In this article,we critically appraise the study by Wu et al,which investigated the prognostic value of preoperative inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis.This r...In this article,we critically appraise the study by Wu et al,which investigated the prognostic value of preoperative inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis.This retrospective cohort study included 133 patients.The findings indicate that patients with high neutrophil-to-lymphocyte ratios(NLRs)or lower hemoglobin(Hb)levels have significantly shorter overall survival(OS)than those with lower NLRs or normal Hb levels,respectively.Furthermore,age,carbohydrate antigen 199 levels,the NLR,Hb,and the peritoneal cancer index were identified as independent prognostic factors for OS.A nomogram was subsequently developed,demon-strating its ability to accurately predict the OS of colorectal cancer patients with peritoneal metastasis.This study introduces a potentially valuable prognostic tool for these patients.However,further validation in multicenter cohorts is needed to confirm its clinical applicability,to assess its limitations,and to elucidate the underlying mechanism of these identified biomarkers.展开更多
BACKGROUND Gastric cancer is a major global health concern,often diagnosed at advanced stages,leading to poor prognosis.Proximal and distal gastric cancers exhibit distinct clinicopathological features.AIM To investig...BACKGROUND Gastric cancer is a major global health concern,often diagnosed at advanced stages,leading to poor prognosis.Proximal and distal gastric cancers exhibit distinct clinicopathological features.AIM To investigate the diagnostic value of hematological and inflammatory markers in differentiating proximal and distal gastric cancers and to evaluate their association with clinical outcomes.METHODS A retrospective cohort study was conducted on 150 patients diagnosed with gastric adenocarcinoma through histopathological analysis.Patients were categorized into proximal gastric cancer and distal gastric cancer groups.Laboratory parameters were analyzed.RESULTS Of the 150 patients,84 had proximal gastric cancer and 66 had distal gastric cancer.Dysphagia was significantly more common in the proximal gastric cancer group,while anemia and higher platelet-to-lymphocyte ratio values were observed in the distal gastric cancer group(P=0.031).Tumor stage and neutrophil-to-lymphocyte ratio emerged as independent predictors of all-cause mortality.No significant differences were found in other laboratory or biochemical parameters between the groups.CONCLUSION Proximal and distal gastric cancers demonstrate distinct clinical and laboratory profiles.The platelet-to-lymphocyte ratio may serve as a valuable marker in differentiating cancer localization,while the neutrophil-to-lymphocyte ratio is a prognostic indicator for mortality.These findings highlight the potential of hematological markers in optimizing diagnosis and treatment strategies for gastric cancer.展开更多
The retrospective cohort study by Zuo et al investigates the interplay between microsatellite instability(MSI)status,nutritional indicators,and inflammatory profiles in colorectal cancer(CRC).Analyzing 56 patients,the...The retrospective cohort study by Zuo et al investigates the interplay between microsatellite instability(MSI)status,nutritional indicators,and inflammatory profiles in colorectal cancer(CRC).Analyzing 56 patients,the study reveals that MSI-high tumors are associated with significantly lower serum albumin,body mass index,and absolute lymphocyte counts,alongside elevated neutrophil-tolymphocyte ratios compared to microsatellite stable tumors.These findings highlight distinct immunological and nutritional profiles in MSI-high CRC,suggesting potential clinical utility in risk stratification and personalized treat-ment.While the study underscores the importance of MSI status in CRC mana-gement,its single-center design and limited sample size warrant validation through multicenter trials.This article contextualizes these findings within the broader landscape of CRC research,emphasizing the need for integrating bio-markerdriven strategies into clinical practice to optimize outcomes for patients with differing MSI statuses.展开更多
BACKGROUND An increasing number of studies to date have found preoperative magnetic resonance imaging(MRI)features valuable in predicting the prognosis of rectal cancer(RC).However,research is still lacking on the cor...BACKGROUND An increasing number of studies to date have found preoperative magnetic resonance imaging(MRI)features valuable in predicting the prognosis of rectal cancer(RC).However,research is still lacking on the correlation between preoperative MRI features and the risk of recurrence after radical resection of RC,urgently necessitating further in-depth exploration.AIM To investigate the correlation between preoperative MRI parameters and the risk of recurrence after radical resection of RC to provide an effective tool for predicting postoperative recurrence.METHODS The data of 90 patients who were diagnosed with RC by surgical pathology and underwent radical surgical resection at the Second Affiliated Hospital of Bengbu Medical University between May 2020 and December 2023 were collected through retrospective analysis.General demographic data,MRI data,and tumor markers levels were collected.According to the reviewed data of patients six months after surgery,the clinicians comprehensively assessed the recurrence risk and divided the patients into high recurrence risk(37 cases)and low recurrence risk(53 cases)groups.Independent sample t-test andχ2 test were used to analyze differences between the two groups.A logistic regression model was used to explore the risk factors of the high recurrence risk group,and a clinical prediction model was constructed.The clinical prediction model is presented in the form of a nomogram.The receiver operating characteristic curve,Hosmer-Lemeshow goodness of fit test,calibration curve,and decision curve analysis were used to evaluate the efficacy of the clinical prediction model.RESULTS The detection of positive extramural vascular invasion through preoperative MRI[odds ratio(OR)=4.29,P=0.045],along with elevated carcinoembryonic antigen(OR=1.08,P=0.041),carbohydrate antigen 125(OR=1.19,P=0.034),and carbohydrate antigen 199(OR=1.27,P<0.001)levels,are independent risk factors for increased postoperative recurrence risk in patients with RC.Furthermore,there was a correlation between magnetic resonance based T staging,magnetic resonance based N staging,and circumferential resection margin results determined by MRI and the postoperative recurrence risk.Additionally,when extramural vascular invasion was integrated with tumor markers,the resulting clinical prediction model more effectively identified patients at high risk for postoperative recurrence,thereby providing robust support for clinical decision-making.CONCLUSION The results of this study indicate that preoperative MRI detection is of great importance for predicting the risk of postoperative recurrence in patients with RC.Monitoring these markers helps clinicians identify patients at high risk,allowing for more aggressive treatment and monitoring strategies to improve patient outcomes.展开更多
BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derive...BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.展开更多
