The present study examined how students＇ intrinsic and extrinsic value promotes their foreign language proficiency via the mediation effect of self-efficacy beliefs. A total of 1,036 Chinese eighth graders answered a...The present study examined how students＇ intrinsic and extrinsic value promotes their foreign language proficiency via the mediation effect of self-efficacy beliefs. A total of 1,036 Chinese eighth graders answered an English proficiency test and questionnaires assessing motivational beliefs. Structural equation modelling results with bootstrapping procedures revealed that intrinsic value can directly and indirectly influence foreign language proficiency via partial mediation effect of self-efficacy while extrinsic value can only directly influence foreign language proficiency with a small magnitude. Moreover, there is no gender difference in the mediation model. Our findings suggested that intrinsic value can help students improve foreign language proficiency by improving their self-efficacy beliefs. The findings contribute to the documents of self-determination theory and hold substantive theoretical and practical implications for foreign language teachers.展开更多
BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current statu...BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
Background:The phenomenon of academic anxiety has been demonstrated to exert a considerable influence on students’academic engagement,leading to the emergence of a phenomenon known as“learned helplessness”and under...Background:The phenomenon of academic anxiety has been demonstrated to exert a considerable influence on students’academic engagement,leading to the emergence of a phenomenon known as“learned helplessness”and undermining the selfconfidence and motivation of high school students.Using acceptance-rejection theory,this study elucidated how a rejective parenting style affects Chinese high school students’academic anxiety and explored the urban-rural heterogeneity of this relationship.Methods:Data were analyzed using a stratified whole-cluster random sampling method.There are a total of 30,000 high school students in the three regions of northern and central China(from Shanxi,Hebei and Henan).A sample of 2286 high school students aged 14–19 years was ultimately selected from 2760 respondents for this investigation,which was conducted at the beginning of the 2023 school year.Pearson correlation,ordinary least squares(OLS)regression analysis,path analysis,and Fisher’s permutation test(FPT)were used to examine the effects of rejective parenting style on high school students’academic anxiety.Results:Results indicated a significant positive predictive effect between rejective parenting style and academic anxiety among high school students(β=0.815,t=116.211,p<0.001).Students’self-concept was significantly positively related to positive coping style(β=0.424,t=21.208,p<0.001)and chain-mediated this relationship.Therefore,this parenting style may indirectly mitigate academic anxiety through these mediators.The study also found that the effect of rejective parenting style on academic anxiety varied by students’residential background and was more pronounced in urban areas(0.226)than in rural areas(0.130).Conclusion:The research underscores the imperative for Chinese families to reexamine their utilization of rejection parenting and to prioritize the cultivation of students’intrinsic attributes.These findings offer a theoretical framework and practical evidence for policymakers and educators to develop efficacious and targeted interventions.In particular,greater attention should be directed towards the discrepancies in the manifestation of emotional and academic anxiety between urban and rural students,and prompt guidance should be furnished.展开更多
Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we p...Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper and lower limbs, reflected by the variation in the Hmax/Mmax ratio, is crucial for recovery of motor function from hemiplegia.展开更多
As promising anodes for sodium-ion batteries,metal sulfides ubiquitously suffer from low-rate and high-plateau issues,greatly hindering their application in full-cells.Herein,exemplifying carbon nanotubes(CNTs)-string...As promising anodes for sodium-ion batteries,metal sulfides ubiquitously suffer from low-rate and high-plateau issues,greatly hindering their application in full-cells.Herein,exemplifying carbon nanotubes(CNTs)-stringed metal sulfides superstructure(CSC)assembled by nano-dispersed SnS_(2) and CoS_(2) phases,cocktail mediation effect similar to that of high-entropy materials is initially studied in ether-based electrolyte to solve the challenges.The high nano-dispersity of metal sulfides in CSC anode underlies the cocktail-like mediation effect,enabling the circumvention of intrinsic drawbacks of different metal sulfides.By utilizing ether-based electrolyte,the reversibility of metal sulfides is greatly improved,sustaining a long-life effectivity of cocktail-like mediation.As such,CSC effectively overcomes low-rate flaw of SnS_(2) and highplateau demerit of CoS_(2),simultaneously realizes a high rate and a low plateau.In half-cells,CSC delivers an ultrahigh-rate capability of 327.6 mAh g^(−1) anode at 20 A g^(−1),far outperforming those of monometallic sulfides(SnS_(2),CoS_(2))and their mixtures.Compared with CoS_(2) phase and SnS_(2)/CoS_(2) mixture,CSC shows remarkably lowered average charge voltage up to ca.0.62 V.As-assembled CSC//Na1.5VPO4.8F0.7 full-cell shows a good rate capability(0.05~1.0 A g^(−1),120.3 mAh g^(−1) electrode at 0.05 A g^(−1))and a high average discharge voltage up to 2.57 V,comparable to full-cells with alloy-type anodes.Kinetics analysis verifies that the cocktail-like mediation effect largely boosts the charge transfer and ionic diffusion in CSC,compared with single phase and mixed phases.Further mechanism study reveals that alternative and complementary electrochemical processes between nano-dispersed SnS_(2) and CoS_(2) phases are responsible for the lowered charge voltage of CSC.This electrolyte/structure-dependent cocktail-like mediation effect effectively enhances the practicability of metal sulfide anodes,which will boost the development of high-rate/-voltage sodium-ion full batteries.展开更多
The effect of investor sentiment on stock volatility is a highly attractive research question in both the academic field and the real financial industry.With the proposal of China’s"dual carbon"target,green...The effect of investor sentiment on stock volatility is a highly attractive research question in both the academic field and the real financial industry.With the proposal of China’s"dual carbon"target,green stocks have gradually become an essential branch of Chinese stock markets.Focusing on 106 stocks from the new energy,environmental protection,and carbon–neutral sectors,we construct two investor sentiment proxies using Internet text and stock trading data,respectively.The Internet sentiment is based on posts from Eastmoney Guba,and the trading sentiment comes from a variety of trading indicators.In addition,we divide the realized volatility into continuous and jump parts,and then investigate the effects of investor sentiment on different types of volatilities.Our empirical findings show that both sentiment indices impose significant positive impacts on realized,continuous,and jump volatilities,where trading sentiment is the main factor.We further explore the mediating effect of information asymmetry,measured by the volume-synchronized probability of informed trading(VPIN),on the path of investor sentiment affecting stock volatility.It is evidenced that investor sentiments are positively correlated with the VPIN,and they can affect volatilities through the VPIN.We then divide the total sample around the coronavirus disease 2019(COVID-19)pandemic.The empirical results reveal that the market volatility after the COVID-19 pandemic is more susceptible to investor sentiments,especially to Internet sentiment.Our study is of great significance for maintaining the stability of green stock markets and reducing market volatility.展开更多
Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the ef...Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the effects of positive psychological capital(PsyCap)and perceived stress on mediating the social support-PTG relation among 673 CRC patients.Social support,positive PsyCap,perceived stress,and PTG were assessed through questionnaires.The results indicated a direct prediction effect of social support on PTG(LICI=0.481,ULCI=0.644),with the direct effect being 59.5%.Both positive PsyCap and perceived stress exerted a mediating role in the correlation between social support and PTG,with the mediating effects occupying 29.4%(LICI=0.217,ULCI=0.343)and 5.7%(LICI=0.030,ULCI=0.082),respectively.Positive PsyCap further had a chain mediating effect on perceived stress(LICI=0.031,ULCI=0.074),with the chain effect accounting for 5.4%.The total impact of social support on PTG was 100%(LICI=0.882,ULCI=1.008).This model underscores the pivotal role of social support in promoting PTG in CRC patients.Positive PsyCap serves as a crucial mediator in the social support-PTG link,with perceived stress playing a sequential mediating role.Thesefindings suggest that strengthening social support networks and cultivating positive PsyCap may reduce perceived stress and promote the development of PTG in CRC patients.Consequently,intervention programs are recommended to improve the psychosocial well-being of CRC patients.展开更多
Background The present study aimed to investigate the detailed mode and specific sites for their binding as well as the functional relevance of this binding in the phenotypic proliferation of vascular smooth muscle ce...Background The present study aimed to investigate the detailed mode and specific sites for their binding as well as the functional relevance of this binding in the phenotypic proliferation of vascular smooth muscle cells(SMCs). Methods CREG knocked-down SMCs were employed to evaluate the biological activity of wtCREG and mCREG.Expressions of SMC differentiation markers SM myosin heavy chain(SM-MHC),SM-actin,heavy caldesmon and myocardin were determined by Western blotting using specific antibodies. Cellular growth of SMCs was assessed by bromide dewuridine (BrdU) incorporation and cell cycle analysis on fluorescence-activated cell sorting(FACS).A solid-phase binding assay was used to study the binding of CREG to extracellular domains of M6P/IGF2R.The cellular co-localization of the two recombinant CREGs with M6P/IGF2R was detected on SMC surface by immunoprecipitation and immunofluorescence analysis.Results The molecular weight of wtCREG was around 30 kD while that of the mCREG was～25 kD.Treatment of wtCREG with PNGase F reduced its molecular weight from～30 kD to～25 kD,whereas PNGase F treatment had no effect on the molecular weight of mCREG.Both wtCREG and mCREG proteins enhanced SMC differentiation,inhibited BrdU incorporation,and arrested cell cycle progression when added to the culture medium.In CREG knocked-down SMCs,the amount of CREG detected by immunoblotting in M6P/IGF2R immunoprecipitates was significantly reduced when compared to normal cells.Both recombinant CREGs co-immunoprecipitated with M6P/IGF2R, although slightly reduced amount of the mutant CREG was detected in M6P/IGF2R immunoprecipitates.Immunostaining revealed that His-tagged CREGs co-localized with IGF2R on the cell surface in a glycosylation-independent manner.In vitro binding assay showed that CREGs bound to M6P/ IGF2R extracellular domains 7-10 and 11-13 in a glycosylation -dependent and -independent manner,respectively.Further blocking experiments using soluble M6P/IGF2R fragments and M6P/IGF2R neutralizing antibody indicated that the biological activities of recombinant CREGs in SMC growth and the up-regulation of SMC differentiation markers were all abolished by treatment with the M6P/IGF2R neutralizing antibody. However,although the growth inhibitory effect of wtCREG was nearly abolished by D7-10 or D11-13,the effect of mCREG was only reversed by Dll-13,indicating that the binding to domains 11-13 is required for CREG to modulate the proliferation of SMCs.Conclusions These data suggest that solubleCREG proteins can exert their biological function via binding to the extracellular domains 7-10 and 11-13 of cell surface M6P/IGF2R in both a glycosylation-dependent and -independent manner.展开更多
To explore the relationship between social support and sleep quality of community workers in Wuhan during the coronavirus disease 2019(the COVID-19 infection epidemic),this research constructed a mediating effect mode...To explore the relationship between social support and sleep quality of community workers in Wuhan during the coronavirus disease 2019(the COVID-19 infection epidemic),this research constructed a mediating effect model to explore the mediating psychological mechanism of social support influencing sleep quality of front-line community workers.A total of 500 front-line community workers in Wuhan were investigated.We used the perceived social support scale(PSSS),the Connor-Davidson Resilience Scale(CD-RISC),the perceived stress scale(PSS),and the Pittsburgh sleep quality index(PSQI)to measure social support,psychological resilience,perceived stress and sleep quality.Specifically,the higher the PSQI,the worse the sleep quality.Pearson correlation structural equation model was used to analyze the relationship between these factors.The results showed that:(1)There was a significant negative correlation between social support,psychological resilience,and perceived stress of community workers and PSQI,that means,the higher the level of social support,psychological resilience,and perceived stress,the higher the sleep quality.(2)Social support positively predicted psychological resilience and perceived stress,and perceived stress negatively predicted PSQI.(3)Social support can affect sleep quality through the mediating role of psychological resilience and perceived stress,and the mediating role includes two paths:the single mediating role of perceived stress and the chain mediating role of psychological resilience-perceived stress.(4)Gender moderates the relation-ship between social support and perceived stress,and the influence of social support on perceived stress of women is higher than that of men.Gender moderates the relationship between psychological resilience and PSQI,and only women’s psychological resilience had a negatively predictive effect on PSQI,while men did not,which means that psychological resilience of female frontline community workers can positively predict sleep quality.This research reveals the relationship between social support and sleep quality and its mechanism and verifies that social support can indirectly affect physical health through psychological resilience and perceived stress.It provides reference suggestions and intervention guidance for improving the sleep quality of community workers.展开更多
