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New Finite Difference Mapped WENO Schemes with Increasingly High Order of Accuracy 被引量:2
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作者 Jun Zhu Jianxian Qiu 《Communications on Applied Mathematics and Computation》 2023年第1期64-96,共33页
In this paper,a new type of finite difference mapped weighted essentially non-oscillatory(MWENO)schemes with unequal-sized stencils,such as the seventh-order and ninthorder versions,is constructed for solving hyperbol... In this paper,a new type of finite difference mapped weighted essentially non-oscillatory(MWENO)schemes with unequal-sized stencils,such as the seventh-order and ninthorder versions,is constructed for solving hyperbolic conservation laws.For the purpose of designing increasingly high-order finite difference WENO schemes,the equal-sized stencils are becoming more and more wider.The more we use wider candidate stencils,the bigger the probability of discontinuities lies in all stencils.Therefore,one innovation of these new WENO schemes is to introduce a new splitting stencil methodology to divide some fourpoint or five-point stencils into several smaller three-point stencils.By the usage of this new methodology in high-order spatial reconstruction procedure,we get different degree polynomials defined on these unequal-sized stencils,and calculate the linear weights,smoothness indicators,and nonlinear weights as specified in Jiang and Shu(J.Comput.Phys.126:202228,1996).Since the difference between the nonlinear weights and the linear weights is too big to keep the optimal order of accuracy in smooth regions,another crucial innovation is to present the new mapping functions which are used to obtain the mapped nonlinear weights and decrease the difference quantity between the mapped nonlinear weights and the linear weights,so as to keep the optimal order of accuracy in smooth regions.These new MWENO schemes can also be applied to compute some extreme examples,such as the double rarefaction wave problem,the Sedov blast wave problem,and the Leblanc problem with a normal CFL number.Extensive numerical results are provided to illustrate the good performance of the new finite difference MWENO schemes. 展开更多
关键词 Finite difference mapped WENO scheme Mapping function mapped nonlinear weight Unequal-sized stencil Extreme example
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Mapped Finite Element Discrete Variable Representation
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作者 De-quan Yu Shu-lin Cong +1 位作者 Dong H. Zhang Zhi-gang Sun 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第6期755-764,I0005,共11页
