Airborne particulate matter in fine and ultrafine ranges(aerodynamic diameter less than 2.5μm,PM_(2.5))is a primary air pollutant that poses a serious threat to public health.Accumulating evidence has pointed to a cl...Airborne particulate matter in fine and ultrafine ranges(aerodynamic diameter less than 2.5μm,PM_(2.5))is a primary air pollutant that poses a serious threat to public health.Accumulating evidence has pointed to a close association between inhalation exposure to PM_(2.5)and increased morbidity and mortality associated with modern human complex diseases.The adverse health effect of inhalation exposure to PM_(2.5)pollutants is systemic,involving multiple organs,different cell types and various molecular mediators.Organelle damages and oxidative stress appear to play a major role in the cytotoxic effects of PM_(2.5)by mediating stress response pathways related to inflammation,metabolic alteration and cell death programmes.The organs or tissues in the digestive tract,such as the liver,pancreas and small intestines,are susceptible to PM_(2.5)exposure.This review underscores PM_(2.5)-induced inflammatory stress responses and their involvement in digestive diseases caused by PM_(2.5)exposure.展开更多
基金supported by National Institutes of Health(NIH)grants DK126908,DK132065,and DK134361.
文摘Airborne particulate matter in fine and ultrafine ranges(aerodynamic diameter less than 2.5μm,PM_(2.5))is a primary air pollutant that poses a serious threat to public health.Accumulating evidence has pointed to a close association between inhalation exposure to PM_(2.5)and increased morbidity and mortality associated with modern human complex diseases.The adverse health effect of inhalation exposure to PM_(2.5)pollutants is systemic,involving multiple organs,different cell types and various molecular mediators.Organelle damages and oxidative stress appear to play a major role in the cytotoxic effects of PM_(2.5)by mediating stress response pathways related to inflammation,metabolic alteration and cell death programmes.The organs or tissues in the digestive tract,such as the liver,pancreas and small intestines,are susceptible to PM_(2.5)exposure.This review underscores PM_(2.5)-induced inflammatory stress responses and their involvement in digestive diseases caused by PM_(2.5)exposure.
