机器人加工是航天复杂舱段内腔加工的有效手段。针对部分狭窄深腔舱段的加工需求,需在机器人末端附加延长杆以提升操作可达性。然而,延长杆在拓展加工覆盖范围的同时,会增大系统动柔度,极易引发加工颤振,进而影响加工质量与效率。为此,...机器人加工是航天复杂舱段内腔加工的有效手段。针对部分狭窄深腔舱段的加工需求,需在机器人末端附加延长杆以提升操作可达性。然而,延长杆在拓展加工覆盖范围的同时,会增大系统动柔度,极易引发加工颤振,进而影响加工质量与效率。为此,本文提出一种变频可调式调谐质量阻尼器(Tuned mass damper,TMD)的结构设计与参数优化方法,建立了集成调谐质量阻尼器与机器人加工系统的动力学模型。该方法基于偏心曲柄滑块机构实现频率可调,根据电涡流阻尼原理完成阻尼参数调控。进一步开展机器人加工系统动柔度控制试验,结果表明,本文所提方法可使末端动柔度峰值降低67.8%,显著提升加工稳定性边界。展开更多
In performance-based architectural design optimization, the design of building massings and façades is commonly separated, which weakens the effectiveness in performance improvement. In response, this study propo...In performance-based architectural design optimization, the design of building massings and façades is commonly separated, which weakens the effectiveness in performance improvement. In response, this study proposes a hybrid massing-façade integrated design generation and optimization workflow to integrate the two elements in an evolutionary design process. Compared with the existing approaches, the proposed workflow emphasizes the diversity of building design generation, with which various combinations of building massing forms and façade patterns can be systematically explored. Two case studies and a corresponding comparison study are presented to demonstrate the efficacy of the proposed workflow. Results show that the optimization can produce designs coupling the potential of building massings and façades in performance improvement. In addition, the optimization can provide information that supports early-stage architectural design exploration. Such information also enables the architect to understand the performance implications associated with the synergy of building massing and façade design.展开更多
In the past decade,there has been an increasing recognition of the role of computational design optimization in early-stage performance-based architectural design exploration.However,it remains challenging for designe...In the past decade,there has been an increasing recognition of the role of computational design optimization in early-stage performance-based architectural design exploration.However,it remains challenging for designers to apply such optimization-based design explorations in practice.To address this issue,this paper introduces a design tool,called EvoMass,and an associated design method that facilitates design exploration for building massing typologies in performance-based design tasks.EvoMass is capable of offering architects design options reflecting performance-related building massing typologies for the design task,without necessitating advanced computational design skills.More importantly,it can provide architects with insights into the underlying performance implications,thereby enhancing early-stage performance-based design exploration.EvoMass and its associated design method overcome the limitation in the conventional typology-first-optimization-second design procedure adopted by most existing tools,and it promotes a typology-oriented design exploration method of using computational optimization in performance-based architectural design.To demonstrate the efficacy of EvoMass,case studies derived from architectural design studio tasks,incorporating daylighting,solar exposure,and subjective design intents,and the result of a user survey are presented,which highlights how EvoMass and the performance-based design optimization and exploration can enable architects to achieve a more performance-aware design.展开更多
The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of ris...The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.展开更多
Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with tran...Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with trans-scleral excision and antiinflammatory therapy,preserving functional vision.展开更多
Rationale:Infected urinomas are rare complications of urinary tract obstruction and may mimic renal abscess or pyonephrosis.Presentation as a palpable flank mass is highly unusual.Patient’s concern:An 84-year-old man...Rationale:Infected urinomas are rare complications of urinary tract obstruction and may mimic renal abscess or pyonephrosis.Presentation as a palpable flank mass is highly unusual.Patient’s concern:An 84-year-old man with fever,flank pain,and a firm right flank mass.Imaging revealed an acute multiloculated infected urinoma communicating with the proximal ureter,associated with a ureteric calculus.Diagnosis:Infected urinoma.Interventions:He was treated with antibiotics,percutaneous drainage,and nephrostomy.Outcomes:Recurrence occurred three months later due to unresolved obstruction,requiring repeat drainage.Definitive surgical management was deferred due to advanced age and comorbidities,highlighting challenges in high-risk patients.Lessons:This case highlights the importance of considering urinoma in the differential diagnosis of flank masses,the complementary roles of multimodal imaging for accurate diagnosis,and the importance of definitive management of urinary obstruction to prevent recurrence.展开更多
