SINGULUS MASTERING BV于2004 年7月1 5日庆祝其的新厂房落成,Si ngulu s Technology的CE0 Roland Lacher邀请业内人士参加新工程落成的庆典活动.在该庆典活动中,来自美国的Paul West将介绍Universal Music的发展情况,Philips公司也将...SINGULUS MASTERING BV于2004 年7月1 5日庆祝其的新厂房落成,Si ngulu s Technology的CE0 Roland Lacher邀请业内人士参加新工程落成的庆典活动.在该庆典活动中,来自美国的Paul West将介绍Universal Music的发展情况,Philips公司也将演示新一代的光存储产品B l u-R a y,在庆典结束后,所有与会人员还将参观工厂的各种设施.展开更多
A Zimbabwean student devotes his heart and soul to learning one of China’s oldest plucked string instruments Michael Mubaiwa, a 24-year-old Zimbabwean student, received the grand prize in the 2021 China-Africa Video ...A Zimbabwean student devotes his heart and soul to learning one of China’s oldest plucked string instruments Michael Mubaiwa, a 24-year-old Zimbabwean student, received the grand prize in the 2021 China-Africa Video and Photo Competition last October. By displaying his amazing guqin experience, he won the hearts of both the audience and the jury.展开更多
At 82,master craftsman Zhu Bingren,China’s preeminent copper artist,continues to dynamically evolve his ancient heritage,proving that true preservation lies in innovation and bringing tradition into the contemporary ...At 82,master craftsman Zhu Bingren,China’s preeminent copper artist,continues to dynamically evolve his ancient heritage,proving that true preservation lies in innovation and bringing tradition into the contemporary world.THE copper art should not be confined to display cases,believes artist Zhu Bingren.From living rooms to fashion runways,and from the Great Wall in Beijing to the Louvre in Paris,the Chinese master craftsman brings his metal creations to life in diverse settings.展开更多
Confucius was born in the state of Lu,the cultural exemplar of ritual propriety and music during the Zhou Dynasty period.Immersed in this rich cultural environment,the young Confucius enjoyed laying out cups and bowls...Confucius was born in the state of Lu,the cultural exemplar of ritual propriety and music during the Zhou Dynasty period.Immersed in this rich cultural environment,the young Confucius enjoyed laying out cups and bowls fashioned from clay on a table,pretending to officiate at mock rituals.Confucius’early life laid the groundwork for his future development as a master of ritual propriety and music and the founder of the influential Confucian school.展开更多
目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分...目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分别采用Pentacam和IOL Master检查。采集的数据包括:由Pentacam测量的Sim K、角膜中央1.0~7.0 mm直径EKR(Holladay equivalent K reading)、TNP(True net power)和由IOL Master测量的Km,将不同的K值分别联合4种IOL计算公式(SRK/T、Hoffer Q、Haigis和Holladay I)计算每种K值的IOL度数。测量患者术后3个月术眼验光结果,根据验光结果计算各种K值的屈光预测误差(ME)和平均绝对预测误差(MAE)。采用重复测量方差分析比较两种仪器所测K值联合各计算公式计算IOL屈光预测误差之间的差异。结果两种仪器所测不同K值联合四种IOL计算公式的MAE比较,IOL Master测量所得Km值MAE最小,分别为:SRK/T公式:(0.61±0.51)D、Hoffer Q公式(0.59±0.44)D、Haigis公式:(0.80±0.86)D及Holladay I公式(0.6±0.46)D,Pentacam测量所得Sim K值MAE次之,7.0 mm EKR值MAE最大。在1.0~7.0 mm EKR值的MAE比较,3.0 mm EKR值MAE最小。结论在角膜形态正常白内障患者中,应用Pentacam测量所得K值相对IOL Master测量所得Km值不能提高IOL屈光力计算的准确性。展开更多
Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and trans...Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and transcriptional regulatory networks(TRN)inherent in TNBC samples.Methods:We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas(TCGA)to compare triple-positive breast cancer(TPBC)with TNBC.TRN algorithms and virtual inference of protein-enriched regulon(VIPER)were used to identify master regulators and their target genes.Utilizing TNBC cells(MDA-MB-231 and MDA-MB-468),we validated the relationship of nuclear factor erythroid 2-like 3(NFE2L3)and basic helix-loop-helix family member E 40(BHLHE40)by performing a luciferase assay.The expression levels of these targets were measured after transfections with plasmid and siRNA via qRT-PCR and western blots.The effect of these genes on cell proliferation and migration was studied using phenotypic assays.Results:Using computational approaches,we identified NFE2L3 as a master regulator with BHLHE40 as its target gene.NFE2L3 protein binds to the promoter region of BHLHE40 and regulates its transcriptional activity.Additionally,silencing and overexpressing NFE2L3 and BHLHE40 in TNBC cell lines MDA-MB-231 and MDA-MB-468 showed that NFE2L3 directly regulates BHLHE40 at both transcriptional and translational levels.We found that BHLHE40 requires NFE2L3 for cell proliferation and migration in TNBC.Conclusion:These findings underscore the significance of NFE2L3 and BHLHE40 in TNBC,highlighting NFE2L3’s role in regulating the oncogenic activity of BHLHE40 in TNBC cells.展开更多
