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Uniform Attractors for the Kirchhoff Type Suspension Bridge Equation with Nonlinear Damping and Memory Term
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作者 Ling XU Yanni WANG 《Journal of Mathematical Research with Applications》 2026年第1期71-86,共16页
The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and e... The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method. 展开更多
关键词 uniform attractor Kirchhoff type suspension bridge equation nonlinear damping memory term
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A comparative study on the medium-long term results of endovascular repair and open surgical repair in the management of ruptured abdominal aortic aneurysms 被引量:2
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作者 HAN Yan-shuo ZHANG Jian +7 位作者 XIA Qian LIU Zhi-min ZHANG Xiao-yu WU Xiao-yu LUN Yu XIN Shi-jie DUAN Zhi-quan XU Ke 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第24期4771-4779,共9页
Background Although it is generally acknowledged that patients with ruptured abdominal aortic aneurysm (rAAA) obtain the greatest benefit from endovascular repair (EVAR), convincing evidence on the medium-long ter... Background Although it is generally acknowledged that patients with ruptured abdominal aortic aneurysm (rAAA) obtain the greatest benefit from endovascular repair (EVAR), convincing evidence on the medium-long term effect is lacking. The aim of this study was to compare and summarize published results of rAAA that underwent EVAR with open surgical repair (OSR). Methods A search of publicly published literature was performed. Based on an inclusion and exclusion criteria, a systematic meta-analysis was undertaken to compare patient characteristics, complications, short term mortality and medium-long term outcomes. A random-effects model was used to pool the data and calculate pooled odds ratios and weighted mean differences. A quantitative method was used to analyze the differences between these two methods. Results A search of the published literature showed that fourteen English language papers comprising totally 1213 patients with rAAA (435 EVAR and 778 OSR) would be suitable for this study. Furthermore, 13 Chinese studies were included, including 267 patients with rAAA totally, among which 238 patients received operation. The endovascular method was associated with more respiratory diseases before treatment (OR=1.81, P=0.01), while there are more patients with hemodynamic instability before treatment in OSR group (OR=1.53, P=0.031). Mean blood transfusion was 1328 ml for EVAR and 2809 ml for OSR (weighted mean difference (WMD) 1500 ml, P=0.014). The endovascular method was associated with a shorter stay in intensive care (WMD 2.34 days, P 〈0.001) and a shorter total post- operative stay (WMD 6.27 days, P 〈0.001). The pooled post-operative complication rate of respiratory system and visceral ischemia seldom occurred in the EVAR group (OR=0.48, P 〈0.001 and OR=0.28, P=0.043, respectively). The pooled 30-day mortality was 25.7% for EVAR and 39.6% for OSR, and the odds ratio was 0.53 (95% confidence interval (CI) 0.41-0.70, P 〈0.001). There was not, however, any significant reduction in the medium-long all-cause mortality rate (HR=1.13, P=0.381) and re-intervention rate (OR= 2.19, ,~=-0.243) following EVAR. In EVAR group, nevertheless, incidence of type I endoleak was significantly lower than type II endoleak (OR=0.33, P=0.039) at late follow-up period. Conclusions On the basis of this systematic review, rAAA EVAR results in less blood use for transfusion, shorter operation time, shorter intensive care unit and hospital stays, and lower 30-day mortality. However, in the medium-long term, it is not associated with a reduction in all-cause mortality. 展开更多
关键词 aortic aneurysm abdominal aortic rupture endovascular procedures medium-long term effect meta-analysis
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基于SDL Multiterm的汉英双语节气养生术语管理
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作者 邢浩 魏向清 《中国科技术语》 2025年第5期72-79,137,共9页