This study investigates catalytic tar cracking over semi-coke catalysts,addressing reaction kinetics challenges by integrating experimental data with a COMSOL Multiphysics model.A multi-physics framework combines cata...This study investigates catalytic tar cracking over semi-coke catalysts,addressing reaction kinetics challenges by integrating experimental data with a COMSOL Multiphysics model.A multi-physics framework combines catalysis,carbon deposition,and self-consumption to analyze toluene(tar model compound)removal.The model evaluates intrinsic catalytic activity,porosity evolution,and porous media flow,revealing that toluene conversion is governed by diffusion/convective mass transfer,homogeneous reactions,and surface reactions influenced by dynamic carbon deposition/removal.Increasing temperature from 973 to 1173 K enhances gas-film heat and mass transfer coefficient,accelerating tar cracking rates and extending catalyst lifetime.Elevated temperatures improve gas-solid phase heat/mass transfer,promoting efficient tar removal during syngas purification.The results highlight the interplay between reaction kinetics,carbon deposition dynamics,and transport phenomena in optimizing semi-coke catalyst performance under high-temperature conditions.展开更多
AIM:To investigate the causal effect of obesity on cataract risk and explores the potential mediating roles of metabolites using Mendelian randomization(MR).METHODS:Summary-level data from large-scale genome-wide asso...AIM:To investigate the causal effect of obesity on cataract risk and explores the potential mediating roles of metabolites using Mendelian randomization(MR).METHODS:Summary-level data from large-scale genome-wide association studies to examine the relationship between obesity and cataract were utilized.Obesity-related traits,including body mass index(BMI),waist-to-hip ratio(WHR),and waist circumference(WC).A two-sample MR approach was employed to assess the causal effect of obesity on cataract risk,while potential mediators were identified from suitable genome-wide association studies(GWAS)datasets.Additionally,a metabolic pathway analysis was conducted.RESULTS:An increase of 1 standard deviation(SD)in BMI,WHR,and WC was associated with a significantly higher risk of cataract(BMI:odds ratio(OR)1.0017,95%confidence interval(CI):1.0001-1.0032,P=0.0320;WHR:OR 1.0029,95%CI:1.0006-1.0051,P=0.0129;WC:OR 1.0020,95%CI:1.0001-1.0038,P=0.0390].These associations remained robust after adjusting for confounding factors in multivariable MR analysis.Furthermore,a two-step MR analysis identified eight potential metabolic mediators,with one mediator showing a significant causal role in the relationship between obesity and cataract.CONCLUSION:This work highlights the importance of addressing obesity as a modifiable risk factor for cataracts,particularly through metabolic pathways.展开更多
Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monito...Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.展开更多
Mass wasting is globally recognized as a key geomorphic agent in permanent gully expansion and greatly contributes to watershed sediment losses.Though its formation process has been assessed by some physical models,th...Mass wasting is globally recognized as a key geomorphic agent in permanent gully expansion and greatly contributes to watershed sediment losses.Though its formation process has been assessed by some physical models,the occurrence and rainfall threshold have been rarely documented.In this study,rainfall-induced mass wasting events in two permanent gullies located in the Mollisols region of Northeast China,with Mollisols(gully 1)and sandy soil(gully 2)underneath were observed,and their differences were explored based on their soil strengths,hydraulic properties,excess topographies,and theoretical rainfall amounts.The sandy soil had a higher strength,faster pore water pressure dissipation rate,and lower suction stress at a specific soil moisture content compared to the black soil.The erosion thickness of the gully bed and sidewalls in gully 1 was shallower compared to gully 2.This was confirmed by the relationship between the erosion thickness and excess topography.The differences in the mass wasting erosion of the gully bed and sidewalls were due to the higher shear strength and well-drained hydraulic properties of the sandy soil compared to the black-soil.An infinite model was chosen to examine the temporal order of the mass wasting in the two gullies.It was found that the mass wasting in gully 2 occurred earlier than that in gully 1.This was likely due to the occurrence of an intense storm with less rainfall at the location of gully 2,while a light storm with heavier rainfall occurred in the location of gully 1.As Mollisols and sandy soil are the typical soil horizons in the Mollisols region worldwide,the results of this work could provide insightful knowledge for understanding the physical process of permanent gully expansion,which may be helpful for developing prediction models for sediment losses in some watersheds with vast Mollisols and highly developed gully system.展开更多