Jiang Zemin, Chairman of thePRC Central Military Commis-sion, said when he receivedofficers above division com-mander level of the army sta-tioned in Chongqing, "It wasn’teasy for Zhang Ke, as a woman,to gain he...Jiang Zemin, Chairman of thePRC Central Military Commis-sion, said when he receivedofficers above division com-mander level of the army sta-tioned in Chongqing, "It wasn’teasy for Zhang Ke, as a woman,to gain her Master’s degree andget her commission as a deputyregimental commander in acombat troop."展开更多
Modern approach to mastering 300 basic characters.A unique cartoon drawing for each character aids recollection.The formation of each character is learnt by the novel method of listening to and repeating a catchphrase...Modern approach to mastering 300 basic characters.A unique cartoon drawing for each character aids recollection.The formation of each character is learnt by the novel method of listening to and repeating a catchphrase.Pupils on average learn each character within 5 minutes.展开更多
法国远东学院的著名学者 Michela Bussotti(米盖拉)研究员和 Fran?ois Lachaud 研究员共同主编的Mastering Languages, Taming the World: The Production and Circulation of European Dictionaries and Lexicons of Asian Languages (...法国远东学院的著名学者 Michela Bussotti(米盖拉)研究员和 Fran?ois Lachaud 研究员共同主编的Mastering Languages, Taming the World: The Production and Circulation of European Dictionaries and Lexicons of Asian Languages (16th–19th Centuries)(《掌握语言 走向世界:16 —19 世纪欧洲和亚洲语言的词表和词典的生产与流通》)2023年由école fran?aise d’Extrême-Orient(法国东方外语学院)出版,全书共504页。展开更多
无人机技术的发展,为工程土方测量开辟了新思路。针对传统测量方法的弊端,以上海交通大学医学院浦东校区工程(标段二)为背景,阐述采用无人机倾斜摄影测量技术开展土方测量的应用全过程。利用无人机倾斜摄影测量技术对项目土石方阶段场...无人机技术的发展,为工程土方测量开辟了新思路。针对传统测量方法的弊端,以上海交通大学医学院浦东校区工程(标段二)为背景,阐述采用无人机倾斜摄影测量技术开展土方测量的应用全过程。利用无人机倾斜摄影测量技术对项目土石方阶段场地数据进行采集,通过Context Capture Center Master软件进行数据处理,生成项目的场地数字表面模型(DSM);对土方量进行测算并与实际开挖量进行对比,通过差值比例验证土方量的测算精度,证实采用无人机倾斜摄影实景三维建模进行土方测量的可行性。展开更多
Based on thermodynamic calculations and continuous rheological extrusion(CRE)technology,Al-Ti-V-B master alloys were designed and prepared.The morphology and the distribution of the refined phases in the master alloys...Based on thermodynamic calculations and continuous rheological extrusion(CRE)technology,Al-Ti-V-B master alloys were designed and prepared.The morphology and the distribution of the refined phases in the master alloys were analyzed by XRD,SEM,and TEM.The effects of master alloy addition and holding time on the microstructure and mechanical properties of A356 alloy were investigated.Under the optimum refiner addition of 0.3wt.%and the holding time of 20 min,the average grain size of the refined A356 alloy is 151.8±9.11μm,89.62%lower than that of original A356 alloy.The tensile strength and elongation of as-cast A356refined alloy are 196.11 MPa and 5.75%,respectively.After T6 treatment,the tensile strength and elongation of A356 refined alloy are 290.1 MPa and 3.09%,respectively.The fracture morphology is characterized by a predominance of along-crystal fracture with a small amount of through-crystal fracture,attributed to the refined grains.Finer grains promote crack path deflection and localized plastic deformation,enhancing energy dissipation and reducing the tendency for brittle fracture.This study provides a novel approach to improving the mechanical properties of A356 alloy through grain refinement using CRE Al-Ti-V-B master alloy.展开更多
文摘SINGULUS MASTERING BV于2004 年7月1 5日庆祝其的新厂房落成,Si ngulu s Technology的CE0 Roland Lacher邀请业内人士参加新工程落成的庆典活动.在该庆典活动中,来自美国的Paul West将介绍Universal Music的发展情况,Philips公司也将演示新一代的光存储产品B l u-R a y,在庆典结束后,所有与会人员还将参观工厂的各种设施.
