This study investigates the integration of geo-logistics as a strategic framework for enhancing sustainability within Small and Medium-sized Ports(SMPs)in Thailand,focusing on improving environmental,innovation and ec...This study investigates the integration of geo-logistics as a strategic framework for enhancing sustainability within Small and Medium-sized Ports(SMPs)in Thailand,focusing on improving environmental,innovation and economic performance.The geo-logistics framework in this study considers the spatial aspects of logistics activities around the port areas to achieve sustainability goals.This research employs a mixedmethods approach statistical analysis(ANOVA),combined with semi-structured interviews and an intensive literature review to assess both internal and external management criteria across three key regional ports—Songkhla,Map Ta Phut,and Ranong.Findings reveal significant variations of internal factors to assess digitalization,waste management,green procurement,and energy-efficient operations.Beside that externally explores ecosystem protection,stakeholder collaboration,and regulatory compliance.The results showed that Map Ta Phut port demonstrated the most comprehensive sustainability initiatives within its geo-logistics framework,while Songkhla port and Ranong port showed moderate progress.These variations highlight the differing levels of preparedness and commitment to sustainability across the selected ports.Successful implementation of geo-logistics in this research requires strong governmental support,financial incentives,and capacity building to empower Thai SMPs toward long-term sustainability and enhanced competitiveness in the global maritime sector.Lastly,this framework offers a practical roadmap for transforming regional ports into resilient,green,and smart logistics hubs.展开更多
Objective Electronic cigarettes(ECs)differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling.Pulmonary hypertension(PH),characterized by pulmonary artery and right ventricle remodeling,po...Objective Electronic cigarettes(ECs)differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling.Pulmonary hypertension(PH),characterized by pulmonary artery and right ventricle remodeling,poses a significant risk of mortality in infants,children,and adolescents.However,the impact of maternal EC exposure on PH development in offspring remains unclear.To address this,we established a PH rat model with maternal EC exposure.Methods Maternal EC exposure was initiated on gestation day 12 via electronic nicotine delivery systems.Offspring were administered monocrotaline(MCT)at 6 weeks of age(6-wo)to induce PH.Mechanistic experiments were conducted at 10-week-old(10-wo).Protein expression of NADPH oxidases,DNA methyltransferases,and autophagy-related markers was analyzed by Western blot.Morphological changes and the severity of PH were evaluated via hematoxylin and eosin(HE)staining and echocardiography,respectively.Furthermore,the involvement of the oxidative stress/DNA methylation/autophagy axis in response to maternal EC exposure was confirmed through a combination of ELISA,Western blot,HE staining,and echocardiography.Additionally,ATG5 mRNA expression was measured by qRT-PCR.Results Compared with control conditions,maternal EC exposure significantly worsened MCT-induced PH in male offspring.This was associated with increased oxidative stress,DNA hypomethylation,and anomalous autophagy in the offspring.In vivo treatment with chloroquine inhibited autophagy and ameliorated PH development in offspring exposed to maternal EC.Furthermore,N-acetylcysteine(NAC),an antioxidant,attenuated maternal EC exposure-induced oxidative stress,DNA hypomethylation,and excessive autophagy,thereby improving PH.DNA hypermethylation also reversed PH development,accompanied by reduced oxidative stress and suppressed autophagy.ATG5,a key regulator of autophagy,was identified as a potential therapeutic target,as its repression mitigated PH in maternal EC-exposed offspring.Conclusion Maternal EC exposure induces oxidative stress and DNA hypomethylation in offspring,leading to anomalous autophagy and exacerbation of PH development.Targeting ATG5-mediated autophagy may represent a novel therapeutic approach for improving PH outcomes in offspring exposed to maternal EC.Graphical Abstract Pregnant rats were exposed to either EC vapor or standard air from gestation day 12 until 2 days before delivery,with all offspring undergoing PH induction at 6-wo.Offspring exposed to maternal EC presented increased oxidative stress,which in turn affected DNA methylation patterns.The decreased DNA methylation in male offspring led to the activation of autophagy,exacerbating the development of PH.Treatment with ATG5 siRNA inhibited autophagy and alleviated heightened PH in male offspring with maternal EC exposure.展开更多
The establishment of Hainan Free Trade Port provides a new opportunity for the financing of small and medium-sized enterprises.In the process of the country continuously promoting the development of a free trade port,...The establishment of Hainan Free Trade Port provides a new opportunity for the financing of small and medium-sized enterprises.In the process of the country continuously promoting the development of a free trade port,the financing environment of small and medium-sized enterprises has gradually improved,and the financing environment has been greatly improved.But the small and medium-sized enterprises“financing difficult”“financing expensive”problem still exists.The problems of difficult and expensive financing of small and medium-sized enterprises in Haikou city have their reasons as well as the influence of external environmental factors.Therefore,to better solve the financing problems of small and medium-sized enterprises in Haikou,this paper analyzes the reasons for the difficulty and expensive financing of small and medium-sized enterprises according to the existing research results and summarizes the financing experience of small and medium-sized enterprises at home and abroad.This article finds that the financing systems for small and medium-sized enterprises(SMEs)in developed countries are relatively well-established,and both the government and society offer significant support to SMEs.Therefore,this paper believes that the government should adjust the business strategy to improve the financing ecological environment and enhance the financing ability of SMEs.The government should take the lead in perfecting the guarantee system,continuously improving the credit information system of enterprises and various financial service institutions,promoting the opening and institutionalization of private credit,and developing Internet finance[1].展开更多
