The 17th ITMF Global Textile Industry Survey(GTIS,formerly known as ITMF Corona-Survey)shows that on average the business situation in the global textile industry has deteriorated further in November 2022.At the same ...The 17th ITMF Global Textile Industry Survey(GTIS,formerly known as ITMF Corona-Survey)shows that on average the business situation in the global textile industry has deteriorated further in November 2022.At the same time,global business expectations in six months’time remained in negative territory but did not get gloomier.The indicators for order intake,order backlog,and capacity utilisation rate dropped,globally.展开更多
Dear Editor,Currently,there are no FDA-approved disease-modifying therapies that can prevent,halt,or reverse Alzheimer's disease(AD).As the unsatisfactory of amyloid-p-targeted treatment in recent years,developmen...Dear Editor,Currently,there are no FDA-approved disease-modifying therapies that can prevent,halt,or reverse Alzheimer's disease(AD).As the unsatisfactory of amyloid-p-targeted treatment in recent years,development of Tau-targeted active immunotherapy takes much concern.1 Tau protein,a major microtubule-associated protein in the nervous system,was found to be abnormally hyperphosphorylated at six epitopes:Ser396/404,Ser202,Thr205,Ser238,and Ser262 in AD patients.2 Hence,immunotherapy targeting more highly-expressed phosphorylated Tau(pTau)species may induce a sufficient pool of pTau antibodies to eliminate pathological tau and elicit cognitive improvement.展开更多
In the process of collating the published data,the authors noticed one inadvertent mistake occurred during the production process in Fig.1u that needs to be corrected.1 The authors mistakenly placed the wrong western ...In the process of collating the published data,the authors noticed one inadvertent mistake occurred during the production process in Fig.1u that needs to be corrected.1 The authors mistakenly placed the wrong western blot figure for the level of pTauS404 in the urea fraction of mice from the onset cohort in Fig.lu.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected.展开更多
Fibrotic remodeling of nucleus pulposus(NP)leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration,leading to low back pain incidence and disability.Emergence of fibroblastic ce...Fibrotic remodeling of nucleus pulposus(NP)leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration,leading to low back pain incidence and disability.Emergence of fibroblastic cells in disc degeneration has been reported,yet their nature and origin remain elusive.In this study,we performed an integrative analysis of multiple single-cell RNA sequencing datasets to interrogate the cellular heterogeneity and fibroblast-like entities in degenerative human NP specimens.We found that disc degeneration severity is associated with an enrichment of fibrocyte phenotype,characterized by CD45 and collagen I dual positivity,and expression of myofibroblast markerα-smooth muscle actin.Refined clustering and classification distinguished the fibrocyte-like populations as subtypes in the NP cells-and immunocytes-clusters,expressing disc degeneration markers HTRA1 and ANGPTL4 and genes related to response to TGF-β.In injury-induced mouse disc degeneration model,fibrocytes were found recruited into the NP undergoing fibrosis and adopted a myofibroblast phenotype.Depleting the fibrocytes in CD11b-DTR mice in which myeloid-derived lineages were ablated by diphtheria toxin could markedly attenuate fibrous modeling and myofibroblast formation in the NP of the degenerative discs,and prevent disc height loss and histomorphological abnormalities.Marker analysis supports that disc degeneration progression is dependent on a function of CD45^(+)COL1A1^(+)andαSMA^(+)cells.Our findings reveal that myeloid-derived fibrocytes play a pivotal role in NP fibrosis and may therefore be a target for modifying disc degeneration and promoting its repair.展开更多
Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell types.While we and others have previously demonstrated that the expression of Piezo1 in osteo...Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell types.While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in cartilage.Here we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)development.Mice with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate postnatally.Moreover,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth plates.While skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of age.Likewise,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage degeneration.Importantly,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) mice.We further observed increased Piezo1 protein abundance in cartilaginous zones of human osteophytes.Finally,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in chondrocytes.Collectively,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.展开更多
The Yishoujiangzhi (de-blood-lipid) tablets (composed of Radix Polygori Multiflori, Rhizoma Polygonati, Fructus Lycii, Crataegus Pinnatifida and Cassia Tora) were used in the treatment of 130 cases of hyperlipemia, ac...The Yishoujiangzhi (de-blood-lipid) tablets (composed of Radix Polygori Multiflori, Rhizoma Polygonati, Fructus Lycii, Crataegus Pinnatifida and Cassia Tora) were used in the treatment of 130 cases of hyperlipemia, achieving an effective rate of 87.0% in lowering serum cholesterol and 80.8% in lowering triglyceride.展开更多