Malaria continues to pose a significant global health challenge despite a significant achievement in control and elimination in certain areas.Accurate and timely diagnosis is crucial for effective disease management a...Malaria continues to pose a significant global health challenge despite a significant achievement in control and elimination in certain areas.Accurate and timely diagnosis is crucial for effective disease management and control,and finally leading to elimination.However,microscopy and rapid diagnostic tests(RDTs)have traditionally been the primary malaria diagnostic tools used globally,with certain shortcomings,including their limited sensitivity,specificity,and inability to identify asymptomatic infections.Serological markers have emerged as promising alternatives in malaria serosurveillance,particularly in countries where targets have already been set for elimination.This review highlights the advantages of serological markers over conventional diagnostic techniques and discusses some of the most promising serological markers against Plasmodium species-specific antigens.The implementation of serosurveillance,coupled with the utilization of these serological markers represents a transformative shift in malaria surveillance.By capitalizing on the immune memory of individuals,serosurveillance also enables the identification of recent and past infections.This approach is particularly valuable in low-transmission settings and for tracking changes in malaria prevalence over time.While recognizing the use of serological markers across various global contexts,this review predominantly emphasizes their significance within the framework of India.展开更多
Colorectal cancer(CRC)is the third most common malignancy and the second leading cause of cancer-related mortality worldwide,responsible for approximately 900000 deaths annually.Inflammation and malnutrition significa...Colorectal cancer(CRC)is the third most common malignancy and the second leading cause of cancer-related mortality worldwide,responsible for approximately 900000 deaths annually.Inflammation and malnutrition significantly influence patients'responses to treatment.Markers such as serum albumin concentration,the prognostic nutritional index,nutritional risk index(NRI),geriatric NRI,and the systemic immune-inflammation index enable the early identification of high-risk patients,facilitating timely interventions that can improve survival and reduce morbidity.A comprehensive understanding and application of these markers allow for better risk stratification in CRC patients,optimizing their management and outcomes.展开更多
Background Cotton is a significant crop for fiber production;however,seed shape-related traits have been less investigated in comparison to fiber quality.Comprehending the genetic foundation of traits associated with ...Background Cotton is a significant crop for fiber production;however,seed shape-related traits have been less investigated in comparison to fiber quality.Comprehending the genetic foundation of traits associated with seed shape is crucial for improving the seed and fiber quality in cotton.Results A total of 238 cotton accessions were evaluated in four different environments over a period of two years.Traits including thousand grain weight(TGW),aspect ratio(AR),seed length,seed width,diameter,and roundness demonstrated high heritability and significant genetic variation,as indicated by phenotypic analysis.The association analysis involved 145 simple sequence repeats(SSR)markers and identified 50 loci significantly associated with six traits related to seed shape.The markers MON_DPL0504aa and BNL2535ba were identified as influencing multiple traits,including aspect ratio and thousand grain weight.Notably,markers such as HAU2588a and MUSS422aa had considerable influence on seed diameter and roundness.The identified markers represented an average phenotypic variance between 3.92%for seed length and 16.54%for TGW.Conclusions The research finds key loci for seed shape-related traits in cotton,providing significant potential for marker-assisted breeding.These findings establish a framework for breeding initiatives focused on enhancing seed quality,hence advancing the cotton production.展开更多
Peanut kernels rich in oil,particularly those with oleic acid as their primary fatty acid,are in high demand among consumers,the food industry,and farmers due to their superior nutritional content,extended shelf life,...Peanut kernels rich in oil,particularly those with oleic acid as their primary fatty acid,are in high demand among consumers,the food industry,and farmers due to their superior nutritional content,extended shelf life,and health benefits.The oil content and fatty acid composition are governed by multiple genetic factors.Identifying the quantitative trait loci(QTLs)related to these attributes will facilitate marker-assisted selection and genomic selection,thus enhancing quality-focused peanut breeding programs.For this purpose,we developed a population of 521 recombinant inbred lines(RILs)and tested their kernel quality traits across five different environments.We identified two major and stable QTLs for oil content,qOCAh12.1 and qOCAh16.1.The markers linked to these QTLs were designed by Kompetitive allele-specific PCR(KASP)and subsequently validated.Moreover,we found that the superior haplotype of oil content in the qOCAh16.1 region was conserved within the plant introduction(PI)germplasm cluster,as evidenced by a diverse peanut accession panel.In addition,we determined that qAh09 and qAh19.1,which harbor the key gene encoding fatty acid desaturase 2(FAD2),influence all seven fatty acids,palmitic,stearic,oleic,linoleic,arachidic,gadoleic,and behenic acids.Regarding the protein content and the long-chain saturated fatty acid behenic acid,qAh07 emerged as the major and stable QTL,accounting for over 10%of the phenotypic variation explained(PVE).These findings can enhance marker-assisted selection in peanut breeding,with the aim of improving the oil content,and deepen our understanding of the genetic mechanisms that shape fatty acid composition.展开更多
BACKGROUND The deleterious effects of surgical trauma and subsequent postoperative complications pose significant challenges to the smooth recovery of patients after gastric cancer(GC)resection despite the substantial...BACKGROUND The deleterious effects of surgical trauma and subsequent postoperative complications pose significant challenges to the smooth recovery of patients after gastric cancer(GC)resection despite the substantial curative benefits provided by surgical interventions for GC.Hence,the investigation of more optimal and efficacious treatment approaches has become an urgent necessity in the medical community.AIM To investigate the association of Sijunzi decoction plus chemotherapy with the gastrointestinal function and serum markers of patients after GC surgery.METHODS This study included patients who underwent GC surgery from June 2022 to February 2024.The control group included 45 patients who received chemotherapy(oxaliplatin+calcium folinate+5-fluorouracil),whereas the research group consisted of 54 patients who received Sijunzi decoction therapy in addition to the treatment administered in the control group.Comparative analyses were conducted from the following perspectives:Gastrointestinal function(defecation time,intestinal gas discharge time,and hospitalization time),serum markers[carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,and CA199],nutritional indicators total protein(TP)and transferrin(TRF),traditional Chinese medicine(TCM)syndrome score,and grades Ⅲ–Ⅳ adverse events(gastrointestinal reactions,renal/liver function impairment,and myelosuppression).RESULTS The two groups demonstrated similar defecation time(P>0.05),but the intestinal gas discharge time and hospitalization time were significantly shortened in the research group(P<0.05).Further,the research group exhibited significant CEA,CA125,and CA199 reductions after treatment,which were lower compared to the control group,as well as notable increases in TP and TRF that were statistically higher than the control group(all P<0.05).Furthermore,the research group demonstrated an evident decrease in TCM syndrome scores in areas,such as poor appetite,epigastric distension and pain,fatigue and weakness(P<0.01),and abdominal distension after eating,which are notably lower than those in the control group(P<0.01),with a comparable incidence of grades Ⅲ-Ⅳ adverse events(P>0.05).CONCLUSION Our research results indicate that Sijunzi decoction plus chemotherapy exerts a good rehabilitation-promoting effect on gastrointestinal function in patients after GC surgery and significantly downregulates abnormally increased CEA,CA125,and CA199 levels.展开更多