文摘A Zimbabwean student devotes his heart and soul to learning one of China’s oldest plucked string instruments Michael Mubaiwa, a 24-year-old Zimbabwean student, received the grand prize in the 2021 China-Africa Video and Photo Competition last October. By displaying his amazing guqin experience, he won the hearts of both the audience and the jury.
文摘At 82,master craftsman Zhu Bingren,China’s preeminent copper artist,continues to dynamically evolve his ancient heritage,proving that true preservation lies in innovation and bringing tradition into the contemporary world.THE copper art should not be confined to display cases,believes artist Zhu Bingren.From living rooms to fashion runways,and from the Great Wall in Beijing to the Louvre in Paris,the Chinese master craftsman brings his metal creations to life in diverse settings.
文摘Confucius was born in the state of Lu,the cultural exemplar of ritual propriety and music during the Zhou Dynasty period.Immersed in this rich cultural environment,the young Confucius enjoyed laying out cups and bowls fashioned from clay on a table,pretending to officiate at mock rituals.Confucius’early life laid the groundwork for his future development as a master of ritual propriety and music and the founder of the influential Confucian school.
文摘目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分别采用Pentacam和IOL Master检查。采集的数据包括:由Pentacam测量的Sim K、角膜中央1.0~7.0 mm直径EKR(Holladay equivalent K reading)、TNP(True net power)和由IOL Master测量的Km,将不同的K值分别联合4种IOL计算公式(SRK/T、Hoffer Q、Haigis和Holladay I)计算每种K值的IOL度数。测量患者术后3个月术眼验光结果,根据验光结果计算各种K值的屈光预测误差(ME)和平均绝对预测误差(MAE)。采用重复测量方差分析比较两种仪器所测K值联合各计算公式计算IOL屈光预测误差之间的差异。结果两种仪器所测不同K值联合四种IOL计算公式的MAE比较,IOL Master测量所得Km值MAE最小,分别为:SRK/T公式:(0.61±0.51)D、Hoffer Q公式(0.59±0.44)D、Haigis公式:(0.80±0.86)D及Holladay I公式(0.6±0.46)D,Pentacam测量所得Sim K值MAE次之,7.0 mm EKR值MAE最大。在1.0~7.0 mm EKR值的MAE比较,3.0 mm EKR值MAE最小。结论在角膜形态正常白内障患者中,应用Pentacam测量所得K值相对IOL Master测量所得Km值不能提高IOL屈光力计算的准确性。
文摘Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and transcriptional regulatory networks(TRN)inherent in TNBC samples.Methods:We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas(TCGA)to compare triple-positive breast cancer(TPBC)with TNBC.TRN algorithms and virtual inference of protein-enriched regulon(VIPER)were used to identify master regulators and their target genes.Utilizing TNBC cells(MDA-MB-231 and MDA-MB-468),we validated the relationship of nuclear factor erythroid 2-like 3(NFE2L3)and basic helix-loop-helix family member E 40(BHLHE40)by performing a luciferase assay.The expression levels of these targets were measured after transfections with plasmid and siRNA via qRT-PCR and western blots.The effect of these genes on cell proliferation and migration was studied using phenotypic assays.Results:Using computational approaches,we identified NFE2L3 as a master regulator with BHLHE40 as its target gene.NFE2L3 protein binds to the promoter region of BHLHE40 and regulates its transcriptional activity.Additionally,silencing and overexpressing NFE2L3 and BHLHE40 in TNBC cell lines MDA-MB-231 and MDA-MB-468 showed that NFE2L3 directly regulates BHLHE40 at both transcriptional and translational levels.We found that BHLHE40 requires NFE2L3 for cell proliferation and migration in TNBC.Conclusion:These findings underscore the significance of NFE2L3 and BHLHE40 in TNBC,highlighting NFE2L3’s role in regulating the oncogenic activity of BHLHE40 in TNBC cells.
