In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ...In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.展开更多
Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes ...Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes a novel image encryption algorithm specifically designed for grayscale image security.This research introduces a new Cantor diagonal matrix permutation method.The proposed permutation method uses row and column index sequences to control the Cantor diagonal matrix,where the row and column index sequences are generated by a spatiotemporal chaotic system named coupled map lattice(CML).The high initial value sensitivity of the CML system makes the permutation method highly sensitive and secure.Additionally,leveraging fractal theory,this study introduces a chaotic fractal matrix and applies this matrix in the diffusion process.This chaotic fractal matrix exhibits selfsimilarity and irregularity.Using the Cantor diagonal matrix and chaotic fractal matrix,this paper introduces a fast image encryption algorithm involving two diffusion steps and one permutation step.Moreover,the algorithm achieves robust security with only a single encryption round,ensuring high operational efficiency.Experimental results show that the proposed algorithm features an expansive key space,robust security,high sensitivity,high efficiency,and superior statistical properties for the ciphered images.Thus,the proposed algorithm not only provides a practical solution for secure image transmission but also bridges fractal theory with image encryption techniques,thereby opening new research avenues in chaotic cryptography and advancing the development of information security technology.展开更多
We read with great interest the investigation of Kang et al related the applications of the multiparametric magnetic resonance imaging-based predictive model for assessing chemotherapy efficacy in colorectal cancer pa...We read with great interest the investigation of Kang et al related the applications of the multiparametric magnetic resonance imaging-based predictive model for assessing chemotherapy efficacy in colorectal cancer patients with gene mutations.The authors focused on decision-making based on the integration of tumor differentiation,signal intensity ratio,margin distance,and magnetic resonance imaging-detected lymph node metastasis.Indeed,these multiparameter predictive models could also be used for diagnosis as an alternative to invasive tissue examination methods.However,progress in this field enables us to shift the paradigm to radiology biopsies,particularly given the nonlinear effects of various radiation sources.展开更多
We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-l...We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-like state withoutapoptosis.The results obtained by the authors highlight the features of theeffects of senescent drift induction in surrounding tissues.In the light of thesefindings,the role of the properties of extracellular matrix and cellular glycocalyxin responses of human tumors to therapy remain uninvestigated.These extracellularbarriers appear to be significant obstacles to effective cancer therapy,especiallyin relation to the use of unique properties of tumor microenvironment forthe immunotherapy-resistant cancer treatment.展开更多
Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China ...Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.展开更多
Access to clean drinking water is essential for human health,economic development,and environmental sustain-ability.To effectively preserve water quality and ensure a safe and stable water supply,it is essential to de...Access to clean drinking water is essential for human health,economic development,and environmental sustain-ability.To effectively preserve water quality and ensure a safe and stable water supply,it is essential to determine the priority control factors of potentially hazardous elements in water.This study focused on public drinking wa-ter fountains in Zaječar City(Serbia),examining water hydrochemistry,quality,potential sources of hazardous elements,and the health risks associated with consumption or dermal exposure.Among all potentially hazardous elements,iron showed a deviation from the limit in drinking water prescribed by the World Health Organization,reaching 631μg/L.However,all samples were categorized as excellent quality for drinking.Water composition was governed by water-rock interactions,distinguishing Na-HCO_(3)as the dominant water type.A total of 3.3%and 6.6%of samples exceeded the threshold of 1 for non-carcinogenic health risk for adults and children,re-spectively,with the mean HIa value of 0.35 and the mean HIc value of 0.57.However,the carcinogenic risk was within the allowable limits for children,whereas it surpassed the threshold of 1.0×10^(–4)for adults in 10%of the samples.The positive matrix factorization model identified four sources responsible for water quality,i.e.,natural source,industrial source,sewage source,and agricultural source,with contributions of 37.1%,35.0%,17.8%,and 10.1%,respectively.The Monte Carlo simulation of source-specific health risks revealed that the industrial source was the main contributor to both non-carcinogenic and carcinogenic risks,attributed to its high arsenic load.展开更多
Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological prop...Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological properties and tissue specificity,highlighting its potential as a biomedical material for the repair of severe peripheral nerve injury;however,its role in modulating neuroinflammation post-peripheral nerve injury remains unknown.Here,we aimed to characterize the anti-inflammatory properties of porcine decellularized nerve matrix hydrogel and their underlying molecular mechanisms.Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel,we evaluated structural and functional recovery,macrophage phenotype alteration,specific cytokine expression,and changes in related signaling molecules in vivo.Similar parameters were evaluated in vitro using monocyte/macrophage cell lines stimulated with lipopolysaccharide and cultured on porcine decellularized nerve matrix hydrogel-coated plates in complete medium.These comprehensive analyses revealed that porcine decellularized nerve matrix hydrogel attenuated the activation of excessive inflammation at the early stage of peripheral nerve injury and increased the proportion of the M2 subtype in monocytes/macrophages.Additionally,porcine decellularized nerve matrix hydrogel negatively regulated the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB axis both in vivo and in vitro.Our findings suggest that the efficacious anti-inflammatory properties of porcine decellularized nerve matrix hydrogel induce M2 macrophage polarization via suppression of the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway,providing new insights into the therapeutic mechanism of porcine decellularized nerve matrix hydrogel in peripheral nerve injury.展开更多
In underwater target search path planning,the accuracy of sonar models directly dictates the accurate assessment of search coverage.In contrast to physics-informed sonar models,traditional geometric sonar models fail ...In underwater target search path planning,the accuracy of sonar models directly dictates the accurate assessment of search coverage.In contrast to physics-informed sonar models,traditional geometric sonar models fail to accurately characterize the complex influence of marine environments.To overcome these challenges,we propose an acoustic physics-informed intelligent path planning framework for underwater target search,integrating three core modules:The acoustic-physical modeling module adopts 3D ray-tracing theory and the active sonar equation to construct a physics-driven sonar detection model,explicitly accounting for environmental factors that influence sonar performance across heterogeneous spaces.The hybrid parallel computing module adopts a message passing interface(MPI)/open multi-processing(Open MP)hybrid strategy for large-scale acoustic simulations,combining computational domain decomposition and physics-intensive task acceleration.The search path optimization module adopts the covariance matrix adaptation evolution algorithm to solve continuous optimization problems of heading angles,which ensures maximum search coverage for targets.Largescale experiments conducted in the Pacific and Atlantic Oceans demonstrate the framework's effectiveness:(1)Precise capture of sonar detection range variations from 5.45 km to 50 km in heterogeneous marine environments.(2)Significant speedup of 453.43×for acoustic physics modeling through hybrid parallelization.(3)Notable improvements of 7.23%in detection coverage and 15.86%reduction in optimization time compared to the optimal baseline method.The framework provides a robust solution for underwater search missions in complex marine environments.展开更多
In tomato,early fruit development involves rapid cell division and expansion,which are highly dependent on sugar availability(Huang et al.,2025;Yuan et al.,2025).After fruit set,soluble sugars are loaded into pericarp...In tomato,early fruit development involves rapid cell division and expansion,which are highly dependent on sugar availability(Huang et al.,2025;Yuan et al.,2025).After fruit set,soluble sugars are loaded into pericarp cells through the symplasmic(cytosol)or apoplasmic pathway(cell wall and extracellular matrix)(Patrick and Offler,1996).Sucrose,as the major form of carbon translocated to tomato fruit,can be directly unloaded into fruit cells.However,some sucrose can be hydrolyzed by extracellular invertase,producing glucose and fructose for metabolism and biosynthesis in pericarp cells(Ruan,2014).展开更多
Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protei...Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.展开更多
Rheplpgy of castables is greatly affected and controlled by rheological behavior of their matrix. In this work ,the rheological properties of bauxite-based castable matrix have been studied. The effects of super-fine ...Rheplpgy of castables is greatly affected and controlled by rheological behavior of their matrix. In this work ,the rheological properties of bauxite-based castable matrix have been studied. The effects of super-fine silica and alumina addition , water/ cement ratio, dispersants and bauxite particle-size on viscosity, shear rate and shear stress of the slur-ries have been investigated . Based on these results, the range of optimum composition of the matrix with good rheological behavior has been obtained.展开更多
The Cr^3＋：BeAl2O4 crystal, Cr^3＋：LiNbO3 crystal, and ZnO-Al2O3-SiO2 glass-ceramic were obtained by the Czochralski technique, Bridgman method, and melting processing, respectively. The optical absorption and emiss...The Cr^3＋：BeAl2O4 crystal, Cr^3＋：LiNbO3 crystal, and ZnO-Al2O3-SiO2 glass-ceramic were obtained by the Czochralski technique, Bridgman method, and melting processing, respectively. The optical absorption and emission spectra of the above Cr^3＋-incorporated solid-state materials were recorded. The technical parameters for growing high-quality Cr^3＋：BeAl2O4 and Cr^3＋：LINbO3 crystals were obtained. The results indicate that the optical absorption and fluorescence spectra of Cr^3＋ show quite a few differences in various matrixes. The sharp line emissions were observed in the Cr^3＋：BeAl2O4 and Cr^3＋：LiNbO3 crystals. The crystal-field parameters （Dq） for Cr^3＋. in different matrixes were calculated from their corresponding spectra. It is indicated that Cr^3＋：BeAl2O4 and Cr^3＋：LiNbO3 belong to the high-field site crystal, while the Cr^3＋ ZnO-Al2O3-SiO2 glass and glass-ceramic belong to the weak-field site crystal.展开更多
