The calculation of the mean difference for the inverse normal distribution can be obtained by a transformation of variable or a hard integration by parts. This paper shows a simpler formula of the mean difference of t...The calculation of the mean difference for the inverse normal distribution can be obtained by a transformation of variable or a hard integration by parts. This paper shows a simpler formula of the mean difference of the inverse normal distribution that highlights the role of the two parameters on the mean difference of the model. It makes it easier to study the relation of the mean difference with the other indexes of variability for the inverse normal distribution.展开更多
In the study by Baliarsingh and Dutta [Internat. J.Anal., Vol.2014（2014）, Article ID 786437], the authors computed the spectrum and the fine spectrum of the product operator G （u, v; A） over the sequence space e1....In the study by Baliarsingh and Dutta [Internat. J.Anal., Vol.2014（2014）, Article ID 786437], the authors computed the spectrum and the fine spectrum of the product operator G （u, v; A） over the sequence space e1. The product operator G （u, v; △） over l1 is defined by （G（u,v;△）x）k=^k∑i=0ukvi（xi- xi-1） with xk = 0 for all k 〈 0, where x = （xk）∈e1,and u and v axe either constant or strictly decreasing sequences of positive real numbers satisfying certain conditions. In this article we give some improvements of the computation of the spectrum of the operator G （u, v; △） on the sequence space gl.展开更多
The purpose of this paper is to broaden the knowledge of mean difference and, in particular, of an important distribution model known as truncated normal distribution, which is widely used in applied sciences and econ...The purpose of this paper is to broaden the knowledge of mean difference and, in particular, of an important distribution model known as truncated normal distribution, which is widely used in applied sciences and economics. In this work, we obtained the general formula of mean difference, which is not yet reported in literature, for the aforementioned distribution model and also for particular truncated cases.展开更多
The purpose of this paper is to broaden the knowledge of mean difference and,<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="fon...The purpose of this paper is to broaden the knowledge of mean difference and,<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in particular, of an important distribution model known as Tukey lambda, which is generally used to choose a model to fit data.<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">We have obtained compact formulas, which are not yet reported in literature, of mean deviation and mean difference related to the said distribution model.<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">These results made it possible to analyze the relationships among variability indexes, namely standard deviation, mean deviation and mean difference, regarding Tukey lambda model.展开更多
The purpose of this paper is to obtain the expression of the sample mean difference variance of the Student’s distributive model. In the 2007 the study of the mean difference variance, after some decades, was resumed...The purpose of this paper is to obtain the expression of the sample mean difference variance of the Student’s distributive model. In the 2007 the study of the mean difference variance, after some decades, was resumed by Campobasso</span><span style="font-family:Verdana;"> [1]</span><span style="font-family:Verdana;">. Using the Nair’s </span><span style="font-family:Verdana;">[2]</span><span style="font-family:Verdana;"> and Lomnicki’s general results</span><span style="font-family:Verdana;"> [3]</span><span style="font-family:Verdana;">, he obtained the variance of sample mean difference for different distributive models (Laplace</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s, triangular, power, logit, Pareto</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s and Gumbel’s model). In addition he extended the knowledge comparing to the ones already known for the other distributive model (normal, rectangular and exponential model).展开更多
The calculation of the mean difference for the lognormal distribution involves several hard integrals featuring the error function. In this paper, considering two particular cases of an integral of the exponential fun...The calculation of the mean difference for the lognormal distribution involves several hard integrals featuring the error function. In this paper, considering two particular cases of an integral of the exponential function for the complement to one of the error functions, and using various symmetries, we have achieved the result of an extremely simple and useful formula of the mean difference for the lognormal distribution.展开更多
Equations(2)and(6)and the corresponding discussion in the paper[Chin.Phys.Lett.42,056301(2025)]have been corrected.These modiffcations do not affect the results derived in the paper.
A graph G is said to be one modulo N-difference mean graph if there is an injective function f from the vertex set of G to the set , where N is the natural number and q is the number of edges of G and f induces a bije...A graph G is said to be one modulo N-difference mean graph if there is an injective function f from the vertex set of G to the set , where N is the natural number and q is the number of edges of G and f induces a bijection from the edge set of G to given by and the function f is called a one modulo N-difference mean labeling of G. In this paper, we show that the graphs such as arbitrary union of paths, , ladder, slanting ladder, diamond snake, quadrilateral snake, alternately quadrilateral snake, , , , , friendship graph and admit one modulo N-difference mean labeling.展开更多
Tarnavas established mixed weighted power mean inequality in 1999. A separation of weighted power mean inequslity was derived in this paper. As its applications, some separations of other inequalities were given.
BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflamma...BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel disease.Despite current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic strategies.AIM To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC specimens.Additionally,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic targets.METHODS The expression of the KIF14 protein in CRC was analyzed using immunohistochemical staining.The integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA levels.The assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ratios.Additionally,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in CRC.Survival analysis established the prognostic value of KIF14 in CRC.The molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and KIF14.RESULTS KIF14 was highly expressed in 208 CRC patients.Data from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative likelihood ratios were 8.38(95%CI:5.39-13.02)and 0.17(95%CI:0.11-0.26),respectively.At the single-cell level,significant overexpression of KIF14 was observed in CRC cells(P<0.001),with 35 CRC cell lines dependent on KIF14 for growth.The K-M plots demonstrated that KIF14 possesses prognostic value in CRC patients within the GSE71187 and GSE103679 datasets(P<0.05).Binding energy calculations indicated that KIF14 is a potential target for NC(binding energy:10.3 kcal/mol).CONCLUSION KIF14 promotes the growth of CRC cells and acts as an oncogenic factor,potentially serving as a therapeutic target for NC in the treatment of CRC.展开更多
BACKGROUND The stearoyl-coenzyme A desaturase(SCD)gene influences colorectal cancer(CRC)pathogenesis,with its expression linked to tumor cell survival and resistance,necessitating further investigation into its role i...BACKGROUND The stearoyl-coenzyme A desaturase(SCD)gene influences colorectal cancer(CRC)pathogenesis,with its expression linked to tumor cell survival and resistance,necessitating further investigation into its role in CRC.AIM To explore the clinical and pathological significance of SCD expression in CRC tissues and to evaluate the affinity between nitidine chloride(NC)and SCD as a target.METHODS Multi-center high-throughput data related to CRC were integrated to calculate the standardized mean difference of SCD mRNA expression levels.Immunohistochemical staining results,Clustered Regularly Interspaced Short Palindromic Repeats knockout screening results of cell growth,and single-cell sequencing were employed to verify the significance of SCD expression in CRC.The clinical and pathological significance of SCD was assessed using pooled receiver operating characteristic curves,sensitivity,specificity,and likelihood ratios.The molecular mechanism of NC against CRC was clarified using the SwissTarget Prediction and functional enrichment,and molecular docking techniques were utilized to explore the targeting affinity between NC and SCD.RESULTS Data from 18 platforms,including 2482 CRC samples and 1334 non-cancerous colorectal tissue controls.SCD expression was significantly upregulated in CRC,with a standardized mean difference of 2.05[95%confidence interval(CI):1.69-2.41].The area under the pooled receiver operating characteristic curve was 0.95(95%CI:0.92-0.96),with a sensitivity of 0.86(95%CI:0.81-0.90)and a specificity of 0.90(95%CI:0.87-0.93).Positive and negative likelihood ratios were 9.02(95%CI:6.49-12.51)and 0.15(95%CI:0.10-0.22),respectively.High SCD protein expression was noted in 208 CRC patients,significantly associated with vascular invasion(P<0.001).At the singlecell level,SCD was significantly overexpressed in CRC cells(P<0.001).A total of 33 CRC cell lines depended on SCD for growth.The potential mechanism of NC against CRC might involve modulation of the cell cycle,positioning SCD as a potential target for NC.CONCLUSION SCD promotes CRC cell growth and thus acts as an oncogenic factor,making it a potential therapeutic target for NC in CRC treatment.展开更多
BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this period.Early detection and targ...BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this period.Early detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy outcomes.Previous studies have inconsistently suggested that the level of glycated albumin(GA)might predict GDM.AIM To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of GDM.METHODS We sought to compare GA levels between GDM and control groups in this metaanalysis by systematically searching the Web of Science,PubMed,Cochrane Library,and Embase databases for articles published up to June 2023.The analysis utilized the weighted mean difference(WMD)as the primary metric.The data were meticulously extracted,and the quality of the included studies was assessed.Additionally,we conducted a subgroup analysis based on study region and sample size.We assessed heterogeneity using I2 statistics and evaluated publication bias through funnel plots.Additionally,trim-and-fill analysis was employed to detect and address any potential publication bias.RESULTS The meta-analysis included a total of 11 studies involving 5477 participants,comprising 1900 patients with GDM and 3577 control individuals.The synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to GDM.The calculated WMD was 0.42,with a 95%confidence interval(95%CI)ranging from 0.11 to 0.74,yielding a P value less than 0.001.Concerning specific GA levels,the mean GA level in the GDM group was 12.6,while for the control group,it was lower,at 11.6.This discrepancy underscores the potential of GA as a biomarker for assessing GDM risk.Moreover,we explored the levels of glycated haemoglobin(HbA1c)in both cohorts.The WMD for HbA1c was 0.19,with a 95%CI ranging from 0.15 to 0.22 and a P value less than 0.001.This observation suggested that both GA and HbA1c levels were elevated in individuals in the GDM group compared to those in the control group.CONCLUSION Our meta-analysis revealed a substantial correlation between elevated GA levels and increased GDM risk.Furthermore,our findings revealed elevated levels of HbA1c in GDM patients,emphasizing the significance of monitoring both GA and HbA1c levels for early GDM detection and effective management.展开更多