The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective h...The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective here was to investigate how a macrocrack develops.Incubating detached sweet cherry fruit in deionized water induces microcracking.Incubating fruit in D2O and concurrent magnetic resonance imaging demonstrates that water penetration occurs only(principally)through the microcracks,with nondetectable amounts penetrating the intact cuticle.Optical coherence tomography of detached,whole fruit incubated in deionized water,allowed generation of virtual cross-sections through the zone of a developing macrocrack.Outer mesocarp cell volume increased before macrocracks developed but increased at a markedly higher rate thereafter.Little change in mesocarp cell volume occurred in a control zone distant from the crack.As water incubation continued,the cell volume in the crack zone decreased,indicating leaking/bursting of individual mesocarp cells.As incubation continued still longer,the crack propagated between cells both to form a long,deep macrocrack.Outer mesocarp cell turgor did not differ significantly before and after incubation between fruit with or without macrocracks;nor between cells within the crack zone and those in a control zone distant from the macrocrack.The cumulative frequency distribution of the logtransformed turgor pressure of a population of outer mesocarp cells reveals all cell turgor data followed a normal distribution.The results demonstrate that microcracks develop into macrocracks following the volume increase of a few outer mesocarp cells and is soon accompanied by cell bursting.展开更多
Herba Epimedii (淫羊藿) is an herbalmedicine used for tonifying and invigoratingkidney-yang.In animal experiments forscreening effective drugs for coronary heartdisease,we found that Herba Epimediimarkedly increased c...Herba Epimedii (淫羊藿) is an herbalmedicine used for tonifying and invigoratingkidney-yang.In animal experiments forscreening effective drugs for coronary heartdisease,we found that Herba Epimediimarkedly increased coronary blood flow,al-leviating myocardial ischemia and relievinganoxia.Clinical trials of this drug weremade in 120 coronary heart disease展开更多
5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor...5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor,could partially inhibit the EAA,abolish the effects ofEA’s increasing the 5-HT content in the medulla oblongata plus pons and the DA level in thebrain stem,and decrease the NA level in the diencephalon after EA.These results indicate thatEA may mediate the metabolism of the central monoamine neurotransmitters partially via opiatereceptor to exert its analgesic effect.展开更多
One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of complications.In particular,both ischemi...One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of complications.In particular,both ischemic and haemorrhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these patients.The recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack validation.In particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy results.The present review provides an updated overview on the emerging evidencefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS.展开更多
Much research has been conductedabroad in recent years concerningacupuncture and moxibustion on theimmunologic functions of the organism.Anoutline of this is presented as follows.EFFECTS OF ACUPUNCTUREAND MOXIBUSTION ...Much research has been conductedabroad in recent years concerningacupuncture and moxibustion on theimmunologic functions of the organism.Anoutline of this is presented as follows.EFFECTS OF ACUPUNCTUREAND MOXIBUSTION ON NORMALIMMUNOLOGIC FUNCTIONS展开更多
In the present paper, 45 cases of acute trigemina] neuralgia were treated and observed by comparative method. Results showed no significant difference in transient analgesic effect (P】 0.05) but a significant differe...In the present paper, 45 cases of acute trigemina] neuralgia were treated and observed by comparative method. Results showed no significant difference in transient analgesic effect (P】 0.05) but a significant difference in therapeutic effect (P【 0.01) between the treatment and control groups. This indicates that blood-letting puncture with cupping is an effective therapy for the disease.展开更多
Nasopharyngeal Carcinoma (NPC) is acommon carcinoma in Southern China.The5-year survival rate achieved byradiotherapy alone is still relatively low.Wetreated NPC patients with Yi Qi Yang YinDecoction (YQYYD,decoction ...Nasopharyngeal Carcinoma (NPC) is acommon carcinoma in Southern China.The5-year survival rate achieved byradiotherapy alone is still relatively low.Wetreated NPC patients with Yi Qi Yang YinDecoction (YQYYD,decoction for invigo-rating qi and nourishing yin) combined withradiotherapy with satisfactory results.Acomparison was made in such aspects as re-展开更多
Peripheral facial paralysis,a commondisease referring mainly to Bell’s palsy,iscaused by peripheral nerve malfunction dueto the effect of cold and wind,the exactcause of which still remains unascertained.
