The growing demand for seafood safety necessitates smart sensors with real-time monitoring capability for the biomarker triethylamine(TEA).However,it still faces tremendous challenges due to the limited sensitivity an...The growing demand for seafood safety necessitates smart sensors with real-time monitoring capability for the biomarker triethylamine(TEA).However,it still faces tremendous challenges due to the limited sensitivity and selectivity of the sensing material.This study develops a topological transformation from a Ru-MIL-68 precursor to a Ru-doped In_(2)O_(3)hollow hexagonal prism.These structural merits,including hierarchical porosity,uniform Ru dispersion,and abundant oxygen vacancies,endow this material with enhanced gas adsorption-diffusion kinetics and surface reactivity.The optimized Ru-In_(2)O_(3)-0.8 sensor exhibits exceptional TEA sensing performance:ultrahigh response(R_(a)/R_(g)=493-100 ppm),fast recovery(τ_(rec)=22 s),and a low detection limit(LOD=11.3 ppb).Density functional theory calculations delineate that TEA binds preferentially to the Ru-In_(2)O_(3)surface with a much larger adsorption energy than that of TEA on bare In_(2)O_(3)or other gas molecules on Ru-In_(2)O_(3),supporting the enhanced sensitivity and selectivity achieved by introducing Ru.Furthermore,a smart gas sensing system based on the Ru-In_(2)O_(3)-0.8 material demonstrates a real-time half-fin anchovy freshness monitoring application on mobile phones.This work not only proposes the structural modulations for exploration of advanced sensing materials but also guides the potential for real-time analysis,monitoring and diagnosis.展开更多
The development of genomic sequencing technology,from conventional techniques to state-of-the-art inventions,has greatly improved our understanding of genetic material.This review examines important advancements in se...The development of genomic sequencing technology,from conventional techniques to state-of-the-art inventions,has greatly improved our understanding of genetic material.This review examines important advancements in sequencing techniques and how they have revolutionized genomics research.Highthroughput capabilities made possible by next-generation sequencing(NGS)have enabled quick and affordable genomic analysis.Digital gene expression profiling was made possible by methods such as serial analysis of gene expression(SAGE),whereas long-read capabilities without amplification were analyzed by single-molecule sequencing,as demonstrated by Oxford Nanopore’s nanopore-based sequencing and PacBio’s single-molecule real-time(SMRT)technology.Synthetic long-read sequencing is one example of a hybrid technique that enhances genome assembly.New techniques,such as epigenetic sequencing,have revealed that DNA alterations are essential for gene control,and spatial transcriptomics has connected gene expression to tissue-specific patterns.Target analysis and knowledge of microbial ecosystems were further enhanced via the use of sophisticated techniques,including metagenomics and CRISPRCas9-based sequencing.When combined,these techniques allow researchers to examine microbial communities,transcriptome diversity,genomic structure,and epigenetic changes with new clarity.For example,single-cell sequencing has shown molecular heterogeneity between cells,and long-read sequencing has revealed intricate isoform variants.Personalized medicine has advanced owing to spatial transcriptomics,which targets gene expression in specific organs.Digital sequencing has also improved the sensitivity of mutation identification,transforming the diagnosis of the disease.The convergence of sequencing technologies has ushered in a new era of genomic studies,opening the door to groundbreaking findings in ecology,biology,and medicine.Future developments will improve knowledge of human genetics by further improving sequencing accuracy,affordability,and applicability.展开更多
基金financial support from the National Natural Science Foundation of China(grant No.22271036)the Natural Science Foundation of Liaoning Province of China(No.2024-MSBA-17 and 2023-MSBA-012)+3 种基金the Fundamental Research Funds for the Central Universities of China(DUT24MS012 and DUT25Z2764)the Health Development Promotion Project-Spark Program Research Project(XHJH-0092)the Open Research Fund of Guangdong Advanced Carbon Materials Co.,Ltd(Kargen-2024B0802)Dalian Handisen Electronic Technology Co.,Ltd..
文摘The growing demand for seafood safety necessitates smart sensors with real-time monitoring capability for the biomarker triethylamine(TEA).However,it still faces tremendous challenges due to the limited sensitivity and selectivity of the sensing material.This study develops a topological transformation from a Ru-MIL-68 precursor to a Ru-doped In_(2)O_(3)hollow hexagonal prism.These structural merits,including hierarchical porosity,uniform Ru dispersion,and abundant oxygen vacancies,endow this material with enhanced gas adsorption-diffusion kinetics and surface reactivity.The optimized Ru-In_(2)O_(3)-0.8 sensor exhibits exceptional TEA sensing performance:ultrahigh response(R_(a)/R_(g)=493-100 ppm),fast recovery(τ_(rec)=22 s),and a low detection limit(LOD=11.3 ppb).Density functional theory calculations delineate that TEA binds preferentially to the Ru-In_(2)O_(3)surface with a much larger adsorption energy than that of TEA on bare In_(2)O_(3)or other gas molecules on Ru-In_(2)O_(3),supporting the enhanced sensitivity and selectivity achieved by introducing Ru.Furthermore,a smart gas sensing system based on the Ru-In_(2)O_(3)-0.8 material demonstrates a real-time half-fin anchovy freshness monitoring application on mobile phones.This work not only proposes the structural modulations for exploration of advanced sensing materials but also guides the potential for real-time analysis,monitoring and diagnosis.
文摘The development of genomic sequencing technology,from conventional techniques to state-of-the-art inventions,has greatly improved our understanding of genetic material.This review examines important advancements in sequencing techniques and how they have revolutionized genomics research.Highthroughput capabilities made possible by next-generation sequencing(NGS)have enabled quick and affordable genomic analysis.Digital gene expression profiling was made possible by methods such as serial analysis of gene expression(SAGE),whereas long-read capabilities without amplification were analyzed by single-molecule sequencing,as demonstrated by Oxford Nanopore’s nanopore-based sequencing and PacBio’s single-molecule real-time(SMRT)technology.Synthetic long-read sequencing is one example of a hybrid technique that enhances genome assembly.New techniques,such as epigenetic sequencing,have revealed that DNA alterations are essential for gene control,and spatial transcriptomics has connected gene expression to tissue-specific patterns.Target analysis and knowledge of microbial ecosystems were further enhanced via the use of sophisticated techniques,including metagenomics and CRISPRCas9-based sequencing.When combined,these techniques allow researchers to examine microbial communities,transcriptome diversity,genomic structure,and epigenetic changes with new clarity.For example,single-cell sequencing has shown molecular heterogeneity between cells,and long-read sequencing has revealed intricate isoform variants.Personalized medicine has advanced owing to spatial transcriptomics,which targets gene expression in specific organs.Digital sequencing has also improved the sensitivity of mutation identification,transforming the diagnosis of the disease.The convergence of sequencing technologies has ushered in a new era of genomic studies,opening the door to groundbreaking findings in ecology,biology,and medicine.Future developments will improve knowledge of human genetics by further improving sequencing accuracy,affordability,and applicability.