Fuzziness is one of the general characteristics of human thinking and objective things. Introducing fuzzy techniques into decision-making yields very good results. Fuzzy consistent matrix has many excellent characteri...Fuzziness is one of the general characteristics of human thinking and objective things. Introducing fuzzy techniques into decision-making yields very good results. Fuzzy consistent matrix has many excellent characteristics, especially cen- ter-division transitivity conforming to the reality of the human thinking process in decision-making. This paper presents a new approach for creating fuzzy consistent matrix from mutual supplementary matrix in fuzzy decision-making. At the same time, based on the distance between individual fuzzy consistent matrix and average fuzzy consistent matrix, a kind of combined opera- tion for several fuzzy consistent matrixes is presented which reflects most opinions of experienced experts. Finally, a practical example shows its flexibility and practicability further.展开更多
[Objective] This study aimed to verify the effects of new matrixes on tobacco seedlings on floating platform or field, and their effects on tobacco leaf yield and quality. [Method] The ratio of peat： carbonized rice ...[Objective] This study aimed to verify the effects of new matrixes on tobacco seedlings on floating platform or field, and their effects on tobacco leaf yield and quality. [Method] The ratio of peat： carbonized rice hull： perlite： sand in the four new matrixes was 10∶40∶30∶20, 20∶40∶10∶30, 20∶40∶30∶10 and 20∶50∶10∶20, marked as T1, T2, T3 and T4, respectively. The ratio in control matrix was 35∶40∶25∶0. [Result]In formulas T1, T2, T3 and T4, the peat consumption was reduced by 70.1%,41.5%, 41.5%, and 41.5% respectively, which saved 12.5%, 23.1%, 8.2% and 12.8%of the cost. The new matrixes can effectively increase the seedling emergence rate of tobacco. The quality and duration of seedlings in float system with new matrixes showed no difference from those of control matrix. The values of output using the new matrixes were 323.10, 92.25, 39.30 and 2 250.60 Yuan/hm2higher than that of the control. Besides, the proportion of the first- and second-rate tobacco leaves was also improved. [Conclusion] These four new matrixes can be widely applied to raise seedling in a float system, and T4 is the best choice.展开更多
SiC_(f)/Ti composite owns the attractive advantages of lightweight and excellent high-temperature performance,which make it have great significance to the development of aerospace industry.However,the complicated fabr...SiC_(f)/Ti composite owns the attractive advantages of lightweight and excellent high-temperature performance,which make it have great significance to the development of aerospace industry.However,the complicated fabrication route and novel architecture of SiC_(f)/Ti composite bring about more difficulties for controlling its microstructure.In this work,the method of regulating the structure and performance of the composite matrix by adjusting the characteristics of the precursor wire was explored.The physical vapor deposition(PVD)method was applied to fabricate precursor wires.Ti6242 coatings with bamboo leaf-shaped grains and chrysanthemumshaped grains were deposited on SiC fibers by changing the PVD condition.It is found that the original structure of the Ti6242 coating of precursor wire has significant impact on the microstructure of the composite matrix after hot isostatic pressing(HIP).The matrix transformed from the Ti6242 coating with bamboo leaf-shaped grains exhibits equiaxed grain structure.While the other matrix has a columnar crystal structure,and the inside of the columnar crystal inherits the original chrysanthemum-shaped structure.The columnar crystal matrix has lower hardness and modulus than the equiaxed grain matrix.展开更多
During the process that implant materials are used for bone replacement,the cell responses to implant materials determine the long-term stability of bone replacement.The microstructure of implant materials is consider...During the process that implant materials are used for bone replacement,the cell responses to implant materials determine the long-term stability of bone replacement.The microstructure of implant materials is considered as a critical factor that influences the cell responses.Carbon/Carbon composites(C/C composites)are novel implant materials,but there are few reports on the effect of their microstructure,especially the carbon matrixes and holes,on cell behavior.In this paper,C/C composites with different carbon matrixes are prepared by chemical vapor infiltration and pressure impregnation carbonization technique,respectively.The structure of holes is analyzed.The cell responses to C/C composites with different carbon matrixes are evaluated with MG63 osteoblast-like cells.The morphologies of MG63 osteoblast-like cells on the surface of C/C composites,especially in the holes are assessed by scanning electron microscope,and cell proliferation behavior is evaluated by 3-[4,5-dimethylthiozol-2-yl]-2,5-diphenyltetrazolium bromide(MTT)assay.The results show that MG63 osteoblast-like cells have a lamellar morphology with similar sizes and spreading areas as well as the same proliferation behaviors for C/C composites with different carbon matrixes.Carbon matrix shows unapparent influence on the cell growth behavior.Besides,MG63 osteoblast-like cells have various interactions with the holes of C/C composites.The cells stride over the holes with 6~8μm in size,and connect with each other or grow along the curvature wall of the holes with a size of 30-40μm;the cells present three-dimensional morphologies inside the holes and display circular shapes along the ridge of the holes.Diverse cell-material interactions are found according to the size and position of the holes,which provides theoretical foundation for the microstructure design of clinical C/C composites.展开更多