文章以《黄帝内经·素问》之《四气调神大论篇》为实践案例,借助SDL Multiterm的专业功能,分析了术语管理工具在提升节气养生知识翻译效率与质量、促进文化理解与交流方面的作用,并探讨了术语库在构建标准化术语体系、增强中医养生... 文章以《黄帝内经·素问》之《四气调神大论篇》为实践案例,借助SDL Multiterm的专业功能,分析了术语管理工具在提升节气养生知识翻译效率与质量、促进文化理解与交流方面的作用,并探讨了术语库在构建标准化术语体系、增强中医养生文化国际影响力方面的潜力。研究阐明了术语管理的持续性与复杂性,提出了人工智能与机器学习用于术语自动识别与智能匹配等方面的探索方向,以期进一步优化术语管理流程,拓宽节气养生文化的国际传播路径,推动中医养生文化的国际化进程。 展开更多
关键词 SDL Multiterm 节气养生 术语管理 中华文化传播
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Non-existence of the nontrivial solution for a Sobolev type evolution inequality with nonlinear convolution term
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作者 SU Jiahui LIU Dengming 《中山大学学报(自然科学版)(中英文)》 北大核心 2025年第5期146-153,共8页
An evolution inequality of Sobolev type involving a nonlinear convolution term is considered.By using the nonlinear capacity method and the contradiction argument,the non-existence of the nontrivial local weak solutio... An evolution inequality of Sobolev type involving a nonlinear convolution term is considered.By using the nonlinear capacity method and the contradiction argument,the non-existence of the nontrivial local weak solution is proved. 展开更多
关键词 Sobolev type evolution inequality nonlinear convolution term nontrivial solution nonexistence
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Blow-Up for a Pseudo-Parabolic Equation with Memory and Convection Terms
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作者 LIU Dengming LI Na 《Wuhan University Journal of Natural Sciences》 2025年第6期523-528,共6页
In this article,we deal with the blow-up phenomenon of a pseudo-parabolic equation with memory and convection terms.By constructing some appropriate auxiliary functions and using the modified concavity method,the blow... In this article,we deal with the blow-up phenomenon of a pseudo-parabolic equation with memory and convection terms.By constructing some appropriate auxiliary functions and using the modified concavity method,the blow-up criterion of the weak solution is given. 展开更多
关键词 BLOW-UP pseudo-parabolic equation memory term convection term
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Research on the English Translation Strategy of Qigong Terminology based on Hermeneutics
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作者 Liqin Wu Penghui Yu 《Journal of Contemporary Educational Research》 2025年第4期108-115,共8页
Qigong is an important part of traditional Chinese health preservation culture,and the accurate translation of its terms is of great significance for international communication.Currently,there are many deficiencies i... Qigong is an important part of traditional Chinese health preservation culture,and the accurate translation of its terms is of great significance for international communication.Currently,there are many deficiencies in the translation of Qigong terms,such as a lack of systematicity and inconsistent translations.Based on hermeneutics theory,this study analyzes the factors influencing the acceptance of Qigong term translations,and constructs an evaluation model for translation acceptance,covering three dimensions:culture,language,and readers.Accordingly,translation strategies are proposed,including culturally adaptive translation,optimization of language structure,reader stratification strategies,horizon fusion,and the hermeneutic circle,etc.The aim is to balance the cultural connotations and readers’acceptance,and to promote the international communication of Qigong culture. 展开更多
关键词 Qigong terms Translation strategies HERMENEUTICS ACCEPTANCE
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Unequal Exchange and Food Terms of Trade for China
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作者 Pedro Cango Fander FalconíBenítez Jesús Ramos-Martín 《Journal of Environmental & Earth Sciences》 2025年第3期99-111,共13页