Carbon-based low-dimensional materials(CLDM)with elemental carbon as the main component have unique physical and chemical properties,and become the focus of research in many fields including energy,environmental prote...Carbon-based low-dimensional materials(CLDM)with elemental carbon as the main component have unique physical and chemical properties,and become the focus of research in many fields including energy,environmental protection,and information technology.Notably,cellulose acetate,the main component of cigarette butts(CBs),is a one-dimensional precursor with a large specific surface area and aspect ratio.Still,their usefulness as building fillers has often been underestimated before.This review summarizes recent advances in CBs recycling and provides suggested guidelines for its use as a CLDM material in renewable energy.Specifically,we first describe the harmful effects of CBs as pollutants in our lives to emphasize the importance of proper recycling.We then summarize previous methods of recycling CBs waste,including clay bricks,asphalt concrete pavement,gypsum,acoustic materials,chemisorption,vector control,and corrosion control.The potential applications of CBs include triboelectric nanogenerator applications,flexible batteries,enhanced metal-organic framework material energy storage devices,and carbon-based hydrogen storage.Finally,the advantages of utilizing CBs-derived CLDM materials over conventional solutions in the energy field are discussed.This review will provide new avenues for solving the intractable problem of CBs and reducing the manufacturing costs of renewable materials.展开更多
As an important tool to achieve sustainable economic and environmental development,green finance can effectively alleviate the financing constraints of small and medium-sized enterprises(SMEs),especially in promoting ...As an important tool to achieve sustainable economic and environmental development,green finance can effectively alleviate the financing constraints of small and medium-sized enterprises(SMEs),especially in promoting green transformation plays a key role.SMEs play an important role in economic growth,innovation,and job creation,but due to a lack of collateral,imperfect credit history,and opaque financial information,they face great obstacles in the financing process,especially in the early capital investment required for green transformation.Green finance,through innovative financial instruments such as green credit and green bonds,provides new financing channels for SMEs,helping them reduce financing costs,optimize financing structure,and promote their green transformation and sustainable development.This paper analyzes the current situation and root causes of SMEs’financing dilemma from the perspective of green finance,and probes into the influence of green finance policies on financing behavior.展开更多
In the context of the digital economy,digital finance is becoming an important tool and service model to support the technological innovation of small and medium-sized enterprises.However,insufficient awareness among ...In the context of the digital economy,digital finance is becoming an important tool and service model to support the technological innovation of small and medium-sized enterprises.However,insufficient awareness among managers,an imperfect service system,limited supply capacity,and a weak risk prevention and control mechanism have restricted its support effect.To give better play to the role of digital finance,it is necessary to accelerate the construction of a service platform connecting digital finance and technological innovation,promote inclusive development,improve the service system,and strengthen risk supervision.By optimizing resource allocation,enhancing the accuracy and security of services,it can provide strong support for the technological innovation and digital transformation of small and medium-sized enterprises and promote the high-quality development of digital finance.展开更多
Under the socialist market economic system of our country,the government,through the“invisible hand,”carries on macro regulation and control to improve the financing constraints that small and medium-sized enterpris...Under the socialist market economic system of our country,the government,through the“invisible hand,”carries on macro regulation and control to improve the financing constraints that small and medium-sized enterprises are facing.But because of the huge base number of small and medium-sized enterprises in our country,there are many kinds,and the problem of financing constraints is still puzzling the development of enterprises at present.With the continuous promotion of inclusive finance in our country,the problems plaguing SMEs in the last mile of financing are gradually improved.In this context,small and medium-sized enterprises in Hainan Free Trade Port are taken as the research object to study the role of digital inclusive finance on the financing constraints of SMEs.The research shows that,first of all,small and medium-sized enterprises in Hainan Free Trade Port generally have financing problems.The development of digital inclusive finance solves the“last kilometer”problem of traditional finance,enhances financial access ability,broadens the financial service group,provides convenience and diversified services for SMEs'financing,and provides inexhaustible impetus for the long-term healthy development of SMEs.Secondly,digital inclusive finance alleviates the financing difficulties faced by SMEs on the island by reducing financial costs and expanding the scale of credit.展开更多
With the acceleration of the iterative process of artificial intelligence technology,small and medium-sized enterprises have encountered innovative solutions in the field of financial decision-making,significantly enh...With the acceleration of the iterative process of artificial intelligence technology,small and medium-sized enterprises have encountered innovative solutions in the field of financial decision-making,significantly enhancing their dynamic response capabilities to complex and changing market environments.This article summarizes the specific application scenarios and development trends of artificial intelligence in the financial management practice of small and medium-sized enterprises,and explores the path and positive impact of artificial intelligence on the optimization of financial decision-making in small and medium-sized enterprises from the current application status of artificial intelligence in financial decision-making,the unique challenges of financial management in small and medium-sized enterprises and the impact of AI technology on it,the application of artificial intelligence in financial decision-making optimization,and prospects.展开更多
Rurbanization,characterized by the integration of rural and urban attributes,holds significant implications for the development and marketing of small and medium-sized cities.This study investigates the effects of rur...Rurbanization,characterized by the integration of rural and urban attributes,holds significant implications for the development and marketing of small and medium-sized cities.This study investigates the effects of rurbanization on city marketing strategies and urban growth through a comprehensive review of recent literature.Key factors influencing rurbanization are identified,along with their impacts on city marketing practices.The findings indicate that rurbanization enhances city branding,attracts new residents and businesses,and promotes sustainable urban development.However,the phenomenon also presents challenges,including infrastructural strain and socio-cultural integration issues.Furthermore,rurbanization influences the socio-economic dynamics of cities,resulting in both opportunities and inequalities that require careful management.The study concludes with actionable recommendations for leveraging rurbanization to achieve positive city marketing outcomes while addressing associated challenges.This research aims to deepen the understanding of rurbanization and provide practical insights for policymakers,urban planners,and marketers in small and medium-sized cities,enabling them to optimize their growth strategies effectively.展开更多