A method for ranking complementary judgment matrixes with traspezoidal fuzzy numbers based on Hausdorff metric distance and fuzzy compromise decision approach is proposed. With regard to fuzzy number complementary jud...A method for ranking complementary judgment matrixes with traspezoidal fuzzy numbers based on Hausdorff metric distance and fuzzy compromise decision approach is proposed. With regard to fuzzy number complementary judgment matrixes given by a decider group whose members have various weights, the expert＇s information was aggregated first by means of simple weight average（SWA） method and Bonissone calculational method. Hence a matrix including all the experts＇ preference information was got. Then the matrix＇ column members were added up and the fuzzy evaluation values of the alternatives were got. Lastly, the Hausdorff metric distance and fuzzy compromise decision approach were used to rank the fuzzy evaluation values and then the ranking values of all the alternatives were got. Because exact numbers and triangular fuzzy numbers could all be transformed into trapezoidal fuzzy numbers, the method developed can rank complementary judgment matrixes with trapezoidal fuzzy numbers, triangular fuzzy numbers and exact numbers as well. An illustrative example is also given to verify the developed method and to demonstrate its feasibility and practicality.展开更多
The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to...The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to open a new structural subdivision. We have researched types of risks, their identification, classification, and assessment possibilities in activities of small and medium-sized enterprises. We have used our own algorithm of identification, classification, and assessment of enterprises＇ risks. The goal of this research is to study the economic and financial risks＇ impact on small and medium-sized enterprises＇ development in Latvia. For study purpose, we have carried out the questionnaire of representative small and medium-sized enterprises about the economic and financial risks＇ impact on enterprises＇ development in Latvia. We have created classification of Latvian services sectors＇ economic and financial risks in the period from 2011 to 2012. Those risks have been included in the questionnaire. The risks matrix is a quantitative assessment tool of risks. We have created Latvian service sector economic and financial risks matrix. We have arranged risks by their sizes of possible losses for enterprises. For each risk has been assessed its probability of realization. We have created Latvian accommodations （hotel） and food services technological process risks map. Several parts of the risk map （segments） make it possible to assess each type of the risk separately in its segment. Risks matrix can be used to choose enterprises＇ strategy of risk management. Enterprise＇s strategy of risk management is developed by analysing zones of risk level.展开更多
Objective To investigate the regulatory effects of somatostatin (SST) and octreotide (OCT) on the extracellular matrixes (ECM) metabolism of rat hepatic stellate cells (HSCs). Methods Being treated with different conc...Objective To investigate the regulatory effects of somatostatin (SST) and octreotide (OCT) on the extracellular matrixes (ECM) metabolism of rat hepatic stellate cells (HSCs). Methods Being treated with different concentrations of SST or OCT, the mRNA levels of collage type I, III and the expression of collagen, matrix metalloproteinase-1(MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) in activated HSCs were assessed by in situ hybridization (ISH), 3H-proline incorporation and immunocytochemistry, respectively. In addition, levels of hyaluronic acid (HA), laminin (LM), and procollagen type III (PCIII) in the culture supernatant of HSCs were also detected by means of enzyme-linked immunosorbent assay (ELISA). ResultsBoth SST and OCT markedly down-regulated the transcription of collagen type I, III in activated HSCs within the range of 10-6-10-7 mol/L and 10-5-10-7 mol/L, respectively (P<0.05). SST-treated groups of 10-6-10-7 mol/L and OCT-treated groups of 10-5-10-7 mol/L also demonstrated statistically decreased production of collagen, HA, LM, PCIII in a dose-dependent way (P<0.05). Furthermore, HSCs cocultured with SST (10-6 mol/L) or OCT (10-5-10-6 mol/L) exhibited TIMP-1 levels much lower than that of normal control (P<0.05), which resulted in an elevated ratio of MMP/TIMP. Conclusion SST and its analog may play a negative regulatory role in the ECM metabolism of HSCs. Their effect may be benefit for prevention and therapy of hepatic fibrosis.展开更多
基金Supported in part by Natural Science Foundation of Guangxi(2023GXNSFAA026246)in part by the Central Government's Guide to Local Science and Technology Development Fund(GuikeZY23055044)in part by the National Natural Science Foundation of China(62363003)。
文摘In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.