Thirty cases of IgA nephropathy having been diagnosed by biopsy with kidney puncture were selected. The treatment was based on the differentiation of syndromes in traditional Chinese medicine (TCM). The disease was di...Thirty cases of IgA nephropathy having been diagnosed by biopsy with kidney puncture were selected. The treatment was based on the differentiation of syndromes in traditional Chinese medicine (TCM). The disease was divided into 4 stages: the initial stage with the lesion in the lung and kidney, the stable stage with the lesion in the spleen and kidney, the late stage with the lesion in the liver and kidney, and the recurrent stage. They were treated by TCM. Of them, 10 cases were completely alleviated, 13 markedly alleviated, 4 improved, and 3 ineffective, the total effective rate being 90%.展开更多
Liu Wei Di Huang Tang (LWDHT), a Chinese Prescription for strengthening the body re-sistance, restoring the normal functions of the body to consolidate the constitution, and nour-ishing and invigorating the kidney yin...Liu Wei Di Huang Tang (LWDHT), a Chinese Prescription for strengthening the body re-sistance, restoring the normal functions of the body to consolidate the constitution, and nour-ishing and invigorating the kidney yin, has been used to prevent and treat severe hypeplasiaof esophageal epithelium for many years. The results of this experiment show that LWDHTcan increase markedly the number of lymphocytes, mainly T lymphocytes, in tumor--bearingmice. Free--flow electrophoresis shows that in tumor--bearing mice the electrophoretic char-acteristics of T lymphocytes are changed, i.e., reduction of the number of T lymphocyteswith a higher electrophoretic rate, but LWDHT can alleviate this disorder. Study on the cellmembrane fluidity of carcinoma cells in EAC mice demonstrates that LWDHT can decreasethe cell membrane fluidity. suggesting that it can inhibit division of carcinoma展开更多
Electrical stimulation of the median nerve is a noninvasive technique that facilitates awakening from coma. In rats with traumatic brain injury-induced coma, median nerve stimulation markedly enhances prefrontal corte...Electrical stimulation of the median nerve is a noninvasive technique that facilitates awakening from coma. In rats with traumatic brain injury-induced coma, median nerve stimulation markedly enhances prefrontal cortex expression of orexin-A and its receptor, orexin receptor 1. To further understand the mechanism underlying wakefulness mediated by electrical stimulation of the median nerve, we evaluated its effects on the expression of the N-methyl-D-aspartate receptor subunit NR1 in the prefrontal cortex in rat models of traumatic brain injury-induced coma, using immunohistochemistry and western blot assays. In rats with traumatic brain injury, NR1 expression increased with time after injury. Rats that underwent electrical stimulation of the median nerve（30 Hz, 0.5 ms, 1.0 m A for 15 minutes） showed elevated NR1 expression and greater recovery of consciousness than those without stimulation. These effects were reduced by intracerebroventricular injection of the orexin receptor 1 antagonist SB334867. Our results indicate that electrical stimulation of the median nerve promotes recovery from traumatic brain injury-induced coma by increasing prefrontal cortex NR1 expression via an orexin-A-mediated pathway.展开更多
In recent years,extended life expectancies and lifestyle changes have markedly contributed to the increased incidence of heart failure(HF)worldwide[1].In China,while the age of patients with chronic HF has increased a...In recent years,extended life expectancies and lifestyle changes have markedly contributed to the increased incidence of heart failure(HF)worldwide[1].In China,while the age of patients with chronic HF has increased annually,the mortality rate has not decreased significantly[1].展开更多