Small and Medium-sized Enterprises (SMEs) are considered the backbone of global economy, but they often face cyberthreats which threaten their financial stability and operational continuity. This work aims to offer a ...Small and Medium-sized Enterprises (SMEs) are considered the backbone of global economy, but they often face cyberthreats which threaten their financial stability and operational continuity. This work aims to offer a proactive cybersecurity approach to safeguard SMEs against these threats. Furthermore, to mitigate these risks, we propose a comprehensive framework of practical and scalable cybersecurity measurements/protocols specifically for SMEs. These measures encompass a spectrum of solutions, from technological fortifications to employee training initiatives and regulatory compliance strategies, in an effort to cultivate resilience and awareness among SMEs. Additionally, we introduce a specially designed a Java-based questionnaire software tool in order to provide an initial framework for essential cybersecurity measures and evaluation for SMEs. This tool covers crucial topics such as social engineering and phishing attempts, implementing antimalware and ransomware defense mechanisms, secure data management and backup strategies and methods for preventing insider threats. By incorporating globally recognized frameworks and standards like ISO/IEC 27001 and NIST guidelines, this questionnaire offers a roadmap for establishing and enhancing cybersecurity measures.展开更多
Digital financial inclusion provides financial services through digital platforms,aiming to improve the ability of MSMEs and low-income groups to access financial resources,thereby easing their financing constraints a...Digital financial inclusion provides financial services through digital platforms,aiming to improve the ability of MSMEs and low-income groups to access financial resources,thereby easing their financing constraints and promoting economic growth and inclusive development.As an innovative financial model,digital financial inclusion utilizes modern technological means to significantly improve the accessibility and convenience of financial services,especially in areas where traditional banking services are under-covered.Digital finance has promoted the popularization of financial services such as micro-credit,micro-savings,and micro-insurance,and helped improve the financing environment of low-income groups and small and micro enterprises.At the same time,digital financial inclusion promotes financial literacy education and digital inclusion construction,and enhances the acceptance and use of digital financial instruments by the general public,which is the key to achieving sustainable development of digital financial inclusion.Therefore,digital financial inclusion can better ease the financing constraints of small and medium-sized enterprises and promote economic development.展开更多
The rapid development of digital financial inclusion is profoundly changing the financing environment for small and medium-sized enterprises(SMEs).As an important driver of economic growth and innovation,SMEs account ...The rapid development of digital financial inclusion is profoundly changing the financing environment for small and medium-sized enterprises(SMEs).As an important driver of economic growth and innovation,SMEs account for a significant share of employment and GDP globally.However,the traditional bank credit model has long failed to effectively meet the financing needs of SMEs due to issues such as information asymmetry,high cost,and difficulty in risk assessment,resulting in serious financing constraints.Digital financial inclusion,through technological innovation and big data analysis,has significantly reduced credit costs,alleviated information asymmetry,and provided SMEs with more flexible and efficient financing channels.Research shows that digital financial inclusion can not only ease the financing constraints of SMEs,but also promote their innovation and growth,providing important support for building a more inclusive and sustainable financial ecosystem.展开更多
This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and ha...This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and have no money to transform(lack of funds).”Using literature analysis and multiple case comparisons,the study summarizes five major categories of technology services:technical support,consulting and planning,training and empowerment,resource integration,and financing connectivity.It constructs a“service–capability–performance”catalytic framework.Tracking of 58 enterprises in the Yangtze River Delta reveals that resource integration contributes the most to digital maturity,with absorptive capacity playing a significant mediating role;the configuration of“high technology services+high absorptive capacity+high environmental dynamism”is a sufficient condition for high transformation performance.Based on these findings,countermeasures are proposed,including improving the technology service system,strengthening government-industry-academia collaboration,and optimizing funding and talent supply,providing replicable experience for SMEs,governments,and technology service institutions.展开更多
It is an important standard to judge the flood disaster in the basin whether the rainfall at the flood-inducing interface is reached.In this paper,the Xin'anjiang model,Topmodel model and SCS model were selected t...It is an important standard to judge the flood disaster in the basin whether the rainfall at the flood-inducing interface is reached.In this paper,the Xin'anjiang model,Topmodel model and SCS model were selected to calculate and compare the rainfall at the flood-inducing interface in the Zhanghe Reservoir basin in Hubei Province.The results showed that average relative error and average absolute error of Xin'anjiang model were-3.36%and-21.46×10^(5)m^(3),which were the minimum,followed by Topmodel model with 5.72%and 26.22×10^(5)m^(3),SCS model with 11.33%and 58.13×10^(5)m^(3).The minimum absolute error of the three hydrological models in calculating the rainfall at the critical interface was 3.26 mm,while the maximum was 49.24 mm.When the initial water level exceeded 120 m,the difference among the three models in calculating the rainfall at the critical interface became more and more obvious.When the reservoir water level was lower than 120 m,it mainly referred to the calculation results of Xin'anjiang model.When the reservoir water level was higher than 120 m,it mainly referred to the calculation results of Topmodel model.The research conclusion can provide reference for small and medium-sized basins selecting hydrological model to calculate the rainfall at the flood-inducing interface.展开更多