This study investigates the impact of investor protection on corporate R&D investment using panel data from Chinese A-share listed companies spanning 2015 to 2022.By employing OLS regression,mediation,and moderati...This study investigates the impact of investor protection on corporate R&D investment using panel data from Chinese A-share listed companies spanning 2015 to 2022.By employing OLS regression,mediation,and moderation analyses,the results demonstrate that robust investor protection mechanisms significantly enhance corporate R&D expenditures.The mediation analysis reveals that investor protection alleviates financing constraints and improves information disclosure quality,both of which serve as key channels for fostering R&D investment.Furthermore,internal control systems and media attention are identified as positive moderators,amplifying the beneficial effects of investor protection on R&D.In contrast,the equity Herfindahl index(HHI)does not exhibit a significant moderating role.The study also highlights that financial leverage,profitability,and equity concentration negatively influence R&D,while revenue growth exerts a positive effect.These findings underscore the critical role of investor protection in driving corporate innovation and sustainable growth,offering valuable insights for policymakers and corporate managers aiming to optimize R&D strategies through improved governance frameworks.展开更多
Objective The study aim was to investigate the effects of exposure to multiple environmental organic pollutants on cardiopulmonary health with a focus on the potential mediating role of oxidative stress.Methods A repe...Objective The study aim was to investigate the effects of exposure to multiple environmental organic pollutants on cardiopulmonary health with a focus on the potential mediating role of oxidative stress.Methods A repeated-measures randomized crossover study involving healthy college students in Beijing was conducted. Biological samples, including morning urine and venous blood, were collected to measure concentrations of 29 typical organic pollutants, including hydroxy polycyclic aromatic hydrocarbons(OH-PAHs), bisphenol A and its substitutes, phthalates and their metabolites, parabens,and five biomarkers of oxidative stress. Health assessments included blood pressure measurements and lung function indicators.Results Urinary concentrations of 2-hydroxyphenanthrene(2-OH-PHE)(β = 4.35% [95% confidence interval(CI): 0.85%, 7.97%]), 3-hydroxyphenanthrene(β = 3.44% [95% CI: 0.19%, 6.79%]), and 4-hydroxyphenanthrene(4-OH-PHE)(β = 5.78% [95% CI: 1.27%, 10.5%]) were significantly and positively associated with systolic blood pressure. Exposures to 1-hydroxypyrene(1-OH-PYR)(β = 3.05% [95% CI:-4.66%,-1.41%]), 2-OH-PHE(β = 2.68% [95% CI:-4%,-1.34%]), and 4-OH-PHE(β = 3% [95% CI:-4.68%,-1.29%]) were negatively associated with the ratio of forced expiratory volume in the first second to forced vital capacity. These findings highlight the adverse effects of exposure to multiple pollutants on cardiopulmonary health. Biomarkers of oxidative stress, including 8-hydroxy-2'-deoxyguanosine and extracellular superoxide dismutase, mediated the effects of multiple OH-PAHs on blood pressure and lung function.Conclusion Exposure to multiple organic pollutants can adversely affect cardiopulmonary health.Oxidative stress is a key mediator of the effects of OH-PAHs on blood pressure and lung function.展开更多
Objective:To analyze the mediating effect of psychological flexibility between death anxiety and quality of life in cancer patients.Methods:A convenience sampling method was used to select cancer patients who received...Objective:To analyze the mediating effect of psychological flexibility between death anxiety and quality of life in cancer patients.Methods:A convenience sampling method was used to select cancer patients who received treatment at our hospital from January 2022 to January 2024,by the inclusion and exclusion criteria.General information,psychological flexibility,death anxiety,and quality of life scores were collected for analysis.Result:The psychological flexibility and quality of life scores of cancer patients with an annual family income≤100,000 RMB were significantly lower than those of cancer patients with an annual family income>100,000 RMB(P<0.05),while the death anxiety scores were significantly lower for the former group as well(P<0.05).Cancer patients staged as Ⅰ-Ⅱ had significantly higher psychological flexibility and quality of life scores than those staged as Ⅲ-Ⅳ(P<0.05),while their death anxiety scores were significantly lower(P<0.05).Psychological flexibility in cancer patients was negatively correlated with death anxiety(r=-0.614,P<0.05)and positively correlated with quality of life(r=0.628,P<0.05),while death anxiety was negatively correlated with quality of life(r=-0.112,P<0.05).The direct effect of death anxiety on quality of life was-0.232,accounting for 58.32%of the total effect.The mediating effect of psychological flexibility between death anxiety and quality of life was-0.218,accounting for 41.83%of the total effect.Conclusion:Death anxiety can directly affect the quality of life of cancer patients,and it can also indirectly affect the quality of life through psychological flexibility.Clinicians should promptly address patients’death anxiety and provide interventions to enhance psychological flexibility,thereby improving the quality of life.展开更多
To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 particip...To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with NGT.Plasma isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass spectrometry.Generalized linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and T2DM.Inflammatory cell was used as mediators to estimate the mediating effects on the above associations.Isocarbophos and isofenphos were positively related with T2DM after adjusting for other factors.The odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in ln-isocarbophos.The prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,respectively.Furthermore,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,respectively.Isofenphos and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.展开更多
BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Mo...BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Moreover,it has not been confirmed whether,considering the effect of daytime sleepiness on suicide risk,daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.AIM To explore the pathway relationships among nurses'work-family behavioral role conflict,daytime sleepiness,and suicide risk.METHODS Convenience and purposive sampling methods were used to select 750 nurses from six provinces,including Jiangxi,Sichuan,and Shanxi.The work-family behavioral role conflict scale,the Chinese adult daytime sleepiness scale,and the suicide behavior questionnaire were used for the survey.The data were statistically analyzed via SPSS 25.0 software,Pearson correlation analysis was used to explore the correlations between the variables,the PROCESS 4.0 program was used for the mediation effect analysis,and the mediation effect model was tested via the bootstrap method.RESULTS Nurses'work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk(r=734,0.717).Work-family behavioral role conflict positively predicted suicide risk(β=0.118),and daytime sleepiness positively predicted suicide risk(β=0.152).Daytime sleepiness partially mediated the role of nurses'work-family behavioral role conflict and suicide risk,with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.CONCLUSION The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses'work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.展开更多