Background: Post-workout supplementation has been used in athletes and recreational exercisers;however, responses between normal and overweight individuals on exercise performance and muscle recovery are less known.Me...Background: Post-workout supplementation has been used in athletes and recreational exercisers;however, responses between normal and overweight individuals on exercise performance and muscle recovery are less known.Methods: Normal and overweight young adult males(21 subjects/group) participated in resistance and fatiguing exercises before receiving post-workout supplements: placebo, coenzyme Q10(CoQ10), or sports drink in a crossover design. Resistance exercises included upper body exercise(bench press, upright row, and standing shoulder press) and lower body exercise(dead lift, back squat, and front squat) at 75% of one-repetition maximum(1 RM). Fatiguing exercise was performed on a cycle ergometer with 3 min of all-out effort at 3.5% of body mass. Participants consumed post-workout supplements within 10 min of exercise completion and repeated-bout exercise was performed 1 h later, followed by cardiovascular responses, urinary biomarkers, and delayed onset muscle soreness(DOMS) assessments.Results: There were effects of overweight on resistance exercise volume, critical power, fatigue index, and postexercise diastolic blood pressure(DBP). However, no differences in urinary biomarkers of muscle damage(potassium and creatinine) or DOMS between normal and overweight individuals. After supplementation, CoQ10 and sports drink increased resistance exercise volume regardless of body mass and increased critical power in the normal group. Additionally, CoQ10 supplementation was associated with a reduction in urinary biomarkers and DOMS in both groups.Conclusion: These findings are beneficial for sport scientists, nutritionists, and exercise physiologists in guiding post-workout supplementation with CoQ10 and sports drink to improve exercise performance and muscle recovery in normal and overweight individuals.展开更多
The negative Poisson’s ratio(NPR)bolt is an innovative support element distinguished by its high strength,elongation,and a slightly negative Poisson’s ratio.Unlike conventional prestressed(PR)bolts with a positive P...The negative Poisson’s ratio(NPR)bolt is an innovative support element distinguished by its high strength,elongation,and a slightly negative Poisson’s ratio.Unlike conventional prestressed(PR)bolts with a positive Poisson’s ratio,the NPR bolt exhibits a quasi-ideal plastic response without a prominent yield platform,enabling it to sustain high prestress with a substantial safety margin,which is particularly advantageous for jointed rock masses.However,investigations into the shear resistance mechanisms of NPR bolts under varying prestress levels remain limited.This study conducted full-scale double shear tests to assess the shear strength,deformation behavior,energy absorption,and failure mechanisms of NPR bolts under different prestress conditions.To ensure a fair comparison with PR bolts,a prestress utilization coefficient(PUC)was introduced.The results reveal that at a PUC of 0.25,the NPR bolt achieved peak axial force,shear displacement,and peak shear force values that are 2.41,1.88,and 2.13 times greater than those of the PR bolt,respectively.Shear performance was optimized at a prestress level of 100 kN,with energy absorption reaching 47.1 kJ,which is 2.8 times that of the PR bolt.Furthermore,the necking ratio was significantly reduced,indicating more distributed plastic deformation and delayed failure.Field applications verified the superior performance,resulting in a 27.4%reduction in roof settlement and enhanced structural integrity.These findings confirm that NPR bolts possess excellent shear resistance,energy absorption,and deformation adaptability,and optimizing prestress significantly enhances their support performance,providing a strong basis for geotechnical engineering applications.展开更多
Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association betw...Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.展开更多