文摘Jiang Zemin, Chairman of thePRC Central Military Commis-sion, said when he receivedofficers above division com-mander level of the army sta-tioned in Chongqing, "It wasn’teasy for Zhang Ke, as a woman,to gain her Master’s degree andget her commission as a deputyregimental commander in acombat troop."
文摘Modern approach to mastering 300 basic characters.A unique cartoon drawing for each character aids recollection.The formation of each character is learnt by the novel method of listening to and repeating a catchphrase.Pupils on average learn each character within 5 minutes.
文摘法国远东学院的著名学者 Michela Bussotti(米盖拉)研究员和 Fran?ois Lachaud 研究员共同主编的Mastering Languages, Taming the World: The Production and Circulation of European Dictionaries and Lexicons of Asian Languages (16th–19th Centuries)(《掌握语言 走向世界:16 —19 世纪欧洲和亚洲语言的词表和词典的生产与流通》)2023年由école fran?aise d’Extrême-Orient(法国东方外语学院)出版,全书共504页。
文摘无人机技术的发展,为工程土方测量开辟了新思路。针对传统测量方法的弊端,以上海交通大学医学院浦东校区工程(标段二)为背景,阐述采用无人机倾斜摄影测量技术开展土方测量的应用全过程。利用无人机倾斜摄影测量技术对项目土石方阶段场地数据进行采集,通过Context Capture Center Master软件进行数据处理,生成项目的场地数字表面模型(DSM);对土方量进行测算并与实际开挖量进行对比,通过差值比例验证土方量的测算精度,证实采用无人机倾斜摄影实景三维建模进行土方测量的可行性。
基金supported by the National Key Research and Development Program of China (Grant No.2022YFB3706801)the National Natural Science Foundation of China (Grant Nos.U2341253,52371019,U2241232)+2 种基金the Dalian High-level Talents Innovation Support Program (Grant No.2021RD06)the Applied Basic Research Program of Liaoning Province (Grant No.2022JH2/101300003)the Natural Science Foundation of Liaoning Province (Grant Nos.2022-BS-262,JYTMS20230031)。
文摘Based on thermodynamic calculations and continuous rheological extrusion(CRE)technology,Al-Ti-V-B master alloys were designed and prepared.The morphology and the distribution of the refined phases in the master alloys were analyzed by XRD,SEM,and TEM.The effects of master alloy addition and holding time on the microstructure and mechanical properties of A356 alloy were investigated.Under the optimum refiner addition of 0.3wt.%and the holding time of 20 min,the average grain size of the refined A356 alloy is 151.8±9.11μm,89.62%lower than that of original A356 alloy.The tensile strength and elongation of as-cast A356refined alloy are 196.11 MPa and 5.75%,respectively.After T6 treatment,the tensile strength and elongation of A356 refined alloy are 290.1 MPa and 3.09%,respectively.The fracture morphology is characterized by a predominance of along-crystal fracture with a small amount of through-crystal fracture,attributed to the refined grains.Finer grains promote crack path deflection and localized plastic deformation,enhancing energy dissipation and reducing the tendency for brittle fracture.This study provides a novel approach to improving the mechanical properties of A356 alloy through grain refinement using CRE Al-Ti-V-B master alloy.