Bariatric surgery significantly improves glycemic control and can lead to type 2 diabetes remission.However,the reliability of glycated hemoglobin(HbA1c)as a type 2 diabetes biomarker post-surgery can be confounded by...Bariatric surgery significantly improves glycemic control and can lead to type 2 diabetes remission.However,the reliability of glycated hemoglobin(HbA1c)as a type 2 diabetes biomarker post-surgery can be confounded by conditions such as anemia and gastrointestinal complications.Hence,we explored the use of alter-native biomarkers such as glycated albumin(GA),1,5-anhydroglucitol(1,5-AG),and insulin-like growth factor binding protein-1(IGFBP-1)to monitor glycemic control more effectively in post-bariatric surgery patients.Measuring GA and 1,5-AG levels can detect glycemic variability more sensitively than HbA1c,especially under non-fasting conditions.GA shows promise for short-term monitoring post-surgery while 1,5-AG could be useful for real-time glucose monitoring.IGFBP-1 can be used to monitor metabolic improvement and to predict HbA1c normal-ization.However,challenges in assay standardization and cost remain significant barriers to their clinical adoption.Although these biomarkers could offer a more personalized approach to glucose monitoring(thereby addressing the limitations of utilizing HbA1c in this endeavor in post-bariatric surgery patients),this would require overcoming technical,logistical,and cost-related challenges.While using GA,1,5-AG,and IGFBP-1 shows promise for glycemic monitoring,further research and validation are crucial for their routine clinical implementation,espe-cially in the context of diabetes management post-bariatric surgery.展开更多
One of the main causes of cancer-related morbidity and mortality globally is hepatocellular carcinoma(HCC).At every stage of the disease,HCC may now be treated using a variety of therapy techniques.Nevertheless,despit...One of the main causes of cancer-related morbidity and mortality globally is hepatocellular carcinoma(HCC).At every stage of the disease,HCC may now be treated using a variety of therapy techniques.Nevertheless,despite the abundance of effective therapeutic choices,the prognosis for patients with HCC is still typically dismal.Prognostic indicators are crucial when assessing prognosis and tracking tumor metastases or recurrence.There are many prognostic markers in HCC.We mainly focused on newly reported prognostic markers such as MEX3A,apolipoprotein B,alpha-fetoprotein,circulating tumor cells,SAMD13,Agrin,and Glypican-3 in the pathogenesis of HCC.Further,we highlighted how these prognostic markers correlated to clinical parameters such as tumor node metastasis,tumor diameter,differentiation,hepatocirrhosis,vascular invasion,and others in HCC.Therefore,identifying specific prognostic biomarkers of HCC helps to provide a great opportunity to improve the prognosis in patients with HCC and provide therapeutic targets.展开更多
Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor sympto...Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.展开更多
BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have...BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have gradually received attention in early screening,treatment monitoring and prognostic evaluation of cancer,but their predictive role in rectal cancer staging and differentiation is still unclear.AIM To assess the prognostic value of tumor markers alpha-fetoprotein(AFP)cancer antigen 72-4(CA72-4),carbohydrate antigen 19-9(CA19-9),and carcinoembryonic antigen(CEA),alongside multimodal magnetic resonance imaging(MRI),for staging and differentiating rectal cancer in patients.METHODS This study retrospectively analyzed 167 patients with rectal cancer who were treated at our institution from January 2020 to December 2024.Each patient underwent serological testing and multimodal MRI for diagnosis.Histopathological examination after surgical resection or imaging based on follow-up was used as the gold standard.According to the T stage and differentiation degree,patients were divided into low stage group(T1-T2)and high stage group(T3-T4).In addition,they were divided into low-differentiation groups and high-differentiation groups according to their differentiation degree.We compared the accuracy,sensitivity and specificity of tumor marker levels and MRI in rectal cancer stage and differentiation.RESULTS The study's findings indicate that in the context of rectal cancer T staging,there is substantial concordance between MRI and clinicopathological assessments,with a Kappa coefficient of 0.789(P<0.001).Similarly,for various degrees of tumor differentiation,MRI and clinicopathological evaluations demonstrated substantial agreement,with a Kappa coefficient of 0.651(P<0.001).Notably,the concentrations of tumor markers CA19-9,CA72-4,CEA,and AFP were significantly elevated in the T3-T4 stage compared to the T1-T2 stage.Furthermore,these markers were significantly higher in the low-differentiation group compared to the high-differentiation group(P<0.05).The combined use of tumor markers and MRI for preoperative T staging of rectal cancer yielded a diagnostic sensitivity of 93.7%and a specificity of 94.6%,as evidenced by the receiver operating characteristic analysis,with an area under the curve of 0.947.For tumor differentiation,the diagnostic sensitivity and specificity were 93.6%and 97.1%,respectively,with an area under the curve of 0.978(95%confidence interval:0.946-1.000),surpassing the accuracy of individual detection methods.CONCLUSION The CA19-9,CA72-4,CEA and AFP tumor markers combined with multimodal MRI have high sensitivity and specificity in diagnosing rectal cancer stage and differentiation.Their diagnostic efficacy is significantly better than that of single tests,which can effectively improve the predictive ability of rectal cancer stage and differentiation,provide a more reliable diagnostic reference for clinical practice,and have important clinical significance.展开更多
Based on conversation analysis theory,this study explored how teachers and students used discourse markers in foreign language classrooms and how these markers affect classroom interaction.The results showed that teac...Based on conversation analysis theory,this study explored how teachers and students used discourse markers in foreign language classrooms and how these markers affect classroom interaction.The results showed that teachers use different discourse markers in different teaching stages such as lead-in,presentation,practice and summary to make their teaching more organized and clearer.However,students used these markers less often,and their expressions are often less coherent.Based on these findings,the study suggests teaching strategies for teachers and learning strategies for students to improve how they use discourse markers.This can help make foreign language teaching more effective and interactive.展开更多