Pulsed dynamic electrolysis(PDE),driven by renewable energy,has emerged as an innovative electrocatalytic conversion method,demonstrating significant potential in addressing global energy challenges and promoting sust...Pulsed dynamic electrolysis(PDE),driven by renewable energy,has emerged as an innovative electrocatalytic conversion method,demonstrating significant potential in addressing global energy challenges and promoting sustainable development.Despite significant progress in various electrochemical systems,the regulatory mechanisms of PDE in energy and mass transfer and the lifespan extension of electrolysis systems,particularly in water electrolysis(WE)for hydrogen production,remain insufficiently explored.Therefore,there is an urgent need for a deeper understanding of the unique contributions of PDE in mass transfer enhancement,microenvironment regulation,and hydrogen production optimization,aiming to achieve low-energy consumption,high catalytic activity,and long-term stability in the generation of target products.Here,this review critically examines the microenvironmental effects of PDE on energy and mass transfer,the electrode degradation mechanisms in the lifespan extension of electrolysis systems,and the key factors in enhancing WE for hydrogen production,providing a comprehensive summary of current research progress.The review focuses on the complex regulatory mechanisms of frequency,duty cycle,amplitude,and other factors in hydrogen evolution reaction(HER)performance within PDE strategies,revealing the interrelationships among them.Finally,the potential future directions and challenges for transitioning from laboratory studies to industrial applications are proposed.展开更多
Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^(...Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.展开更多
The development of collinear resonance ionization spectroscopy for studying the nuclear structure of nickel isotopes far from the stability line relies on high-efficiency two-color two-step photoionization pathways.We...The development of collinear resonance ionization spectroscopy for studying the nuclear structure of nickel isotopes far from the stability line relies on high-efficiency two-color two-step photoionization pathways.We systematically investigated the even-parity autoionization spectrum of atomic nickel through resonance ionization mass spectrometry(RIMS).Fifteen intense single-color photoionization lines and corresponding transitions in the 300-325 nm range were identified and excluded as potential interference peaks for subsequent two-color studies.Fifty-one even-parity autoionization states in the 64000-66800 cm^(-1)range were identified for the first time by scanning from five intermediate excited states of the3d^(8)(^(3)F)4s4p(^(3)P^(o))configuration.Forty-eight of these states were assigned unique total angular momentum quantum numbers(J)based on electric dipole transition selection rules.The autoionization state at 64437.77 cm^(-1)was identified as an optimal final state for enhancing photoionization efficiency in two-color two-step pathways.This study provides comprehensive datasets of even-parity autoionization states of nickel,supporting both the advancement of collinear resonance ionization spectroscopy for exotic nickel isotopes and theoretical modeling of autoionization states.The datasets are openly available at https://doi.org/10.57760/sciencedb.j00113.00280.展开更多
This study examined non-uniform loading in goaf cantilever rock masses via testing,modeling,and mechanical analysis to solve instantaneous fracture and section buckling from mining abutment pressure.The study investig...This study examined non-uniform loading in goaf cantilever rock masses via testing,modeling,and mechanical analysis to solve instantaneous fracture and section buckling from mining abutment pressure.The study investigates the non-uniform load gradient effect on fracture characteristics,including load characteristics,fracture location,fracture distribution,and section roughness.A digital model for fracture interface buckling analysis was developed,elucidating the influence of non-uniform load gradients on Fracture Interface Curvature(FIC),Buckling Rate of Change(BRC),and Buckling Domain Field(BDF).The findings reveal that nonlinear tensile stress concentration and abrupt tensile-compressive-shear strain mutations under non-uniform loading are fundamental mechanisms driving fracture path buckling in cantilever rock mass structures.The buckling process of rock mass under non-uniform load can be divided into two stages:low load gradient and high gradient load.In the stage of low gradient load,the buckling behavior is mainly reflected in the compression-shear fracture of the edge.In the stage of high gradient load,a buckling band along the loading direction is gradually formed in the rock mass.These buckling principles establish a theoretical basis for accurately characterizing bearing fractures,fracture interface instability,and vibration sources within overlying cantilever rock masses in goaf.展开更多