基金supported by the National Natural Science Foundation of China(62376106)The Science and Technology Development Plan of Jilin Province(20250102212JC).
文摘Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes a novel image encryption algorithm specifically designed for grayscale image security.This research introduces a new Cantor diagonal matrix permutation method.The proposed permutation method uses row and column index sequences to control the Cantor diagonal matrix,where the row and column index sequences are generated by a spatiotemporal chaotic system named coupled map lattice(CML).The high initial value sensitivity of the CML system makes the permutation method highly sensitive and secure.Additionally,leveraging fractal theory,this study introduces a chaotic fractal matrix and applies this matrix in the diffusion process.This chaotic fractal matrix exhibits selfsimilarity and irregularity.Using the Cantor diagonal matrix and chaotic fractal matrix,this paper introduces a fast image encryption algorithm involving two diffusion steps and one permutation step.Moreover,the algorithm achieves robust security with only a single encryption round,ensuring high operational efficiency.Experimental results show that the proposed algorithm features an expansive key space,robust security,high sensitivity,high efficiency,and superior statistical properties for the ciphered images.Thus,the proposed algorithm not only provides a practical solution for secure image transmission but also bridges fractal theory with image encryption techniques,thereby opening new research avenues in chaotic cryptography and advancing the development of information security technology.
基金Supported by Russian Science Foundation,No.24-64-00028.
文摘We read with great interest the investigation of Kang et al related the applications of the multiparametric magnetic resonance imaging-based predictive model for assessing chemotherapy efficacy in colorectal cancer patients with gene mutations.The authors focused on decision-making based on the integration of tumor differentiation,signal intensity ratio,margin distance,and magnetic resonance imaging-detected lymph node metastasis.Indeed,these multiparameter predictive models could also be used for diagnosis as an alternative to invasive tissue examination methods.However,progress in this field enables us to shift the paradigm to radiology biopsies,particularly given the nonlinear effects of various radiation sources.
文摘We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-like state withoutapoptosis.The results obtained by the authors highlight the features of theeffects of senescent drift induction in surrounding tissues.In the light of thesefindings,the role of the properties of extracellular matrix and cellular glycocalyxin responses of human tumors to therapy remain uninvestigated.These extracellularbarriers appear to be significant obstacles to effective cancer therapy,especiallyin relation to the use of unique properties of tumor microenvironment forthe immunotherapy-resistant cancer treatment.
基金supported by the National Natural Science Foundation of China(No.41975156)and the Fundamental Research Funds for the Central Universities.
文摘Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.
基金supported by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia(No.451-03-136/2025-03/200135)。
文摘Access to clean drinking water is essential for human health,economic development,and environmental sustain-ability.To effectively preserve water quality and ensure a safe and stable water supply,it is essential to determine the priority control factors of potentially hazardous elements in water.This study focused on public drinking wa-ter fountains in Zaječar City(Serbia),examining water hydrochemistry,quality,potential sources of hazardous elements,and the health risks associated with consumption or dermal exposure.Among all potentially hazardous elements,iron showed a deviation from the limit in drinking water prescribed by the World Health Organization,reaching 631μg/L.However,all samples were categorized as excellent quality for drinking.Water composition was governed by water-rock interactions,distinguishing Na-HCO_(3)as the dominant water type.A total of 3.3%and 6.6%of samples exceeded the threshold of 1 for non-carcinogenic health risk for adults and children,re-spectively,with the mean HIa value of 0.35 and the mean HIc value of 0.57.However,the carcinogenic risk was within the allowable limits for children,whereas it surpassed the threshold of 1.0×10^(–4)for adults in 10%of the samples.The positive matrix factorization model identified four sources responsible for water quality,i.e.,natural source,industrial source,sewage source,and agricultural source,with contributions of 37.1%,35.0%,17.8%,and 10.1%,respectively.The Monte Carlo simulation of source-specific health risks revealed that the industrial source was the main contributor to both non-carcinogenic and carcinogenic risks,attributed to its high arsenic load.
基金supported by the Shenzhen Hong Kong Joint Funding Project,No.SGDX20230116093645007(to LY)the Shenzhen Science and Technology Innovation Committee International Cooperation Project,No.GJHZ20200731095608025(to LY)+7 种基金Shenzhen Development and Reform Commission’s Intelligent Diagnosis,Treatment and Prevention of Adolescent Spinal Health Public Service Platform,No.S2002Q84500835(to LY)Shenzhen Medical Research Fund,No.B2303005(to LY)Team-based Medical Science Research Program,No.2024YZZ02(to LY)Zhejiang Provincial Natural Science Foundation of China,No.LWQ20H170001(to RL)Basic Research Project of Shenzhen Science and Technology from Shenzhen Science and Technology Innovation Commission,No.JCYJ20210324103010029(to BY)Shenzhen Second People’s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project,Nos.2023yjlcyj029(to BY),2023yjlcyj021(to LL)Guangdong Basic and Applied Basic Research Foundation,No.2022A1515110679(to LL)China Postdoctoral Science Foundation,No.2022M722203(to GL).