The two-tier shareholding structure,which originated in the United States,has become popular around the world.Unlike the traditional model of“equal shares with equal rights”,the core feature of the two-tier sharehol...The two-tier shareholding structure,which originated in the United States,has become popular around the world.Unlike the traditional model of“equal shares with equal rights”,the core feature of the two-tier shareholding structure is that the company issues two classes of shares with different voting rights.It enables the concentration and stabilization of corporate control,which has a positive effect on the long-term development of the company and resistance to hostile takeovers.Against the background of the rapid development of the capital market and the continuous innovation of corporate governance structure,the two-tier shareholding structure has begun to be adopted by many enterprises.While this structure can improve the efficiency of corporate governance and promote corporate growth,it also raises a number of challenges.In particular,for small and medium-sized shareholders,their shareholdings may face the problem of limited or no voting rights,as well as the lack of an effective internal and external monitoring mechanism for the company.These issues may lead to the impairment of the rights of small and medium-sized shareholders.Currently,challenges in practice include inadequate laws and regulations,insufficient disclosure of information,and inadequate monitoring mechanisms.Therefore,exploring the path to protect the rights and interests of small and medium-sized shareholders and analyzing their current situation has become an important area in the study of two-tier shareholding structures.This paper starts from the actual situation,analyzes the problems exposed in the operation process of two-tier shareholding structure,and then explores the practical and feasible methods to protect the rights and interests of small and medium-sized shareholders on this basis,with a view to putting forward valuable references for the development of China’s securities market.展开更多
[Objective] The deliver amount and deliver rate of heavy metal elements during smoking were studied, which could provide a reference for reducing the damage of cigarette products. [Method] Two pretreatment methodsof m...[Objective] The deliver amount and deliver rate of heavy metal elements during smoking were studied, which could provide a reference for reducing the damage of cigarette products. [Method] Two pretreatment methodsof microwave di- gestion and acid extraction were used to process the ash content, the total particu- late matter of mainstream smoke （TPM） and cigarette filter. Detection results of heavy metal elements were compared by the two methods. [Result] The microwave digestion method was better than acid solution extraction method on analysis of TPM, but presented disadvantages on analysis of ash and filter. Meanwhile, the migration amount and rate were studied and resultsshowed that most heavy metal elements were escaped along with sidestream smoke between 66.89% and 95.48%, and almost all Hg escaped through sidestream smoke. Other heavy metal elements, except Hg, were separately found in ash, TPM and filter. Cr, Ni, As and Se were mostly residual in ash, followed by TPM, and filter had the least, while Cd and Pb were just in the reverse order. Normally, 5% or less heavy metal elements were transferred to TPM, only a small part of which could reach 5%-10%. [Conclusion] Most of the heavy metal elements are taken by sidestream smoke, ash and filter, while the migration amounts to mainstream smoke are extremely low.展开更多
OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease i...OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions.展开更多
The three-dimensional(3 D)model of cigarette was accurately constructed through reverse engineering as the research object of numerical simulation.The combustion process of cigarette was studied with computational flu...The three-dimensional(3 D)model of cigarette was accurately constructed through reverse engineering as the research object of numerical simulation.The combustion process of cigarette was studied with computational fluid dynamics(CFD).Standard Laminar models with species transport approach were applied,and numerical simulation of the cigarette was analyzed with semi-implicit method for pressure–velocity coupling.The results showed that the model could predict velocity of cigarette smoke,the distributions of temperature and pressure at different times.In order to verify the correctness of model,it was found that the relationship between the velocity of smoke and pressure according to Darcy’s law on z position(x=4 mm,y=0,0 mm≤z≤50.61 mm).展开更多
AIM:To evaluate the outcomes of patients withmedium-sized hepatocellular carcinoma(HCC)who underwent percutaneous microwave ablation(MWA).METHODS:We retrospectively reviewed all patients with a single medium-sized HCC...AIM:To evaluate the outcomes of patients withmedium-sized hepatocellular carcinoma(HCC)who underwent percutaneous microwave ablation(MWA).METHODS:We retrospectively reviewed all patients with a single medium-sized HCC who underwent percutaneous MWA from January 2010 to January2013.Technical success,technical effectiveness and complications were subsequently observed.Survival curves were constructed using the Kaplan-Meier method.The Cox proportional hazards model was fitted to each variable.The relative prognostic significance o f t h e va r i a b l e s fo r p re d i c t i n g ove ra l l s u r v i va l rate,recurrence-free survival rate and local tumor recurrence(s)was assessed using univariate analysis.All variables with a P value<0.20 were subjected to multivariate analysis.RESULTS:The study included 182 patients(mean age,58 years;age range:22-86 years)with a single HCC(mean size,3.72±0.54 cm;range:3.02-5.00cm).The estimated technical effectiveness rate was93%in 182 patients.The major complication rate was2.7%(5/182),including liver abscess in 4 cases,and abdominal bleeding at the puncture site in 1 case.Thirty-day mortality rate was 0.5%(1/182).One patient died due to liver abscess-related septicemia.Cumulative recurrence-free survival and overall survival(OS)rates were 51%,36%,27%and 89%,74%,60%at 1,2,and 3 years,respectively.Age(P=0.017)and tumor diameter(P=0.029)were independent factors associated with local tumor recurrence.None of the factors had a statistically significant impact on recurrence-free survival.Serum albumin level(P=0.009)and new lesion(s)(P=0.029)were independently associated with OS.CONCLUSION:Percutaneous MWA is a relatively safe and effective treatment for patients with medium-sized HCC.展开更多
In this study, the effect of prophylactic anti inflammation on the development of smoke induced emphysema was investigated. Young male guinea pigs aged 1.5 - 2 months (weighing 198.3±26.9 g) were randomly divi...In this study, the effect of prophylactic anti inflammation on the development of smoke induced emphysema was investigated. Young male guinea pigs aged 1.5 - 2 months (weighing 198.3±26.9 g) were randomly divided into 4 groups: group A (cigarette smoke exposure only), group B (cigarette smoke exposure plus pentoxifylline rich (PTX, 10 mg/d) forage feeding), group C (cigarette smoke exposure plus intermittent cortical steroid injection (Triamcinolone acetonide, 3 mg, im, every three weeks) and control group (group D: animals with sham smoke exposure, raised under the same conditions). Animals in group A, B and C were exposed to smoke of cigarettes for 1 to 1.5 h twice a day, 5 days a week. All animals were killed at the 16th week and followed by morphometrical analysis of the midsagittal sectioned lung slices. Smoke exposure of 16 weeks resulted in visible emphysematous development in Group A but not in Group B and C. It was evidenced by the indicator of air space size, mean linear intercept (L m): 120.6±16.0 μm in Group A; 89.8±9.2 μm in Group B and 102.4±17.7 μm in Group C. The average L m in either group B or group C was shorter than that in Group A (ANOVA and Newman Keuls test, F=8.80, P =0.0002) but comparable to that (94.8±13.2 μm) in group D ( P >0.05). It is concluded that long term prophylactic anti inflammation inhibits pulmonary emphysema induced by cigarette smoking in the guinea pigs.展开更多
基金funded by faculty of International Maritime Studies,Kasetsart University.