文摘机器人加工是航天复杂舱段内腔加工的有效手段。针对部分狭窄深腔舱段的加工需求,需在机器人末端附加延长杆以提升操作可达性。然而,延长杆在拓展加工覆盖范围的同时,会增大系统动柔度,极易引发加工颤振,进而影响加工质量与效率。为此,本文提出一种变频可调式调谐质量阻尼器(Tuned mass damper,TMD)的结构设计与参数优化方法,建立了集成调谐质量阻尼器与机器人加工系统的动力学模型。该方法基于偏心曲柄滑块机构实现频率可调,根据电涡流阻尼原理完成阻尼参数调控。进一步开展机器人加工系统动柔度控制试验,结果表明,本文所提方法可使末端动柔度峰值降低67.8%,显著提升加工稳定性边界。
文摘In performance-based architectural design optimization, the design of building massings and façades is commonly separated, which weakens the effectiveness in performance improvement. In response, this study proposes a hybrid massing-façade integrated design generation and optimization workflow to integrate the two elements in an evolutionary design process. Compared with the existing approaches, the proposed workflow emphasizes the diversity of building design generation, with which various combinations of building massing forms and façade patterns can be systematically explored. Two case studies and a corresponding comparison study are presented to demonstrate the efficacy of the proposed workflow. Results show that the optimization can produce designs coupling the potential of building massings and façades in performance improvement. In addition, the optimization can provide information that supports early-stage architectural design exploration. Such information also enables the architect to understand the performance implications associated with the synergy of building massing and façade design.
基金supported by the Xi’an Jiaotong-Liverpool University Research Development Fund(RDF-23-01-107)the National Natural Science Foundation of China(52178017)。
文摘In the past decade,there has been an increasing recognition of the role of computational design optimization in early-stage performance-based architectural design exploration.However,it remains challenging for designers to apply such optimization-based design explorations in practice.To address this issue,this paper introduces a design tool,called EvoMass,and an associated design method that facilitates design exploration for building massing typologies in performance-based design tasks.EvoMass is capable of offering architects design options reflecting performance-related building massing typologies for the design task,without necessitating advanced computational design skills.More importantly,it can provide architects with insights into the underlying performance implications,thereby enhancing early-stage performance-based design exploration.EvoMass and its associated design method overcome the limitation in the conventional typology-first-optimization-second design procedure adopted by most existing tools,and it promotes a typology-oriented design exploration method of using computational optimization in performance-based architectural design.To demonstrate the efficacy of EvoMass,case studies derived from architectural design studio tasks,incorporating daylighting,solar exposure,and subjective design intents,and the result of a user survey are presented,which highlights how EvoMass and the performance-based design optimization and exploration can enable architects to achieve a more performance-aware design.
文摘The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.
基金Supported by National Natural Science Foundation of China(No.82101113).
文摘Dear Editor,Ciliary body masses are diagnostically challenging due to their hidden location,diverse pathologies,and limited examination methods[1].We report a case of a ciliary body inflammatory mass treated with trans-scleral excision and antiinflammatory therapy,preserving functional vision.
文摘Rationale:Infected urinomas are rare complications of urinary tract obstruction and may mimic renal abscess or pyonephrosis.Presentation as a palpable flank mass is highly unusual.Patient’s concern:An 84-year-old man with fever,flank pain,and a firm right flank mass.Imaging revealed an acute multiloculated infected urinoma communicating with the proximal ureter,associated with a ureteric calculus.Diagnosis:Infected urinoma.Interventions:He was treated with antibiotics,percutaneous drainage,and nephrostomy.Outcomes:Recurrence occurred three months later due to unresolved obstruction,requiring repeat drainage.Definitive surgical management was deferred due to advanced age and comorbidities,highlighting challenges in high-risk patients.Lessons:This case highlights the importance of considering urinoma in the differential diagnosis of flank masses,the complementary roles of multimodal imaging for accurate diagnosis,and the importance of definitive management of urinary obstruction to prevent recurrence.
基金the National Key Research and Development Program of China(2022YFE0208400)the Shanxi Province Key Research and Development Program(202202090301002)the Natural Science Foundation of Shanxi Province,China(202103021224096).
