The International GNSS Service(IGS) final products(ephemeris and clocks-correction) have made the GNSS an indispensable low-cost tool for scientific research, for example sub-daily atmospheric water vapor monitoring. ...The International GNSS Service(IGS) final products(ephemeris and clocks-correction) have made the GNSS an indispensable low-cost tool for scientific research, for example sub-daily atmospheric water vapor monitoring. In this study, we investigate if there is a systematic difference coming from the choice between the Vienna Mapping Function 1(VMF1) and the Global Mapping Function(GMF) for the modeling of Zenith Total Delay(ZTD) estimates, as well as the Integrated Precipitable Water Vapor(IPWV) estimates that are deduced from them. As ZTD estimates cannot be fully separated from coordinate estimates, we also investigated the coordinate repeatability between subsequent measurements.For this purpose, we monitored twelve GNSS stations on a global scale, for each of the three climatic zones(polar, mid-latitudes and tropical), with four stations on each zone. We used an automated processing based on the Bernese GNSS Software Version 5.2 by applying the Precise Point Positioning(PPP)approach, L3 Ionosphere-free linear combination, 7 cutoff elevation angle and 2 h sampling. We noticed an excellent agreement with the ZTD estimates and coordinate repeatability for all the stations w.r.t to CODE(the Center for Orbit Determination in Europe) and USNO(US Naval Observatory) products, except for the Antarctic station(Davis) which shows systematic biases for the GMF related results. As a final step, we investigated the effect of using two mapping functions(VMF1 and GMF) to estimate the IPWV,w.r.t the IPWV estimates provided by the Integrated Global Radiosonde Archive(IGRA). The GPS-derived IPWV estimates are very close to the radiosonde-derived IPWV estimates, except for one station in the tropics(Tahiti).展开更多
Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends a...Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.展开更多
We have defined the environmental interface through the exchange processes between media forming this interface. Considering the environmental interface as a complex system we elaborated the advanced mathematical tool...We have defined the environmental interface through the exchange processes between media forming this interface. Considering the environmental interface as a complex system we elaborated the advanced mathematical tools for its modelling. We have suggested two coupled maps serving the exchange processes on the environmental interfaces spatially ranged from cellular to planetary level, i.e. 1) the map with diffusive coupling for energy exchange simulation and 2) the map with affinity, which is suitable for matter exchange processes at the cellular level. We have performed the dynamical analysis of the coupled maps using the Lyapunov exponent, cross sample as well as the permutation entropy in dependence on different map parameters. Finally, we discussed the map with affinity, which shows some features making it a promising toll in simulation of exchange processes on the environmental interface at the cellular level.展开更多
We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly ...We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.展开更多
The Kehdolan area is located at 20 kilometers to the?south-east of Dozdozan Town (Eastern Azarbaijan Province). According to structural geology, volconic rocks are situated in Alborz-Azarbyjan zone, and faults?are?obs...The Kehdolan area is located at 20 kilometers to the?south-east of Dozdozan Town (Eastern Azarbaijan Province). According to structural geology, volconic rocks are situated in Alborz-Azarbyjan zone, and faults?are?observed?in?the?same direction to this system with SE-NW trend. The results show that kaolinite alteration trend with Argilic and propylitic veins?is the?same direction with SW-NE faults in this area. Therefore, these faults with these trends can be considered as the mineralization control for determination of the alterations. Different image processing techniques,?such as false color composite?(FCC), band ratios, color ratio composite?(CRC), principal component?analysis?(PCA), Crosta technique, supervised spectral angle mapping?(SAM), are used for?identification of the alteration zones associated with copper mineralization. In this project ASTER?data are process and spectral analysis to fit for recognizing intensity and kind of argillic, propylitic,?philic, and ETM+ data?which?are process and to fit for iron oxide and relation to metal mineralization of the area. For recognizing different alterations of the study area, some chemical and mineralogical analysis data from the samples showed that ASTER data and ETM+ data were?capable of hydrothermal alteration mapping with copper mineralization.?Copper mineralization in the region is in agreement with argillic alteration. SW-NE trending faults controlled the mineralization process.展开更多