文摘This study investigates the integration of geo-logistics as a strategic framework for enhancing sustainability within Small and Medium-sized Ports(SMPs)in Thailand,focusing on improving environmental,innovation and economic performance.The geo-logistics framework in this study considers the spatial aspects of logistics activities around the port areas to achieve sustainability goals.This research employs a mixedmethods approach statistical analysis(ANOVA),combined with semi-structured interviews and an intensive literature review to assess both internal and external management criteria across three key regional ports—Songkhla,Map Ta Phut,and Ranong.Findings reveal significant variations of internal factors to assess digitalization,waste management,green procurement,and energy-efficient operations.Beside that externally explores ecosystem protection,stakeholder collaboration,and regulatory compliance.The results showed that Map Ta Phut port demonstrated the most comprehensive sustainability initiatives within its geo-logistics framework,while Songkhla port and Ranong port showed moderate progress.These variations highlight the differing levels of preparedness and commitment to sustainability across the selected ports.Successful implementation of geo-logistics in this research requires strong governmental support,financial incentives,and capacity building to empower Thai SMPs toward long-term sustainability and enhanced competitiveness in the global maritime sector.Lastly,this framework offers a practical roadmap for transforming regional ports into resilient,green,and smart logistics hubs.
基金supported by National Natural Science Foundation of China(No.82300268)Guangzhou Municipal Science and Technology Project(No.2023B03J1255).
文摘Objective Electronic cigarettes(ECs)differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling.Pulmonary hypertension(PH),characterized by pulmonary artery and right ventricle remodeling,poses a significant risk of mortality in infants,children,and adolescents.However,the impact of maternal EC exposure on PH development in offspring remains unclear.To address this,we established a PH rat model with maternal EC exposure.Methods Maternal EC exposure was initiated on gestation day 12 via electronic nicotine delivery systems.Offspring were administered monocrotaline(MCT)at 6 weeks of age(6-wo)to induce PH.Mechanistic experiments were conducted at 10-week-old(10-wo).Protein expression of NADPH oxidases,DNA methyltransferases,and autophagy-related markers was analyzed by Western blot.Morphological changes and the severity of PH were evaluated via hematoxylin and eosin(HE)staining and echocardiography,respectively.Furthermore,the involvement of the oxidative stress/DNA methylation/autophagy axis in response to maternal EC exposure was confirmed through a combination of ELISA,Western blot,HE staining,and echocardiography.Additionally,ATG5 mRNA expression was measured by qRT-PCR.Results Compared with control conditions,maternal EC exposure significantly worsened MCT-induced PH in male offspring.This was associated with increased oxidative stress,DNA hypomethylation,and anomalous autophagy in the offspring.In vivo treatment with chloroquine inhibited autophagy and ameliorated PH development in offspring exposed to maternal EC.Furthermore,N-acetylcysteine(NAC),an antioxidant,attenuated maternal EC exposure-induced oxidative stress,DNA hypomethylation,and excessive autophagy,thereby improving PH.DNA hypermethylation also reversed PH development,accompanied by reduced oxidative stress and suppressed autophagy.ATG5,a key regulator of autophagy,was identified as a potential therapeutic target,as its repression mitigated PH in maternal EC-exposed offspring.Conclusion Maternal EC exposure induces oxidative stress and DNA hypomethylation in offspring,leading to anomalous autophagy and exacerbation of PH development.Targeting ATG5-mediated autophagy may represent a novel therapeutic approach for improving PH outcomes in offspring exposed to maternal EC.Graphical Abstract Pregnant rats were exposed to either EC vapor or standard air from gestation day 12 until 2 days before delivery,with all offspring undergoing PH induction at 6-wo.Offspring exposed to maternal EC presented increased oxidative stress,which in turn affected DNA methylation patterns.The decreased DNA methylation in male offspring led to the activation of autophagy,exacerbating the development of PH.Treatment with ATG5 siRNA inhibited autophagy and alleviated heightened PH in male offspring with maternal EC exposure.
文摘The establishment of Hainan Free Trade Port provides a new opportunity for the financing of small and medium-sized enterprises.In the process of the country continuously promoting the development of a free trade port,the financing environment of small and medium-sized enterprises has gradually improved,and the financing environment has been greatly improved.But the small and medium-sized enterprises“financing difficult”“financing expensive”problem still exists.The problems of difficult and expensive financing of small and medium-sized enterprises in Haikou city have their reasons as well as the influence of external environmental factors.Therefore,to better solve the financing problems of small and medium-sized enterprises in Haikou,this paper analyzes the reasons for the difficulty and expensive financing of small and medium-sized enterprises according to the existing research results and summarizes the financing experience of small and medium-sized enterprises at home and abroad.This article finds that the financing systems for small and medium-sized enterprises(SMEs)in developed countries are relatively well-established,and both the government and society offer significant support to SMEs.Therefore,this paper believes that the government should adjust the business strategy to improve the financing ecological environment and enhance the financing ability of SMEs.The government should take the lead in perfecting the guarantee system,continuously improving the credit information system of enterprises and various financial service institutions,promoting the opening and institutionalization of private credit,and developing Internet finance[1].