Efficient numerical solver for the SchrSdinger equation is very important in physics and chemistry. The finite element discrete variable representation (FE-DVR) was first proposed by Rescigno and Mc-Curdy [Phys. Rev... Efficient numerical solver for the SchrSdinger equation is very important in physics and chemistry. The finite element discrete variable representation (FE-DVR) was first proposed by Rescigno and Mc-Curdy [Phys. Rev. A 62, 032706 (2000)] for solving quantum-mechanical scattering problems. In this work, an FE-DVR method in a mapped coordinate was proposed to improve the efficiency of the original FE-DVR method. For numerical demonstration, the proposed approach is applied for solving the electronic eigenfunctions and eigenvalues of the hydrogen atom and vibrational states of the electronic state 3E+ of the Cs2 molecule which has long-range interaction potential. The numerical results indicate that the numerical efficiency of the original FE-DVR has been improved much using our proposed mapped coordinate scheme. 展开更多
关键词 Discrete variable representation mapped Fourier method Ultra-cold atomic photoassociation Schrodinger equation solver Singularity of Coulomb potential
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A blueprint mapped out for constructing five large hydropower projects
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《Electricity》 1998年第3期37-37,共1页
关键词 A blueprint mapped out for constructing five large hydropower projects
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Charting the Way Forward China’s lianghui mapped out a promising blueprint for the country’s future development
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作者 Ni Yanshuo 《ChinAfrica》 2018年第4期14-15,共2页
The lianghui, or the annual Two Sessions of the National People's Congress (NPC) and the Chinese People's Political Consultative Conference (CPPCC) National Committee, are always a great political event in China... The lianghui, or the annual Two Sessions of the National People's Congress (NPC) and the Chinese People's Political Consultative Conference (CPPCC) National Committee, are always a great political event in China, but more so this year, with groundbreaking outcomes. 展开更多
关键词 NPC Charting the Way Forward China’s lianghui mapped out a promising blueprint for the country’s future development
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Photodissociation Dynamics of Carbon Dioxide Cation via the Vibrationally Mediated A^2Hu,1/2 State: A Time-Sliced Velocity-Mapped Ion Imaging Study
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作者 茆锐 何超 +3 位作者 陈旻 周丹娜 张群 陈旸 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2017年第2期123-127,I0001,共6页
We report on the photodissociation dynamics of CO2^+ via its A2Пu,1/2 state using the scheme of [1+1] photon excitation that is intermediated by the mode-selected A2Hu,1/2(Vl,V2,0) vibronic states. Photodissociat... We report on the photodissociation dynamics of CO2^+ via its A2Пu,1/2 state using the scheme of [1+1] photon excitation that is intermediated by the mode-selected A2Hu,1/2(Vl,V2,0) vibronic states. Photodissociation fragment exciation spectrum and images of photofragment CO+ have been measured to obtain reaction dynamics parameters such as the available energy and the average translational energy. Combining with the potential energy functions of CO2^+, the dissociation mechanism of CO2^+ is discussed. The conformational variation of CO2^+ from linear to bent on the photodissociation dynamics of CO2^+ is verified. 展开更多