In this editorial we comment on the article published in the recent issue of World Journal of Gastrointestinal Oncology.This study aims to explore the relationship be-tween preoperative inflammation markers and the re...In this editorial we comment on the article published in the recent issue of World Journal of Gastrointestinal Oncology.This study aims to explore the relationship be-tween preoperative inflammation markers and the recurrence of gastrointestinal stromal tumors(GIST)after surgery.It is well known that the best-documented prognostic parameters for GIST are mitotic activity,tumor size and anatomical site.Besides,mutation status represents a prognostic as well as predictive factor.This study provides a new tool for postoperative recurrence risk assessment of GIST patients by establishing a line chart prediction model,which is certificated by previous research that high platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio correlated with increased tumour sizes,more advanced tumour stages and mitotic index.However,as a retrospective study,inevitable bias exists in the results;furthermore,the sample size of this study is relatively small,in-fluencing the universality of the results.Moreover,when assessing risk rating and prognosis of GIST,some novel inflammatory makers could be taken into consi-deration,such as proenkephalin and SLITRK3.Overall,this study can offer an additional model for GIST prognosis and recurrence risk assessment,indepen-dent of the traditional prognostic factors of GIST.展开更多
This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly i...This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms occur.Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive.Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.展开更多
Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum ku...Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum kusnezoffii Reichb.,and Piper longum,and is known for its effects in eliminating“mucus,”relieving pain,and reducing swelling,with significant efficacy in treating joint effusion and lumbar pain.In recent years,researchers have summarized its chemical components and pharmacological effects,and employed network pharmacology methods based on the core theory of Traditional Chinese Medicine quality markers(Q-Markers)to analyze and predict its markers.The results identified potential Q-Markers for Naru-3,providing a scientific basis for quality control and further research.展开更多
BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor remo...BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor removal.METHODS A prospective cohort study was conducted to analyze the clinical data of patients with GC.Patients were divided into two groups based on the surgical approach:The membrane dissection(MD)group,which underwent membrane-guided laparoscopic radical gastrectomy with D2 lymph node dissection plus complete mesocolic excision,and the D2 group,which underwent traditional laparoscopic radical gastrectomy with D2 lymph node dissection.Abdominal lavage fluid was collected pre-and postoperatively from patients in both groups.The expression of carcinoembryonic antigen(CEA)and cytokeratin-19(CK-19)message RNAs in the abdominal lavage fluid was detected using reverse transcription polymerase chain reaction.The factors influencing the increase of the tumor markers were analyzed,and the short-term efficacy of the two surgery types was compared.RESULTS In total,135 eligible patients were included in this study,with 69 and 66 cases in the MD and D2 groups,respectively.Fourteen patients with benign gastric lesions were selected to detect tumor marker expression.After excluding patients positive for preoperative cancer leakage,we found that 9.52%and 26.67%of patients in the MD and D2 groups developed postoperative CEA positivity,respectively.Multivariate analysis revealed that the degree of differentiation and surgical approach were independent risk factors for postoperative CEA positivity.The surgical approach was an independent risk factor affecting postoperative CK-19 positivity and postoperative CEA and CK-19 positivity.Surgical time,intraoperative blood loss,number of lymph nodes dissected,time to first postoperative flatus,and time to first liquid intake were all significantly different between the two surgical approaches.There were no significant differences in the incision length,duration of postoperative hospital stays,or postoperative complications.CONCLUSION MD is a better radical surgical treatment than traditional D2 surgery and is worthy of further clinical promotion and application.展开更多
Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance,often leading to severe complications.Hemogram markers have attracted great attention from researcher...Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance,often leading to severe complications.Hemogram markers have attracted great attention from researchers for their established role in inflammatory conditions.In this respect,T2DM and its mi-crovascular complications are characterized by high inflammatory burden.Hence,recent studies in the literature have reported an association between T2DM and hemogram-derived markers.Emerging evidence highlights the utility of hemo-gram-derived markers,including the neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,red cell distribution width,and mean platelet volume,as potential predictors of T2DM onset and progression.These markers,readily available from routine hemogram tests,offer valuable insights into the systemic inflammation and vascular changes associated with T2DM and its complications,such as cardiovascular disease,nephropathy,and retinopathy.This review syn-thesizes current research on the association between hemogram-derived markers and T2DM,emphasizing their prognostic value in predicting disease severity and complications.We also explore the underlying pathophysiological mechanisms linking these markers to inflammation and metabolic dysfunction.The findings suggest that hemogram-derived markers could serve as cost-effective,non-invasive tools for risk stratification and early intervention in T2DM management.Future research should focus on standardizing reference ranges and validating these markers in diverse populations to enhance their clinical utility.展开更多
文摘In this article,we critically appraise the study by Wu et al,which investigated the prognostic value of preoperative inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis.This retrospective cohort study included 133 patients.The findings indicate that patients with high neutrophil-to-lymphocyte ratios(NLRs)or lower hemoglobin(Hb)levels have significantly shorter overall survival(OS)than those with lower NLRs or normal Hb levels,respectively.Furthermore,age,carbohydrate antigen 199 levels,the NLR,Hb,and the peritoneal cancer index were identified as independent prognostic factors for OS.A nomogram was subsequently developed,demon-strating its ability to accurately predict the OS of colorectal cancer patients with peritoneal metastasis.This study introduces a potentially valuable prognostic tool for these patients.However,further validation in multicenter cohorts is needed to confirm its clinical applicability,to assess its limitations,and to elucidate the underlying mechanism of these identified biomarkers.