TNNI3K is a cardiac-specific and cardiac troponin I(cT n I)-interacting MAP kinase, known to play important roles in promoting cardiac differentiation, maintenance of beating rhythm and contractual force. The molecula...TNNI3K is a cardiac-specific and cardiac troponin I(cT n I)-interacting MAP kinase, known to play important roles in promoting cardiac differentiation, maintenance of beating rhythm and contractual force. The molecular structure of TNNI3 K contains three kinds of domain: a seven or ten NH2-terminal ankyrin repeat domain followed by a protein kinase domain and a COOH-terminal serine-rich domain. There are many binding sites in the structure of TNNI3 K for binding to ATP, magnesium, nucleotide, protein kinase C, antioxidant protein 1(AOP-1) and cT n I, indicating TNNI3 K has many interacting partners. This review summarizes the evidence, hypothesis and significance of TNNI3 K interacting with TNNI3 and its other putative interaction partners. From the literature, the interaction partners of TNNI3 K are divided into 2 types following their phenotypic pattern of functions, positive interaction(to increase the cardiac performance) or negative interaction(to suppress the cardiac performance). Following their binding sites, it also can be divided into other 2 types: binding to C-terminal domain(e.g., cT n I) or binding to both ankyrin repeat domain and C-terminal domains(AOP-1).To date, a well understood partner of TNNI3 K is cT nI, from the molecular structure, physiological function, mechanisms and its significance in some physiological and pathophysiological conditions. There are many reasons to believe that, with more understanding on the TNNI3 K interacting with its partners, we can understand more roles of TNNI3 K in some cardiac diseases.展开更多
The paper reviews goals and objectives, stages and components of a seismotectonic study conducted in Eastern Siberia, Russia. Based on a comprehensive analysis of geological and geophysical data, our study establishes...The paper reviews goals and objectives, stages and components of a seismotectonic study conducted in Eastern Siberia, Russia. Based on a comprehensive analysis of geological and geophysical data, our study establishes whether the local earthquakes are of tectonic origin and reveals relationships among earthquakes with recent geodynamic processes in the area under study. Seismic hazard assessment and evaluation of tectonic processes are the two major closely interrelated aspects of seismotectonic studies. A seismotectonic study is generally combined with a seismic study and conducted prior to the stage of detailed seismic zonation (DSZ) which is followed by seismic micro-zonation (SMZ). In three stages of the seismotectonic study, we analyze specific geological structures, reveal the regional dynamics of seismotectonic processes, clarify details of potential seismic hazard locations and identify sites of the potential instantaneous deformation of the crust which may take place due to active faulting. Based on results of our longterm studies, a seismotectonic zonation map of Eastern Siberia is compiled. The paper briefly reviews the methods of mapping and refers to data on active faults and neotectonic structures revealed in the area under study, which are closely related to regional earthquake sources.展开更多
Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network ...Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network security. From a random sequencing viewpoint, both sequences of HC-256 and real DNA data may have intrinsic pseudo-random properties respectively. In a recent decade, many DNA sequencing projects are developed on cells, plants and animals over the world into huge DNA databases. Researchers notice that mammalian genomes encode thousands of large noncoding RNAs (lncRNAs), interact with chromatin regulatory complexes, and are thought to play a role in localizing these complexes to target loci across the genome. It is a challenge target using higher dimensional visualization tools to organize various complex interactive properties as visual maps. The Variant Map System (VMS) as an emerging scheme is systematically proposed in this paper to apply multiple maps that used four Meta symbols as same as DNA or RNA representations. System architecture of key components and core mechanism on the VMS are described. Key modules, equations and their I/O parameters are discussed. Applying the VM System, two sets of real DNA sequences from both sample human (noncoding DNA) and corn (coding DNA) genomes are collected in comparison with pseudo DNA sequences generated by HC-256 to show their intrinsic properties in higher levels of similar relationships among relevant DNA sequences on 2D maps. Sample 2D maps are listed and their characteristics are illustrated under controllable environment. Visual results are briefly analyzed to explore their intrinsic properties on selected genome sequences.展开更多
This contribution proposes a new combination symbol mapper/8-ary constellation, which is a joint optimization of an 8-ary signal constellation and its symbol mapping operation, to improve the performance of Bit Interl...This contribution proposes a new combination symbol mapper/8-ary constellation, which is a joint optimization of an 8-ary signal constellation and its symbol mapping operation, to improve the performance of Bit Interleaved Coded Modulation with Iterative Decoding (BICM-ID). The basic idea was to use the so called (1,7) constellation (which is a capacitive efficient constellation) instead of the conventional 8-PSK constellation and to choose the most suitable mapping for it. A comparative study between the combinations most suitable mapping/(1,7) constellation and SSP mapping/conventional 8-PSK constellation has been carried out. Simulation results showed that the 1st combination significantly outperforms the 2nd combination and with only 4 iterations, it gives better performance than the 2nd combination with 8 iterations. A gain of 4 dB is given by iteration 4 of the 1st combination compared to iteration 8 of the 2nd combination at a BER level equal to 10-5, and it (iteration 4 of the 1st combination) can attain a BER equal to 10-7 for, only, a SNR = 5.6 dB.展开更多