This paper introduced an efficient compression technique that uses the compressive sensing(CS)method to obtain and recover sparse electrocardiography(ECG)signals.The recovery of the signal can be achieved by using sam...This paper introduced an efficient compression technique that uses the compressive sensing(CS)method to obtain and recover sparse electrocardiography(ECG)signals.The recovery of the signal can be achieved by using sampling rates lower than the Nyquist frequency.A novel analysis was proposed in this paper.To apply CS on ECG signal,the first step is to generate a sparse signal,which can be obtained using Modified Discrete Cosine Transform(MDCT)on the given ECGsignal.This transformation is a promising key for other transformations used in this search domain and can be considered as the main contribution of this paper.A small number of wavelet components can describe the ECG signal as related work to obtain a sparse ECGsignal.Asensing technique for ECGsignal compression,which is a novel area of research,is proposed.ECG signals are introduced randomly between any successive beats of the heart.MIT-BIH database can be represented as the experimental database in this domain of research.TheMIT-BIH database consists of various ECG signals involving a patient and standard ECG signals.MATLAB can be considered as the simulation tool used in this work.The proposed method’s uniqueness was inspired by the compression ratio(CR)and achieved by MDCT.The performance measurement of the recovered signal was done by calculating the percentage root mean difference(PRD),mean square error(MSE),and peak signal to noise ratio(PSNR)besides the calculation of CR.Finally,the simulation results indicated that this work is one of the most important works in ECG signal compression.展开更多
It is well-known that classical quality measures,such as Mean Squared Error(MSE),Weighted Mean Squared Error(WMSE)or Peak Signal-to-Noise Ratio(PSNR),are not always corresponding with visual observations.Structural si...It is well-known that classical quality measures,such as Mean Squared Error(MSE),Weighted Mean Squared Error(WMSE)or Peak Signal-to-Noise Ratio(PSNR),are not always corresponding with visual observations.Structural similarity based image quality assessment was proposed under the assumption that the Human Visual System(HVS)is highly adapted for extracting structural information from an image.While the demand on high color quality increases in the media industry,color loss will make the visual quality different.In this paper,we proposed an improved quality assessment(QA)method by adding color comparison into the structural similarity(SSIM)measurement system for evaluating color image quality.Then we divided the task of similarity measurement into four comparisons:luminance,contrast,structure,and color.Experimental results show that the predicted quality scores of the proposed method are more effective and consistent with visual quality than the classical methods using five different distortion types of color image sets.展开更多
Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective ...Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after 3-4 months, muscle strength usually recovers because function- al recovery is mediated by nerve sprouting and reconstruction of the neuromuscular junction. Acrylamide may produce neurotoxic substances that cause retrograde necrotizing neuropathy and inhibit nerve sprouting caused by botulinum toxin type A. This study investigated whether acrylamide inhibits nerve sprouting after intramuscular injection of botulinum toxin type A. A tibial nerve sprouting model was established through local injection of botulinum toxin type A into the right gastrocnemius muscle of Sprague-Dawley rats. Following intramuscular injection, rats were given intraperitoneal injection of 3% acrylamide every 3 days for 21 days. Nerve sprout- ing appeared 2 weeks after intramuscular injection of botulinum toxin type A and single-fiber electromyography revealed abnormal conduction at the neuromuscular junction I week after intra- muscular injection of botulinum toxin type A. Following intraperitoneal injection of acrylamide, the peak muscle fiber density decreased. Electromyography jitter value were restored to normal levels 6 weeks after injection. This indicates that the maximal decrease in fiber density and the time at which functional conduction of neuromuscular junction was restored were delayed. Addition- ally, the increase in tibial nerve fibers was reduced. Acrylamide inhibits nerve sprouting caused by botulinum toxin type A and may be used to prolong the clinical dosage of botulinum toxin type A.展开更多
This paper presents an improved rate control method for H.264. First, the scene changes are detected by the average absolute difference of the brightness histograms between the adjacent frames. Then, the bit allocatio...This paper presents an improved rate control method for H.264. First, the scene changes are detected by the average absolute difference of the brightness histograms between the adjacent frames. Then, the bit allocation and quantization parameters are adjusted, using a certain threshold. In addition, the calculation of the mean absolute difference （MAD） is modified in an alternative way, which makes the rate distortion optimization （RDO） more accurate. Extensive simulation results show that the proposed method, compared with G012, can improve the average peak signal-to-noise ratio （PSNR） and moderate the image quality.展开更多