This article aims to analyze the repercussions of food trade between China and various regions of the world to understand the dynamics of food flows and offer a novel perspective on the contemporary globalization proc... This article aims to analyze the repercussions of food trade between China and various regions of the world to understand the dynamics of food flows and offer a novel perspective on the contemporary globalization process.Understanding these flows involves analyzing the global production and commercialization of food and the effects of these movements on exporting and importing countries in economic terms and food security.The concept of unequal caloric exchange is applied to the case of China,which allows for an understanding of how its economic growth and participation in international trade have transformed its global and internal commercial dynamics by establishing links with self-sufficiency and the composition of its population’s diet.The results show that China is increasingly dependent on international markets for its food supply.From 1961 to 2021,food consumption in China has tripled in calories and experienced qualitative changes,with a reduction in high-quality carbohydrates and vegetable proteins and an increase in cereals,vegetable oils,alcohol,and vegetables.This dietary transformation is related to economic growth and greater dependence on international trade.From 1987 to 2022,China has shown a growing deficit in the food trade balance,with imports exceeding exports in volume,value,and calories,although it maintains favorable terms of trade.Food self-sufficiency has decreased from 95%in 1961 to 76%in 2022,and the diet has diversified,replacing traditional foods with products demanded in international trade. 展开更多
关键词 Unequal Exchange FOOD terms of Trade SELF-SUFFICIENCY China
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Translation Strategies for Chinese Cultural Terms in Academic Texts:A Case Study of“Jade Myth Belief and Chinese Spirit”
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作者 WANG Han-qing ZHAO Meng-yuan 《Journal of Literature and Art Studies》 2025年第4期324-328,共5页
This study investigates translation strategies for Chinese cultural terms in academic texts through a case study of Chapter 7 from“Jade Myth Belief and Chinese Spirit”.Using a qualitative research approach based on ... This study investigates translation strategies for Chinese cultural terms in academic texts through a case study of Chapter 7 from“Jade Myth Belief and Chinese Spirit”.Using a qualitative research approach based on cultural context framework and cognitive model,the study analyzes translation challenges and solutions in rendering cultural terms related to jade mythology and archaeological concepts.The research identifies three primary translation strategies:transliteration with annotation,domestication with explanation,and cognitive-based translation.The findings reveal that effective translation requires a balanced approach between maintaining academic precision and preserving cultural authenticity.The study demonstrates that successful translation of cultural terms in academic contexts demands a sophisticated understanding of both source and target cultural contexts,along with careful consideration of the academic audience’s needs.This research contributes to the field by providing practical insights for translators working with Chinese cultural texts in academic settings and proposing an approach to handling complex cultural terminology. 展开更多
关键词 cultural terms translation strategies academic texts Chinese culture jade mythology
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壮大耐心资本:“长钱长投”的理论逻辑与推进路径
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作者 方先明 刘韫尔 《江苏社会科学》 北大核心 2026年第1期131-139,I0004,共10页
壮大耐心资本是推动资本市场高质量发展的重要举措,而加快推进中长期资金入市、实现“长钱长投”是壮大耐心资本的主要途径。基于“长钱长投”与壮大耐心资本目标的一致性,“长钱长投”是增强资本市场内在稳定性的关键举措、强化投融资... 壮大耐心资本是推动资本市场高质量发展的重要举措,而加快推进中长期资金入市、实现“长钱长投”是壮大耐心资本的主要途径。基于“长钱长投”与壮大耐心资本目标的一致性,“长钱长投”是增强资本市场内在稳定性的关键举措、强化投融资协同性的重要抓手和推动金融回归服务实体经济本源的现实需求。当前,制约我国长期资金入市的因素在于投资价值和回报不足、投资工具和策略受限以及资本市场制度环境不完善等。为此,投资端应扩大长期资本供应,融资端应提升长期投资吸引力,市场交易环节应着力构建适宜“长钱长投”的市场环境。 展开更多
关键词 中长期资金 长期投资 耐心资本
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Long-term monitoring of active large-scale landslides for non-structural risk mitigation-integrated sensors and web-based platform