The relatively rapid recession of glaciers in the Himalayas and formation of moraine dammed glacial lakes(MDGLs) in the recent past have increased the risk of glacier lake outburst floods(GLOF) in the countries of Nep...The relatively rapid recession of glaciers in the Himalayas and formation of moraine dammed glacial lakes(MDGLs) in the recent past have increased the risk of glacier lake outburst floods(GLOF) in the countries of Nepal and Bhutan and in the mountainous territory of Sikkim in India. As a product of climate change and global warming, such a risk has not only raised the level of threats to the habitation and infrastructure of the region, but has also contributed to the worsening of the balance of the unique ecosystem that exists in this domain that sustains several of the highest mountain peaks of the world. This study attempts to present an up to date mapping of the MDGLs in the central and eastern Himalayan regions using remote sensing data, with an objective to analyse their surface area variations with time from 1990 through 2015, disaggregated over six episodes. The study also includes the evaluation for susceptibility of MDGLs to GLOF with the least criteria decision analysis(LCDA). Forty two major MDGLs, each having a lake surface area greater than 0.2 km2, that were identified in the Himalayan ranges of Nepal, Bhutan, and Sikkim, have been categorized according to their surface area expansion rates in space and time. The lakes have been identified as located within the elevation range of 3800 m and6800 m above mean sea level(a msl). With a total surface area of 37.9 km2, these MDGLs as a whole were observed to have expanded by an astonishing 43.6% in area over the 25 year period of this study. A factor is introduced to numerically sort the lakes in terms of their relative yearly expansion rates, based on their interpretation of their surface area extents from satellite imageries. Verification of predicted GLOF events in the past using this factor with the limited field data as reported in literature indicates that the present analysis may be considered a sufficiently reliable and rapid technique for assessing the potential bursting susceptibility of the MDGLs. The analysis also indicates that, as of now, there are eight MDGLs in the region which appear to be in highly vulnerable states and have high chances in causing potential GLOF events anytime in the recent future.展开更多
District Ghizer is a rugged mountainous territory which experiences several landslides each year. There are 16 major landslide areas and 53 villages that are at high risk to hazards. Keeping in view the severity of na...District Ghizer is a rugged mountainous territory which experiences several landslides each year. There are 16 major landslide areas and 53 villages that are at high risk to hazards. Keeping in view the severity of natural hazards, the present study was designed to generate landslide susceptibility map based on twelve causative factors viz., slope, aspect, elevation, drainage network, Stream Power Index (SPI), Topographic Wetness Index (TWI), lithological units, fault lines, rainfall, road network, land cover and soil texture. Soil texture was determined by particle size analysis and data for other factors were acquired from freely available sources. Analytical Hierarchy Process (AHP) was employed to identify major landslide causative factors in the district Ghizer. Further, a temporal assessment from 1999 till 2015 was generated to assess the impact of land cover change on landslides. It indicated that the barren soil/ exposed rocks and glaciers have reduced while the vegetation and water classes have shown increment. The total area that lies in moderate to very high landslide susceptible zones was 74.38%, while slope is the main landslide causative factor in the district Ghizer. Validation of the susceptibility map showed 88.1% of the landslides in the study area had occurred in the moderate to very high susceptible zones.展开更多
Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role cand...Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes.展开更多
ABSTRACT: This paper generalizes the makeup and forming dynamic mechanism of natural disaster systems, principles and methods of comprehensive division of natural disasters, as well as structure, function and up-build...ABSTRACT: This paper generalizes the makeup and forming dynamic mechanism of natural disaster systems, principles and methods of comprehensive division of natural disasters, as well as structure, function and up-build routes of map and file information visualization system (MFIVS). Taking the Changjiang(Yangtze) Valley as an example, on the basis of revealing up the integrated mechanism on the formations of its natural disasters and its distributing law, thereafter, the paper relies on the MFIVS technique, adopts two top-down and bottom-up approaches to study a comprehensive division of natural disasters. It is relatively objective and precise that the required division results include three natural disaster sections and nine natural disaster sub-sections, which can not only provide a scientific basis for utilizing natural resources and controlling natural disaster and environmental degradation, but also be illuminated to a concise, practical and effective technique on comprehensive division.展开更多