关键词 Photodissociation dynamics Velocity map imaging Carbon dioxide cation
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Changes in land use/cover mapped over 80 years in the Highlands of Northern Ethiopia 被引量:7
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作者 ETEFA Guyassa Amaury FRANKL +5 位作者 Sil LANCKRIET BIADGILGN Demissie GEBREYOHANNES Zenebe AMANUEL Zenebe Jean POESEN Jan NYSSEN 《Journal of Geographical Sciences》 SCIE CSCD 2018年第10期1538-1559,共22页
Despite many studies on land degradation in the Highlands of Northern Ethiopia, quantitative information regarding long-term changes in land use/cover(LUC) is rare. Hence, this study aims to investigate the LUC change... Despite many studies on land degradation in the Highlands of Northern Ethiopia, quantitative information regarding long-term changes in land use/cover(LUC) is rare. Hence, this study aims to investigate the LUC changes in the Geba catchment(5142 km2), Northern Ethiopia, over 80 years(1935–2014). Aerial photographs(APs) of the 1930 s and Google Earth(GE) images(2014) were used. The point-count technique was utilized by overlaying a grid on APs and GE images. The occurrence of cropland, forest, grassland, shrubland, bare land, built-up areas and water body was counted to compute their fractions. A multivariate adaptive regression spline was applied to identify the explanatory factors of LUC and to create fractional maps of LUC. The results indicate significant changes of most types, except for forest and cropland. In the 1930 s, shrubland(48%) was dominant, followed by cropland(39%). The fraction of cropland in 2014(42%) remained approximately the same as in the 1930 s, while shrubland significantly dropped to 37%. Forests shrank further from a meagre 6.3% in the 1930 s to 2.3% in 2014. High overall accuracies(93% and 83%) and strong Kappa coefficients(89% and 72%) for point counts and fractional maps respectively indicate the validity of the techniques used for LUC mapping. 展开更多
关键词 fractional map Google Earth land use/cover multivariate adaptive regression Italian aerial photographs
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A maize bundle sheath defective mutation mapped on chromosome 1 between SSR markers umc1395 and umc1603 被引量:2
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作者 PAN Yu CHEN Xu-qing +7 位作者 XIE Hua DENG Lei LI Xiang-long ZHANG Xiao-dong HAN Li-xin YANG Feng-ping XUE Jing ZHANG Li-quan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2015年第10期1949-1957,共9页
The bsd-pg(bundle sheath defective pale green) mutant is a novel maize mutation, controlled by a single recessive gene, which was isolated from offspring of maize plantlets regenerated from tissue callus of the maiz... The bsd-pg(bundle sheath defective pale green) mutant is a novel maize mutation, controlled by a single recessive gene, which was isolated from offspring of maize plantlets regenerated from tissue callus of the maize inbred line 501. The characterization was that the biogenesis and development of the chloroplasts was mainly