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Engineered iTreg-Mediated Immune Tolerance in Zebrafish Overcomes Allograft Rejection for Rapid Gamete Production
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《Bulletin of the Chinese Academy of Sciences》 2026年第1期60-61,共2页
The generation of genetically modified lines in model and economically important species typically requires months or even years.Developing strategies to accelerate this process thus represents a critical need in the ... The generation of genetically modified lines in model and economically important species typically requires months or even years.Developing strategies to accelerate this process thus represents a critical need in the field.Transplantation of allogeneic gonadal primordia into near-mature recipients offers a promising route to rapid gamete production.However,a major obstacle lies in overcoming the immune rejection of donor tissues. 展开更多
关键词 allogeneic gonadal primordia engineered itreg mediatedimmune tolerance overcoming immune rejection allograft rejection rapid gamete production model economically important species zebrafish generation genetically modified lines
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