A new methodology of comparing digital raster maps was proposed which allows not only detecting changes in the maps, but also obtaining quantitative measures of the importance of selected differences. Procedure of obj...A new methodology of comparing digital raster maps was proposed which allows not only detecting changes in the maps, but also obtaining quantitative measures of the importance of selected differences. Procedure of object interpretation of satellite images and forming of OMT (Object Map of Territory) is described. A list of allowable differences between two OMTs is defined. Two steps technique of quantitative measuring is proposed. At the first stage functions are constructed for calculating local measures of differences in the amount, areas and locations of objects on the map, as well as relations between the objects. In the second stage local measures are used to calculate the integral measure in order to get generalized assessment of difference between maps. The methods for constructing functions which calculate local and integral measures of differences are described. Examples of comparing and measuring the differences between OMTs are provided. Obtained results by utilizing this technique can be used to analyze trends, forecast of development and might be helpful for choosing most efficient scenarios for sustainable spatial planning and land management.展开更多
A hierarchical mobile robot simultaneous localization and mapping (SLAM) method that allows us to obtain accurate maps was presented. The local map level is composed of a set of local metric feature maps that are guar...A hierarchical mobile robot simultaneous localization and mapping (SLAM) method that allows us to obtain accurate maps was presented. The local map level is composed of a set of local metric feature maps that are guaranteed to be statistically independent. The global level is a topological graph whose arcs are labeled with the relative location between local maps. An estimation of these relative locations is maintained with local map alignment algorithm, and more accurate estimation is calculated through a global minimization procedure using the loop closure constraint. The local map is built with Rao-Blackwellised particle filter (RBPF), where the particle filter is used to extending the path posterior by sampling new poses. The landmark position estimation and update is implemented through extended Kalman filter (EKF). Monocular vision mounted on the robot tracks the 3D natural point landmarks, which are structured with matching scale invariant feature transform (SIFT) feature pairs. The matching for multi-dimension SIFT features is implemented with a KD-tree in the time cost of O(lbN). Experiment results on Pioneer mobile robot in a real indoor environment show the superior performance of our proposed method.展开更多
基金the innovation carrier project by Zhejiang provincial science and Technology Department (2017F10008)the French Space Agency (CNES) for their funding, through a DAR grant to the Geodesy Observatory of Tahiti
文摘The International GNSS Service(IGS) final products(ephemeris and clocks-correction) have made the GNSS an indispensable low-cost tool for scientific research, for example sub-daily atmospheric water vapor monitoring. In this study, we investigate if there is a systematic difference coming from the choice between the Vienna Mapping Function 1(VMF1) and the Global Mapping Function(GMF) for the modeling of Zenith Total Delay(ZTD) estimates, as well as the Integrated Precipitable Water Vapor(IPWV) estimates that are deduced from them. As ZTD estimates cannot be fully separated from coordinate estimates, we also investigated the coordinate repeatability between subsequent measurements.For this purpose, we monitored twelve GNSS stations on a global scale, for each of the three climatic zones(polar, mid-latitudes and tropical), with four stations on each zone. We used an automated processing based on the Bernese GNSS Software Version 5.2 by applying the Precise Point Positioning(PPP)approach, L3 Ionosphere-free linear combination, 7 cutoff elevation angle and 2 h sampling. We noticed an excellent agreement with the ZTD estimates and coordinate repeatability for all the stations w.r.t to CODE(the Center for Orbit Determination in Europe) and USNO(US Naval Observatory) products, except for the Antarctic station(Davis) which shows systematic biases for the GMF related results. As a final step, we investigated the effect of using two mapping functions(VMF1 and GMF) to estimate the IPWV,w.r.t the IPWV estimates provided by the Integrated Global Radiosonde Archive(IGRA). The GPS-derived IPWV estimates are very close to the radiosonde-derived IPWV estimates, except for one station in the tropics(Tahiti).