interfered in bundle sheath cells rather than in mesophyll cells. For mapping the bsd-pg, an F2 population was derived from a cross between the mutant bsd-pg and an inbred line Xianzao 17. Using specific locus amplified fragment sequencing(SLAF-Seq) technology, a total of 5 783 polymorphic SLAFs were analysed with 1 771 homozygous alleles between maternal and paternal parents. There were 49 SLAFs, which had a ratio of paternal to maternal alleles of 2:1 in bulked normal lines, and three trait-related candidate regions were obtained on chromosome 1 with a size of 3.945 Mb. For the fine mapping, new simple sequence repeats(SSRs) markers were designed by utilizing information of the B73 genome and the candidate regions were localized a size of 850 934 bp on chromosome 1 between umc1603 and umc1395, including 35 candidate genes. These results provide a foundation for the cloning of bsd-pg by map-based strategy, which is essential for revealing the functional differentiation and coordination of the two cell types, and helps to elucidate a comprehensive understanding of the C4 photosynthesis pathway and related processes in maize leaves. 展开更多
关键词 MAIZE bsd-pg SLAF SSR assossiation analysis fine mapping
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Mapped Displacement Discontinuity Method:Numerical Implementation and Analysis for Crack Problems 被引量:1
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作者 姜锋 沈泳星 《Journal of Shanghai Jiaotong university(Science)》 EI 2018年第1期158-165,共8页
The displacement discontinuity method(DDM) is a kind of boundary element method aiming at modeling two-dimensional linear elastic crack problems. The singularity around the crack tip prevents the DDM from optimally co... The displacement discontinuity method(DDM) is a kind of boundary element method aiming at modeling two-dimensional linear elastic crack problems. The singularity around the crack tip prevents the DDM from optimally converging when the basis functions are polynomials of first order or higher. To overcome this issue,enlightened by the mapped finite element method(FEM) proposed in Ref. [13], we present an optimally convergent mapped DDM in this work, called the mapped DDM(MDDM). It is essentially based on approximating a much smoother function obtained by reformulating the problem with an appropriate auxiliary map. Two numerical examples of crack problems are presented in comparison with the conventional DDM. The results show that the proposed method improves the accuracy of the DDM; moreover, it yields an optimal convergence rate for quadratic interpolating polynomials. 展开更多
关键词 displacement discontinuity method(DDM) SINGULARITY auxiliary map convergence rate Hadamard finite part
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The Boundary Mapped Collocation Method for Heat Conduction Problems with Heat Generation Spatially Varying Conductivity
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作者 Zhentian Huang Dong Lei +2 位作者 Zi Han Heping Xie Jianbo Zhu 《Advances in Applied Mathematics and Mechanics》 2025年第1期240-262,共23页