文摘This study investigates catalytic tar cracking over semi-coke catalysts,addressing reaction kinetics challenges by integrating experimental data with a COMSOL Multiphysics model.A multi-physics framework combines catalysis,carbon deposition,and self-consumption to analyze toluene(tar model compound)removal.The model evaluates intrinsic catalytic activity,porosity evolution,and porous media flow,revealing that toluene conversion is governed by diffusion/convective mass transfer,homogeneous reactions,and surface reactions influenced by dynamic carbon deposition/removal.Increasing temperature from 973 to 1173 K enhances gas-film heat and mass transfer coefficient,accelerating tar cracking rates and extending catalyst lifetime.Elevated temperatures improve gas-solid phase heat/mass transfer,promoting efficient tar removal during syngas purification.The results highlight the interplay between reaction kinetics,carbon deposition dynamics,and transport phenomena in optimizing semi-coke catalyst performance under high-temperature conditions.
基金Supported by the National Natural Science Foundation of China(No.82501261)Medical Research Projects of the Jiangsu Provincial Health Commission(No.M2024041).
文摘AIM:To investigate the causal effect of obesity on cataract risk and explores the potential mediating roles of metabolites using Mendelian randomization(MR).METHODS:Summary-level data from large-scale genome-wide association studies to examine the relationship between obesity and cataract were utilized.Obesity-related traits,including body mass index(BMI),waist-to-hip ratio(WHR),and waist circumference(WC).A two-sample MR approach was employed to assess the causal effect of obesity on cataract risk,while potential mediators were identified from suitable genome-wide association studies(GWAS)datasets.Additionally,a metabolic pathway analysis was conducted.RESULTS:An increase of 1 standard deviation(SD)in BMI,WHR,and WC was associated with a significantly higher risk of cataract(BMI:odds ratio(OR)1.0017,95%confidence interval(CI):1.0001-1.0032,P=0.0320;WHR:OR 1.0029,95%CI:1.0006-1.0051,P=0.0129;WC:OR 1.0020,95%CI:1.0001-1.0038,P=0.0390].These associations remained robust after adjusting for confounding factors in multivariable MR analysis.Furthermore,a two-step MR analysis identified eight potential metabolic mediators,with one mediator showing a significant causal role in the relationship between obesity and cataract.CONCLUSION:This work highlights the importance of addressing obesity as a modifiable risk factor for cataracts,particularly through metabolic pathways.
基金supported by the National Key R&D Plan“Inter-governmental International Science&Technology Innovation Cooperation”Key Specialized Program,China(2025YFE0102800)the Program of the State Key Laboratory of Cryospheric Science and Frozen Soil Engineering,Chinese Academy of Sciences(CSFSE-ZZ-2403).
文摘Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.
基金primarily supported by the National Key Research and Development Program of China(Grant No.2024YFD1501201-3)partially supported by the National Key Research and Development Program of China(Grant No.2021YFD1500700)。
文摘Mass wasting is globally recognized as a key geomorphic agent in permanent gully expansion and greatly contributes to watershed sediment losses.Though its formation process has been assessed by some physical models,the occurrence and rainfall threshold have been rarely documented.In this study,rainfall-induced mass wasting events in two permanent gullies located in the Mollisols region of Northeast China,with Mollisols(gully 1)and sandy soil(gully 2)underneath were observed,and their differences were explored based on their soil strengths,hydraulic properties,excess topographies,and theoretical rainfall amounts.The sandy soil had a higher strength,faster pore water pressure dissipation rate,and lower suction stress at a specific soil moisture content compared to the black soil.The erosion thickness of the gully bed and sidewalls in gully 1 was shallower compared to gully 2.This was confirmed by the relationship between the erosion thickness and excess topography.The differences in the mass wasting erosion of the gully bed and sidewalls were due to the higher shear strength and well-drained hydraulic properties of the sandy soil compared to the black-soil.An infinite model was chosen to examine the temporal order of the mass wasting in the two gullies.It was found that the mass wasting in gully 2 occurred earlier than that in gully 1.This was likely due to the occurrence of an intense storm with less rainfall at the location of gully 2,while a light storm with heavier rainfall occurred in the location of gully 1.As Mollisols and sandy soil are the typical soil horizons in the Mollisols region worldwide,the results of this work could provide insightful knowledge for understanding the physical process of permanent gully expansion,which may be helpful for developing prediction models for sediment losses in some watersheds with vast Mollisols and highly developed gully system.