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作者 CATELAN Filippo Tommaso BOSSI Giulia +8 位作者 SCHENATO Luca TONDO Melissa CRITELLI Vincenzo MULAS Marco CICCARESE Giuseppe CORSINI Alessandro TONIDANDEL David MAIR Volkmar MARCATO Gianluca 《Journal of Mountain Science》 2025年第1期1-15,共15页
Large-scale deep-seated landslides pose a significant threat to human life and infrastructure.Therefore,closely monitoring these landslides is crucial for assessing and mitigating their associated risks.In this paper,... Large-scale deep-seated landslides pose a significant threat to human life and infrastructure.Therefore,closely monitoring these landslides is crucial for assessing and mitigating their associated risks.In this paper,the authors introduce the So Lo Mon framework,a comprehensive monitoring system developed for three large-scale landslides in the Autonomous Province of Bolzano,Italy.A web-based platform integrates various monitoring data(GNSS,topographic data,in-place inclinometer),providing a user-friendly interface for visualizing and analyzing the collected data.This facilitates the identification of trends and patterns in landslide behaviour,enabling the triggering of warnings and the implementation of appropriate mitigation measures.The So Lo Mon platform has proven to be an invaluable tool for managing the risks associated with large-scale landslides through non-structural measures and driving countermeasure works design.It serves as a centralized data repository,offering visualization and analysis tools.This information empowers decisionmakers to make informed choices regarding risk mitigation,ultimately ensuring the safety of communities and infrastructures. 展开更多
关键词 Web-based platform South Tyrol landslides Long term monitoring Risk mitigation
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关于国内天然气供用企业签订实施中长期购销合同的思考
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作者 贺志明 杜奇平 +3 位作者 杨雅雯 袁灿 谭琦 宋小琼 《天然气技术与经济》 2026年第1期51-57,共7页
在我国深化天然气“X+1+X”市场化改革和产运储销新格局加速构建的背景下,提升天然气供用企业合同意识与风险管理能力十分重要。为了给促进国内天然气市场长期可持续发展提供理论支撑与实践参考,基于现代合同经济基本理论,剖析了天然气... 在我国深化天然气“X+1+X”市场化改革和产运储销新格局加速构建的背景下,提升天然气供用企业合同意识与风险管理能力十分重要。为了给促进国内天然气市场长期可持续发展提供理论支撑与实践参考,基于现代合同经济基本理论,剖析了天然气中长期购销合同主要特征,对国内天然气供用企业签订实施中长期购销合同的意义、原则、条款和措施等方面开展了研究。研究结果表明:(1)国内天然气供用企业签订的购销合同主要特征为期限不定性、开放包容性和适度灵活性;(2)签订实施的主要原则为遵循市场规律、遵循科学配比、遵循供用底线、遵循统一量价和遵循自愿选择;(3)签订天然气中长期购销合同的关键内容设计有合同量动态配置模型、合同定价差异化模式、违约赔付约定和其他条款约定。为促进国内天然气供用企业积极主动地签订实施中长期购销合同,建议做好动态把准供用规律、积极强化宣贯引导、科学编制购销合同、精选签订实施对象和有序组织签订实施等措施。 展开更多
关键词 供用企业 天然气 中长期 购销合同
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Solutions and quantum dynamics of the quantum Rabi model with A-square terms
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作者 Xiang-You Chen Tian Ye Qing-Hu Chen 《Communications in Theoretical Physics》 2025年第5期45-49,共5页
It is well known that the A-square term must be considered in both cavity and circuit quantum electrodynamics systems,because it arises in the derivation from the minimal coupling Hamiltonian at any finite coupling st... It is well known that the A-square term must be considered in both cavity and circuit quantum electrodynamics systems,because it arises in the derivation from the minimal coupling Hamiltonian at any finite coupling strength.In this paper,we study the quantum Rabi model with A-square terms using the Bogoliubov operator approach.After a unitary transformation,the A-square terms can be eliminated,resulting in a modified quantum Rabi model with renormalized parameters.A transcendental function responsible for the exact solution is then derived.The presence of the A-square terms is found to significantly alter the energy spectrum.The dynamics are also studied using the obtained exact wave function,which is sensitive to the strength of the A-square terms at strong coupling.We believe that these results could be observed in future light–matter interaction systems in the ultra-strong and deep strong coupling regimes. 展开更多
