Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to...Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to regulate the administration time and dosage[2].The depth of drug permeability is mainly impeded by geometry obstruction and diffusional resistance of the stratum corneum,which consists of 10 to 30 layers of keratinized corneocytes embedded in an extracellular lipid matrix.It is a great challenge to overcome stratum corneum to enhance drug permeation across skin[3].The latest publication in Advanced Materials from the teams of Cai,Cui,and Bai introduced a new type of nanobubble ultrasonic coupling hydrogel,which is built by dynamic Schiff base cross-linking between nanobubbles and aminated hyaluronic acid(HA)[4].This ultrasound coupling hydrogel opens new insights in noninvasive drug delivery because it effciently overcomes the skin barrier and achieves precise spatiotemporal drug delivery by ultrasound-amplified cavitation effect.展开更多
基金support from the UMCG Research Fundssupport from China Scholarship Council.
文摘Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to regulate the administration time and dosage[2].The depth of drug permeability is mainly impeded by geometry obstruction and diffusional resistance of the stratum corneum,which consists of 10 to 30 layers of keratinized corneocytes embedded in an extracellular lipid matrix.It is a great challenge to overcome stratum corneum to enhance drug permeation across skin[3].The latest publication in Advanced Materials from the teams of Cai,Cui,and Bai introduced a new type of nanobubble ultrasonic coupling hydrogel,which is built by dynamic Schiff base cross-linking between nanobubbles and aminated hyaluronic acid(HA)[4].This ultrasound coupling hydrogel opens new insights in noninvasive drug delivery because it effciently overcomes the skin barrier and achieves precise spatiotemporal drug delivery by ultrasound-amplified cavitation effect.