基金supported by Hubei Province Technology Innovation Program Project(2024BCB073)the National Natural Science Foundation of China(52402249)the China Postdoctoral Science Foundation(2021M690930).
文摘Carbon-based low-dimensional materials(CLDM)with elemental carbon as the main component have unique physical and chemical properties,and become the focus of research in many fields including energy,environmental protection,and information technology.Notably,cellulose acetate,the main component of cigarette butts(CBs),is a one-dimensional precursor with a large specific surface area and aspect ratio.Still,their usefulness as building fillers has often been underestimated before.This review summarizes recent advances in CBs recycling and provides suggested guidelines for its use as a CLDM material in renewable energy.Specifically,we first describe the harmful effects of CBs as pollutants in our lives to emphasize the importance of proper recycling.We then summarize previous methods of recycling CBs waste,including clay bricks,asphalt concrete pavement,gypsum,acoustic materials,chemisorption,vector control,and corrosion control.The potential applications of CBs include triboelectric nanogenerator applications,flexible batteries,enhanced metal-organic framework material energy storage devices,and carbon-based hydrogen storage.Finally,the advantages of utilizing CBs-derived CLDM materials over conventional solutions in the energy field are discussed.This review will provide new avenues for solving the intractable problem of CBs and reducing the manufacturing costs of renewable materials.
文摘As an important tool to achieve sustainable economic and environmental development,green finance can effectively alleviate the financing constraints of small and medium-sized enterprises(SMEs),especially in promoting green transformation plays a key role.SMEs play an important role in economic growth,innovation,and job creation,but due to a lack of collateral,imperfect credit history,and opaque financial information,they face great obstacles in the financing process,especially in the early capital investment required for green transformation.Green finance,through innovative financial instruments such as green credit and green bonds,provides new financing channels for SMEs,helping them reduce financing costs,optimize financing structure,and promote their green transformation and sustainable development.This paper analyzes the current situation and root causes of SMEs’financing dilemma from the perspective of green finance,and probes into the influence of green finance policies on financing behavior.
基金Exploration of the Impact of Financial Reforms in the Hainan Free Trade Port on Enterprises,General Project(Project No.:HKKY2024-13)。
文摘In the context of the digital economy,digital finance is becoming an important tool and service model to support the technological innovation of small and medium-sized enterprises.However,insufficient awareness among managers,an imperfect service system,limited supply capacity,and a weak risk prevention and control mechanism have restricted its support effect.To give better play to the role of digital finance,it is necessary to accelerate the construction of a service platform connecting digital finance and technological innovation,promote inclusive development,improve the service system,and strengthen risk supervision.By optimizing resource allocation,enhancing the accuracy and security of services,it can provide strong support for the technological innovation and digital transformation of small and medium-sized enterprises and promote the high-quality development of digital finance.
文摘Under the socialist market economic system of our country,the government,through the“invisible hand,”carries on macro regulation and control to improve the financing constraints that small and medium-sized enterprises are facing.But because of the huge base number of small and medium-sized enterprises in our country,there are many kinds,and the problem of financing constraints is still puzzling the development of enterprises at present.With the continuous promotion of inclusive finance in our country,the problems plaguing SMEs in the last mile of financing are gradually improved.In this context,small and medium-sized enterprises in Hainan Free Trade Port are taken as the research object to study the role of digital inclusive finance on the financing constraints of SMEs.The research shows that,first of all,small and medium-sized enterprises in Hainan Free Trade Port generally have financing problems.The development of digital inclusive finance solves the“last kilometer”problem of traditional finance,enhances financial access ability,broadens the financial service group,provides convenience and diversified services for SMEs'financing,and provides inexhaustible impetus for the long-term healthy development of SMEs.Secondly,digital inclusive finance alleviates the financing difficulties faced by SMEs on the island by reducing financial costs and expanding the scale of credit.
文摘With the acceleration of the iterative process of artificial intelligence technology,small and medium-sized enterprises have encountered innovative solutions in the field of financial decision-making,significantly enhancing their dynamic response capabilities to complex and changing market environments.This article summarizes the specific application scenarios and development trends of artificial intelligence in the financial management practice of small and medium-sized enterprises,and explores the path and positive impact of artificial intelligence on the optimization of financial decision-making in small and medium-sized enterprises from the current application status of artificial intelligence in financial decision-making,the unique challenges of financial management in small and medium-sized enterprises and the impact of AI technology on it,the application of artificial intelligence in financial decision-making optimization,and prospects.
文摘Rurbanization,characterized by the integration of rural and urban attributes,holds significant implications for the development and marketing of small and medium-sized cities.This study investigates the effects of rurbanization on city marketing strategies and urban growth through a comprehensive review of recent literature.Key factors influencing rurbanization are identified,along with their impacts on city marketing practices.The findings indicate that rurbanization enhances city branding,attracts new residents and businesses,and promotes sustainable urban development.However,the phenomenon also presents challenges,including infrastructural strain and socio-cultural integration issues.Furthermore,rurbanization influences the socio-economic dynamics of cities,resulting in both opportunities and inequalities that require careful management.The study concludes with actionable recommendations for leveraging rurbanization to achieve positive city marketing outcomes while addressing associated challenges.This research aims to deepen the understanding of rurbanization and provide practical insights for policymakers,urban planners,and marketers in small and medium-sized cities,enabling them to optimize their growth strategies effectively.