In this paper,the boundary mapped collocation(BMC)approach is presented for the analysis of heat conduction problems involving heat generation and non-homogeneous thermal conductivity.The proposed methodology is intro... In this paper,the boundary mapped collocation(BMC)approach is presented for the analysis of heat conduction problems involving heat generation and non-homogeneous thermal conductivity.The proposed methodology is introduced to produce the numerical solutions of the temperature field within the framework of the BMC method,a novel boundary meshless method,without resorting to requiring any integral calculation,neither in the domain nor at the boundary.In particular,the arrangement of discrete nodes is restricted to the axis,which brings the spatial dimension down by one.The technique also reduced the traditional complex shape functions to succinct one-dimensional boundary shape functions by using one-dimensional basis functions and weight functions for two-and three-dimensional approximation implementation.In addition,four numerical applications and comparisons with the outcomes of the finite element approach and another meshfree method are used to demonstrate the correctness,convergence,and stability of the BMC method. 展开更多
关键词 Boundary mapped collocation method heat conduction heat generation spatially varying conductivity meshless method
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A Boundary Mapped Collocation Method for the Analysis of the Arbitrarily Shaped Plates
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作者 Zhentian Huang Dong Lei +2 位作者 Zi Han Heping Xie Jianbo Zhu 《Advances in Applied Mathematics and Mechanics》 2025年第1期350-372,共23页
An innovative meshless method is proposed in this paper for the bending problem of arbitrary Kirchhoff plates subjected to external force with various shapes and different boundary conditions.Without using a numerical... An innovative meshless method is proposed in this paper for the bending problem of arbitrary Kirchhoff plates subjected to external force with various shapes and different boundary conditions.Without using a numerical integral,the deflection of the thin plate is approximated by using the boundary mapped collocation approach.Moreover,the computational domain discretization is just dependent on discretized nodes on the axis,while tensor product nodes have been mapped in the domain automatically.Hence,in the boundary mapped collocation implementation,the approximation functions are derived by employing the one-dimensional moving least squares technique for two-dimensional and higher-dimensional problems.Further,the virtual boundary technique is introduced to enforce the boundary conditions in the proposed method.Additionally,four numerical experiments are presented to illustrate the excellent convergence and high precision of the proposed approach. 展开更多
关键词 Boundary mapped collocation method moving least squares Kirchhoff plate meshless method
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基于Maps统计分析的冶金尘泥还原焙烧机理