基金supported by the National Natural Science Foundation of China,No.81471308(to JL)the Stem Cell Clinical Research Project in China,No.CMR-20161129-1003(to JL)the Innovation Technology Funding of Dalian in China,No.2018J11CY025(to JL)
文摘Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.
文摘We have defined the environmental interface through the exchange processes between media forming this interface. Considering the environmental interface as a complex system we elaborated the advanced mathematical tools for its modelling. We have suggested two coupled maps serving the exchange processes on the environmental interfaces spatially ranged from cellular to planetary level, i.e. 1) the map with diffusive coupling for energy exchange simulation and 2) the map with affinity, which is suitable for matter exchange processes at the cellular level. We have performed the dynamical analysis of the coupled maps using the Lyapunov exponent, cross sample as well as the permutation entropy in dependence on different map parameters. Finally, we discussed the map with affinity, which shows some features making it a promising toll in simulation of exchange processes on the environmental interface at the cellular level.
基金grants fromthe Chinese Academy of Sciences (No. KJ951-BI608), the National Natural Sciences FOundation ofChina (No. 39625007 and
文摘We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.
文摘The Kehdolan area is located at 20 kilometers to the?south-east of Dozdozan Town (Eastern Azarbaijan Province). According to structural geology, volconic rocks are situated in Alborz-Azarbyjan zone, and faults?are?observed?in?the?same direction to this system with SE-NW trend. The results show that kaolinite alteration trend with Argilic and propylitic veins?is the?same direction with SW-NE faults in this area. Therefore, these faults with these trends can be considered as the mineralization control for determination of the alterations. Different image processing techniques,?such as false color composite?(FCC), band ratios, color ratio composite?(CRC), principal component?analysis?(PCA), Crosta technique, supervised spectral angle mapping?(SAM), are used for?identification of the alteration zones associated with copper mineralization. In this project ASTER?data are process and spectral analysis to fit for recognizing intensity and kind of argillic, propylitic,?philic, and ETM+ data?which?are process and to fit for iron oxide and relation to metal mineralization of the area. For recognizing different alterations of the study area, some chemical and mineralogical analysis data from the samples showed that ASTER data and ETM+ data were?capable of hydrothermal alteration mapping with copper mineralization.?Copper mineralization in the region is in agreement with argillic alteration. SW-NE trending faults controlled the mineralization process.
文摘TNNI3K is a cardiac-specific and cardiac troponin I(cT n I)-interacting MAP kinase, known to play important roles in promoting cardiac differentiation, maintenance of beating rhythm and contractual force. The molecular structure of TNNI3 K contains three kinds of domain: a seven or ten NH2-terminal ankyrin repeat domain followed by a protein kinase domain and a COOH-terminal serine-rich domain. There are many binding sites in the structure of TNNI3 K for binding to ATP, magnesium, nucleotide, protein kinase C, antioxidant protein 1(AOP-1) and cT n I, indicating TNNI3 K has many interacting partners. This review summarizes the evidence, hypothesis and significance of TNNI3 K interacting with TNNI3 and its other putative interaction partners. From the literature, the interaction partners of TNNI3 K are divided into 2 types following their phenotypic pattern of functions, positive interaction(to increase the cardiac performance) or negative interaction(to suppress the cardiac performance). Following their binding sites, it also can be divided into other 2 types: binding to C-terminal domain(e.g., cT n I) or binding to both ankyrin repeat domain and C-terminal domains(AOP-1).To date, a well understood partner of TNNI3 K is cT nI, from the molecular structure, physiological function, mechanisms and its significance in some physiological and pathophysiological conditions. There are many reasons to believe that, with more understanding on the TNNI3 K interacting with its partners, we can understand more roles of TNNI3 K in some cardiac diseases.