关键词 light-matter interaction quantum Rabi model A-square terms ultra-strong strong coupling dynamics
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Source term estimation of hazardous gas leakages under turbulent atmospheric transport dispersion scenarios
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作者 Chuantao Ni Ziqiang Lang +4 位作者 Bing Wang Ang Li Chenxi Cao Wenli Du Feng Qian 《Chinese Journal of Chemical Engineering》 2025年第12期222-238,共17页
Source term estimation(STE)of hazardous gas leakages in chemical industrial parks(CIPs)is important for addressing environmental pollution and improving safety and reliability in engineering practice.To achieve real-t... Source term estimation(STE)of hazardous gas leakages in chemical industrial parks(CIPs)is important for addressing environmental pollution and improving safety and reliability in engineering practice.To achieve real-time STE,least squares-based STE methods have recently been developed.However,these methods require the number and locations of potential hazardous gas leakage sources are known as a priori,which is difficult in many practical scenarios.To address this limitation,we propose a new datadriven STE approach,which enables the STE to be implemented in real time and applicable to complicated turbulent dispersion scenarios.The linear independent analysis in data science is applied to historically collected concentration data of a hazardous gas of concern from a network of sensors to extract the sensor data which represent independent hazardous gas leakage scenarios(IHGLSs).An appropriate Gaussian model approximation to a high-fidelity computational fluid dynamics(CFD)model that must be used to represent the hazardous gas leakage scenarios of concern is built,and the off-line STE of IHGLSs using the approximating Gaussian model is then performed to build the datadriven STE model.The performance of the proposed approach is evaluated by using data that are generated by simulating ethane leakage scenarios in a CIP using a CFD model.Results indicate that the leakage localization accuracy is 100%and the mean relative estimation error for the leakage strength is6.76%.Moreover,the proposed approach is validated with real data in Prairie Grass field dispersion experiments,demonstrating the practical applicability of the proposed approach. 展开更多
关键词 Computation fluiddynamics Hazardous gas leakage OPTIMIZATION Source term estimation Turbulent flow
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Blow-up Phenomenon for a Class of Logarithmic Viscoelastic Equations with Delay and Nonlocal Term under Acoustic Boundary Conditions
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作者 DUAN Jisong XIANG Changyong 《数学理论与应用》 2025年第2期76-92,共17页
In this paper,we investigate the blow-up phenomenon for a class of logarithmic viscoelastic equations with delay and nonlocal terms under acoustic boundary conditions.Using the energy method,we prove that nontrivial s... In this paper,we investigate the blow-up phenomenon for a class of logarithmic viscoelastic equations with delay and nonlocal terms under acoustic boundary conditions.Using the energy method,we prove that nontrivial solutions with negative initial energy will blow up in finite time,and provide an upper bound estimate for the blow-up time.Additionally,we also derive a lower bound estimate for the blow-up time. 展开更多
关键词 Finite-time blow-up Logarithmic viscoelastic equation Nonlocal term Damping delay Acoustic boundary condition
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Challenge of long-term benzodiazepine use in primary care:insights from a real-world cohort study in Catalonia
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作者 María Teresa Peñarrubia-María Lucy Anne Parker +10 位作者 Marta Puig-García Marina Fuente-Moreno Blanca Lumbreras Elsa Lopez-Pintor Joan Domenech Abella Marc Saez Alexandra Lelia Dima Adolfo Figueiras Guzman Elisa Chilet Rosell Antoni Serrano-Blanco Ignacio Aznar-Lou 《Family Medicine and Community Health》 2025年第3期52-61,共10页