The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H.264/AVC rate control.In our scheme,we propose an enhancement method of ...The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H.264/AVC rate control.In our scheme,we propose an enhancement method of the target frame rate based H.264/AVC bit allocation.The enhancement uses a frame complexity estimation to improve the existing mean absolute difference(MAD)complexity measurement Bit allocation to each frame is not just computed by target frame rate but also adjusted by a combined frame complexity measure.Using the statistical characteristic,we obtain change of occurrence bit about QP to apply the bit amount by QP from the video characteristic and applied in the estimated bit amount of the current frame. Simulation results show that the proposed rate control scheme could not only achieves time saving of more than 99%over existing rate control algorithm,but also increase the average PSNR of reconstructed video for around 0.02～0.78 dB in all the sequences.展开更多
The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H. 264/AVC rate control. The scheme ImPoses an enhancement method of the ...The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H. 264/AVC rate control. The scheme ImPoses an enhancement method of the target frame rate based on H. 264/AVC bit allocation. The enhancement uses a frame complexion estimation to improve the existing Mean Absolute Difference （MAD） complexity measurement. Bit allocation to each frame is not just computed by target frame rote but also adjusted by a combined frame complexity measure. Using the statistical characteristic, the scheme obtains change of occurrence bit about QP to apply the bit amount by QP from the video characteristic and apply it in the estimated bit amount of the current frame. Simulation results show that the proposed rate eontrol scheme achieves time saving of mine than 99% over existing rate control algorithm. Nevertheless, Peak Signal-to-Noise Ration （PSNR） and bit rate were almost the same as the performances.展开更多
BACKGROUND Advanced chronic kidney disease(CKD) is a common complication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose monitoring(CGM) helps users monitor and stab...BACKGROUND Advanced chronic kidney disease(CKD) is a common complication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose monitoring(CGM) helps users monitor and stabilize their glucose levels. To date, CGM and intermittent scanning CGM are only approved for people with diabetes but not for those with advanced CKD.AIM To compare the performance of Dexcom G5 and FreeStyle Libre sensors in adults with type 1 or 2 diabetes and advanced CKD.METHODS This was a non-randomized clinical trial that took place in two outpatient clinics in western Sweden. All patients with type 1 or 2 diabetes and an estimated glomerular filtration rate(eGFR) of < 30 mL/min per 1.73 m^(2) were invited to participate. Forty patients(full analysis set = 33) carried the Dexcom G5 sensor for 7 d and FreeStyle Libre sensor for 14 d simultaneously. For referencing capillary blood glucose(SMBG) was measured with a high accuracy glucose meter(HemoCue®) during the study period. At the end of the study, all patients were asked to answer a questionnaire on their experience using the sensors.RESULTS The mean age was 64.1(range 41-77) years, hemoglobin A1 c was 7.0% [standard deviation(SD) 3.2], and diabetes duration was 28.5(SD 14.7) years. A total of 27.5% of the study population was on hemodialysis and 22.5% on peritoneal dialysis. The mean absolute relative difference for Dexcom G5 vs SMBG was significantly lower than that for FreeStyle Libre vs SMBG [15.2%(SD 12.2) vs 20.9%(SD 8.6)], with a mean difference of 5.72 [95% confidence interval(CI): 2.11-9.32;P = 0.0036]. The mean absolute difference was also significantly lower for Dexcom G5 than for FreeStyle Libre, 1.21 mmol/L(SD 0.78) and 1.76 mmol/L(SD 0.78), with a mean diffrenec of 0.55(95%CI: 0.27-0.83;P = 0.0004).The mean difference(MD) was-0.107 mmol/L and-1.10 mmol/L(P = 0.0002), respectively. In all, 66% of FreeStyle Libre values were in the no risk zone on the surveillance error grid compared to 82% of Dexcom G5 values.CONCLUSION Dexcom G5 produces more accurate sensor values than FreeStyle Libre in people with diabetes and advanced CKD and is likely safe to be used by those with advanced CKD.展开更多
The HKO （Hong Kong Observatory） has been carrying out an inter-comparison of automatic raingauges since 2011 for identifying raingauges that can meet the ~ 5% accuracy requirement of the WMO （World Meteorological O...The HKO （Hong Kong Observatory） has been carrying out an inter-comparison of automatic raingauges since 2011 for identifying raingauges that can meet the ~ 5% accuracy requirement of the WMO （World Meteorological Organization） in measuring rainfall amount. The inter-comparison was conducted at HKO＇s meteorological stations at King＇s Park and Hong Kong International Airport in Hong Kong. Two 0.1-mm resolution Pluvio-OTT weighing gauges were introduced in 2013. This type of raingauges has outperformed others in the WMO＇s field inter-comparison held between October 2007 and April 2009. The performances of 14 raingauges, comprising five different measurement methods, viz. drop-counting, weighing, tipping bucket with software correction, tipping bucket with extra pulse correction and tipping bucket without correction, were evaluated. The focus was to study their performances in rainfall intensity measurement, especially during heavy rain situations. Different high rainfall intensity episodes were selected for analysis. Among these episodes, the maximum 1-minute rainfall intensity as high as around 130 mm/hr was recorded by the Pluvio-OTT raingauges. This paper serves to conclude the 3-year （2011-2013） inter-comparison exercise for rainfall amount measurements and to provide preliminary 1-year （2013） comparison results on rainfall intensity measurements.展开更多
文摘The calculation of the mean difference for the inverse normal distribution can be obtained by a transformation of variable or a hard integration by parts. This paper shows a simpler formula of the mean difference of the inverse normal distribution that highlights the role of the two parameters on the mean difference of the model. It makes it easier to study the relation of the mean difference with the other indexes of variability for the inverse normal distribution.