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作者 李强 陈铁军 +3 位作者 陈佳乐 黄宇平 李圣辉 李奇勇 《钢铁》 北大核心 2026年第1期188-200,共13页
冶金尘泥的转底炉处理工艺是目前钢铁行业采用的主要处置工艺,但在实际生产过程中经常出现还原焙烧不均匀的问题。利用微观扫描电子显微镜(scanning electron microscopy,SEM)分析结合宏观Maps统计分析,对冶金尘泥还原焙烧的不均匀性进... 冶金尘泥的转底炉处理工艺是目前钢铁行业采用的主要处置工艺,但在实际生产过程中经常出现还原焙烧不均匀的问题。利用微观扫描电子显微镜(scanning electron microscopy,SEM)分析结合宏观Maps统计分析,对冶金尘泥还原焙烧的不均匀性进行详细的可视化、数据化分析。研究结果表明,冶金尘泥在焙烧温度为1250℃、焙烧时间为15 min的条件下,熟球金属化率达到89.04%、脱锌率达到81.66%、抗压强度达到3.03 kN,熟球金属化率和脱锌率会随着焙烧温度提高和焙烧时间延长而进一步提高,但熟球抗压强度在焙烧时间过长时反而逐渐降低;熟球Maps统计分析表明,提高焙烧温度更有利于提高熟球外圈和下部的还原程度,而延长焙烧时间也更有利于提高熟球下部还原程度,但对熟球内部和外圈还原程度的提升作用比较相似;同时,提高焙烧温度也更有利于提升熟球下部的致密化程度,降低熟球上、下孔隙结构的不均匀性,进而显著提高熟球整体抗压强度;但焙烧时间过长会导致熟球中小孔隙融合为大孔隙,反而降低熟球抗压强度。此外,熟球中硅酸盐(渣相)和浮氏体(FexO)更容易破裂,而金属铁(Fe)可延缓裂纹蔓延,因而,适当提高熟球金属化率、降低硅酸盐(渣相)含量也有利于提高其抗压强度。基于Maps统计分析探究了冶金尘泥还原焙烧过程中物相及孔隙的变化规律,分析结果可以为转底炉工艺处理冶金尘泥的生产实践提供指导和建议。 展开更多
关键词 冶金尘泥 焙烧温度 焙烧时间 Maps统计分析 金属化率 抗压强度 转底炉 熟球
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磁共振集合序列技术替代T_(2) Mapping成像对成人膝关节软骨定量分析价值
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作者 武金龙 杨慧 《实用医学影像杂志》 2026年第1期32-35,共4页
目的分析使用磁共振集合序列(MAGIC)技术替代传统T_(2) Mapping成像定量分析成人膝关节关节软骨的临床价值。方法收集本院体检受试者36例,分为3组21~30岁,11例;31~40岁,10例;41~50岁,15例,分别行MAGIC和T_(2) Mapping扫描,比较软骨MAGIC... 目的分析使用磁共振集合序列(MAGIC)技术替代传统T_(2) Mapping成像定量分析成人膝关节关节软骨的临床价值。方法收集本院体检受试者36例,分为3组21~30岁,11例;31~40岁,10例;41~50岁,15例,分别行MAGIC和T_(2) Mapping扫描,比较软骨MAGIC T_(2)值与T_(2) Mapping T_(2)值是否存在差异。比较各年龄段胫骨内侧平台软骨、胫骨外侧平台软骨、股骨内侧髁软骨、股骨外侧髁软骨、髌骨表面软骨差异。结果MAGIC与T_(2) Mapping 2种方法分别对膝关节的不同部位关节软骨定量T_(2)值分析,2种方法对比差异无统计学意义(P>0.05)。41~50岁与21~30岁关节软骨厚度差异有统计学意义。利用MAGIC技术发现41~50岁与21~30岁各部位关节软骨T_(2)测值差异有统计学意义(P<0.05)。结论MAGIC技术能代替传统T_(2) Mapping成像方法定量分析成人膝关节软骨。 展开更多
关键词 膝关节 软骨 成人 磁共振集合序列 T_(2)Mapping 定量分析
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CO_(3)^(2-)与Ca^(2+)对磷酸铵镁结晶法去除模拟猪场厌氧消化液中磷的影响机制
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作者 贾博涵 孙晨 +2 位作者 谢晓琳 钱锋 宋永会 《环境工程技术学报》 北大核心 2026年第2期507-515,共9页
为提高养殖废水厌氧消化液中磷的回收效率与产物资源化价值,以模拟猪场厌氧消化液为对象,系统探究了碳酸根(CO_(3)^(2-))与钙离子(Ca^(2+))对磷酸铵镁(MAP)结晶法除磷过程的影响机制。通过批次沉淀实验,结合Visual MINTEQ 3.0热力学模型... 为提高养殖废水厌氧消化液中磷的回收效率与产物资源化价值,以模拟猪场厌氧消化液为对象,系统探究了碳酸根(CO_(3)^(2-))与钙离子(Ca^(2+))对磷酸铵镁(MAP)结晶法除磷过程的影响机制。通过批次沉淀实验,结合Visual MINTEQ 3.0热力学模型与X射线衍射分析,揭示了不同pH与镁、氮、磷物质的量比[n(Mg)∶n(N)∶n(P)]条件下磷的去除规律与产物特征。结果表明:在pH=9.5、n(Mg)∶n(P)=1.4∶1时,磷去除率超过96%,继续提高pH或n(Mg)∶n(P)对去除率的提升作用不显著。CO_(3)^(2-)单独存在对磷去除率(>95%)及MAP晶体纯度影响较小;而Ca^(2+)单独存在则显著改变沉淀产物组成,当n(Mg^(2+))∶n(Ca^(2+))=2∶1时,MAP纯度约为66.7%,随着Ca^(2+)浓度升高,产物逐渐转为无定形磷酸钙主导。CO_(3)^(2-)与Ca^(2+)共存时的影响与Ca^(2+)单独存在时基本一致,高Ca^(2+)/CO_(3)^(2-)背景下虽能维持高磷去除率(≥95%),但产物纯度显著下降。在实际应用中,应根据离子浓度比精确控制镁与磷的物质的量比,以平衡磷的去除率及回收产物的资源价值。 展开更多
关键词 猪场厌氧消化液 磷酸铵镁(MAP) 磷去除 竞争沉淀 磷回收 MINTEQ模型
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基于Connectivity Map的药物重定位评价维拉帕米作为治疗帕金森病的药物
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作者 新吉乐 刘晶 +6 位作者 张欣翼 郭家缘 韩文卓 孙怡馨 赵乐 冯卫生 郑晓珂 《中国临床药理学与治疗学》 北大核心 2026年第1期14-27,共14页
目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并... 目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并在6-羟基多巴胺(6-OHDA)诱导损伤的PC12细胞和PD小鼠模型评价其PD治疗作用。结果:维拉帕米(verapamil,Ver)为潜在的候选药物。Ver对6-OHDA损伤的PC12细胞具有保护作用,同时对6-OHDA诱导的PAX5、LEF1、MTF1、IKZF3和SP140等转录因子,以及ITGA6、CDH1、CD40、ESR1、SMAD3、CXCR4等PD发病基因的表达具有调控作用。PD模型小鼠中,Ver可对α-突触核蛋白(α-Syn)表达有一定抑制作用,但对上述PD发病基因及其转录因子和调控作用较弱。结论:Ver对PD的治疗作用部分依赖于对PD发病基因及其相关转录因子的调控作用。 展开更多