文摘The paper reviews goals and objectives, stages and components of a seismotectonic study conducted in Eastern Siberia, Russia. Based on a comprehensive analysis of geological and geophysical data, our study establishes whether the local earthquakes are of tectonic origin and reveals relationships among earthquakes with recent geodynamic processes in the area under study. Seismic hazard assessment and evaluation of tectonic processes are the two major closely interrelated aspects of seismotectonic studies. A seismotectonic study is generally combined with a seismic study and conducted prior to the stage of detailed seismic zonation (DSZ) which is followed by seismic micro-zonation (SMZ). In three stages of the seismotectonic study, we analyze specific geological structures, reveal the regional dynamics of seismotectonic processes, clarify details of potential seismic hazard locations and identify sites of the potential instantaneous deformation of the crust which may take place due to active faulting. Based on results of our longterm studies, a seismotectonic zonation map of Eastern Siberia is compiled. The paper briefly reviews the methods of mapping and refers to data on active faults and neotectonic structures revealed in the area under study, which are closely related to regional earthquake sources.
文摘Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network security. From a random sequencing viewpoint, both sequences of HC-256 and real DNA data may have intrinsic pseudo-random properties respectively. In a recent decade, many DNA sequencing projects are developed on cells, plants and animals over the world into huge DNA databases. Researchers notice that mammalian genomes encode thousands of large noncoding RNAs (lncRNAs), interact with chromatin regulatory complexes, and are thought to play a role in localizing these complexes to target loci across the genome. It is a challenge target using higher dimensional visualization tools to organize various complex interactive properties as visual maps. The Variant Map System (VMS) as an emerging scheme is systematically proposed in this paper to apply multiple maps that used four Meta symbols as same as DNA or RNA representations. System architecture of key components and core mechanism on the VMS are described. Key modules, equations and their I/O parameters are discussed. Applying the VM System, two sets of real DNA sequences from both sample human (noncoding DNA) and corn (coding DNA) genomes are collected in comparison with pseudo DNA sequences generated by HC-256 to show their intrinsic properties in higher levels of similar relationships among relevant DNA sequences on 2D maps. Sample 2D maps are listed and their characteristics are illustrated under controllable environment. Visual results are briefly analyzed to explore their intrinsic properties on selected genome sequences.
文摘This contribution proposes a new combination symbol mapper/8-ary constellation, which is a joint optimization of an 8-ary signal constellation and its symbol mapping operation, to improve the performance of Bit Interleaved Coded Modulation with Iterative Decoding (BICM-ID). The basic idea was to use the so called (1,7) constellation (which is a capacitive efficient constellation) instead of the conventional 8-PSK constellation and to choose the most suitable mapping for it. A comparative study between the combinations most suitable mapping/(1,7) constellation and SSP mapping/conventional 8-PSK constellation has been carried out. Simulation results showed that the 1st combination significantly outperforms the 2nd combination and with only 4 iterations, it gives better performance than the 2nd combination with 8 iterations. A gain of 4 dB is given by iteration 4 of the 1st combination compared to iteration 8 of the 2nd combination at a BER level equal to 10-5, and it (iteration 4 of the 1st combination) can attain a BER equal to 10-7 for, only, a SNR = 5.6 dB.
文摘The relatively rapid recession of glaciers in the Himalayas and formation of moraine dammed glacial lakes(MDGLs) in the recent past have increased the risk of glacier lake outburst floods(GLOF) in the countries of Nepal and Bhutan and in the mountainous territory of Sikkim in India. As a product of climate change and global warming, such a risk has not only raised the level of threats to the habitation and infrastructure of the region, but has also contributed to the worsening of the balance of the unique ecosystem that exists in this domain that sustains several of the highest mountain peaks of the world. This study attempts to present an up to date mapping of the MDGLs in the central and eastern Himalayan regions using remote sensing data, with an objective to analyse their surface area variations with time from 1990 through 2015, disaggregated over six episodes. The study also includes the evaluation for susceptibility of MDGLs to GLOF with the least criteria decision analysis(LCDA). Forty two major MDGLs, each having a lake surface area greater than 0.2 km2, that were identified in the Himalayan ranges of Nepal, Bhutan, and Sikkim, have been categorized according to their surface area expansion rates in space and time. The lakes have been identified as located within the elevation range of 3800 m and6800 m above mean sea level(a msl). With a total surface area of 37.9 km2, these MDGLs as a whole were observed to have expanded by an astonishing 43.6% in area over the 25 year period of this study. A factor is introduced to numerically sort the lakes in terms of their relative yearly expansion rates, based on their interpretation of their surface area extents from satellite imageries. Verification of predicted GLOF events in the past using this factor with the limited field data as reported in literature indicates that the present analysis may be considered a sufficiently reliable and rapid technique for assessing the potential bursting susceptibility of the MDGLs. The analysis also indicates that, as of now, there are eight MDGLs in the region which appear to be in highly vulnerable states and have high chances in causing potential GLOF events anytime in the recent future.