文摘In the study by Baliarsingh and Dutta [Internat. J.Anal., Vol.2014（2014）, Article ID 786437], the authors computed the spectrum and the fine spectrum of the product operator G （u, v; A） over the sequence space e1. The product operator G （u, v; △） over l1 is defined by （G（u,v;△）x）k=^k∑i=0ukvi（xi- xi-1） with xk = 0 for all k 〈 0, where x = （xk）∈e1,and u and v axe either constant or strictly decreasing sequences of positive real numbers satisfying certain conditions. In this article we give some improvements of the computation of the spectrum of the operator G （u, v; △） on the sequence space gl.
文摘The purpose of this paper is to broaden the knowledge of mean difference and, in particular, of an important distribution model known as truncated normal distribution, which is widely used in applied sciences and economics. In this work, we obtained the general formula of mean difference, which is not yet reported in literature, for the aforementioned distribution model and also for particular truncated cases.
文摘The purpose of this paper is to broaden the knowledge of mean difference and,<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in particular, of an important distribution model known as Tukey lambda, which is generally used to choose a model to fit data.<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">We have obtained compact formulas, which are not yet reported in literature, of mean deviation and mean difference related to the said distribution model.<span style="font-family:;" "=""> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">These results made it possible to analyze the relationships among variability indexes, namely standard deviation, mean deviation and mean difference, regarding Tukey lambda model.
文摘The purpose of this paper is to obtain the expression of the sample mean difference variance of the Student’s distributive model. In the 2007 the study of the mean difference variance, after some decades, was resumed by Campobasso</span><span style="font-family:Verdana;"> [1]</span><span style="font-family:Verdana;">. Using the Nair’s </span><span style="font-family:Verdana;">[2]</span><span style="font-family:Verdana;"> and Lomnicki’s general results</span><span style="font-family:Verdana;"> [3]</span><span style="font-family:Verdana;">, he obtained the variance of sample mean difference for different distributive models (Laplace</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s, triangular, power, logit, Pareto</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s and Gumbel’s model). In addition he extended the knowledge comparing to the ones already known for the other distributive model (normal, rectangular and exponential model).
文摘The calculation of the mean difference for the lognormal distribution involves several hard integrals featuring the error function. In this paper, considering two particular cases of an integral of the exponential function for the complement to one of the error functions, and using various symmetries, we have achieved the result of an extremely simple and useful formula of the mean difference for the lognormal distribution.
文摘Equations(2)and(6)and the corresponding discussion in the paper[Chin.Phys.Lett.42,056301(2025)]have been corrected.These modiffcations do not affect the results derived in the paper.
文摘A graph G is said to be one modulo N-difference mean graph if there is an injective function f from the vertex set of G to the set , where N is the natural number and q is the number of edges of G and f induces a bijection from the edge set of G to given by and the function f is called a one modulo N-difference mean labeling of G. In this paper, we show that the graphs such as arbitrary union of paths, , ladder, slanting ladder, diamond snake, quadrilateral snake, alternately quadrilateral snake, , , , , friendship graph and admit one modulo N-difference mean labeling.
基金Project supported by National Natural Science Foundation of China （Grant No. 10271071）
文摘Tarnavas established mixed weighted power mean inequality in 1999. A separation of weighted power mean inequslity was derived in this paper. As its applications, some separations of other inequalities were given.
基金Natural Science Foundation of Shandong Province,No.ZR2020QH185Scientific Research Nurturing Fund of The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0803+2 种基金Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z-A20220415Guangxi Medical University Teacher Teaching Ability Development Project,No.2022JFA02Guangxi Medical University Undergraduate Education and Teaching Reform Project,No.2023Y05.