文摘Small and Medium-sized Enterprises (SMEs) are considered the backbone of global economy, but they often face cyberthreats which threaten their financial stability and operational continuity. This work aims to offer a proactive cybersecurity approach to safeguard SMEs against these threats. Furthermore, to mitigate these risks, we propose a comprehensive framework of practical and scalable cybersecurity measurements/protocols specifically for SMEs. These measures encompass a spectrum of solutions, from technological fortifications to employee training initiatives and regulatory compliance strategies, in an effort to cultivate resilience and awareness among SMEs. Additionally, we introduce a specially designed a Java-based questionnaire software tool in order to provide an initial framework for essential cybersecurity measures and evaluation for SMEs. This tool covers crucial topics such as social engineering and phishing attempts, implementing antimalware and ransomware defense mechanisms, secure data management and backup strategies and methods for preventing insider threats. By incorporating globally recognized frameworks and standards like ISO/IEC 27001 and NIST guidelines, this questionnaire offers a roadmap for establishing and enhancing cybersecurity measures.
文摘Digital financial inclusion provides financial services through digital platforms,aiming to improve the ability of MSMEs and low-income groups to access financial resources,thereby easing their financing constraints and promoting economic growth and inclusive development.As an innovative financial model,digital financial inclusion utilizes modern technological means to significantly improve the accessibility and convenience of financial services,especially in areas where traditional banking services are under-covered.Digital finance has promoted the popularization of financial services such as micro-credit,micro-savings,and micro-insurance,and helped improve the financing environment of low-income groups and small and micro enterprises.At the same time,digital financial inclusion promotes financial literacy education and digital inclusion construction,and enhances the acceptance and use of digital financial instruments by the general public,which is the key to achieving sustainable development of digital financial inclusion.Therefore,digital financial inclusion can better ease the financing constraints of small and medium-sized enterprises and promote economic development.
文摘The rapid development of digital financial inclusion is profoundly changing the financing environment for small and medium-sized enterprises(SMEs).As an important driver of economic growth and innovation,SMEs account for a significant share of employment and GDP globally.However,the traditional bank credit model has long failed to effectively meet the financing needs of SMEs due to issues such as information asymmetry,high cost,and difficulty in risk assessment,resulting in serious financing constraints.Digital financial inclusion,through technological innovation and big data analysis,has significantly reduced credit costs,alleviated information asymmetry,and provided SMEs with more flexible and efficient financing channels.Research shows that digital financial inclusion can not only ease the financing constraints of SMEs,but also promote their innovation and growth,providing important support for building a more inclusive and sustainable financial ecosystem.
基金supported by Anhui Provincial Philosophy&Social Science Fund(AHSKY2023D12)Anqing Normal University Key Project Grant“Research on the Digital Interactive Development of Trade between China Railway Express and Countries along the Belt and Road Initiative”(SK202211ZD)。
文摘This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and have no money to transform(lack of funds).”Using literature analysis and multiple case comparisons,the study summarizes five major categories of technology services:technical support,consulting and planning,training and empowerment,resource integration,and financing connectivity.It constructs a“service–capability–performance”catalytic framework.Tracking of 58 enterprises in the Yangtze River Delta reveals that resource integration contributes the most to digital maturity,with absorptive capacity playing a significant mediating role;the configuration of“high technology services+high absorptive capacity+high environmental dynamism”is a sufficient condition for high transformation performance.Based on these findings,countermeasures are proposed,including improving the technology service system,strengthening government-industry-academia collaboration,and optimizing funding and talent supply,providing replicable experience for SMEs,governments,and technology service institutions.
基金Supported by Open Project Fund of China Meteorological Administration Basin Heavy Rainfall Key Laboratory(2023BHR-Y26)Innovation Project Fund of Wuhan Metropolitan Area Meteorological Joint Science and Technology(WHCSQY202305)+1 种基金Innovation and Development Special Project of China Meteorological Administration(CXFZ2022J019)Project of Huanggang Meteorological Bureau's Scientific Research(2022Y02).
文摘It is an important standard to judge the flood disaster in the basin whether the rainfall at the flood-inducing interface is reached.In this paper,the Xin'anjiang model,Topmodel model and SCS model were selected to calculate and compare the rainfall at the flood-inducing interface in the Zhanghe Reservoir basin in Hubei Province.The results showed that average relative error and average absolute error of Xin'anjiang model were-3.36%and-21.46×10^(5)m^(3),which were the minimum,followed by Topmodel model with 5.72%and 26.22×10^(5)m^(3),SCS model with 11.33%and 58.13×10^(5)m^(3).The minimum absolute error of the three hydrological models in calculating the rainfall at the critical interface was 3.26 mm,while the maximum was 49.24 mm.When the initial water level exceeded 120 m,the difference among the three models in calculating the rainfall at the critical interface became more and more obvious.When the reservoir water level was lower than 120 m,it mainly referred to the calculation results of Xin'anjiang model.When the reservoir water level was higher than 120 m,it mainly referred to the calculation results of Topmodel model.The research conclusion can provide reference for small and medium-sized basins selecting hydrological model to calculate the rainfall at the flood-inducing interface.
文摘The two-tier shareholding structure,which originated in the United States,has become popular around the world.Unlike the traditional model of“equal shares with equal rights”,the core feature of the two-tier shareholding structure is that the company issues two classes of shares with different voting rights.It enables the concentration and stabilization of corporate control,which has a positive effect on the long-term development of the company and resistance to hostile takeovers.Against the background of the rapid development of the capital market and the continuous innovation of corporate governance structure,the two-tier shareholding structure has begun to be adopted by many enterprises.While this structure can improve the efficiency of corporate governance and promote corporate growth,it also raises a number of challenges.In particular,for small and medium-sized shareholders,their shareholdings may face the problem of limited or no voting rights,as well as the lack of an effective internal and external monitoring mechanism for the company.These issues may lead to the impairment of the rights of small and medium-sized shareholders.Currently,challenges in practice include inadequate laws and regulations,insufficient disclosure of information,and inadequate monitoring mechanisms.Therefore,exploring the path to protect the rights and interests of small and medium-sized shareholders and analyzing their current situation has become an important area in the study of two-tier shareholding structures.This paper starts from the actual situation,analyzes the problems exposed in the operation process of two-tier shareholding structure,and then explores the practical and feasible methods to protect the rights and interests of small and medium-sized shareholders on this basis,with a view to putting forward valuable references for the development of China’s securities market.