Objective:To explore the relationship between pain degree and pain catastrophe and medical coping mode in patients with chronic pain.Methods:A visual analogue score scale,medical coping style questionnaire and pain ca...Objective:To explore the relationship between pain degree and pain catastrophe and medical coping mode in patients with chronic pain.Methods:A visual analogue score scale,medical coping style questionnaire and pain catastrophe scale were used to survey 200 patients in the pain department.Results:The average scores of pain degree of patients with chronic pain were(5.97±2.29),the average score of the total score of the Pain Catastrophe Scale was(21.21±11.56),and the average scores of facing,avoidance and surrender in the Medical Response Style Questionnaire were(17.93±3.4),(16.82±2.4),and(8.87±2.83),respectively.Pain degree was positively correlated with the yield dimension in pain catastrophe and medical coping(p<0.05).The yield dimension of medical coping was positively correlated with pain catastrophe(p<0.05).Medical coping methods played a partial mediating role between pain degree and pain catastrophe,and the mediating effect accounted for 21.59%of the total effect.Conclusion:The pain level of chronic pain patients can affect the level of pain catastrophe through medical coping,and clinical medical staff should guide patients to adopt positive coping methods to promote their healthy recovery.展开更多
In the backdrop of“dual-carbon”strategic objectives,understanding the influence of the digital economy(DE)on carbon emissions(CEs)is imperative.However,there is limited research on the DE’s negative impact on CEs a...In the backdrop of“dual-carbon”strategic objectives,understanding the influence of the digital economy(DE)on carbon emissions(CEs)is imperative.However,there is limited research on the DE’s negative impact on CEs and the nonlinear relationship between the DE and CE.To address this gap,we collected data from 270 Chinese cities from 2011 to 2021 and used benchmark regression,mediated effects,and panel threshold models to explore the DE’s impact on CEs.The results showed that DE had a nonlinear,inverted U-shaped effect on CEs,with CEs initially increasing and then being suppressed.This conclusion remained consistent even after a series of robustness tests.Overall,the rate of urbanization and breadth of digital financial coverage mediate the relationship between the DE and CEs.Additionally,the combined effects of economic development,environmental regulation,fiscal decentralization,and population size contribute to the DE’s nonlinear impact on CEs.The impact of the DE on CEs varies among nonresource-based,resource-based,and resource-depleted cities and between urban and nonurban agglomerations.This paper’s findings support the development of the DE and the formulation of CE reduction policies.展开更多
As a novel economic paradigm that drives high-quality economic development,the digital economy(DE)can potentially significantly enhance the utilization efficiency of ecological resources and improve human well-being.B...As a novel economic paradigm that drives high-quality economic development,the digital economy(DE)can potentially significantly enhance the utilization efficiency of ecological resources and improve human well-being.Based on panel data from 285 prefecture-level cities in China spanning 2011-2021,this study empirically investigates the direct effects,transmission mechanisms,and spatial spillover effects of the DE on ecological welfare performance(EWP)using benchmark regression,intermediary effects,and spatial Durbin models.The results show that the DE significantly improved EWP in Chinese cities.This conclusion remains valid even after controlling for relevant influencing factors.Two transmission paths—upgrading of the industrial structure(UIS)and green innovation(GI)—significantly impacted EWP,as verified by the mediation effect model.Additionally,the mediating effect of the UIS was stronger than that of GI.Spatial heterogeneity tests show that the DE had significant effects on the EWP of eastern cities,with little impact on the central and western cities.Accordingly,grounded in regional developmental disparities,the empowering effects of the DE must be fully harnessed to foster an ecological civilization and enhance the well-being of the populace.展开更多
Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Healt...Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Health and Retirement Longitudinal Study(CHARLS),this study included 3,284 participants aged 60 years or older with chronic diseases.The sleep quality,pain status,health-related quality of life,and demographic-related data of these elderly patients were obtained.Pearson correlation analysis was conducted to assess the bivariate relationships among the variables.The mediating role of pain in the sleep quality-HRQoL relationship was tested using linear regression models,complemented by bootstrap sampling to verify the indirect effect.Results:Sleep quality was positively associated with health-related quality of life(r=0.218,p<0.001).Conversely,pain demonstrated significant negative correlations with both sleep quality(r=-0.496,p<0.001)and health-related quality of life(r=-0.067,p<0.001).The mediating effect results showed that pain played a partial mediating role between sleep quality and health-related quality of life in elderly patients with chronic diseases(effect value=0.049),and the mediating effect accounted for 23.33%.Conclusion:Pain is a mediating variable between sleep quality and health-related quality of life in elderly patients with chronic diseases.This suggests that clinical practice should incorporate pain assessment into standard clinical care of elderly patients with sleep disorders and chronic diseases.By alleviating pain,sleep quality can be improved,and subsequently,their health-related quality of life can be enhanced.展开更多
基金funded by National Education Science “13th Five-Year” Planning Key Project of Ministry of Education in China(Grant No.DHA160310)~~
文摘The present study examined how students＇ intrinsic and extrinsic value promotes their foreign language proficiency via the mediation effect of self-efficacy beliefs. A total of 1,036 Chinese eighth graders answered an English proficiency test and questionnaires assessing motivational beliefs. Structural equation modelling results with bootstrapping procedures revealed that intrinsic value can directly and indirectly influence foreign language proficiency via partial mediation effect of self-efficacy while extrinsic value can only directly influence foreign language proficiency with a small magnitude. Moreover, there is no gender difference in the mediation model. Our findings suggested that intrinsic value can help students improve foreign language proficiency by improving their self-efficacy beliefs. The findings contribute to the documents of self-determination theory and hold substantive theoretical and practical implications for foreign language teachers.