基金This study was approved by the Agrı Training and Research Hospital Scientific Research Ethics Committee(No.E-95531838-050.99-86900)conducted in accordance with the Declaration of Helsinki.
文摘BACKGROUND Gastric cancer is a major global health concern,often diagnosed at advanced stages,leading to poor prognosis.Proximal and distal gastric cancers exhibit distinct clinicopathological features.AIM To investigate the diagnostic value of hematological and inflammatory markers in differentiating proximal and distal gastric cancers and to evaluate their association with clinical outcomes.METHODS A retrospective cohort study was conducted on 150 patients diagnosed with gastric adenocarcinoma through histopathological analysis.Patients were categorized into proximal gastric cancer and distal gastric cancer groups.Laboratory parameters were analyzed.RESULTS Of the 150 patients,84 had proximal gastric cancer and 66 had distal gastric cancer.Dysphagia was significantly more common in the proximal gastric cancer group,while anemia and higher platelet-to-lymphocyte ratio values were observed in the distal gastric cancer group(P=0.031).Tumor stage and neutrophil-to-lymphocyte ratio emerged as independent predictors of all-cause mortality.No significant differences were found in other laboratory or biochemical parameters between the groups.CONCLUSION Proximal and distal gastric cancers demonstrate distinct clinical and laboratory profiles.The platelet-to-lymphocyte ratio may serve as a valuable marker in differentiating cancer localization,while the neutrophil-to-lymphocyte ratio is a prognostic indicator for mortality.These findings highlight the potential of hematological markers in optimizing diagnosis and treatment strategies for gastric cancer.
文摘The retrospective cohort study by Zuo et al investigates the interplay between microsatellite instability(MSI)status,nutritional indicators,and inflammatory profiles in colorectal cancer(CRC).Analyzing 56 patients,the study reveals that MSI-high tumors are associated with significantly lower serum albumin,body mass index,and absolute lymphocyte counts,alongside elevated neutrophil-tolymphocyte ratios compared to microsatellite stable tumors.These findings highlight distinct immunological and nutritional profiles in MSI-high CRC,suggesting potential clinical utility in risk stratification and personalized treat-ment.While the study underscores the importance of MSI status in CRC mana-gement,its single-center design and limited sample size warrant validation through multicenter trials.This article contextualizes these findings within the broader landscape of CRC research,emphasizing the need for integrating bio-markerdriven strategies into clinical practice to optimize outcomes for patients with differing MSI statuses.
文摘BACKGROUND An increasing number of studies to date have found preoperative magnetic resonance imaging(MRI)features valuable in predicting the prognosis of rectal cancer(RC).However,research is still lacking on the correlation between preoperative MRI features and the risk of recurrence after radical resection of RC,urgently necessitating further in-depth exploration.AIM To investigate the correlation between preoperative MRI parameters and the risk of recurrence after radical resection of RC to provide an effective tool for predicting postoperative recurrence.METHODS The data of 90 patients who were diagnosed with RC by surgical pathology and underwent radical surgical resection at the Second Affiliated Hospital of Bengbu Medical University between May 2020 and December 2023 were collected through retrospective analysis.General demographic data,MRI data,and tumor markers levels were collected.According to the reviewed data of patients six months after surgery,the clinicians comprehensively assessed the recurrence risk and divided the patients into high recurrence risk(37 cases)and low recurrence risk(53 cases)groups.Independent sample t-test andχ2 test were used to analyze differences between the two groups.A logistic regression model was used to explore the risk factors of the high recurrence risk group,and a clinical prediction model was constructed.The clinical prediction model is presented in the form of a nomogram.The receiver operating characteristic curve,Hosmer-Lemeshow goodness of fit test,calibration curve,and decision curve analysis were used to evaluate the efficacy of the clinical prediction model.RESULTS The detection of positive extramural vascular invasion through preoperative MRI[odds ratio(OR)=4.29,P=0.045],along with elevated carcinoembryonic antigen(OR=1.08,P=0.041),carbohydrate antigen 125(OR=1.19,P=0.034),and carbohydrate antigen 199(OR=1.27,P<0.001)levels,are independent risk factors for increased postoperative recurrence risk in patients with RC.Furthermore,there was a correlation between magnetic resonance based T staging,magnetic resonance based N staging,and circumferential resection margin results determined by MRI and the postoperative recurrence risk.Additionally,when extramural vascular invasion was integrated with tumor markers,the resulting clinical prediction model more effectively identified patients at high risk for postoperative recurrence,thereby providing robust support for clinical decision-making.CONCLUSION The results of this study indicate that preoperative MRI detection is of great importance for predicting the risk of postoperative recurrence in patients with RC.Monitoring these markers helps clinicians identify patients at high risk,allowing for more aggressive treatment and monitoring strategies to improve patient outcomes.