文摘[Objective] The deliver amount and deliver rate of heavy metal elements during smoking were studied, which could provide a reference for reducing the damage of cigarette products. [Method] Two pretreatment methodsof microwave di- gestion and acid extraction were used to process the ash content, the total particu- late matter of mainstream smoke （TPM） and cigarette filter. Detection results of heavy metal elements were compared by the two methods. [Result] The microwave digestion method was better than acid solution extraction method on analysis of TPM, but presented disadvantages on analysis of ash and filter. Meanwhile, the migration amount and rate were studied and resultsshowed that most heavy metal elements were escaped along with sidestream smoke between 66.89% and 95.48%, and almost all Hg escaped through sidestream smoke. Other heavy metal elements, except Hg, were separately found in ash, TPM and filter. Cr, Ni, As and Se were mostly residual in ash, followed by TPM, and filter had the least, while Cd and Pb were just in the reverse order. Normally, 5% or less heavy metal elements were transferred to TPM, only a small part of which could reach 5%-10%. [Conclusion] Most of the heavy metal elements are taken by sidestream smoke, ash and filter, while the migration amounts to mainstream smoke are extremely low.
基金National Natural Science Fund of China(No.81130062,No.81403367)Outstanding Traditional Chinese Medicine Academic Leader Program of Henan Province(No.HNZYLJ201301001)the National Key Technology R&D Program during the 12th Five-Year Plan Period(No.2014BAI10B06)
文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions.
基金Supported by the National Key Research and Development Program of China(2017YFB0307902)Science and Technology Planning Project of Guangdong Province(2015B020241001).
文摘The three-dimensional(3 D)model of cigarette was accurately constructed through reverse engineering as the research object of numerical simulation.The combustion process of cigarette was studied with computational fluid dynamics(CFD).Standard Laminar models with species transport approach were applied,and numerical simulation of the cigarette was analyzed with semi-implicit method for pressure–velocity coupling.The results showed that the model could predict velocity of cigarette smoke,the distributions of temperature and pressure at different times.In order to verify the correctness of model,it was found that the relationship between the velocity of smoke and pressure according to Darcy’s law on z position(x=4 mm,y=0,0 mm≤z≤50.61 mm).
文摘AIM:To evaluate the outcomes of patients withmedium-sized hepatocellular carcinoma(HCC)who underwent percutaneous microwave ablation(MWA).METHODS:We retrospectively reviewed all patients with a single medium-sized HCC who underwent percutaneous MWA from January 2010 to January2013.Technical success,technical effectiveness and complications were subsequently observed.Survival curves were constructed using the Kaplan-Meier method.The Cox proportional hazards model was fitted to each variable.The relative prognostic significance o f t h e va r i a b l e s fo r p re d i c t i n g ove ra l l s u r v i va l rate,recurrence-free survival rate and local tumor recurrence(s)was assessed using univariate analysis.All variables with a P value<0.20 were subjected to multivariate analysis.RESULTS:The study included 182 patients(mean age,58 years;age range:22-86 years)with a single HCC(mean size,3.72±0.54 cm;range:3.02-5.00cm).The estimated technical effectiveness rate was93%in 182 patients.The major complication rate was2.7%(5/182),including liver abscess in 4 cases,and abdominal bleeding at the puncture site in 1 case.Thirty-day mortality rate was 0.5%(1/182).One patient died due to liver abscess-related septicemia.Cumulative recurrence-free survival and overall survival(OS)rates were 51%,36%,27%and 89%,74%,60%at 1,2,and 3 years,respectively.Age(P=0.017)and tumor diameter(P=0.029)were independent factors associated with local tumor recurrence.None of the factors had a statistically significant impact on recurrence-free survival.Serum albumin level(P=0.009)and new lesion(s)(P=0.029)were independently associated with OS.CONCLUSION:Percutaneous MWA is a relatively safe and effective treatment for patients with medium-sized HCC.
文摘In this study, the effect of prophylactic anti inflammation on the development of smoke induced emphysema was investigated. Young male guinea pigs aged 1.5 - 2 months (weighing 198.3±26.9 g) were randomly divided into 4 groups: group A (cigarette smoke exposure only), group B (cigarette smoke exposure plus pentoxifylline rich (PTX, 10 mg/d) forage feeding), group C (cigarette smoke exposure plus intermittent cortical steroid injection (Triamcinolone acetonide, 3 mg, im, every three weeks) and control group (group D: animals with sham smoke exposure, raised under the same conditions). Animals in group A, B and C were exposed to smoke of cigarettes for 1 to 1.5 h twice a day, 5 days a week. All animals were killed at the 16th week and followed by morphometrical analysis of the midsagittal sectioned lung slices. Smoke exposure of 16 weeks resulted in visible emphysematous development in Group A but not in Group B and C. It was evidenced by the indicator of air space size, mean linear intercept (L m): 120.6±16.0 μm in Group A; 89.8±9.2 μm in Group B and 102.4±17.7 μm in Group C. The average L m in either group B or group C was shorter than that in Group A (ANOVA and Newman Keuls test, F=8.80, P =0.0002) but comparable to that (94.8±13.2 μm) in group D ( P >0.05). It is concluded that long term prophylactic anti inflammation inhibits pulmonary emphysema induced by cigarette smoking in the guinea pigs.