BACKGROUND Recurrence of atrial fibrillation(AF)is common in patients with persistent AF even after multiple ablation procedures.His-Purkinje conduction system pacing(HPCSP)combined with atrioventricular node ablation...BACKGROUND Recurrence of atrial fibrillation(AF)is common in patients with persistent AF even after multiple ablation procedures.His-Purkinje conduction system pacing(HPCSP)combined with atrioventricular node ablation(AVNA)is effective in managing patients with AF and heart failure.This study aimed to determine whether HPCSP combined with AVNA can improve quality of life and alleviate symptoms in older patients with symptomatic persistent AF refractory to multiple ablation procedures,as well as evaluate the feasibility and safety of this therapy.METHODS Older patients(≥65 years)with symptomatic persistent AF refractory to at least two ablation procedures were treated with combined HPCSP and AVNA.The success rates and complications were recorded.Pacing parameters,European Heart Rhythm Association(EHRA)scores,and Atrial Fibrillation Effect on Quality-of-Life(AFEQT)scores obtained perioperatively were compared with those recorded at the 6-month follow-up examination.RESULTS Thirty-one patients were enrolled;of those,only thirty patients were eventually treated with AVNA because one patient developed a complete atrioventricular block following the withdrawal of the His bundle pacing lead.The success rates were 100%for HPCSP(22 cases with His bundle pacing,and 9 cases with left bundle branch pacing)and 93.3%(28/30)for AVNA,respectively.By the 6-month follow-up examination,EHRA scores improved significantly(3.00±0.73 vs.2.44±0.63,P=0.014)and AFEQT scores increased markedly(49.6±20.6 vs.70.9±14.0,P=0.001).No severe complications developed.CONCLUSIONS When used in older patients with symptomatic persistent AF refractory to multiple ablation procedures,HPCSP combined with AVNA significantly alleviated symptoms and improved quality of life during short-term follow-up.This therapy was proved to be safe and effective in this patient population.展开更多
Electroacupuncture（EA） has anti-oxidative and anti-inflammatory actions,but whether the neuroprotective effect of EA against cerebral ischemia-reperfusion（I/R） injury involves modulation of the extracellular regul...Electroacupuncture（EA） has anti-oxidative and anti-inflammatory actions,but whether the neuroprotective effect of EA against cerebral ischemia-reperfusion（I/R） injury involves modulation of the extracellular regulated kinase 1/2（ERK1/2） signaling pathway is unclear.Middle cerebral artery occlusion（MCAO） was performed in Sprague-Dawley rats for 2 hours followed by reperfusion for 24 hours.A 30-minute period of EA stimulation was applied to both Baihui（DU20） and Dazhui（DU14） acupoints in each rat（10 mm EA penetration depth,continuous wave with a frequency of 3 Hz,and a current intensity of 1–3 m A） when reperfusion was initiated.EA significantly reduced infarct volume,alleviated neuronal injury,and improved neurological function in rats with MCAO.Furthermore,high m RNA expression of Bax and low m RNA expression of Bcl-2 induced by MCAO was prevented by EA.EA substantially restored total glutathione reductase（GR）,glutathione（GSH） and glutathione peroxidase（GSH-Px） levels.Additionally,Nrf2 and glutamylcysteine synthetase（GCS） expression levels were markedly increased by EA.Interestingly,the neuroprotective effects of EA were attenuated when ERK1/2 activity was blocked by PD98059（a specific MEK inhibitor）.Collectively,our findings indicate that activation of the ERK1/2 signaling pathway contributes to the neuroprotective effects of EA.Our study provides a better understanding of the regulatory mechanisms underlying the therapeutic effectiveness of EA.展开更多
文摘The 17th ITMF Global Textile Industry Survey(GTIS,formerly known as ITMF Corona-Survey)shows that on average the business situation in the global textile industry has deteriorated further in November 2022.At the same time,global business expectations in six months’time remained in negative territory but did not get gloomier.The indicators for order intake,order backlog,and capacity utilisation rate dropped,globally.
基金supported by National Natural Science Foundation of China[No.31971142]Science&Technology Development Plan of Jilin Province[No.20190201185JC,No.20190103073JH,No.2018C004]+1 种基金Fundamental Research Funds for the Central Universities[No.2019JCXK-55]Science&Technology Research Project of The Education Department of Jilin Province[No.JJKH20200949KJ].
文摘Dear Editor,Currently,there are no FDA-approved disease-modifying therapies that can prevent,halt,or reverse Alzheimer's disease(AD).As the unsatisfactory of amyloid-p-targeted treatment in recent years,development of Tau-targeted active immunotherapy takes much concern.1 Tau protein,a major microtubule-associated protein in the nervous system,was found to be abnormally hyperphosphorylated at six epitopes:Ser396/404,Ser202,Thr205,Ser238,and Ser262 in AD patients.2 Hence,immunotherapy targeting more highly-expressed phosphorylated Tau(pTau)species may induce a sufficient pool of pTau antibodies to eliminate pathological tau and elicit cognitive improvement.