文摘BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.
文摘Malaria continues to pose a significant global health challenge despite a significant achievement in control and elimination in certain areas.Accurate and timely diagnosis is crucial for effective disease management and control,and finally leading to elimination.However,microscopy and rapid diagnostic tests(RDTs)have traditionally been the primary malaria diagnostic tools used globally,with certain shortcomings,including their limited sensitivity,specificity,and inability to identify asymptomatic infections.Serological markers have emerged as promising alternatives in malaria serosurveillance,particularly in countries where targets have already been set for elimination.This review highlights the advantages of serological markers over conventional diagnostic techniques and discusses some of the most promising serological markers against Plasmodium species-specific antigens.The implementation of serosurveillance,coupled with the utilization of these serological markers represents a transformative shift in malaria surveillance.By capitalizing on the immune memory of individuals,serosurveillance also enables the identification of recent and past infections.This approach is particularly valuable in low-transmission settings and for tracking changes in malaria prevalence over time.While recognizing the use of serological markers across various global contexts,this review predominantly emphasizes their significance within the framework of India.
文摘Colorectal cancer(CRC)is the third most common malignancy and the second leading cause of cancer-related mortality worldwide,responsible for approximately 900000 deaths annually.Inflammation and malnutrition significantly influence patients'responses to treatment.Markers such as serum albumin concentration,the prognostic nutritional index,nutritional risk index(NRI),geriatric NRI,and the systemic immune-inflammation index enable the early identification of high-risk patients,facilitating timely interventions that can improve survival and reduce morbidity.A comprehensive understanding and application of these markers allow for better risk stratification in CRC patients,optimizing their management and outcomes.
基金supported by the Fund for BTNYGG(NYHXGG,2023AA102)the National Natural Science Foundation of China(32260510)+3 种基金the Key Project for Science,Technology Development of Shihezi city,Xinjiang Production and Construction Crops(2022NY01)Shihezi University high-level talent research project(RCZK202337)Science and Technology Major Project of the Department of Science and Technology of Xinjiang Uygur Autonomous region(2022A03004-1)the Key Programs for Science and Technology Development in Agricultural Field of Xinjiang Production and Construction Corps。
文摘Background Cotton is a significant crop for fiber production;however,seed shape-related traits have been less investigated in comparison to fiber quality.Comprehending the genetic foundation of traits associated with seed shape is crucial for improving the seed and fiber quality in cotton.Results A total of 238 cotton accessions were evaluated in four different environments over a period of two years.Traits including thousand grain weight(TGW),aspect ratio(AR),seed length,seed width,diameter,and roundness demonstrated high heritability and significant genetic variation,as indicated by phenotypic analysis.The association analysis involved 145 simple sequence repeats(SSR)markers and identified 50 loci significantly associated with six traits related to seed shape.The markers MON_DPL0504aa and BNL2535ba were identified as influencing multiple traits,including aspect ratio and thousand grain weight.Notably,markers such as HAU2588a and MUSS422aa had considerable influence on seed diameter and roundness.The identified markers represented an average phenotypic variance between 3.92%for seed length and 16.54%for TGW.Conclusions The research finds key loci for seed shape-related traits in cotton,providing significant potential for marker-assisted breeding.These findings establish a framework for breeding initiatives focused on enhancing seed quality,hence advancing the cotton production.
基金supported by the National Key R&D Program of China(2022YFD1200400)the earmarked fund for CARS-13,the Major Science and Technology Projects of Henan Province,China(221100110300)the Henan Provincial R&D Program of Interregional Cooperation for Local Scientific and Technological Development Guided by Central Government,China(YDZX20214100004191)。
文摘Peanut kernels rich in oil,particularly those with oleic acid as their primary fatty acid,are in high demand among consumers,the food industry,and farmers due to their superior nutritional content,extended shelf life,and health benefits.The oil content and fatty acid composition are governed by multiple genetic factors.Identifying the quantitative trait loci(QTLs)related to these attributes will facilitate marker-assisted selection and genomic selection,thus enhancing quality-focused peanut breeding programs.For this purpose,we developed a population of 521 recombinant inbred lines(RILs)and tested their kernel quality traits across five different environments.We identified two major and stable QTLs for oil content,qOCAh12.1 and qOCAh16.1.The markers linked to these QTLs were designed by Kompetitive allele-specific PCR(KASP)and subsequently validated.Moreover,we found that the superior haplotype of oil content in the qOCAh16.1 region was conserved within the plant introduction(PI)germplasm cluster,as evidenced by a diverse peanut accession panel.In addition,we determined that qAh09 and qAh19.1,which harbor the key gene encoding fatty acid desaturase 2(FAD2),influence all seven fatty acids,palmitic,stearic,oleic,linoleic,arachidic,gadoleic,and behenic acids.Regarding the protein content and the long-chain saturated fatty acid behenic acid,qAh07 emerged as the major and stable QTL,accounting for over 10%of the phenotypic variation explained(PVE).These findings can enhance marker-assisted selection in peanut breeding,with the aim of improving the oil content,and deepen our understanding of the genetic mechanisms that shape fatty acid composition.