文摘BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel disease.Despite current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic strategies.AIM To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC specimens.Additionally,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic targets.METHODS The expression of the KIF14 protein in CRC was analyzed using immunohistochemical staining.The integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA levels.The assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ratios.Additionally,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in CRC.Survival analysis established the prognostic value of KIF14 in CRC.The molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and KIF14.RESULTS KIF14 was highly expressed in 208 CRC patients.Data from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative likelihood ratios were 8.38(95%CI:5.39-13.02)and 0.17(95%CI:0.11-0.26),respectively.At the single-cell level,significant overexpression of KIF14 was observed in CRC cells(P<0.001),with 35 CRC cell lines dependent on KIF14 for growth.The K-M plots demonstrated that KIF14 possesses prognostic value in CRC patients within the GSE71187 and GSE103679 datasets(P<0.05).Binding energy calculations indicated that KIF14 is a potential target for NC(binding energy:10.3 kcal/mol).CONCLUSION KIF14 promotes the growth of CRC cells and acts as an oncogenic factor,potentially serving as a therapeutic target for NC in the treatment of CRC.
基金Supported by Natural Science Foundation of Shandong Province,No.ZR2020QH185Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0803Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z20210442.
文摘BACKGROUND The stearoyl-coenzyme A desaturase(SCD)gene influences colorectal cancer(CRC)pathogenesis,with its expression linked to tumor cell survival and resistance,necessitating further investigation into its role in CRC.AIM To explore the clinical and pathological significance of SCD expression in CRC tissues and to evaluate the affinity between nitidine chloride(NC)and SCD as a target.METHODS Multi-center high-throughput data related to CRC were integrated to calculate the standardized mean difference of SCD mRNA expression levels.Immunohistochemical staining results,Clustered Regularly Interspaced Short Palindromic Repeats knockout screening results of cell growth,and single-cell sequencing were employed to verify the significance of SCD expression in CRC.The clinical and pathological significance of SCD was assessed using pooled receiver operating characteristic curves,sensitivity,specificity,and likelihood ratios.The molecular mechanism of NC against CRC was clarified using the SwissTarget Prediction and functional enrichment,and molecular docking techniques were utilized to explore the targeting affinity between NC and SCD.RESULTS Data from 18 platforms,including 2482 CRC samples and 1334 non-cancerous colorectal tissue controls.SCD expression was significantly upregulated in CRC,with a standardized mean difference of 2.05[95%confidence interval(CI):1.69-2.41].The area under the pooled receiver operating characteristic curve was 0.95(95%CI:0.92-0.96),with a sensitivity of 0.86(95%CI:0.81-0.90)and a specificity of 0.90(95%CI:0.87-0.93).Positive and negative likelihood ratios were 9.02(95%CI:6.49-12.51)and 0.15(95%CI:0.10-0.22),respectively.High SCD protein expression was noted in 208 CRC patients,significantly associated with vascular invasion(P<0.001).At the singlecell level,SCD was significantly overexpressed in CRC cells(P<0.001).A total of 33 CRC cell lines depended on SCD for growth.The potential mechanism of NC against CRC might involve modulation of the cell cycle,positioning SCD as a potential target for NC.CONCLUSION SCD promotes CRC cell growth and thus acts as an oncogenic factor,making it a potential therapeutic target for NC in CRC treatment.
文摘BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this period.Early detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy outcomes.Previous studies have inconsistently suggested that the level of glycated albumin(GA)might predict GDM.AIM To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of GDM.METHODS We sought to compare GA levels between GDM and control groups in this metaanalysis by systematically searching the Web of Science,PubMed,Cochrane Library,and Embase databases for articles published up to June 2023.The analysis utilized the weighted mean difference(WMD)as the primary metric.The data were meticulously extracted,and the quality of the included studies was assessed.Additionally,we conducted a subgroup analysis based on study region and sample size.We assessed heterogeneity using I2 statistics and evaluated publication bias through funnel plots.Additionally,trim-and-fill analysis was employed to detect and address any potential publication bias.RESULTS The meta-analysis included a total of 11 studies involving 5477 participants,comprising 1900 patients with GDM and 3577 control individuals.The synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to GDM.The calculated WMD was 0.42,with a 95%confidence interval(95%CI)ranging from 0.11 to 0.74,yielding a P value less than 0.001.Concerning specific GA levels,the mean GA level in the GDM group was 12.6,while for the control group,it was lower,at 11.6.This discrepancy underscores the potential of GA as a biomarker for assessing GDM risk.Moreover,we explored the levels of glycated haemoglobin(HbA1c)in both cohorts.The WMD for HbA1c was 0.19,with a 95%CI ranging from 0.15 to 0.22 and a P value less than 0.001.This observation suggested that both GA and HbA1c levels were elevated in individuals in the GDM group compared to those in the control group.CONCLUSION Our meta-analysis revealed a substantial correlation between elevated GA levels and increased GDM risk.Furthermore,our findings revealed elevated levels of HbA1c in GDM patients,emphasizing the significance of monitoring both GA and HbA1c levels for early GDM detection and effective management.