文摘In the process of collating the published data,the authors noticed one inadvertent mistake occurred during the production process in Fig.1u that needs to be corrected.1 The authors mistakenly placed the wrong western blot figure for the level of pTauS404 in the urea fraction of mice from the onset cohort in Fig.lu.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected.
基金jointly General Research Fund(17121619)of the Research Grant Council of Hong KongGuangdong Basic and Applied Basic Research Foundation(2024A1515010104 and 2023A1515220095)Scientific Research Foundation of Peking University Shenzhen Hospital(KYQD202100X)。
文摘Fibrotic remodeling of nucleus pulposus(NP)leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration,leading to low back pain incidence and disability.Emergence of fibroblastic cells in disc degeneration has been reported,yet their nature and origin remain elusive.In this study,we performed an integrative analysis of multiple single-cell RNA sequencing datasets to interrogate the cellular heterogeneity and fibroblast-like entities in degenerative human NP specimens.We found that disc degeneration severity is associated with an enrichment of fibrocyte phenotype,characterized by CD45 and collagen I dual positivity,and expression of myofibroblast markerα-smooth muscle actin.Refined clustering and classification distinguished the fibrocyte-like populations as subtypes in the NP cells-and immunocytes-clusters,expressing disc degeneration markers HTRA1 and ANGPTL4 and genes related to response to TGF-β.In injury-induced mouse disc degeneration model,fibrocytes were found recruited into the NP undergoing fibrosis and adopted a myofibroblast phenotype.Depleting the fibrocytes in CD11b-DTR mice in which myeloid-derived lineages were ablated by diphtheria toxin could markedly attenuate fibrous modeling and myofibroblast formation in the NP of the degenerative discs,and prevent disc height loss and histomorphological abnormalities.Marker analysis supports that disc degeneration progression is dependent on a function of CD45^(+)COL1A1^(+)andαSMA^(+)cells.Our findings reveal that myeloid-derived fibrocytes play a pivotal role in NP fibrosis and may therefore be a target for modifying disc degeneration and promoting its repair.
基金supported by the German Research Foundation(SCHI 504/19-1(to TS)and IG 18/22-1(to AI))the Else Kröner-Fresenius foundation under grant no.2021_EKEA.23(to TR)financial support from the Open Access Publication Fund of UKE–Universitatsklinikum Hamburg-Eppendorf and DFG–German Research Foundation.
文摘Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell types.While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in cartilage.Here we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)development.Mice with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate postnatally.Moreover,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth plates.While skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of age.Likewise,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage degeneration.Importantly,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) mice.We further observed increased Piezo1 protein abundance in cartilaginous zones of human osteophytes.Finally,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in chondrocytes.Collectively,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.
文摘The Yishoujiangzhi (de-blood-lipid) tablets (composed of Radix Polygori Multiflori, Rhizoma Polygonati, Fructus Lycii, Crataegus Pinnatifida and Cassia Tora) were used in the treatment of 130 cases of hyperlipemia, achieving an effective rate of 87.0% in lowering serum cholesterol and 80.8% in lowering triglyceride.
基金financed by the Open Access Fund of the Leibniz Universität Hannover.
文摘The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective here was to investigate how a macrocrack develops.Incubating detached sweet cherry fruit in deionized water induces microcracking.Incubating fruit in D2O and concurrent magnetic resonance imaging demonstrates that water penetration occurs only(principally)through the microcracks,with nondetectable amounts penetrating the intact cuticle.Optical coherence tomography of detached,whole fruit incubated in deionized water,allowed generation of virtual cross-sections through the zone of a developing macrocrack.Outer mesocarp cell volume increased before macrocracks developed but increased at a markedly higher rate thereafter.Little change in mesocarp cell volume occurred in a control zone distant from the crack.As water incubation continued,the cell volume in the crack zone decreased,indicating leaking/bursting of individual mesocarp cells.As incubation continued still longer,the crack propagated between cells both to form a long,deep macrocrack.Outer mesocarp cell turgor did not differ significantly before and after incubation between fruit with or without macrocracks;nor between cells within the crack zone and those in a control zone distant from the macrocrack.The cumulative frequency distribution of the logtransformed turgor pressure of a population of outer mesocarp cells reveals all cell turgor data followed a normal distribution.The results demonstrate that microcracks develop into macrocracks following the volume increase of a few outer mesocarp cells and is soon accompanied by cell bursting.