基金Supported by the Shijiazhuang Science and Technology Research and Development Program,No.221460383.
文摘BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
基金funded by the Key Discipline Construction Project of the Liaoning Provincial Social Science Planning Fund(grant ID:L24ZD042)。
文摘Background:The phenomenon of academic anxiety has been demonstrated to exert a considerable influence on students’academic engagement,leading to the emergence of a phenomenon known as“learned helplessness”and undermining the selfconfidence and motivation of high school students.Using acceptance-rejection theory,this study elucidated how a rejective parenting style affects Chinese high school students’academic anxiety and explored the urban-rural heterogeneity of this relationship.Methods:Data were analyzed using a stratified whole-cluster random sampling method.There are a total of 30,000 high school students in the three regions of northern and central China(from Shanxi,Hebei and Henan).A sample of 2286 high school students aged 14–19 years was ultimately selected from 2760 respondents for this investigation,which was conducted at the beginning of the 2023 school year.Pearson correlation,ordinary least squares(OLS)regression analysis,path analysis,and Fisher’s permutation test(FPT)were used to examine the effects of rejective parenting style on high school students’academic anxiety.Results:Results indicated a significant positive predictive effect between rejective parenting style and academic anxiety among high school students(β=0.815,t=116.211,p<0.001).Students’self-concept was significantly positively related to positive coping style(β=0.424,t=21.208,p<0.001)and chain-mediated this relationship.Therefore,this parenting style may indirectly mitigate academic anxiety through these mediators.The study also found that the effect of rejective parenting style on academic anxiety varied by students’residential background and was more pronounced in urban areas(0.226)than in rural areas(0.130).Conclusion:The research underscores the imperative for Chinese families to reexamine their utilization of rejection parenting and to prioritize the cultivation of students’intrinsic attributes.These findings offer a theoretical framework and practical evidence for policymakers and educators to develop efficacious and targeted interventions.In particular,greater attention should be directed towards the discrepancies in the manifestation of emotional and academic anxiety between urban and rural students,and prompt guidance should be furnished.
基金supported by a grant from the Supporting Program of the"Eleventh Five-year Plan"for Science&Technology Research of China,Ministry of Science and Technology of China,No.2006BAI12B02a grant from the Scientific Research Fund for Talent Introduction in the Gansu University of Chinese Medicine of China,No.2012-11
文摘Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper and lower limbs, reflected by the variation in the Hmax/Mmax ratio, is crucial for recovery of motor function from hemiplegia.
基金This work was supported by Guangdong Basic and Applied Basic Research Foundation,China(No.2019A1515110980)research project from the National Natural Science Foundation of China(No.21361162004)China Scholarship Council,and CSIRO.We acknowledge Dr Yesim Gozukara,Dr Malisja de Vries,and Dr Yunxia Yang from CSIRO(Clayton)for their help with material characterization training.
文摘As promising anodes for sodium-ion batteries,metal sulfides ubiquitously suffer from low-rate and high-plateau issues,greatly hindering their application in full-cells.Herein,exemplifying carbon nanotubes(CNTs)-stringed metal sulfides superstructure(CSC)assembled by nano-dispersed SnS_(2) and CoS_(2) phases,cocktail mediation effect similar to that of high-entropy materials is initially studied in ether-based electrolyte to solve the challenges.The high nano-dispersity of metal sulfides in CSC anode underlies the cocktail-like mediation effect,enabling the circumvention of intrinsic drawbacks of different metal sulfides.By utilizing ether-based electrolyte,the reversibility of metal sulfides is greatly improved,sustaining a long-life effectivity of cocktail-like mediation.As such,CSC effectively overcomes low-rate flaw of SnS_(2) and highplateau demerit of CoS_(2),simultaneously realizes a high rate and a low plateau.In half-cells,CSC delivers an ultrahigh-rate capability of 327.6 mAh g^(−1) anode at 20 A g^(−1),far outperforming those of monometallic sulfides(SnS_(2),CoS_(2))and their mixtures.Compared with CoS_(2) phase and SnS_(2)/CoS_(2) mixture,CSC shows remarkably lowered average charge voltage up to ca.0.62 V.As-assembled CSC//Na1.5VPO4.8F0.7 full-cell shows a good rate capability(0.05~1.0 A g^(−1),120.3 mAh g^(−1) electrode at 0.05 A g^(−1))and a high average discharge voltage up to 2.57 V,comparable to full-cells with alloy-type anodes.Kinetics analysis verifies that the cocktail-like mediation effect largely boosts the charge transfer and ionic diffusion in CSC,compared with single phase and mixed phases.Further mechanism study reveals that alternative and complementary electrochemical processes between nano-dispersed SnS_(2) and CoS_(2) phases are responsible for the lowered charge voltage of CSC.This electrolyte/structure-dependent cocktail-like mediation effect effectively enhances the practicability of metal sulfide anodes,which will boost the development of high-rate/-voltage sodium-ion full batteries.
基金supported by the National Natural Science Foundation of China(72171005),to which we are deeply grateful。
文摘The effect of investor sentiment on stock volatility is a highly attractive research question in both the academic field and the real financial industry.With the proposal of China’s"dual carbon"target,green stocks have gradually become an essential branch of Chinese stock markets.Focusing on 106 stocks from the new energy,environmental protection,and carbon–neutral sectors,we construct two investor sentiment proxies using Internet text and stock trading data,respectively.The Internet sentiment is based on posts from Eastmoney Guba,and the trading sentiment comes from a variety of trading indicators.In addition,we divide the realized volatility into continuous and jump parts,and then investigate the effects of investor sentiment on different types of volatilities.Our empirical findings show that both sentiment indices impose significant positive impacts on realized,continuous,and jump volatilities,where trading sentiment is the main factor.We further explore the mediating effect of information asymmetry,measured by the volume-synchronized probability of informed trading(VPIN),on the path of investor sentiment affecting stock volatility.It is evidenced that investor sentiments are positively correlated with the VPIN,and they can affect volatilities through the VPIN.We then divide the total sample around the coronavirus disease 2019(COVID-19)pandemic.The empirical results reveal that the market volatility after the COVID-19 pandemic is more susceptible to investor sentiments,especially to Internet sentiment.Our study is of great significance for maintaining the stability of green stock markets and reducing market volatility.