基金Supported by Liaoning Provincial Science and Technology Plan Joint Plan,No.2023JH2/101700149。
文摘BACKGROUND The deleterious effects of surgical trauma and subsequent postoperative complications pose significant challenges to the smooth recovery of patients after gastric cancer(GC)resection despite the substantial curative benefits provided by surgical interventions for GC.Hence,the investigation of more optimal and efficacious treatment approaches has become an urgent necessity in the medical community.AIM To investigate the association of Sijunzi decoction plus chemotherapy with the gastrointestinal function and serum markers of patients after GC surgery.METHODS This study included patients who underwent GC surgery from June 2022 to February 2024.The control group included 45 patients who received chemotherapy(oxaliplatin+calcium folinate+5-fluorouracil),whereas the research group consisted of 54 patients who received Sijunzi decoction therapy in addition to the treatment administered in the control group.Comparative analyses were conducted from the following perspectives:Gastrointestinal function(defecation time,intestinal gas discharge time,and hospitalization time),serum markers[carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,and CA199],nutritional indicators total protein(TP)and transferrin(TRF),traditional Chinese medicine(TCM)syndrome score,and grades Ⅲ–Ⅳ adverse events(gastrointestinal reactions,renal/liver function impairment,and myelosuppression).RESULTS The two groups demonstrated similar defecation time(P>0.05),but the intestinal gas discharge time and hospitalization time were significantly shortened in the research group(P<0.05).Further,the research group exhibited significant CEA,CA125,and CA199 reductions after treatment,which were lower compared to the control group,as well as notable increases in TP and TRF that were statistically higher than the control group(all P<0.05).Furthermore,the research group demonstrated an evident decrease in TCM syndrome scores in areas,such as poor appetite,epigastric distension and pain,fatigue and weakness(P<0.01),and abdominal distension after eating,which are notably lower than those in the control group(P<0.01),with a comparable incidence of grades Ⅲ-Ⅳ adverse events(P>0.05).CONCLUSION Our research results indicate that Sijunzi decoction plus chemotherapy exerts a good rehabilitation-promoting effect on gastrointestinal function in patients after GC surgery and significantly downregulates abnormally increased CEA,CA125,and CA199 levels.
基金Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS 2023-00237287.
文摘Bariatric surgery significantly improves glycemic control and can lead to type 2 diabetes remission.However,the reliability of glycated hemoglobin(HbA1c)as a type 2 diabetes biomarker post-surgery can be confounded by conditions such as anemia and gastrointestinal complications.Hence,we explored the use of alter-native biomarkers such as glycated albumin(GA),1,5-anhydroglucitol(1,5-AG),and insulin-like growth factor binding protein-1(IGFBP-1)to monitor glycemic control more effectively in post-bariatric surgery patients.Measuring GA and 1,5-AG levels can detect glycemic variability more sensitively than HbA1c,especially under non-fasting conditions.GA shows promise for short-term monitoring post-surgery while 1,5-AG could be useful for real-time glucose monitoring.IGFBP-1 can be used to monitor metabolic improvement and to predict HbA1c normal-ization.However,challenges in assay standardization and cost remain significant barriers to their clinical adoption.Although these biomarkers could offer a more personalized approach to glucose monitoring(thereby addressing the limitations of utilizing HbA1c in this endeavor in post-bariatric surgery patients),this would require overcoming technical,logistical,and cost-related challenges.While using GA,1,5-AG,and IGFBP-1 shows promise for glycemic monitoring,further research and validation are crucial for their routine clinical implementation,espe-cially in the context of diabetes management post-bariatric surgery.
文摘One of the main causes of cancer-related morbidity and mortality globally is hepatocellular carcinoma(HCC).At every stage of the disease,HCC may now be treated using a variety of therapy techniques.Nevertheless,despite the abundance of effective therapeutic choices,the prognosis for patients with HCC is still typically dismal.Prognostic indicators are crucial when assessing prognosis and tracking tumor metastases or recurrence.There are many prognostic markers in HCC.We mainly focused on newly reported prognostic markers such as MEX3A,apolipoprotein B,alpha-fetoprotein,circulating tumor cells,SAMD13,Agrin,and Glypican-3 in the pathogenesis of HCC.Further,we highlighted how these prognostic markers correlated to clinical parameters such as tumor node metastasis,tumor diameter,differentiation,hepatocirrhosis,vascular invasion,and others in HCC.Therefore,identifying specific prognostic biomarkers of HCC helps to provide a great opportunity to improve the prognosis in patients with HCC and provide therapeutic targets.
文摘Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.
基金Supported by the Zhejiang Provincial Natural Science Foundation of China,No.LTGY24H160006Jiaxing Medical Key Discipline,No.2023-ZC-015.
文摘BACKGROUND Rectal cancer is one of the common digestive system malignant tumors around the world.Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis.In recent years,tumor markers have gradually received attention in early screening,treatment monitoring and prognostic evaluation of cancer,but their predictive role in rectal cancer staging and differentiation is still unclear.AIM To assess the prognostic value of tumor markers alpha-fetoprotein(AFP)cancer antigen 72-4(CA72-4),carbohydrate antigen 19-9(CA19-9),and carcinoembryonic antigen(CEA),alongside multimodal magnetic resonance imaging(MRI),for staging and differentiating rectal cancer in patients.METHODS This study retrospectively analyzed 167 patients with rectal cancer who were treated at our institution from January 2020 to December 2024.Each patient underwent serological testing and multimodal MRI for diagnosis.Histopathological examination after surgical resection or imaging based on follow-up was used as the gold standard.According to the T stage and differentiation degree,patients were divided into low stage group(T1-T2)and high stage group(T3-T4).In addition,they were divided into low-differentiation groups and high-differentiation groups according to their differentiation degree.We compared the accuracy,sensitivity and specificity of tumor marker levels and MRI in rectal cancer stage and differentiation.RESULTS The study's findings indicate that in the context of rectal cancer T staging,there is substantial concordance between MRI and clinicopathological assessments,with a Kappa coefficient of 0.789(P<0.001).Similarly,for various degrees of tumor differentiation,MRI and clinicopathological evaluations demonstrated substantial agreement,with a Kappa coefficient of 0.651(P<0.001).Notably,the concentrations of tumor markers CA19-9,CA72-4,CEA,and AFP were significantly elevated in the T3-T4 stage compared to the T1-T2 stage.Furthermore,these markers were significantly higher in the low-differentiation group compared to the high-differentiation group(P<0.05).The combined use of tumor markers and MRI for preoperative T staging of rectal cancer yielded a diagnostic sensitivity of 93.7%and a specificity of 94.6%,as evidenced by the receiver operating characteristic analysis,with an area under the curve of 0.947.For tumor differentiation,the diagnostic sensitivity and specificity were 93.6%and 97.1%,respectively,with an area under the curve of 0.978(95%confidence interval:0.946-1.000),surpassing the accuracy of individual detection methods.CONCLUSION The CA19-9,CA72-4,CEA and AFP tumor markers combined with multimodal MRI have high sensitivity and specificity in diagnosing rectal cancer stage and differentiation.Their diagnostic efficacy is significantly better than that of single tests,which can effectively improve the predictive ability of rectal cancer stage and differentiation,provide a more reliable diagnostic reference for clinical practice,and have important clinical significance.