关键词 帕金森病 转录因子 Connectivity Map 维拉帕米 6-羟基多巴胺
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面向冶金质检的2D/3D视觉协同检测系统关键算法 被引量:1
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作者 华晋军 王思贤 +1 位作者 唐文明 李树丰 《河北冶金》 2026年第2期65-69,84,共6页
针对热态钢轨质检中高温干扰、缺陷复杂及结构与纹理信息割裂等问题,本文提出并验证了一套面向冶金质检的2D/3D视觉系统检测系统的关键算法。在2D检测方面,提出轻量化DFAM-YOLO-Met(Defect-Focused Attention Module YOLO for Metallur... 针对热态钢轨质检中高温干扰、缺陷复杂及结构与纹理信息割裂等问题,本文提出并验证了一套面向冶金质检的2D/3D视觉系统检测系统的关键算法。在2D检测方面,提出轻量化DFAM-YOLO-Met(Defect-Focused Attention Module YOLO for Metallurgy)模型,通过将特征增强技术与注意力模块与YOLO模型进行耦合,实现对微小缺陷的高效识别。在自建图像集上取得91.6%的mAP和0.89的F1-score,在3D建模方面,设计三阶段点云优化与分段曲率拟合策略,引入热响应补偿机制,实现高温下的在线尺寸精测,误差由±0.28 mm降至±0.12 mm,满足国标≤0.15 mm的要求;在多模态融合方面,构建图-点映射与模块互引机制,实现2D与3D检测结果的联动复核,系统误报率由2.4%降至1.5%,复合缺陷Recall提升11.7%。实测表明,系统可在5 m/s钢轨产线上稳定运行72 h,单帧推理时延11.4 ms,GPU功耗低于15 W,具备良好鲁棒性与部署价值,为冶金行业在高温高速工况下实现智能质检提供了技术路径与实践参考。 展开更多
关键词 热态钢轨 表面检测 MAP 多模态融合 数据增强 2D/3D视觉协同
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Native T1 mapping值显著延长心脏纤维瘤一例
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作者 文涛 张辉 +3 位作者 甘铁军 胡万均 李世兰 张静 《磁共振成像》 北大核心 2026年第1期120-122,共3页
本研究为回顾性研究,遵守《赫尔辛基宣言》,并经兰州大学第二医院伦理委员会审核批准,免除受试者知情同意,批准文号:2025A-547。患儿,女,2月8天,因“发现心脏肿瘤2月”于2024年11月就诊于我院,患儿于2个月前出生后外院检查提示左心室肿... 本研究为回顾性研究,遵守《赫尔辛基宣言》,并经兰州大学第二医院伦理委员会审核批准,免除受试者知情同意,批准文号:2025A-547。患儿,女,2月8天,因“发现心脏肿瘤2月”于2024年11月就诊于我院,患儿于2个月前出生后外院检查提示左心室肿瘤,未予特殊诊治,现为进一步明确诊治收住我院心脏外科。患儿足月(38+6周)、顺产、无心脏肿瘤家族史。查体:心前区无隆起,心界不大,心音有力、律齐,胸骨左缘第2~3肋间可闻及3/6及吹风样杂音,静息血氧饱和度100%。 展开更多
关键词 心脏肿瘤 心脏纤维瘤 多模态磁共振成像 心脏磁共振 Native T1 mapping
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基于网络药理学、分子对接及实验验证探讨高良姜等三味山姜属中药治疗胃溃疡寒证的作用机制
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作者 温子帅 梁胜男 +5 位作者 阮雨玲 张文涛 李梦颖 吴芳芳 柳俊辉 秦华珍 《中国临床药理学与治疗学》 北大核心 2026年第1期28-39,共12页
目的:通过网络药理学与分子对接技术探究高良姜等三味山姜属中药治疗胃溃疡寒证的作用机制,并进行实验验证。方法:通过网络药理学常用技术手段,使用TCMSP、CNKI等数据库筛选三味山姜属中药中的活性成分及治疗胃溃疡疾病的相关靶点,并绘... 目的:通过网络药理学与分子对接技术探究高良姜等三味山姜属中药治疗胃溃疡寒证的作用机制,并进行实验验证。方法:通过网络药理学常用技术手段,使用TCMSP、CNKI等数据库筛选三味山姜属中药中的活性成分及治疗胃溃疡疾病的相关靶点,并绘制Venn图、蛋白质网络互作图。对关键靶点进行通路富集分析,将所获得的“药物-活性成分-靶点-通路-疾病”等数据导入Cytoscape 3.10.2进行可视化处理,并选择Degree排名靠前的化合物通过AutoDock软件进行分子对接。72只SPF级SD大鼠分为9组,包括空白对照组、模型组、阳性对照组(干姜10.8 g/kg)、高良姜高、低(10.8和5.4 g/kg)剂量组,大高良姜高、低(9.0和4.5 g/kg)剂量组,红豆蔻高、低(10.8和5.4 g/kg)剂量组,采用冰乙酸和冰知母法复制胃溃疡寒证模型,按不同剂量水煎液灌胃,1 mL/100 g体质量,每天2次,连续4 d。通过计算大鼠溃疡指数及溃疡抑制率,HE染色法观察大鼠胃组织病理学变化,ELISA法检测胃组织中AKT1、MAP2K1、m TOR蛋白的表达,从而与网络药理学的相关结果相互印证。结果:将三味山姜属中药所有成分去重后共筛选出关键成分45个,与疾病交集靶点共124个,蛋白质网络互作图共包含124个节点,923条边,京都基因与基因组百科全书(KEGG)富集共得到138条信号通路。分子对接分数均<-7.0 kcal/mol,即核心成分有效作用于核心靶点。实验验证结果显示:与模型组比较,三味山姜属中药不同剂量组对冰知母-冰乙酸法复制造成的胃溃疡寒证与胃黏膜水肿、充血等症状显著改善,溃疡面及出血点明显减少。与模型组比较,除红豆蔻低剂量组外,其他给药组AKT1蛋白表达水平均显著降低(P<0.05或P<0.01);除大高良姜低剂量组外,其余给药组MAP2K1蛋白表达水平均显著降低(P<0.05或P<0.01);除大高良姜和红豆蔻低剂量组外,各给药组mTOR蛋白表达水平均显著降低(P<0.05或P<0.01)。结论:三味山姜属中药可能通过多成分、多靶点、多通路的网络调控发挥抗炎、调控细胞增殖等作用来治疗胃溃疡。 展开更多
关键词 高良姜 大高良姜 红豆蔻 胃溃疡寒证 网络药理学 AKT1 MAP2K1 mTOR
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Fabry病伴肌小节相关基因突变1例并文献复习