文摘Herba Epimedii (淫羊藿) is an herbalmedicine used for tonifying and invigoratingkidney-yang.In animal experiments forscreening effective drugs for coronary heartdisease,we found that Herba Epimediimarkedly increased coronary blood flow,al-leviating myocardial ischemia and relievinganoxia.Clinical trials of this drug weremade in 120 coronary heart disease
文摘5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor,could partially inhibit the EAA,abolish the effects ofEA’s increasing the 5-HT content in the medulla oblongata plus pons and the DA level in thebrain stem,and decrease the NA level in the diencephalon after EA.These results indicate thatEA may mediate the metabolism of the central monoamine neurotransmitters partially via opiatereceptor to exert its analgesic effect.
文摘One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of complications.In particular,both ischemic and haemorrhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these patients.The recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack validation.In particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy results.The present review provides an updated overview on the emerging evidencefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS.
文摘Much research has been conductedabroad in recent years concerningacupuncture and moxibustion on theimmunologic functions of the organism.Anoutline of this is presented as follows.EFFECTS OF ACUPUNCTUREAND MOXIBUSTION ON NORMALIMMUNOLOGIC FUNCTIONS
文摘In the present paper, 45 cases of acute trigemina] neuralgia were treated and observed by comparative method. Results showed no significant difference in transient analgesic effect (P】 0.05) but a significant difference in therapeutic effect (P【 0.01) between the treatment and control groups. This indicates that blood-letting puncture with cupping is an effective therapy for the disease.
文摘Nasopharyngeal Carcinoma (NPC) is acommon carcinoma in Southern China.The5-year survival rate achieved byradiotherapy alone is still relatively low.Wetreated NPC patients with Yi Qi Yang YinDecoction (YQYYD,decoction for invigo-rating qi and nourishing yin) combined withradiotherapy with satisfactory results.Acomparison was made in such aspects as re-
文摘Peripheral facial paralysis,a commondisease referring mainly to Bell’s palsy,iscaused by peripheral nerve malfunction dueto the effect of cold and wind,the exactcause of which still remains unascertained.
文摘Thirty cases of IgA nephropathy having been diagnosed by biopsy with kidney puncture were selected. The treatment was based on the differentiation of syndromes in traditional Chinese medicine (TCM). The disease was divided into 4 stages: the initial stage with the lesion in the lung and kidney, the stable stage with the lesion in the spleen and kidney, the late stage with the lesion in the liver and kidney, and the recurrent stage. They were treated by TCM. Of them, 10 cases were completely alleviated, 13 markedly alleviated, 4 improved, and 3 ineffective, the total effective rate being 90%.
文摘Liu Wei Di Huang Tang (LWDHT), a Chinese Prescription for strengthening the body re-sistance, restoring the normal functions of the body to consolidate the constitution, and nour-ishing and invigorating the kidney yin, has been used to prevent and treat severe hypeplasiaof esophageal epithelium for many years. The results of this experiment show that LWDHTcan increase markedly the number of lymphocytes, mainly T lymphocytes, in tumor--bearingmice. Free--flow electrophoresis shows that in tumor--bearing mice the electrophoretic char-acteristics of T lymphocytes are changed, i.e., reduction of the number of T lymphocyteswith a higher electrophoretic rate, but LWDHT can alleviate this disorder. Study on the cellmembrane fluidity of carcinoma cells in EAC mice demonstrates that LWDHT can decreasethe cell membrane fluidity. suggesting that it can inhibit division of carcinoma
基金supported by the National Natural Science Foundation of China,No.81260295the Natural Science Foundation of Jiangxi Province of China,No.20132BAB205063
文摘Electrical stimulation of the median nerve is a noninvasive technique that facilitates awakening from coma. In rats with traumatic brain injury-induced coma, median nerve stimulation markedly enhances prefrontal cortex expression of orexin-A and its receptor, orexin receptor 1. To further understand the mechanism underlying wakefulness mediated by electrical stimulation of the median nerve, we evaluated its effects on the expression of the N-methyl-D-aspartate receptor subunit NR1 in the prefrontal cortex in rat models of traumatic brain injury-induced coma, using immunohistochemistry and western blot assays. In rats with traumatic brain injury, NR1 expression increased with time after injury. Rats that underwent electrical stimulation of the median nerve（30 Hz, 0.5 ms, 1.0 m A for 15 minutes） showed elevated NR1 expression and greater recovery of consciousness than those without stimulation. These effects were reduced by intracerebroventricular injection of the orexin receptor 1 antagonist SB334867. Our results indicate that electrical stimulation of the median nerve promotes recovery from traumatic brain injury-induced coma by increasing prefrontal cortex NR1 expression via an orexin-A-mediated pathway.