基金Survey on the Use of Discourse Markers by Teachers and Students in Foreign Language Classrooms:Taking Teaching Stages and Contexts as Examples(Project No.:20240847)Ideological and Political Teaching Practice of Linguistics Course Under New Liberal Arts(Project No.:JG2023074)。
文摘Based on conversation analysis theory,this study explored how teachers and students used discourse markers in foreign language classrooms and how these markers affect classroom interaction.The results showed that teachers use different discourse markers in different teaching stages such as lead-in,presentation,practice and summary to make their teaching more organized and clearer.However,students used these markers less often,and their expressions are often less coherent.Based on these findings,the study suggests teaching strategies for teachers and learning strategies for students to improve how they use discourse markers.This can help make foreign language teaching more effective and interactive.
文摘In this editorial we comment on the article published in the recent issue of World Journal of Gastrointestinal Oncology.This study aims to explore the relationship be-tween preoperative inflammation markers and the recurrence of gastrointestinal stromal tumors(GIST)after surgery.It is well known that the best-documented prognostic parameters for GIST are mitotic activity,tumor size and anatomical site.Besides,mutation status represents a prognostic as well as predictive factor.This study provides a new tool for postoperative recurrence risk assessment of GIST patients by establishing a line chart prediction model,which is certificated by previous research that high platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio correlated with increased tumour sizes,more advanced tumour stages and mitotic index.However,as a retrospective study,inevitable bias exists in the results;furthermore,the sample size of this study is relatively small,in-fluencing the universality of the results.Moreover,when assessing risk rating and prognosis of GIST,some novel inflammatory makers could be taken into consi-deration,such as proenkephalin and SLITRK3.Overall,this study can offer an additional model for GIST prognosis and recurrence risk assessment,indepen-dent of the traditional prognostic factors of GIST.
文摘This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms occur.Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive.Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.
文摘Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum kusnezoffii Reichb.,and Piper longum,and is known for its effects in eliminating“mucus,”relieving pain,and reducing swelling,with significant efficacy in treating joint effusion and lumbar pain.In recent years,researchers have summarized its chemical components and pharmacological effects,and employed network pharmacology methods based on the core theory of Traditional Chinese Medicine quality markers(Q-Markers)to analyze and predict its markers.The results identified potential Q-Markers for Naru-3,providing a scientific basis for quality control and further research.
基金Supported by Putian Science and Technology Plan Project,No.2022SY003.
文摘BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor removal.METHODS A prospective cohort study was conducted to analyze the clinical data of patients with GC.Patients were divided into two groups based on the surgical approach:The membrane dissection(MD)group,which underwent membrane-guided laparoscopic radical gastrectomy with D2 lymph node dissection plus complete mesocolic excision,and the D2 group,which underwent traditional laparoscopic radical gastrectomy with D2 lymph node dissection.Abdominal lavage fluid was collected pre-and postoperatively from patients in both groups.The expression of carcinoembryonic antigen(CEA)and cytokeratin-19(CK-19)message RNAs in the abdominal lavage fluid was detected using reverse transcription polymerase chain reaction.The factors influencing the increase of the tumor markers were analyzed,and the short-term efficacy of the two surgery types was compared.RESULTS In total,135 eligible patients were included in this study,with 69 and 66 cases in the MD and D2 groups,respectively.Fourteen patients with benign gastric lesions were selected to detect tumor marker expression.After excluding patients positive for preoperative cancer leakage,we found that 9.52%and 26.67%of patients in the MD and D2 groups developed postoperative CEA positivity,respectively.Multivariate analysis revealed that the degree of differentiation and surgical approach were independent risk factors for postoperative CEA positivity.The surgical approach was an independent risk factor affecting postoperative CK-19 positivity and postoperative CEA and CK-19 positivity.Surgical time,intraoperative blood loss,number of lymph nodes dissected,time to first postoperative flatus,and time to first liquid intake were all significantly different between the two surgical approaches.There were no significant differences in the incision length,duration of postoperative hospital stays,or postoperative complications.CONCLUSION MD is a better radical surgical treatment than traditional D2 surgery and is worthy of further clinical promotion and application.
文摘Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance,often leading to severe complications.Hemogram markers have attracted great attention from researchers for their established role in inflammatory conditions.In this respect,T2DM and its mi-crovascular complications are characterized by high inflammatory burden.Hence,recent studies in the literature have reported an association between T2DM and hemogram-derived markers.Emerging evidence highlights the utility of hemo-gram-derived markers,including the neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,red cell distribution width,and mean platelet volume,as potential predictors of T2DM onset and progression.These markers,readily available from routine hemogram tests,offer valuable insights into the systemic inflammation and vascular changes associated with T2DM and its complications,such as cardiovascular disease,nephropathy,and retinopathy.This review syn-thesizes current research on the association between hemogram-derived markers and T2DM,emphasizing their prognostic value in predicting disease severity and complications.We also explore the underlying pathophysiological mechanisms linking these markers to inflammation and metabolic dysfunction.The findings suggest that hemogram-derived markers could serve as cost-effective,non-invasive tools for risk stratification and early intervention in T2DM management.Future research should focus on standardizing reference ranges and validating these markers in diverse populations to enhance their clinical utility.