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作者 周彦孜 王子雯 +2 位作者 魏榕辰 杨秀春 武柏林 《中国心血管杂志》 北大核心 2026年第1期101-105,共5页
1病例资料患者女性,46岁,因“活动后胸痛伴纳差1年余”于2024年1月29日入院。患者自1年前间断出现活动后胸痛,无肩背部放射痛,无恶心、呕吐,休息后约10 min可自行缓解。由于症状反复出现且未见明显改善,患者于我院门诊行初步检查,超声... 1病例资料患者女性,46岁,因“活动后胸痛伴纳差1年余”于2024年1月29日入院。患者自1年前间断出现活动后胸痛,无肩背部放射痛,无恶心、呕吐,休息后约10 min可自行缓解。由于症状反复出现且未见明显改善,患者于我院门诊行初步检查,超声心动图示左心房扩大及左心室壁非对称性肥厚,提示可能存在心脏结构性异常。 展开更多
关键词 法布里病 梗阻性肥厚型心肌病 心脏磁共振 T1 mapping
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T2 Mapping联合DWI序列评估直肠癌脉管侵犯价值研究
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作者 李茜玮 陈安良 +2 位作者 王楠 林良杰 刘爱连 《中国CT和MRI杂志》 2026年第1期149-152,共4页
目的探讨T2 mapping与DWI序列预测直肠癌脉管侵犯的价值。方法回顾性分析经本院行3.0T MRI扫描且经术后病理证实的直肠癌脉管侵犯13例,脉管非侵犯20例,2名观察者分别于瘤体显示最大层面参考增强动脉期图像及DWI图像于T2 mapping及ADC图... 目的探讨T2 mapping与DWI序列预测直肠癌脉管侵犯的价值。方法回顾性分析经本院行3.0T MRI扫描且经术后病理证实的直肠癌脉管侵犯13例,脉管非侵犯20例,2名观察者分别于瘤体显示最大层面参考增强动脉期图像及DWI图像于T2 mapping及ADC图像上测量病灶T2值及ADC值。采用组内相关系数(intraclass correlation cofficient,ICC)评估两名观察者测量参数值的一致性。采用独立样本t检验或Mann-Whitney U检验分析两组病例各参数的差异。采用Logistic回归计算有统计学差异的参数联合评估直肠癌LVI的预测值。采用ROC曲线评估有差异参数单独或联合的诊断效能,并利用De-Long检验比较各ROC曲线间的差异。采用Pearson相关性检验分析两参数值的相关性。结果2名观察者测量T2值及ADC值一致性好(ICC>0.75)。脉管侵犯组的T2值及ADC值低于非脉管侵犯组(77.15±6.95ms、0.69±0.15mm^(2)/s vs 87.04±7.75ms、0.90±0.21 mm^(2)/s,P<0.05)。ADC值与ADC-T2联合鉴别两组疾病的AUC值比较差异具有统计学意义(P=0.036)。结论T2 mapping和DWI序列可预测直肠癌脉管侵犯,两序列联合效能提升,因此T2值与ADC值联合可为临床诊疗直肠癌脉管侵犯提供参考信息。 展开更多
关键词 直肠癌 脉管侵犯 磁共振成像 T2 mapping成像 弥散加权成像
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心脏磁共振对COVID-19轻症患者心肌损伤的诊断价值
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作者 旦增曲央 肖活源 +4 位作者 张清晨 刘雨婷 康桑 冯锐 潘静薇 《上海交通大学学报(医学版)》 北大核心 2026年第3期322-331,共10页
目的·基于心脏磁共振(cardiac magnetic resonance,CMR)构建新型冠状病毒感染(coronavirus disease 2019,COVID-19)轻症患者心肌损伤的诊断模型。方法·纳入2024年1月—2025年6月就诊于上海交通大学医学院附属第六人民医院的CO... 目的·基于心脏磁共振(cardiac magnetic resonance,CMR)构建新型冠状病毒感染(coronavirus disease 2019,COVID-19)轻症患者心肌损伤的诊断模型。方法·纳入2024年1月—2025年6月就诊于上海交通大学医学院附属第六人民医院的COVID-19核酸检测阳性并伴有心血管症状的患者64例;患者均于感染后6个月内完成肌钙蛋白I(cardiac troponin I,cTnI)检测及CMR检查。依据cTnI水平将患者分为cTnI升高组[cTnI(+)组,n=26]、cTnI未升高组[cTnI(-)组,n=38],并纳入年龄、性别匹配的37例未感染COVID-19的人群作为健康对照组。收集并比较3组受试者的基线临床资料、CMR参数(包括心功能与容积参数、左心室整体及节段心肌应变参数、心肌组织学参数)。采用Spearman秩相关分析评估cTnI与基线临床资料及CMR参数的相关性。通过单因素和多因素Logistic回归分析构建能够早期识别COVID-19相关心肌损伤的诊断模型。采用受试者操作特征(receiver operator characteristic,ROC)曲线及Delong检验验证该模型的判别效能。结果·心功能与容积参数对比分析显示,左心室射血分数(left ventricular ejection fraction,LVEF)等指标的组间差异无统计学意义。与健康对照组相比,cTnI(+)组患者的左心室整体周向应变(global circumferential strain,GCS)、左室基底段周向应变(left ventricular basal-level circumferential strain,CS_(Basal))、左室中段周向应变(left ventricular mid-level circumferential strain,CS_(Mid))有所降低(均P<0.001),Native T1 mapping值有所升高(P<0.001);cTnI(-)组患者的Native T1 mapping值也有升高(P=0.007)。相关性分析显示,cTnI与CS_(Mid)呈显著负相关(r=‒0.600,P<0.001)。多因素Logistic回归分析显示,CS_(Mid)和Native T1 mapping均为COVID-19相关心肌损伤的独立预测因子(均P<0.001)。ROC曲线显示,基于CS_(Mid)与Native T1 mapping构建的联合诊断模型具有良好的判别效能(AUC=0.950)。结论·基于CS_(Mid)与Native T1 mapping的CMR联合诊断模型能够有效识别COVID-19轻症患者的潜在心肌损伤,或可为COVID-19相关心肌损伤的早期识别和临床评估提供客观影像学依据。 展开更多
关键词 新型冠状病毒感染 心肌损伤 心肌应变 Native T1 mapping 心脏磁共振
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