基金supported by the MUSC-TU Scholarship for Human Resource Development in Science & Technology in the Remembrance of Late King Rama Ⅸ of ThailandPartial Funding for Graduate Student Thesis for the Year 2021 by the Faculty of Graduate Studies and Graduate Studies of Mahidol University Alumni Association。
文摘Background: Post-workout supplementation has been used in athletes and recreational exercisers;however, responses between normal and overweight individuals on exercise performance and muscle recovery are less known.Methods: Normal and overweight young adult males(21 subjects/group) participated in resistance and fatiguing exercises before receiving post-workout supplements: placebo, coenzyme Q10(CoQ10), or sports drink in a crossover design. Resistance exercises included upper body exercise(bench press, upright row, and standing shoulder press) and lower body exercise(dead lift, back squat, and front squat) at 75% of one-repetition maximum(1 RM). Fatiguing exercise was performed on a cycle ergometer with 3 min of all-out effort at 3.5% of body mass. Participants consumed post-workout supplements within 10 min of exercise completion and repeated-bout exercise was performed 1 h later, followed by cardiovascular responses, urinary biomarkers, and delayed onset muscle soreness(DOMS) assessments.Results: There were effects of overweight on resistance exercise volume, critical power, fatigue index, and postexercise diastolic blood pressure(DBP). However, no differences in urinary biomarkers of muscle damage(potassium and creatinine) or DOMS between normal and overweight individuals. After supplementation, CoQ10 and sports drink increased resistance exercise volume regardless of body mass and increased critical power in the normal group. Additionally, CoQ10 supplementation was associated with a reduction in urinary biomarkers and DOMS in both groups.Conclusion: These findings are beneficial for sport scientists, nutritionists, and exercise physiologists in guiding post-workout supplementation with CoQ10 and sports drink to improve exercise performance and muscle recovery in normal and overweight individuals.
基金supported by the State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering(Grant No.SDGZ2505)the Postdoctoral Fellowship Program of the China Postdoctoral Science Foundation(Grant No.GZB20250742)the General Program of the China Postdoctoral Science Foundation(Grant No.2025M773213).
文摘The negative Poisson’s ratio(NPR)bolt is an innovative support element distinguished by its high strength,elongation,and a slightly negative Poisson’s ratio.Unlike conventional prestressed(PR)bolts with a positive Poisson’s ratio,the NPR bolt exhibits a quasi-ideal plastic response without a prominent yield platform,enabling it to sustain high prestress with a substantial safety margin,which is particularly advantageous for jointed rock masses.However,investigations into the shear resistance mechanisms of NPR bolts under varying prestress levels remain limited.This study conducted full-scale double shear tests to assess the shear strength,deformation behavior,energy absorption,and failure mechanisms of NPR bolts under different prestress conditions.To ensure a fair comparison with PR bolts,a prestress utilization coefficient(PUC)was introduced.The results reveal that at a PUC of 0.25,the NPR bolt achieved peak axial force,shear displacement,and peak shear force values that are 2.41,1.88,and 2.13 times greater than those of the PR bolt,respectively.Shear performance was optimized at a prestress level of 100 kN,with energy absorption reaching 47.1 kJ,which is 2.8 times that of the PR bolt.Furthermore,the necking ratio was significantly reduced,indicating more distributed plastic deformation and delayed failure.Field applications verified the superior performance,resulting in a 27.4%reduction in roof settlement and enhanced structural integrity.These findings confirm that NPR bolts possess excellent shear resistance,energy absorption,and deformation adaptability,and optimizing prestress significantly enhances their support performance,providing a strong basis for geotechnical engineering applications.
基金supported by the Yanzhao Gold Talent Project of Hebei Province(NO.HJZD202506)。
文摘Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.
基金financially supported by the Key Research and Development Program of Heilongjiang Province(No.2024ZXJ03C06)National Natural Science Foundation of China(No.52476192,No.52106237)+1 种基金Natural Science Foundation of Heilongjiang Province(No.YQ2022E027)Technology Project of China Datang Technology Innovation Co.,Ltd(No.DTKC-2024-20610).