文摘Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological properties and tissue specificity,highlighting its potential as a biomedical material for the repair of severe peripheral nerve injury;however,its role in modulating neuroinflammation post-peripheral nerve injury remains unknown.Here,we aimed to characterize the anti-inflammatory properties of porcine decellularized nerve matrix hydrogel and their underlying molecular mechanisms.Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel,we evaluated structural and functional recovery,macrophage phenotype alteration,specific cytokine expression,and changes in related signaling molecules in vivo.Similar parameters were evaluated in vitro using monocyte/macrophage cell lines stimulated with lipopolysaccharide and cultured on porcine decellularized nerve matrix hydrogel-coated plates in complete medium.These comprehensive analyses revealed that porcine decellularized nerve matrix hydrogel attenuated the activation of excessive inflammation at the early stage of peripheral nerve injury and increased the proportion of the M2 subtype in monocytes/macrophages.Additionally,porcine decellularized nerve matrix hydrogel negatively regulated the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB axis both in vivo and in vitro.Our findings suggest that the efficacious anti-inflammatory properties of porcine decellularized nerve matrix hydrogel induce M2 macrophage polarization via suppression of the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway,providing new insights into the therapeutic mechanism of porcine decellularized nerve matrix hydrogel in peripheral nerve injury.
基金supported by Natural Science Foundation of Hu'nan Province(2024JJ5409)。
文摘In underwater target search path planning,the accuracy of sonar models directly dictates the accurate assessment of search coverage.In contrast to physics-informed sonar models,traditional geometric sonar models fail to accurately characterize the complex influence of marine environments.To overcome these challenges,we propose an acoustic physics-informed intelligent path planning framework for underwater target search,integrating three core modules:The acoustic-physical modeling module adopts 3D ray-tracing theory and the active sonar equation to construct a physics-driven sonar detection model,explicitly accounting for environmental factors that influence sonar performance across heterogeneous spaces.The hybrid parallel computing module adopts a message passing interface(MPI)/open multi-processing(Open MP)hybrid strategy for large-scale acoustic simulations,combining computational domain decomposition and physics-intensive task acceleration.The search path optimization module adopts the covariance matrix adaptation evolution algorithm to solve continuous optimization problems of heading angles,which ensures maximum search coverage for targets.Largescale experiments conducted in the Pacific and Atlantic Oceans demonstrate the framework's effectiveness:(1)Precise capture of sonar detection range variations from 5.45 km to 50 km in heterogeneous marine environments.(2)Significant speedup of 453.43×for acoustic physics modeling through hybrid parallelization.(3)Notable improvements of 7.23%in detection coverage and 15.86%reduction in optimization time compared to the optimal baseline method.The framework provides a robust solution for underwater search missions in complex marine environments.
基金supported by The National Natural Science Foundation of China(Grant Nos.32120103010,32341045,and 32272729).
文摘In tomato,early fruit development involves rapid cell division and expansion,which are highly dependent on sugar availability(Huang et al.,2025;Yuan et al.,2025).After fruit set,soluble sugars are loaded into pericarp cells through the symplasmic(cytosol)or apoplasmic pathway(cell wall and extracellular matrix)(Patrick and Offler,1996).Sucrose,as the major form of carbon translocated to tomato fruit,can be directly unloaded into fruit cells.However,some sucrose can be hydrolyzed by extracellular invertase,producing glucose and fructose for metabolism and biosynthesis in pericarp cells(Ruan,2014).
文摘Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.
文摘Rheplpgy of castables is greatly affected and controlled by rheological behavior of their matrix. In this work ,the rheological properties of bauxite-based castable matrix have been studied. The effects of super-fine silica and alumina addition , water/ cement ratio, dispersants and bauxite particle-size on viscosity, shear rate and shear stress of the slur-ries have been investigated . Based on these results, the range of optimum composition of the matrix with good rheological behavior has been obtained.
基金This work is financially supported by the Project of Science and Technology of Zhejiang Province (No. 011066)Project of Education Committee of Zhejiang Province (No. 20010231)the Doctoral Science Foundation of Ningbo City (No. 02J20101-12)the Personal Bureau of Ningbo City, China (No. 2002182).