文摘Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the effects of positive psychological capital(PsyCap)and perceived stress on mediating the social support-PTG relation among 673 CRC patients.Social support,positive PsyCap,perceived stress,and PTG were assessed through questionnaires.The results indicated a direct prediction effect of social support on PTG(LICI=0.481,ULCI=0.644),with the direct effect being 59.5%.Both positive PsyCap and perceived stress exerted a mediating role in the correlation between social support and PTG,with the mediating effects occupying 29.4%(LICI=0.217,ULCI=0.343)and 5.7%(LICI=0.030,ULCI=0.082),respectively.Positive PsyCap further had a chain mediating effect on perceived stress(LICI=0.031,ULCI=0.074),with the chain effect accounting for 5.4%.The total impact of social support on PTG was 100%(LICI=0.882,ULCI=1.008).This model underscores the pivotal role of social support in promoting PTG in CRC patients.Positive PsyCap serves as a crucial mediator in the social support-PTG link,with perceived stress playing a sequential mediating role.Thesefindings suggest that strengthening social support networks and cultivating positive PsyCap may reduce perceived stress and promote the development of PTG in CRC patients.Consequently,intervention programs are recommended to improve the psychosocial well-being of CRC patients.
文摘Background The present study aimed to investigate the detailed mode and specific sites for their binding as well as the functional relevance of this binding in the phenotypic proliferation of vascular smooth muscle cells(SMCs). Methods CREG knocked-down SMCs were employed to evaluate the biological activity of wtCREG and mCREG.Expressions of SMC differentiation markers SM myosin heavy chain(SM-MHC),SM-actin,heavy caldesmon and myocardin were determined by Western blotting using specific antibodies. Cellular growth of SMCs was assessed by bromide dewuridine (BrdU) incorporation and cell cycle analysis on fluorescence-activated cell sorting(FACS).A solid-phase binding assay was used to study the binding of CREG to extracellular domains of M6P/IGF2R.The cellular co-localization of the two recombinant CREGs with M6P/IGF2R was detected on SMC surface by immunoprecipitation and immunofluorescence analysis.Results The molecular weight of wtCREG was around 30 kD while that of the mCREG was～25 kD.Treatment of wtCREG with PNGase F reduced its molecular weight from～30 kD to～25 kD,whereas PNGase F treatment had no effect on the molecular weight of mCREG.Both wtCREG and mCREG proteins enhanced SMC differentiation,inhibited BrdU incorporation,and arrested cell cycle progression when added to the culture medium.In CREG knocked-down SMCs,the amount of CREG detected by immunoblotting in M6P/IGF2R immunoprecipitates was significantly reduced when compared to normal cells.Both recombinant CREGs co-immunoprecipitated with M6P/IGF2R, although slightly reduced amount of the mutant CREG was detected in M6P/IGF2R immunoprecipitates.Immunostaining revealed that His-tagged CREGs co-localized with IGF2R on the cell surface in a glycosylation-independent manner.In vitro binding assay showed that CREGs bound to M6P/ IGF2R extracellular domains 7-10 and 11-13 in a glycosylation -dependent and -independent manner,respectively.Further blocking experiments using soluble M6P/IGF2R fragments and M6P/IGF2R neutralizing antibody indicated that the biological activities of recombinant CREGs in SMC growth and the up-regulation of SMC differentiation markers were all abolished by treatment with the M6P/IGF2R neutralizing antibody. However,although the growth inhibitory effect of wtCREG was nearly abolished by D7-10 or D11-13,the effect of mCREG was only reversed by Dll-13,indicating that the binding to domains 11-13 is required for CREG to modulate the proliferation of SMCs.Conclusions These data suggest that solubleCREG proteins can exert their biological function via binding to the extracellular domains 7-10 and 11-13 of cell surface M6P/IGF2R in both a glycosylation-dependent and -independent manner.
基金supported and granted by the“National Social Science Fund Emergency Management System Construction Research Special Project(20VYJ040),”“Central China Think Tank Special Key Projects(2020HZZK031),”+1 种基金“Key Projects of Educational Science Planning of Hubei Province(2019CFB425)”“Ministry of Education of Humanities and Social Sciences Research Fund(19YJA880082)”to YZ.
文摘To explore the relationship between social support and sleep quality of community workers in Wuhan during the coronavirus disease 2019(the COVID-19 infection epidemic),this research constructed a mediating effect model to explore the mediating psychological mechanism of social support influencing sleep quality of front-line community workers.A total of 500 front-line community workers in Wuhan were investigated.We used the perceived social support scale(PSSS),the Connor-Davidson Resilience Scale(CD-RISC),the perceived stress scale(PSS),and the Pittsburgh sleep quality index(PSQI)to measure social support,psychological resilience,perceived stress and sleep quality.Specifically,the higher the PSQI,the worse the sleep quality.Pearson correlation structural equation model was used to analyze the relationship between these factors.The results showed that:(1)There was a significant negative correlation between social support,psychological resilience,and perceived stress of community workers and PSQI,that means,the higher the level of social support,psychological resilience,and perceived stress,the higher the sleep quality.(2)Social support positively predicted psychological resilience and perceived stress,and perceived stress negatively predicted PSQI.(3)Social support can affect sleep quality through the mediating role of psychological resilience and perceived stress,and the mediating role includes two paths:the single mediating role of perceived stress and the chain mediating role of psychological resilience-perceived stress.(4)Gender moderates the relation-ship between social support and perceived stress,and the influence of social support on perceived stress of women is higher than that of men.Gender moderates the relationship between psychological resilience and PSQI,and only women’s psychological resilience had a negatively predictive effect on PSQI,while men did not,which means that psychological resilience of female frontline community workers can positively predict sleep quality.This research reveals the relationship between social support and sleep quality and its mechanism and verifies that social support can indirectly affect physical health through psychological resilience and perceived stress.It provides reference suggestions and intervention guidance for improving the sleep quality of community workers.