文摘Pulsed dynamic electrolysis(PDE),driven by renewable energy,has emerged as an innovative electrocatalytic conversion method,demonstrating significant potential in addressing global energy challenges and promoting sustainable development.Despite significant progress in various electrochemical systems,the regulatory mechanisms of PDE in energy and mass transfer and the lifespan extension of electrolysis systems,particularly in water electrolysis(WE)for hydrogen production,remain insufficiently explored.Therefore,there is an urgent need for a deeper understanding of the unique contributions of PDE in mass transfer enhancement,microenvironment regulation,and hydrogen production optimization,aiming to achieve low-energy consumption,high catalytic activity,and long-term stability in the generation of target products.Here,this review critically examines the microenvironmental effects of PDE on energy and mass transfer,the electrode degradation mechanisms in the lifespan extension of electrolysis systems,and the key factors in enhancing WE for hydrogen production,providing a comprehensive summary of current research progress.The review focuses on the complex regulatory mechanisms of frequency,duty cycle,amplitude,and other factors in hydrogen evolution reaction(HER)performance within PDE strategies,revealing the interrelationships among them.Finally,the potential future directions and challenges for transitioning from laboratory studies to industrial applications are proposed.
文摘Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.
基金supported by the China National Nuclear Corporation Basic Research Project(Grant No.CNNC-JCYJ-202327)。
文摘The development of collinear resonance ionization spectroscopy for studying the nuclear structure of nickel isotopes far from the stability line relies on high-efficiency two-color two-step photoionization pathways.We systematically investigated the even-parity autoionization spectrum of atomic nickel through resonance ionization mass spectrometry(RIMS).Fifteen intense single-color photoionization lines and corresponding transitions in the 300-325 nm range were identified and excluded as potential interference peaks for subsequent two-color studies.Fifty-one even-parity autoionization states in the 64000-66800 cm^(-1)range were identified for the first time by scanning from five intermediate excited states of the3d^(8)(^(3)F)4s4p(^(3)P^(o))configuration.Forty-eight of these states were assigned unique total angular momentum quantum numbers(J)based on electric dipole transition selection rules.The autoionization state at 64437.77 cm^(-1)was identified as an optimal final state for enhancing photoionization efficiency in two-color two-step pathways.This study provides comprehensive datasets of even-parity autoionization states of nickel,supporting both the advancement of collinear resonance ionization spectroscopy for exotic nickel isotopes and theoretical modeling of autoionization states.The datasets are openly available at https://doi.org/10.57760/sciencedb.j00113.00280.
基金support provided by the National Natural Science Foundation of China(No.52274077)the Natural Science Foundation of Henan(No.242300421072)+2 种基金the Youth Elite Teachers Cultivation Program for Higher Education Institutions in Henan Province(No.2024GGJS036)the Funds for Distinguished Young Scholars of Henan Polytechnic University(No.J2023-3)the Young Core Teacher Funding Scheme of Henan Polytechnic University(No.2023XQG-09).
文摘This study examined non-uniform loading in goaf cantilever rock masses via testing,modeling,and mechanical analysis to solve instantaneous fracture and section buckling from mining abutment pressure.The study investigates the non-uniform load gradient effect on fracture characteristics,including load characteristics,fracture location,fracture distribution,and section roughness.A digital model for fracture interface buckling analysis was developed,elucidating the influence of non-uniform load gradients on Fracture Interface Curvature(FIC),Buckling Rate of Change(BRC),and Buckling Domain Field(BDF).The findings reveal that nonlinear tensile stress concentration and abrupt tensile-compressive-shear strain mutations under non-uniform loading are fundamental mechanisms driving fracture path buckling in cantilever rock mass structures.The buckling process of rock mass under non-uniform load can be divided into two stages:low load gradient and high gradient load.In the stage of low gradient load,the buckling behavior is mainly reflected in the compression-shear fracture of the edge.In the stage of high gradient load,a buckling band along the loading direction is gradually formed in the rock mass.These buckling principles establish a theoretical basis for accurately characterizing bearing fractures,fracture interface instability,and vibration sources within overlying cantilever rock masses in goaf.