文摘The Cr^3＋：BeAl2O4 crystal, Cr^3＋：LiNbO3 crystal, and ZnO-Al2O3-SiO2 glass-ceramic were obtained by the Czochralski technique, Bridgman method, and melting processing, respectively. The optical absorption and emission spectra of the above Cr^3＋-incorporated solid-state materials were recorded. The technical parameters for growing high-quality Cr^3＋：BeAl2O4 and Cr^3＋：LINbO3 crystals were obtained. The results indicate that the optical absorption and fluorescence spectra of Cr^3＋ show quite a few differences in various matrixes. The sharp line emissions were observed in the Cr^3＋：BeAl2O4 and Cr^3＋：LiNbO3 crystals. The crystal-field parameters （Dq） for Cr^3＋. in different matrixes were calculated from their corresponding spectra. It is indicated that Cr^3＋：BeAl2O4 and Cr^3＋：LiNbO3 belong to the high-field site crystal, while the Cr^3＋ ZnO-Al2O3-SiO2 glass and glass-ceramic belong to the weak-field site crystal.
基金Project (No. 20040335129) supported by the Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) China
文摘Fuzziness is one of the general characteristics of human thinking and objective things. Introducing fuzzy techniques into decision-making yields very good results. Fuzzy consistent matrix has many excellent characteristics, especially cen- ter-division transitivity conforming to the reality of the human thinking process in decision-making. This paper presents a new approach for creating fuzzy consistent matrix from mutual supplementary matrix in fuzzy decision-making. At the same time, based on the distance between individual fuzzy consistent matrix and average fuzzy consistent matrix, a kind of combined opera- tion for several fuzzy consistent matrixes is presented which reflects most opinions of experienced experts. Finally, a practical example shows its flexibility and practicability further.
文摘[Objective] This study aimed to verify the effects of new matrixes on tobacco seedlings on floating platform or field, and their effects on tobacco leaf yield and quality. [Method] The ratio of peat： carbonized rice hull： perlite： sand in the four new matrixes was 10∶40∶30∶20, 20∶40∶10∶30, 20∶40∶30∶10 and 20∶50∶10∶20, marked as T1, T2, T3 and T4, respectively. The ratio in control matrix was 35∶40∶25∶0. [Result]In formulas T1, T2, T3 and T4, the peat consumption was reduced by 70.1%,41.5%, 41.5%, and 41.5% respectively, which saved 12.5%, 23.1%, 8.2% and 12.8%of the cost. The new matrixes can effectively increase the seedling emergence rate of tobacco. The quality and duration of seedlings in float system with new matrixes showed no difference from those of control matrix. The values of output using the new matrixes were 323.10, 92.25, 39.30 and 2 250.60 Yuan/hm2higher than that of the control. Besides, the proportion of the first- and second-rate tobacco leaves was also improved. [Conclusion] These four new matrixes can be widely applied to raise seedling in a float system, and T4 is the best choice.
基金financially supported by the Key Laboratory Foundation of China(No.61429040301)。
文摘SiC_(f)/Ti composite owns the attractive advantages of lightweight and excellent high-temperature performance,which make it have great significance to the development of aerospace industry.However,the complicated fabrication route and novel architecture of SiC_(f)/Ti composite bring about more difficulties for controlling its microstructure.In this work,the method of regulating the structure and performance of the composite matrix by adjusting the characteristics of the precursor wire was explored.The physical vapor deposition(PVD)method was applied to fabricate precursor wires.Ti6242 coatings with bamboo leaf-shaped grains and chrysanthemumshaped grains were deposited on SiC fibers by changing the PVD condition.It is found that the original structure of the Ti6242 coating of precursor wire has significant impact on the microstructure of the composite matrix after hot isostatic pressing(HIP).The matrix transformed from the Ti6242 coating with bamboo leaf-shaped grains exhibits equiaxed grain structure.While the other matrix has a columnar crystal structure,and the inside of the columnar crystal inherits the original chrysanthemum-shaped structure.The columnar crystal matrix has lower hardness and modulus than the equiaxed grain matrix.