Introduction Long-term use of benzodiazepines(BZD)triggers health problems.Although Spain leads European use of BZD,the number of long-term users(LTUs)remains unknown.Objective The aim of the study is to estimate the ... Introduction Long-term use of benzodiazepines(BZD)triggers health problems.Although Spain leads European use of BZD,the number of long-term users(LTUs)remains unknown.Objective The aim of the study is to estimate the proportion of primary care(PC)patients who initiate a BDZ prescription that subsequently become LTU and to identify its associated factors.Design Retrospective real-world data cohort.Setting and participant It included the population over 15 years with a new prescription of BZD in PC in Catalonia.Users were considered LTU if they had been dispensed at least three prescriptions within 3 months.Sociodemographic characteristics of patients and prescribers,pathologies,previous BZD use,number and type of visits,and prescription quality standard were considered.We estimated the proportion of LTU among patients with a new prescription,stratified by age and sex,and estimated risk factors by multivariate generalised linear models.Result 100638 users with a new BZD prescription were included.27.1%were LTU at 3 months and 14.5%at 6 months.LTU increases with age and is higher in women.Predictors of LTU are Spanish nationality,living in rural areas,having a mental illness,having used BZD,having virtual visits or not meeting pharmacy-therapeutic quality standards.Conclusion The number of patients who develop LTU is high,especially in the elderly.Exploring the causes of this phenomenon could contribute to the development of future interventions. 展开更多
关键词 associated factors Catalonia BENZODIAZEPINES health problems PROPORTION long term use primary care RETROSPECTIVE
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Climatology and long-term trends in middle atmospheric temperatures at mid-latitudes observed by the Rayleigh/Sodium Lidar over Hefei,China(32°N,117°E)
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作者 Jian Li Wen Yi +4 位作者 XiangHui Xue MaoLin Lu JianYuan Wang HaiLun Ye TingDi Chen 《Earth and Planetary Physics》 2025年第4期915-924,共10页
In this study,the climatology and long-term trends of middle atmospheric temperatures at mid-latitudes are investigated using Rayleigh/Sodium lidar observations collected from January 2010 to December 2021 over Hefei,... In this study,the climatology and long-term trends of middle atmospheric temperatures at mid-latitudes are investigated using Rayleigh/Sodium lidar observations collected from January 2010 to December 2021 over Hefei,China(32°N,117°E).The seasonal variations and vertical profiles of lidar-derived temperatures demonstrate strong agreement with temperature measurements from the Microwave Limb Sounder(MLS)instrument on the Earth Observing System(EOS)Aura satellite.In terms of seasonal variation,middle atmospheric temperatures primarily exhibit annual oscillations(AO)and semi-annual oscillations(SAO).Harmonic analysis of the lidar and MLS temperature data reveals close phase alignment for both AO and SAO,with AO amplitudes ranging from 2 to 6 K,and SAO amplitudes from 1 to 4 K.The dependence of temperature on solar forcing was analyzed using the F10.7 index as a proxy,showing positive solar response coefficients at all altitudes,with a maximum of 15±1.1 K/100 SFU observed near 42–44 km.After removing the temperature response to solar cycle variations,a cooling trend in mid-latitude temperatures is evident across all altitudes,ranging from 3 to 6 K/decade. 展开更多
关键词 rayleigh and sodium lidar middle atmosphere temperature long term trend annual oscillation semi-annual oscillation
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Long-Term Governance and Global Stability
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作者 AUGUSTO SOTO 《China Today》 2025年第10期34-36,共3页
Through its unique five-year planning system,China demonstrates how long-term,strategic policy continuity can effectively address both domestic and global challenges.