文摘In recent years,extended life expectancies and lifestyle changes have markedly contributed to the increased incidence of heart failure(HF)worldwide[1].In China,while the age of patients with chronic HF has increased annually,the mortality rate has not decreased significantly[1].
基金the Beijing Natural Science Foundation(No.7202050)the Project of Hebei Province Medical Science Research(No.20210483).
文摘BACKGROUND Recurrence of atrial fibrillation(AF)is common in patients with persistent AF even after multiple ablation procedures.His-Purkinje conduction system pacing(HPCSP)combined with atrioventricular node ablation(AVNA)is effective in managing patients with AF and heart failure.This study aimed to determine whether HPCSP combined with AVNA can improve quality of life and alleviate symptoms in older patients with symptomatic persistent AF refractory to multiple ablation procedures,as well as evaluate the feasibility and safety of this therapy.METHODS Older patients(≥65 years)with symptomatic persistent AF refractory to at least two ablation procedures were treated with combined HPCSP and AVNA.The success rates and complications were recorded.Pacing parameters,European Heart Rhythm Association(EHRA)scores,and Atrial Fibrillation Effect on Quality-of-Life(AFEQT)scores obtained perioperatively were compared with those recorded at the 6-month follow-up examination.RESULTS Thirty-one patients were enrolled;of those,only thirty patients were eventually treated with AVNA because one patient developed a complete atrioventricular block following the withdrawal of the His bundle pacing lead.The success rates were 100%for HPCSP(22 cases with His bundle pacing,and 9 cases with left bundle branch pacing)and 93.3%(28/30)for AVNA,respectively.By the 6-month follow-up examination,EHRA scores improved significantly(3.00±0.73 vs.2.44±0.63,P=0.014)and AFEQT scores increased markedly(49.6±20.6 vs.70.9±14.0,P=0.001).No severe complications developed.CONCLUSIONS When used in older patients with symptomatic persistent AF refractory to multiple ablation procedures,HPCSP combined with AVNA significantly alleviated symptoms and improved quality of life during short-term follow-up.This therapy was proved to be safe and effective in this patient population.
基金supported by the National Natural Science Foundation of China,No.81373748,81171659,11574156 and 81403136a grant from the 333 Project of Jiangsu Province in China No.BRA2014341a grant from the Jiangsu Province Science and Technology Support Project in China,No.BE2010769
文摘Electroacupuncture（EA） has anti-oxidative and anti-inflammatory actions,but whether the neuroprotective effect of EA against cerebral ischemia-reperfusion（I/R） injury involves modulation of the extracellular regulated kinase 1/2（ERK1/2） signaling pathway is unclear.Middle cerebral artery occlusion（MCAO） was performed in Sprague-Dawley rats for 2 hours followed by reperfusion for 24 hours.A 30-minute period of EA stimulation was applied to both Baihui（DU20） and Dazhui（DU14） acupoints in each rat（10 mm EA penetration depth,continuous wave with a frequency of 3 Hz,and a current intensity of 1–3 m A） when reperfusion was initiated.EA significantly reduced infarct volume,alleviated neuronal injury,and improved neurological function in rats with MCAO.Furthermore,high m RNA expression of Bax and low m RNA expression of Bcl-2 induced by MCAO was prevented by EA.EA substantially restored total glutathione reductase（GR）,glutathione（GSH） and glutathione peroxidase（GSH-Px） levels.Additionally,Nrf2 and glutamylcysteine synthetase（GCS） expression levels were markedly increased by EA.Interestingly,the neuroprotective effects of EA were attenuated when ERK1/2 activity was blocked by PD98059（a specific MEK inhibitor）.Collectively,our findings indicate that activation of the ERK1/2 signaling pathway contributes to the neuroprotective effects of EA.Our study provides a better understanding of the regulatory mechanisms underlying the therapeutic effectiveness of EA.