基金supported by National Natural Science Foundation of China(Grant No.50972120,Grant No.50902111 and Grant No.51072107)"111"Project of China(Grant No.B08040)
文摘During the process that implant materials are used for bone replacement,the cell responses to implant materials determine the long-term stability of bone replacement.The microstructure of implant materials is considered as a critical factor that influences the cell responses.Carbon/Carbon composites(C/C composites)are novel implant materials,but there are few reports on the effect of their microstructure,especially the carbon matrixes and holes,on cell behavior.In this paper,C/C composites with different carbon matrixes are prepared by chemical vapor infiltration and pressure impregnation carbonization technique,respectively.The structure of holes is analyzed.The cell responses to C/C composites with different carbon matrixes are evaluated with MG63 osteoblast-like cells.The morphologies of MG63 osteoblast-like cells on the surface of C/C composites,especially in the holes are assessed by scanning electron microscope,and cell proliferation behavior is evaluated by 3-[4,5-dimethylthiozol-2-yl]-2,5-diphenyltetrazolium bromide(MTT)assay.The results show that MG63 osteoblast-like cells have a lamellar morphology with similar sizes and spreading areas as well as the same proliferation behaviors for C/C composites with different carbon matrixes.Carbon matrix shows unapparent influence on the cell growth behavior.Besides,MG63 osteoblast-like cells have various interactions with the holes of C/C composites.The cells stride over the holes with 6~8μm in size,and connect with each other or grow along the curvature wall of the holes with a size of 30-40μm;the cells present three-dimensional morphologies inside the holes and display circular shapes along the ridge of the holes.Diverse cell-material interactions are found according to the size and position of the holes,which provides theoretical foundation for the microstructure design of clinical C/C composites.
文摘A method for ranking complementary judgment matrixes with traspezoidal fuzzy numbers based on Hausdorff metric distance and fuzzy compromise decision approach is proposed. With regard to fuzzy number complementary judgment matrixes given by a decider group whose members have various weights, the expert＇s information was aggregated first by means of simple weight average（SWA） method and Bonissone calculational method. Hence a matrix including all the experts＇ preference information was got. Then the matrix＇ column members were added up and the fuzzy evaluation values of the alternatives were got. Lastly, the Hausdorff metric distance and fuzzy compromise decision approach were used to rank the fuzzy evaluation values and then the ranking values of all the alternatives were got. Because exact numbers and triangular fuzzy numbers could all be transformed into trapezoidal fuzzy numbers, the method developed can rank complementary judgment matrixes with trapezoidal fuzzy numbers, triangular fuzzy numbers and exact numbers as well. An illustrative example is also given to verify the developed method and to demonstrate its feasibility and practicality.
文摘The enterprises need to assess the risk dynamic of financial instability and its impact on small and medium-sized enterprises＇ development, because it is important for enterprises to extend commercial activity and to open a new structural subdivision. We have researched types of risks, their identification, classification, and assessment possibilities in activities of small and medium-sized enterprises. We have used our own algorithm of identification, classification, and assessment of enterprises＇ risks. The goal of this research is to study the economic and financial risks＇ impact on small and medium-sized enterprises＇ development in Latvia. For study purpose, we have carried out the questionnaire of representative small and medium-sized enterprises about the economic and financial risks＇ impact on enterprises＇ development in Latvia. We have created classification of Latvian services sectors＇ economic and financial risks in the period from 2011 to 2012. Those risks have been included in the questionnaire. The risks matrix is a quantitative assessment tool of risks. We have created Latvian service sector economic and financial risks matrix. We have arranged risks by their sizes of possible losses for enterprises. For each risk has been assessed its probability of realization. We have created Latvian accommodations （hotel） and food services technological process risks map. Several parts of the risk map （segments） make it possible to assess each type of the risk separately in its segment. Risks matrix can be used to choose enterprises＇ strategy of risk management. Enterprise＇s strategy of risk management is developed by analysing zones of risk level.
基金the Scientific and Technological Committee of Shanghai (974119003)
文摘Objective To investigate the regulatory effects of somatostatin (SST) and octreotide (OCT) on the extracellular matrixes (ECM) metabolism of rat hepatic stellate cells (HSCs). Methods Being treated with different concentrations of SST or OCT, the mRNA levels of collage type I, III and the expression of collagen, matrix metalloproteinase-1(MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) in activated HSCs were assessed by in situ hybridization (ISH), 3H-proline incorporation and immunocytochemistry, respectively. In addition, levels of hyaluronic acid (HA), laminin (LM), and procollagen type III (PCIII) in the culture supernatant of HSCs were also detected by means of enzyme-linked immunosorbent assay (ELISA). ResultsBoth SST and OCT markedly down-regulated the transcription of collagen type I, III in activated HSCs within the range of 10-6-10-7 mol/L and 10-5-10-7 mol/L, respectively (P<0.05). SST-treated groups of 10-6-10-7 mol/L and OCT-treated groups of 10-5-10-7 mol/L also demonstrated statistically decreased production of collagen, HA, LM, PCIII in a dose-dependent way (P<0.05). Furthermore, HSCs cocultured with SST (10-6 mol/L) or OCT (10-5-10-6 mol/L) exhibited TIMP-1 levels much lower than that of normal control (P<0.05), which resulted in an elevated ratio of MMP/TIMP. Conclusion SST and its analog may play a negative regulatory role in the ECM metabolism of HSCs. Their effect may be benefit for prevention and therapy of hepatic fibrosis.