文摘This study investigates the impact of investor protection on corporate R&D investment using panel data from Chinese A-share listed companies spanning 2015 to 2022.By employing OLS regression,mediation,and moderation analyses,the results demonstrate that robust investor protection mechanisms significantly enhance corporate R&D expenditures.The mediation analysis reveals that investor protection alleviates financing constraints and improves information disclosure quality,both of which serve as key channels for fostering R&D investment.Furthermore,internal control systems and media attention are identified as positive moderators,amplifying the beneficial effects of investor protection on R&D.In contrast,the equity Herfindahl index(HHI)does not exhibit a significant moderating role.The study also highlights that financial leverage,profitability,and equity concentration negatively influence R&D,while revenue growth exerts a positive effect.These findings underscore the critical role of investor protection in driving corporate innovation and sustainable growth,offering valuable insights for policymakers and corporate managers aiming to optimize R&D strategies through improved governance frameworks.
基金supported by the National Key Research&Development Program of the Ministry of Science and Technology of China(2022YFE0134900,2023YFC3708305,2023YFC3708302)Strategy Priority Research Program(Category B)of the Chinese Academy of Sciences(No.XDB0750300)National Natural Science Foundation of China(Grant No.42477455,42077390).
文摘Objective The study aim was to investigate the effects of exposure to multiple environmental organic pollutants on cardiopulmonary health with a focus on the potential mediating role of oxidative stress.Methods A repeated-measures randomized crossover study involving healthy college students in Beijing was conducted. Biological samples, including morning urine and venous blood, were collected to measure concentrations of 29 typical organic pollutants, including hydroxy polycyclic aromatic hydrocarbons(OH-PAHs), bisphenol A and its substitutes, phthalates and their metabolites, parabens,and five biomarkers of oxidative stress. Health assessments included blood pressure measurements and lung function indicators.Results Urinary concentrations of 2-hydroxyphenanthrene(2-OH-PHE)(β = 4.35% [95% confidence interval(CI): 0.85%, 7.97%]), 3-hydroxyphenanthrene(β = 3.44% [95% CI: 0.19%, 6.79%]), and 4-hydroxyphenanthrene(4-OH-PHE)(β = 5.78% [95% CI: 1.27%, 10.5%]) were significantly and positively associated with systolic blood pressure. Exposures to 1-hydroxypyrene(1-OH-PYR)(β = 3.05% [95% CI:-4.66%,-1.41%]), 2-OH-PHE(β = 2.68% [95% CI:-4%,-1.34%]), and 4-OH-PHE(β = 3% [95% CI:-4.68%,-1.29%]) were negatively associated with the ratio of forced expiratory volume in the first second to forced vital capacity. These findings highlight the adverse effects of exposure to multiple pollutants on cardiopulmonary health. Biomarkers of oxidative stress, including 8-hydroxy-2'-deoxyguanosine and extracellular superoxide dismutase, mediated the effects of multiple OH-PAHs on blood pressure and lung function.Conclusion Exposure to multiple organic pollutants can adversely affect cardiopulmonary health.Oxidative stress is a key mediator of the effects of OH-PAHs on blood pressure and lung function.
文摘Objective:To analyze the mediating effect of psychological flexibility between death anxiety and quality of life in cancer patients.Methods:A convenience sampling method was used to select cancer patients who received treatment at our hospital from January 2022 to January 2024,by the inclusion and exclusion criteria.General information,psychological flexibility,death anxiety,and quality of life scores were collected for analysis.Result:The psychological flexibility and quality of life scores of cancer patients with an annual family income≤100,000 RMB were significantly lower than those of cancer patients with an annual family income>100,000 RMB(P<0.05),while the death anxiety scores were significantly lower for the former group as well(P<0.05).Cancer patients staged as Ⅰ-Ⅱ had significantly higher psychological flexibility and quality of life scores than those staged as Ⅲ-Ⅳ(P<0.05),while their death anxiety scores were significantly lower(P<0.05).Psychological flexibility in cancer patients was negatively correlated with death anxiety(r=-0.614,P<0.05)and positively correlated with quality of life(r=0.628,P<0.05),while death anxiety was negatively correlated with quality of life(r=-0.112,P<0.05).The direct effect of death anxiety on quality of life was-0.232,accounting for 58.32%of the total effect.The mediating effect of psychological flexibility between death anxiety and quality of life was-0.218,accounting for 41.83%of the total effect.Conclusion:Death anxiety can directly affect the quality of life of cancer patients,and it can also indirectly affect the quality of life through psychological flexibility.Clinicians should promptly address patients’death anxiety and provide interventions to enhance psychological flexibility,thereby improving the quality of life.
基金supported by the National Natural Science Foundation of China(Nos.42177415 and 21806146)the Scientific and Technological Innovation of Colleges and Universities in Henan Province Talent Support Program(No.22HASTIT044)the Young Backbone Teachers Programof Colleges and Universities in Henan Province(No.2021GGJS015).
文摘To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with NGT.Plasma isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass spectrometry.Generalized linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and T2DM.Inflammatory cell was used as mediators to estimate the mediating effects on the above associations.Isocarbophos and isofenphos were positively related with T2DM after adjusting for other factors.The odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in ln-isocarbophos.The prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,respectively.Furthermore,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,respectively.Isofenphos and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.
