levels.However,due to the absence of well-established in vitro organ culture techniques and models,research at the mesoscopic level of organs significantly lags behind microscopic and macroscopic investigations.This lag restricts the efficient translation of research outcomes and constrains the potential for regional research and precise treatment of diseased organs.Although murine models and cell lines contribute to the understanding of organ biology and associated diseases,they fail to replicate crucial aspects of human organ complexity and metabolic functions.Notably,failures in clinical trials have often been attributed to inaccurate modeling,particularly in animal models.