关键词 domestic challenges global challenges policy continuity five year planning system long term governance global stability
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Short⁃Term Wind Speed Prediction Based on CEEMDAN⁃ PSO⁃BiLSTM⁃Attention
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作者 Zhongda Tian Xinru Shao 《Journal of Harbin Institute of Technology(New Series)》 2025年第6期15-25,共11页
One of the cornerstones for guaranteeing the stability of wind generation and electric power system operation is wind speed prediction.This research offers a method based on Particle Swarm Optimization(PSO)to optimize... One of the cornerstones for guaranteeing the stability of wind generation and electric power system operation is wind speed prediction.This research offers a method based on Particle Swarm Optimization(PSO)to optimize the Bidirectional Long Short⁃term Memory Network(BiLSTM)in order to improve the wind speed prediction accuracy,taking into account the highly stochastic and regular aspects of wind speed.Firstly,the wind speed time sequence is subjected to the Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN).The complexity of the wind speed pattern is reduced by decomposing it into components with different local feature information.The BiLSTM model,which incorporates the attention mechanism for prediction,is then fitted to the decomposed data,and its parameters are optimized using the particle swarm technique,reducing errors in predictive modeling.To get the final prediction,the components are finally superimposed.The empirical evidence shows that the CEEMDAN⁃PSO⁃BiLSTM⁃attention model decreases the RMSE(Root⁃Mean⁃Square⁃Error)by 15%-44%,the MAE by 18%-45%,the MAPE by 24%-52%,and the R2 by 1.4%-2.7%in comparison to the BiLSTM and other models.The validation of CEEMDAN⁃PSO⁃BiLSTM⁃attention model in short⁃term wind speed prediction is verified. 展开更多
关键词 short⁃term wind speed prediction Particle Swarm Optimization(PSO) attention mechanism BiLSTM
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MicroRNA-320аas a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects
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作者 Ekaterina K Zaikova Aleksandra V Kaplina +4 位作者 Natalia A Petrova Tatiana M Pervunina Alexey S Golovkin Anna A Kostareva Olga V Kalinina 《World Journal of Clinical Pediatrics》 2025年第3期257-271,共15页
BACKGROUND Necrotizing enterocolitis(NEC)remains a prominent gastrointestinal emergency among infants,particularly term infants with congenital heart defects(CHD)being at high risk.The molecular processes that contrib... BACKGROUND Necrotizing enterocolitis(NEC)remains a prominent gastrointestinal emergency among infants,particularly term infants with congenital heart defects(CHD)being at high risk.The molecular processes that contribute to NEC have yet to be completely understood.The high mortality rates necessitate an active search for noninvasive biomarkers that can aid in the preclinical diagnosis and prognosis of NEC.MicroRNAs(miRs),which are involved in many biological processes in both health and disease,have been discovered to play an important role in regulating inflammation and immune responses via various signaling pathways.AIM To determine the plasma levels of miR-155,miR-221,miR-223,miR-320a,miR-451a as potential NEC biomarkers in term newborns with CHD.METHODS This prospective cohort study included twenty-tree term newborns with CHD who underwent cardiac surgery on the median day of life(DOL)=7.Nine of them developed NEC(Bell’s stage IIA and IIIA)within 1 week of cardiac surgery(NEC newborns).Blood samples were collected before(median DOL=5)and following(median DOL=13)cardiac surgery.Levels of plasma miR-155-5p,miR-221-3p,miR-223-3p,miR-320a-3p,and miR-451a were determined using real-time polymerase chain reaction.The functional analysis was executed using the DIANA-miRPath v4.0.RESULTS Preoperatively,NEC newborns had significantly lower plasma levels of miR-155(2.70-fold,P=0.020),miR-223(2.42-fold,P=0.030),and miR-320a(3.62-fold,P=0.006)than newborns without NEC.Postoperatively,miR-451a levels differed significantly between the newborn groups,showing a 4.70-fold decrease(P=0.014)in expression when clinical NEC symptoms appeared.According to receiver operating characteristic analysis,miR-320a was found to be the most effective predictive biomarker for NEC[area under the curve(AUC)=0.835,63%sensitivity,100%specificity],while miR-451a was identified as a NEC biomarker(AUC=0.835,85.7%sensitivity,76.9%specificity).Preoperatively,miR-155-5p,miR-223-3p,and miR-320a-3p were differentially expressed and targeted the forkhead box O and Hippo pathways(P<0.01).CONCLUSION Our study demonstrates,for the first time,that plasma miR-320a-3p levels can be used as a preclinical biomarker for NEC in term newborns with CHD. 展开更多
关键词 MicroRNA-320a term newborns Necrotizing enterocolitis Congenital heart defects Plasma biomarker Quantitative real-time polymerase chain reaction
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