文摘BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Moreover,it has not been confirmed whether,considering the effect of daytime sleepiness on suicide risk,daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.AIM To explore the pathway relationships among nurses'work-family behavioral role conflict,daytime sleepiness,and suicide risk.METHODS Convenience and purposive sampling methods were used to select 750 nurses from six provinces,including Jiangxi,Sichuan,and Shanxi.The work-family behavioral role conflict scale,the Chinese adult daytime sleepiness scale,and the suicide behavior questionnaire were used for the survey.The data were statistically analyzed via SPSS 25.0 software,Pearson correlation analysis was used to explore the correlations between the variables,the PROCESS 4.0 program was used for the mediation effect analysis,and the mediation effect model was tested via the bootstrap method.RESULTS Nurses'work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk(r=734,0.717).Work-family behavioral role conflict positively predicted suicide risk(β=0.118),and daytime sleepiness positively predicted suicide risk(β=0.152).Daytime sleepiness partially mediated the role of nurses'work-family behavioral role conflict and suicide risk,with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.CONCLUSION The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses'work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.
文摘Objective:To explore the relationship between pain degree and pain catastrophe and medical coping mode in patients with chronic pain.Methods:A visual analogue score scale,medical coping style questionnaire and pain catastrophe scale were used to survey 200 patients in the pain department.Results:The average scores of pain degree of patients with chronic pain were(5.97±2.29),the average score of the total score of the Pain Catastrophe Scale was(21.21±11.56),and the average scores of facing,avoidance and surrender in the Medical Response Style Questionnaire were(17.93±3.4),(16.82±2.4),and(8.87±2.83),respectively.Pain degree was positively correlated with the yield dimension in pain catastrophe and medical coping(p<0.05).The yield dimension of medical coping was positively correlated with pain catastrophe(p<0.05).Medical coping methods played a partial mediating role between pain degree and pain catastrophe,and the mediating effect accounted for 21.59%of the total effect.Conclusion:The pain level of chronic pain patients can affect the level of pain catastrophe through medical coping,and clinical medical staff should guide patients to adopt positive coping methods to promote their healthy recovery.
基金supported by the National Social Science Foundation of China(Grant No.22BTJ048)the National Natural Science Foundation of China(Grant No.72403001)+4 种基金the Social Sciences Planning Youth Project of Anhui Province(Grant No.AHSKQ2022D138)the Natural Science Foundation of Anhui Province(Grant No.2408085QG228)the Anhui Province Excellent Young Talents Fund Program of Higher Education Institutions(Grant No.2023AH030015)the Innovation Development Research Project of Anhui Province(Grant No.2023CX507)the Scientific Research Project of Anhui University of Finance and Economics(Grant No.ACYC2022505).
文摘In the backdrop of“dual-carbon”strategic objectives,understanding the influence of the digital economy(DE)on carbon emissions(CEs)is imperative.However,there is limited research on the DE’s negative impact on CEs and the nonlinear relationship between the DE and CE.To address this gap,we collected data from 270 Chinese cities from 2011 to 2021 and used benchmark regression,mediated effects,and panel threshold models to explore the DE’s impact on CEs.The results showed that DE had a nonlinear,inverted U-shaped effect on CEs,with CEs initially increasing and then being suppressed.This conclusion remained consistent even after a series of robustness tests.Overall,the rate of urbanization and breadth of digital financial coverage mediate the relationship between the DE and CEs.Additionally,the combined effects of economic development,environmental regulation,fiscal decentralization,and population size contribute to the DE’s nonlinear impact on CEs.The impact of the DE on CEs varies among nonresource-based,resource-based,and resource-depleted cities and between urban and nonurban agglomerations.This paper’s findings support the development of the DE and the formulation of CE reduction policies.
基金funded by the Natural Science Foundation of Shandong Province[Grant No.ZR2022MD104]Rizhao Natural Science Foundation Youth Fund Project[Grant No.RZ2021ZR36]Taishan Scholars Youth Expert Support Plan of Shandong Province[Grant No.tsqn202306183].
文摘As a novel economic paradigm that drives high-quality economic development,the digital economy(DE)can potentially significantly enhance the utilization efficiency of ecological resources and improve human well-being.Based on panel data from 285 prefecture-level cities in China spanning 2011-2021,this study empirically investigates the direct effects,transmission mechanisms,and spatial spillover effects of the DE on ecological welfare performance(EWP)using benchmark regression,intermediary effects,and spatial Durbin models.The results show that the DE significantly improved EWP in Chinese cities.This conclusion remains valid even after controlling for relevant influencing factors.Two transmission paths—upgrading of the industrial structure(UIS)and green innovation(GI)—significantly impacted EWP,as verified by the mediation effect model.Additionally,the mediating effect of the UIS was stronger than that of GI.Spatial heterogeneity tests show that the DE had significant effects on the EWP of eastern cities,with little impact on the central and western cities.Accordingly,grounded in regional developmental disparities,the empowering effects of the DE must be fully harnessed to foster an ecological civilization and enhance the well-being of the populace.
基金Henan Provincial Government-funded Excellent Clinical Medicine Talent Training Project(Project No.:ZF2024006)Hebei Province Medical Science Research Project Plan(Project No.:20240083)。
文摘Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Health and Retirement Longitudinal Study(CHARLS),this study included 3,284 participants aged 60 years or older with chronic diseases.The sleep quality,pain status,health-related quality of life,and demographic-related data of these elderly patients were obtained.Pearson correlation analysis was conducted to assess the bivariate relationships among the variables.The mediating role of pain in the sleep quality-HRQoL relationship was tested using linear regression models,complemented by bootstrap sampling to verify the indirect effect.Results:Sleep quality was positively associated with health-related quality of life(r=0.218,p<0.001).Conversely,pain demonstrated significant negative correlations with both sleep quality(r=-0.496,p<0.001)and health-related quality of life(r=-0.067,p<0.001).The mediating effect results showed that pain played a partial mediating role between sleep quality and health-related quality of life in elderly patients with chronic diseases(effect value=0.049),and the mediating effect accounted for 23.33%.Conclusion:Pain is a mediating variable between sleep quality and health-related quality of life in elderly patients with chronic diseases.This suggests that clinical practice should incorporate pain assessment into standard clinical care of elderly patients with sleep disorders and chronic diseases.By alleviating pain,sleep quality can be improved,and subsequently,their health-related quality of life can be enhanced.