文摘This paper introduced an efficient compression technique that uses the compressive sensing(CS)method to obtain and recover sparse electrocardiography(ECG)signals.The recovery of the signal can be achieved by using sampling rates lower than the Nyquist frequency.A novel analysis was proposed in this paper.To apply CS on ECG signal,the first step is to generate a sparse signal,which can be obtained using Modified Discrete Cosine Transform(MDCT)on the given ECGsignal.This transformation is a promising key for other transformations used in this search domain and can be considered as the main contribution of this paper.A small number of wavelet components can describe the ECG signal as related work to obtain a sparse ECGsignal.Asensing technique for ECGsignal compression,which is a novel area of research,is proposed.ECG signals are introduced randomly between any successive beats of the heart.MIT-BIH database can be represented as the experimental database in this domain of research.TheMIT-BIH database consists of various ECG signals involving a patient and standard ECG signals.MATLAB can be considered as the simulation tool used in this work.The proposed method’s uniqueness was inspired by the compression ratio(CR)and achieved by MDCT.The performance measurement of the recovered signal was done by calculating the percentage root mean difference(PRD),mean square error(MSE),and peak signal to noise ratio(PSNR)besides the calculation of CR.Finally,the simulation results indicated that this work is one of the most important works in ECG signal compression.
文摘It is well-known that classical quality measures,such as Mean Squared Error(MSE),Weighted Mean Squared Error(WMSE)or Peak Signal-to-Noise Ratio(PSNR),are not always corresponding with visual observations.Structural similarity based image quality assessment was proposed under the assumption that the Human Visual System(HVS)is highly adapted for extracting structural information from an image.While the demand on high color quality increases in the media industry,color loss will make the visual quality different.In this paper,we proposed an improved quality assessment(QA)method by adding color comparison into the structural similarity(SSIM)measurement system for evaluating color image quality.Then we divided the task of similarity measurement into four comparisons:luminance,contrast,structure,and color.Experimental results show that the predicted quality scores of the proposed method are more effective and consistent with visual quality than the classical methods using five different distortion types of color image sets.
基金supported by TCM General Research Project of Zhejiang Province,No.2014ZA071Health General Research Project of Zhejiang Province,No.2014KYA106
文摘Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after 3-4 months, muscle strength usually recovers because function- al recovery is mediated by nerve sprouting and reconstruction of the neuromuscular junction. Acrylamide may produce neurotoxic substances that cause retrograde necrotizing neuropathy and inhibit nerve sprouting caused by botulinum toxin type A. This study investigated whether acrylamide inhibits nerve sprouting after intramuscular injection of botulinum toxin type A. A tibial nerve sprouting model was established through local injection of botulinum toxin type A into the right gastrocnemius muscle of Sprague-Dawley rats. Following intramuscular injection, rats were given intraperitoneal injection of 3% acrylamide every 3 days for 21 days. Nerve sprout- ing appeared 2 weeks after intramuscular injection of botulinum toxin type A and single-fiber electromyography revealed abnormal conduction at the neuromuscular junction I week after intra- muscular injection of botulinum toxin type A. Following intraperitoneal injection of acrylamide, the peak muscle fiber density decreased. Electromyography jitter value were restored to normal levels 6 weeks after injection. This indicates that the maximal decrease in fiber density and the time at which functional conduction of neuromuscular junction was restored were delayed. Addition- ally, the increase in tibial nerve fibers was reduced. Acrylamide inhibits nerve sprouting caused by botulinum toxin type A and may be used to prolong the clinical dosage of botulinum toxin type A.
基金Supported by the National Natural Science Foundation of China (60372057)
文摘This paper presents an improved rate control method for H.264. First, the scene changes are detected by the average absolute difference of the brightness histograms between the adjacent frames. Then, the bit allocation and quantization parameters are adjusted, using a certain threshold. In addition, the calculation of the mean absolute difference （MAD） is modified in an alternative way, which makes the rate distortion optimization （RDO） more accurate. Extensive simulation results show that the proposed method, compared with G012, can improve the average peak signal-to-noise ratio （PSNR） and moderate the image quality.
基金supported by Seoul R&BD Program(10544)supported by the MKE(The Ministry of Knowledge Economy),Korea,under the ITRC(Information Technology Research Center)support program supervised by the NIPA(National IT Industry Promotion Agency)"(NIPA-2010-(C1090-1011-0003))
文摘The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H.264/AVC rate control.In our scheme,we propose an enhancement method of the target frame rate based H.264/AVC bit allocation.The enhancement uses a frame complexity estimation to improve the existing mean absolute difference(MAD)complexity measurement Bit allocation to each frame is not just computed by target frame rate but also adjusted by a combined frame complexity measure.Using the statistical characteristic,we obtain change of occurrence bit about QP to apply the bit amount by QP from the video characteristic and applied in the estimated bit amount of the current frame. Simulation results show that the proposed rate control scheme could not only achieves time saving of more than 99%over existing rate control algorithm,but also increase the average PSNR of reconstructed video for around 0.02～0.78 dB in all the sequences.