文摘District Ghizer is a rugged mountainous territory which experiences several landslides each year. There are 16 major landslide areas and 53 villages that are at high risk to hazards. Keeping in view the severity of natural hazards, the present study was designed to generate landslide susceptibility map based on twelve causative factors viz., slope, aspect, elevation, drainage network, Stream Power Index (SPI), Topographic Wetness Index (TWI), lithological units, fault lines, rainfall, road network, land cover and soil texture. Soil texture was determined by particle size analysis and data for other factors were acquired from freely available sources. Analytical Hierarchy Process (AHP) was employed to identify major landslide causative factors in the district Ghizer. Further, a temporal assessment from 1999 till 2015 was generated to assess the impact of land cover change on landslides. It indicated that the barren soil/ exposed rocks and glaciers have reduced while the vegetation and water classes have shown increment. The total area that lies in moderate to very high landslide susceptible zones was 74.38%, while slope is the main landslide causative factor in the district Ghizer. Validation of the susceptibility map showed 88.1% of the landslides in the study area had occurred in the moderate to very high susceptible zones.
基金Israeli Centers of Research ExcellenceWellcome Trust,Grant/Award Number:085906/Z/08/Z,075491/Z/04,090532/Z/09/Z+1 种基金Edmond J.Safra Center for Bioinformatics at Tel-Aviv UniversityTel-Aviv University
文摘Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes.
基金Under the auspices of President Foundation of the Chinese Academy of Sciences(1999).
文摘ABSTRACT: This paper generalizes the makeup and forming dynamic mechanism of natural disaster systems, principles and methods of comprehensive division of natural disasters, as well as structure, function and up-build routes of map and file information visualization system (MFIVS). Taking the Changjiang(Yangtze) Valley as an example, on the basis of revealing up the integrated mechanism on the formations of its natural disasters and its distributing law, thereafter, the paper relies on the MFIVS technique, adopts two top-down and bottom-up approaches to study a comprehensive division of natural disasters. It is relatively objective and precise that the required division results include three natural disaster sections and nine natural disaster sub-sections, which can not only provide a scientific basis for utilizing natural resources and controlling natural disaster and environmental degradation, but also be illuminated to a concise, practical and effective technique on comprehensive division.
文摘A new methodology of comparing digital raster maps was proposed which allows not only detecting changes in the maps, but also obtaining quantitative measures of the importance of selected differences. Procedure of object interpretation of satellite images and forming of OMT (Object Map of Territory) is described. A list of allowable differences between two OMTs is defined. Two steps technique of quantitative measuring is proposed. At the first stage functions are constructed for calculating local measures of differences in the amount, areas and locations of objects on the map, as well as relations between the objects. In the second stage local measures are used to calculate the integral measure in order to get generalized assessment of difference between maps. The methods for constructing functions which calculate local and integral measures of differences are described. Examples of comparing and measuring the differences between OMTs are provided. Obtained results by utilizing this technique can be used to analyze trends, forecast of development and might be helpful for choosing most efficient scenarios for sustainable spatial planning and land management.
基金The National High Technology Research and Development Program (863) of China (No2006AA04Z259)The National Natural Sci-ence Foundation of China (No60643005)
文摘A hierarchical mobile robot simultaneous localization and mapping (SLAM) method that allows us to obtain accurate maps was presented. The local map level is composed of a set of local metric feature maps that are guaranteed to be statistically independent. The global level is a topological graph whose arcs are labeled with the relative location between local maps. An estimation of these relative locations is maintained with local map alignment algorithm, and more accurate estimation is calculated through a global minimization procedure using the loop closure constraint. The local map is built with Rao-Blackwellised particle filter (RBPF), where the particle filter is used to extending the path posterior by sampling new poses. The landmark position estimation and update is implemented through extended Kalman filter (EKF). Monocular vision mounted on the robot tracks the 3D natural point landmarks, which are structured with matching scale invariant feature transform (SIFT) feature pairs. The matching for multi-dimension SIFT features is implemented with a KD-tree in the time cost of O(lbN). Experiment results on Pioneer mobile robot in a real indoor environment show the superior performance of our proposed method.