文摘The purpose of this paper is to improve allocation of the number of bits without skipping the frame by accurately estimating the target bits in H. 264/AVC rate control. The scheme ImPoses an enhancement method of the target frame rate based on H. 264/AVC bit allocation. The enhancement uses a frame complexion estimation to improve the existing Mean Absolute Difference （MAD） complexity measurement. Bit allocation to each frame is not just computed by target frame rote but also adjusted by a combined frame complexity measure. Using the statistical characteristic, the scheme obtains change of occurrence bit about QP to apply the bit amount by QP from the video characteristic and apply it in the estimated bit amount of the current frame. Simulation results show that the proposed rate eontrol scheme achieves time saving of mine than 99% over existing rate control algorithm. Nevertheless, Peak Signal-to-Noise Ration （PSNR） and bit rate were almost the same as the performances.
文摘BACKGROUND Advanced chronic kidney disease(CKD) is a common complication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose monitoring(CGM) helps users monitor and stabilize their glucose levels. To date, CGM and intermittent scanning CGM are only approved for people with diabetes but not for those with advanced CKD.AIM To compare the performance of Dexcom G5 and FreeStyle Libre sensors in adults with type 1 or 2 diabetes and advanced CKD.METHODS This was a non-randomized clinical trial that took place in two outpatient clinics in western Sweden. All patients with type 1 or 2 diabetes and an estimated glomerular filtration rate(eGFR) of < 30 mL/min per 1.73 m^(2) were invited to participate. Forty patients(full analysis set = 33) carried the Dexcom G5 sensor for 7 d and FreeStyle Libre sensor for 14 d simultaneously. For referencing capillary blood glucose(SMBG) was measured with a high accuracy glucose meter(HemoCue®) during the study period. At the end of the study, all patients were asked to answer a questionnaire on their experience using the sensors.RESULTS The mean age was 64.1(range 41-77) years, hemoglobin A1 c was 7.0% [standard deviation(SD) 3.2], and diabetes duration was 28.5(SD 14.7) years. A total of 27.5% of the study population was on hemodialysis and 22.5% on peritoneal dialysis. The mean absolute relative difference for Dexcom G5 vs SMBG was significantly lower than that for FreeStyle Libre vs SMBG [15.2%(SD 12.2) vs 20.9%(SD 8.6)], with a mean difference of 5.72 [95% confidence interval(CI): 2.11-9.32;P = 0.0036]. The mean absolute difference was also significantly lower for Dexcom G5 than for FreeStyle Libre, 1.21 mmol/L(SD 0.78) and 1.76 mmol/L(SD 0.78), with a mean diffrenec of 0.55(95%CI: 0.27-0.83;P = 0.0004).The mean difference(MD) was-0.107 mmol/L and-1.10 mmol/L(P = 0.0002), respectively. In all, 66% of FreeStyle Libre values were in the no risk zone on the surveillance error grid compared to 82% of Dexcom G5 values.CONCLUSION Dexcom G5 produces more accurate sensor values than FreeStyle Libre in people with diabetes and advanced CKD and is likely safe to be used by those with advanced CKD.
文摘The HKO （Hong Kong Observatory） has been carrying out an inter-comparison of automatic raingauges since 2011 for identifying raingauges that can meet the ~ 5% accuracy requirement of the WMO （World Meteorological Organization） in measuring rainfall amount. The inter-comparison was conducted at HKO＇s meteorological stations at King＇s Park and Hong Kong International Airport in Hong Kong. Two 0.1-mm resolution Pluvio-OTT weighing gauges were introduced in 2013. This type of raingauges has outperformed others in the WMO＇s field inter-comparison held between October 2007 and April 2009. The performances of 14 raingauges, comprising five different measurement methods, viz. drop-counting, weighing, tipping bucket with software correction, tipping bucket with extra pulse correction and tipping bucket without correction, were evaluated. The focus was to study their performances in rainfall intensity measurement, especially during heavy rain situations. Different high rainfall intensity episodes were selected for analysis. Among these episodes, the maximum 1-minute rainfall intensity as high as around 130 mm/hr was recorded by the Pluvio-OTT raingauges. This paper serves to conclude the 3-year （2011-2013） inter-comparison exercise for rainfall amount measurements and to provide preliminary 1-year （2013） comparison results on rainfall intensity measurements.
